PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20377791-5 2010 As in other cellular systems, proteases such as thrombin and trypsin activate PAR-1 and PAR-2 on neurons of the dorsal motor nucleus of the vagus (DMV), leading to an increase in intracellular calcium levels via signal transduction mechanisms involving activation of phospholipase C and inositol triphosphate (IP3). Inositol triphosphate 287-308 coagulation factor II thrombin receptor Homo sapiens 78-83