PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33096823-12 2020 The increase in [cAMP]i activates protein kinase A (PKA), followed by activation of the Src-epidermal growth factor receptor-Pphospholipase C (Src-EGFR-PLC) cascade, resulting in inositol-triphosphate (IP3) production, which mobilizes Ca2+ from the acrosome, causing a further increase in [Ca2+]i and the development of hyper-activated motility. Inositol triphosphate 179-200 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 88-91