PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18810761-5	2008	Further studies demonstrated that La3+ treatment enhanced phosphorylation of extracellular signal-regulated kinase (ERK).	lanthanum(3+)	34-38	mitogen-activated protein kinase 1	Homo sapiens	77-114	
18810761-5	2008	Further studies demonstrated that La3+ treatment enhanced phosphorylation of extracellular signal-regulated kinase (ERK).	lanthanum(3+)	34-38	mitogen-activated protein kinase 1	Homo sapiens	116-119	
18810761-6	2008	Inhibition of ERK activation by U0126 suppressed the effects of La3+ on osteoblast activity.	lanthanum(3+)	64-68	mitogen-activated protein kinase 1	Homo sapiens	14-17	
18810761-7	2008	Moreover, pretreatment of the cells with pertussis toxin (PTx), a Gi protein inhibitor, suppressed the La3+-enhanced ERK phosphorylation and osteoblast differentiation.	lanthanum(3+)	103-107	mitogen-activated protein kinase 1	Homo sapiens	117-120	
18810761-8	2008	These findings suggest that La3+ exposure enhances in vitro osteoblast differentiation and the effect depends on ERK phosphorylation via PTx-sensitive Gi protein signaling.	lanthanum(3+)	28-32	mitogen-activated protein kinase 1	Homo sapiens	113-116	
16502327-3	2006	In the present work, it was found that La3+ could induce rapid extracellular signal-regulated kinase (ERK) phosphorylation in both HeLa cells and NIH 3T3 cells, but different mechanisms were involved.	lanthanum(3+)	39-43	mitogen-activated protein kinase 1	Homo sapiens	63-100	
16502327-3	2006	In the present work, it was found that La3+ could induce rapid extracellular signal-regulated kinase (ERK) phosphorylation in both HeLa cells and NIH 3T3 cells, but different mechanisms were involved.	lanthanum(3+)	39-43	mitogen-activated protein kinase 1	Homo sapiens	102-105	
16502327-4	2006	At a concentration of 30 microM or higher, La3+ enters the cells and activates ERK through a mechanism involving calmodulin activation inside the cells, which is similar to the action of intracellular Ca2+.	lanthanum(3+)	43-47	mitogen-activated protein kinase 1	Homo sapiens	79-82