PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
1667954-5	1991	For the N-methyl-D-aspartate receptor this non-competitive antagonism probably arises through binding of toxin to the Mg2+ site(s) located in the channel gated by this receptor.	magnesium ion	118-122	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	8-37	
8642401-0	1996	Multiple structural elements determine subunit specificity of Mg2+ block in NMDA receptor channels.	magnesium ion	62-66	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	76-89	
8642401-1	1996	In NMDA receptor channels, subtype-specific differences of Mg2+ block are determined by the NR2 subunits.	magnesium ion	59-63	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	3-16	
8642401-11	1996	Moreover, three elements of the NR2 subunit are the major determinants of subtype-specific differences of Mg2+ block in heteromeric NMDA receptor channels.	magnesium ion	106-110	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	132-145	
8416947-3	1993	The NMDA receptor is distinct from other glutamate receptor channels because of its high Ca2+ permeability and inhibition by selective cationic channel blockers such as Mg2+, Zn2+, and MK-801.	magnesium ion	169-173	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	4-17	
8955083-6	1996	The unitary glutamate receptor has a unique set of properties that denote intersubunit interaction, including a glycine requirement for the responses to non-NMDA as well as to NMDA receptor agonists and voltage-dependent block by Mg2+ of the non-NMDA agonist responses.	magnesium ion	230-234	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	176-189	
7905294-4	1993	The inhibition was unaffected by the clamping-voltage and by a mutation [NR1-NR2A(N595Q)] that prevents the Mg(2+)-blockade of the channels, indicating that the mechanism of action of ethanol differs from that of Mg2+.	magnesium ion	108-114	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	73-76	
7679115-4	1993	Expression in Xenopus oocytes demonstrated that the single protein encoded by the cloned cDNA possesses the electrophysiological and pharmacological properties characteristic of the NMDA receptor, including Ca2+ permeability, voltage-dependent Mg2+ block, and inhibition by selective antagonists such as Zn2+ and channel blockers.	magnesium ion	244-248	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	182-195	
1532151-3	1992	Functional homomeric zeta 1 channels expressed in Xenopus oocytes by injection of the subunit-specific mRNA exhibit current responses characteristic for the NMDA receptor channel such as activation by glycine, Ca2+ permeability, blocking by Mg2+ and activation by polyamine.	magnesium ion	241-245	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	157-170	
12106136-12	1989	We conclude that the neurons rhythmically active in swimming have NMDA receptor channels which show a voltage dependent block in the presence of Mg2+.	magnesium ion	145-149	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	66-79	
19154422-7	2009	Voltage-dependent Mg(2+) block of NR2A(WT)- and NR2A(trunC)-containing NMDARs was similar but low concentrations of Mg(2+) (1 micromol.L(-1)) potentiated NR1/NR2A(delC) NMDARs.	magnesium ion	18-24	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	154-157	
11823786-8	2002	Moreover, NR1/NR3A or -3B receptors form relatively Ca2+-impermeable cation channels that are resistant to Mg2+, MK-801, memantine and competitive antagonists.	magnesium ion	107-111	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	10-13	
17962329-7	2008	Moreover, when responses mediated by NR1/NR2A NMDARs are evoked by the partial agonist homoquinolinate, rather than glutamate, Mg(2+) also displays an increased potency.	magnesium ion	127-133	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	37-40	
16894346-2	2006	Inhibition of NMDA receptor currents by 5-hydroxytryptamine (5-HT) indicated that 5-HT, similar to Mg2+, binds within the membrane electric field.	magnesium ion	99-103	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	14-27	
16894346-4	2006	EXPERIMENTAL APPROACH: The mode of action of 5-HT and Mg2+ on wild-type and mutated NMDA receptor-channels expressed in Xenopus oocytes was investigated using the two-electrode voltage clamp recording technique.	magnesium ion	54-58	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	84-97	
15920196-3	2005	Although the NR3B subunit prominently reduced the current amplitude of NR1/NR2A-B channels, the sensitivities of NR1/NR2A-B channels to Mg2+, ketamine, isoflurane, nitrous oxide, and ethanol were not altered by coexpression of the NR3B subunit.	magnesium ion	136-140	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	113-116	
15920196-5	2005	Mutations of two amino acid residues in the NR3B subunit at positions homologous to the N and N + 1 sites in the NR1 and NR2 subunits, which constitute the blocking sites for Mg2+ and ketamine, did not affect the sensitivities of NR1/NR2B/NR3B channels to Mg2+, ketamine and isoflurane.	magnesium ion	175-179	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	113-116	
18456253-1	2008	Mg2+ is known to gain access to the NMDA receptor channel from both the extra- and intracellular compartments.	magnesium ion	0-4	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	36-49	
18456253-8	2008	In conclusion, intracellular block of the NMDA receptor, as reported for Mg2+, is not of significance for the therapeutic effects of memantine.	magnesium ion	73-77	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	42-55	
10519509-9	1999	CONCLUSIONS: These results, together with previous findings, suggest that the low-affinity NMDA receptor antagonist activity is a common characteristic of various opioid compounds, and that the inhibition is a result of channel-block mechanisms at the site, which partially overlaps with those of Mg2+ and ketamine.	magnesium ion	297-301	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	91-104	
11323343-5	2001	Mg2+ and ketamine alone inhibited NMDA receptors noncompetitively (half-maximal inhibitory effect concentration: Mg2+ 4.2 +/- 1.2 x 10(-)(4) M at NR1/NR2A and 6.3 +/- 2.4 x 10(-)(4) M at NR1/NR2B; racemic ketamine 13.6 +/- 8.5 x 10(-)(6) M at NR1/NR2A and 17.6 +/- 7.2 x 10(-)(6) M at NR1/NR2B; S(+)-ketamine 4.1 +/- 2.5 x 10(-)(6) at NR1/NR2A and 3.0 +/- 0.3 at NR1/NR2B; R(-)-ketamine 24.4 +/- 4.1 x 10(-)(6) M at NR1/NR2A and 26.0 +/- 2.4 x 10(-)(6) M at NR1/NR2B).	magnesium ion	0-4	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	146-149	
11323343-5	2001	Mg2+ and ketamine alone inhibited NMDA receptors noncompetitively (half-maximal inhibitory effect concentration: Mg2+ 4.2 +/- 1.2 x 10(-)(4) M at NR1/NR2A and 6.3 +/- 2.4 x 10(-)(4) M at NR1/NR2B; racemic ketamine 13.6 +/- 8.5 x 10(-)(6) M at NR1/NR2A and 17.6 +/- 7.2 x 10(-)(6) M at NR1/NR2B; S(+)-ketamine 4.1 +/- 2.5 x 10(-)(6) at NR1/NR2A and 3.0 +/- 0.3 at NR1/NR2B; R(-)-ketamine 24.4 +/- 4.1 x 10(-)(6) M at NR1/NR2A and 26.0 +/- 2.4 x 10(-)(6) M at NR1/NR2B).	magnesium ion	0-4	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	187-190	
11323343-5	2001	Mg2+ and ketamine alone inhibited NMDA receptors noncompetitively (half-maximal inhibitory effect concentration: Mg2+ 4.2 +/- 1.2 x 10(-)(4) M at NR1/NR2A and 6.3 +/- 2.4 x 10(-)(4) M at NR1/NR2B; racemic ketamine 13.6 +/- 8.5 x 10(-)(6) M at NR1/NR2A and 17.6 +/- 7.2 x 10(-)(6) M at NR1/NR2B; S(+)-ketamine 4.1 +/- 2.5 x 10(-)(6) at NR1/NR2A and 3.0 +/- 0.3 at NR1/NR2B; R(-)-ketamine 24.4 +/- 4.1 x 10(-)(6) M at NR1/NR2A and 26.0 +/- 2.4 x 10(-)(6) M at NR1/NR2B).	magnesium ion	0-4	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	187-190	
11323343-5	2001	Mg2+ and ketamine alone inhibited NMDA receptors noncompetitively (half-maximal inhibitory effect concentration: Mg2+ 4.2 +/- 1.2 x 10(-)(4) M at NR1/NR2A and 6.3 +/- 2.4 x 10(-)(4) M at NR1/NR2B; racemic ketamine 13.6 +/- 8.5 x 10(-)(6) M at NR1/NR2A and 17.6 +/- 7.2 x 10(-)(6) M at NR1/NR2B; S(+)-ketamine 4.1 +/- 2.5 x 10(-)(6) at NR1/NR2A and 3.0 +/- 0.3 at NR1/NR2B; R(-)-ketamine 24.4 +/- 4.1 x 10(-)(6) M at NR1/NR2A and 26.0 +/- 2.4 x 10(-)(6) M at NR1/NR2B).	magnesium ion	0-4	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	187-190	
11323343-5	2001	Mg2+ and ketamine alone inhibited NMDA receptors noncompetitively (half-maximal inhibitory effect concentration: Mg2+ 4.2 +/- 1.2 x 10(-)(4) M at NR1/NR2A and 6.3 +/- 2.4 x 10(-)(4) M at NR1/NR2B; racemic ketamine 13.6 +/- 8.5 x 10(-)(6) M at NR1/NR2A and 17.6 +/- 7.2 x 10(-)(6) M at NR1/NR2B; S(+)-ketamine 4.1 +/- 2.5 x 10(-)(6) at NR1/NR2A and 3.0 +/- 0.3 at NR1/NR2B; R(-)-ketamine 24.4 +/- 4.1 x 10(-)(6) M at NR1/NR2A and 26.0 +/- 2.4 x 10(-)(6) M at NR1/NR2B).	magnesium ion	0-4	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	187-190	
11323343-5	2001	Mg2+ and ketamine alone inhibited NMDA receptors noncompetitively (half-maximal inhibitory effect concentration: Mg2+ 4.2 +/- 1.2 x 10(-)(4) M at NR1/NR2A and 6.3 +/- 2.4 x 10(-)(4) M at NR1/NR2B; racemic ketamine 13.6 +/- 8.5 x 10(-)(6) M at NR1/NR2A and 17.6 +/- 7.2 x 10(-)(6) M at NR1/NR2B; S(+)-ketamine 4.1 +/- 2.5 x 10(-)(6) at NR1/NR2A and 3.0 +/- 0.3 at NR1/NR2B; R(-)-ketamine 24.4 +/- 4.1 x 10(-)(6) M at NR1/NR2A and 26.0 +/- 2.4 x 10(-)(6) M at NR1/NR2B).	magnesium ion	0-4	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	187-190	
11323343-5	2001	Mg2+ and ketamine alone inhibited NMDA receptors noncompetitively (half-maximal inhibitory effect concentration: Mg2+ 4.2 +/- 1.2 x 10(-)(4) M at NR1/NR2A and 6.3 +/- 2.4 x 10(-)(4) M at NR1/NR2B; racemic ketamine 13.6 +/- 8.5 x 10(-)(6) M at NR1/NR2A and 17.6 +/- 7.2 x 10(-)(6) M at NR1/NR2B; S(+)-ketamine 4.1 +/- 2.5 x 10(-)(6) at NR1/NR2A and 3.0 +/- 0.3 at NR1/NR2B; R(-)-ketamine 24.4 +/- 4.1 x 10(-)(6) M at NR1/NR2A and 26.0 +/- 2.4 x 10(-)(6) M at NR1/NR2B).	magnesium ion	0-4	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	187-190	
11323343-5	2001	Mg2+ and ketamine alone inhibited NMDA receptors noncompetitively (half-maximal inhibitory effect concentration: Mg2+ 4.2 +/- 1.2 x 10(-)(4) M at NR1/NR2A and 6.3 +/- 2.4 x 10(-)(4) M at NR1/NR2B; racemic ketamine 13.6 +/- 8.5 x 10(-)(6) M at NR1/NR2A and 17.6 +/- 7.2 x 10(-)(6) M at NR1/NR2B; S(+)-ketamine 4.1 +/- 2.5 x 10(-)(6) at NR1/NR2A and 3.0 +/- 0.3 at NR1/NR2B; R(-)-ketamine 24.4 +/- 4.1 x 10(-)(6) M at NR1/NR2A and 26.0 +/- 2.4 x 10(-)(6) M at NR1/NR2B).	magnesium ion	0-4	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	187-190	
11323343-5	2001	Mg2+ and ketamine alone inhibited NMDA receptors noncompetitively (half-maximal inhibitory effect concentration: Mg2+ 4.2 +/- 1.2 x 10(-)(4) M at NR1/NR2A and 6.3 +/- 2.4 x 10(-)(4) M at NR1/NR2B; racemic ketamine 13.6 +/- 8.5 x 10(-)(6) M at NR1/NR2A and 17.6 +/- 7.2 x 10(-)(6) M at NR1/NR2B; S(+)-ketamine 4.1 +/- 2.5 x 10(-)(6) at NR1/NR2A and 3.0 +/- 0.3 at NR1/NR2B; R(-)-ketamine 24.4 +/- 4.1 x 10(-)(6) M at NR1/NR2A and 26.0 +/- 2.4 x 10(-)(6) M at NR1/NR2B).	magnesium ion	113-117	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	146-149	
11323343-8	2001	Ketamine and Mg2+ inhibit responses of recombinantly expressed NR1/NR2A and NR1/NR2B glutamate receptors, and combinations of the compounds act in a super-additive manner.	magnesium ion	13-17	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	63-66	
11323343-8	2001	Ketamine and Mg2+ inhibit responses of recombinantly expressed NR1/NR2A and NR1/NR2B glutamate receptors, and combinations of the compounds act in a super-additive manner.	magnesium ion	13-17	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	76-79	
11323343-10	2001	IMPLICATIONS: Ketamine and Mg2+ inhibit functioning of recombinantly expressed NR1/NR2A and NR1/NR2B glutamate receptors, and combinations of the compounds act in a super-additive manner.	magnesium ion	27-31	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	79-82	
11323343-10	2001	IMPLICATIONS: Ketamine and Mg2+ inhibit functioning of recombinantly expressed NR1/NR2A and NR1/NR2B glutamate receptors, and combinations of the compounds act in a super-additive manner.	magnesium ion	27-31	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	92-95	
11323344-7	2001	On both NR1/NR2A and NR1/NR2B receptors, 50% inhibitory concentration for volatile anesthetics was reduced approximately 20% by Mg2+, approximately 30% by S(+)-ketamine, and approximately 50% by the compounds in combination.	magnesium ion	128-132	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	8-11	
11323344-7	2001	On both NR1/NR2A and NR1/NR2B receptors, 50% inhibitory concentration for volatile anesthetics was reduced approximately 20% by Mg2+, approximately 30% by S(+)-ketamine, and approximately 50% by the compounds in combination.	magnesium ion	128-132	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	21-24	
11292060-2	2001	Mg2+ blocks the NMDA receptor by binding to the channel pore with an apparent affinity that depends on the membrane potential.	magnesium ion	0-4	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	16-29	
9707284-7	1998	These results, together with previous findings, suggest that the haloperidol block sites of the NMDA receptor channel partially overlap the Mg2+ block sites.	magnesium ion	140-144	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	96-109	
9481670-0	1998	Adjacent asparagines in the NR2-subunit of the NMDA receptor channel control the voltage-dependent block by extracellular Mg2+.	magnesium ion	122-126	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	47-60	
9490808-2	1998	The NMDA receptor channel is blocked by both external and internal Mg2+ ions, which are assumed to bind inside the channel on each side of a central barrier.	magnesium ion	67-71	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	4-17	
9490808-3	1998	We have analysed the internal Mg2+ block in recombinant NR1-NR2A NMDA receptors expressed in Xenopus oocytes.	magnesium ion	30-34	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	56-59	
9490808-8	1998	This suggests that the NR1 asparagine plays a larger role than the NR2 asparagine in controlling the internal Mg2+ block.	magnesium ion	110-114	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	23-26	
9490808-10	1998	Single-channel current-voltage relations confirm that the internal Mg2+ block is reduced in both the NR1 and NR2 mutants.	magnesium ion	67-71	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	101-104	
9490808-13	1998	The discrepancy between whole-cell and single-channel data is partly due to differential effects of internal Mg2+ on the open probabilities of the two conductance states present in NR1 mutant channels.	magnesium ion	109-113	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	181-184	
9490808-15	1998	The results suggest that mutations of NR1 and NR2 asparagines lower the central barrier to Mg2+.	magnesium ion	91-95	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	38-41	
9481670-25	1998	It is concluded that, at the narrow constriction in the NMDA receptor channel, the adjacent NR2A-subunit asparagines, the N-site and N + 1 site, but not the N-site asparagine of the NR1-subunit, form a critical blocking site for extracellular Mg2+.	magnesium ion	243-247	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	56-69	
9481671-3	1998	Amino acid residues positioned at or near the narrow constriction that interact with intracellular Mg2+ were identified in recombinant NR1-NR2A channels expressed in Xenopus oocytes or human embryonic kidney (HEK) 293 cells.	magnesium ion	99-103	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	135-138