PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19833734-5 2009 Using the crystal structure of CRIg in complex with C3b as a guide for library design, we isolated a CRIg-ECD double mutant (Q64R/M86Y, CRIg-v27) that showed increased binding affinity and improved complement inhibitory activity relative to CRIg-ECD. 1-D-glucopyranosyl cytosine 52-55 V-set and immunoglobulin domain containing 4 Mus musculus 31-35 19833734-5 2009 Using the crystal structure of CRIg in complex with C3b as a guide for library design, we isolated a CRIg-ECD double mutant (Q64R/M86Y, CRIg-v27) that showed increased binding affinity and improved complement inhibitory activity relative to CRIg-ECD. 1-D-glucopyranosyl cytosine 52-55 V-set and immunoglobulin domain containing 4 Mus musculus 101-109 19833734-5 2009 Using the crystal structure of CRIg in complex with C3b as a guide for library design, we isolated a CRIg-ECD double mutant (Q64R/M86Y, CRIg-v27) that showed increased binding affinity and improved complement inhibitory activity relative to CRIg-ECD. 1-D-glucopyranosyl cytosine 52-55 V-set and immunoglobulin domain containing 4 Mus musculus 101-105 19833734-5 2009 Using the crystal structure of CRIg in complex with C3b as a guide for library design, we isolated a CRIg-ECD double mutant (Q64R/M86Y, CRIg-v27) that showed increased binding affinity and improved complement inhibitory activity relative to CRIg-ECD. 1-D-glucopyranosyl cytosine 52-55 V-set and immunoglobulin domain containing 4 Mus musculus 241-249