PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16870173-0	2006	Ni(II) affects ubiquitination of core histones H2B and H2A.	Nickel(2+)	0-6	H2B clustered histone 21	Homo sapiens	47-50	
20358093-6	2010	Cu(2+) and Ni(2+) binding to the N-terminal tail of H2B causes a severe conformational change that might interfere with histone post-translational modifications, possibly leading to epigenetic changes.	Nickel(2+)	11-17	H2B clustered histone 21	Homo sapiens	52-55	
16870173-2	2006	Previously, we found that exposure of cells to Ni(II) resulted in truncation of histones H2A and H2B and thus elimination of some modification sites.	Nickel(2+)	47-53	H2B clustered histone 21	Homo sapiens	97-100	
16870173-3	2006	Here, we investigated the effect of Ni(II) on one such modification, ubiquitination, of histones H2B and H2A in nuclei of cultured 1HAEo- and HPL1D human lung cells.	Nickel(2+)	36-42	H2B clustered histone 21	Homo sapiens	97-100	
16870173-9	2006	Overall, our results suggest that dysregulation of H2B ubiquitination is a part of Ni(II) adverse effects on gene expression and DNA repair which may assist in cell transformation.	Nickel(2+)	83-89	H2B clustered histone 21	Homo sapiens	51-54