PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
8608121-6	1996	The X-ray crystal structures of wild-type IDH soaked with photolabile caged isocitrate and Mg2+ and void of nicotinamide adenine dinucleotide phosphate were solved at 2.5 A resolution before and after photolysis and compared by difference mapping against previously determined enzyme structures.	magnesium ion	91-95	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	42-45	
34725432-5	2021	The isocitrate-Mg2+ complex is the preferred wt IDH1 substrate; with R132H IDH1, separate and weaker binding of 2-oxoglutarate and Mg2+ is preferred.	magnesium ion	15-19	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	48-52	
34725432-4	2021	Mg2+/Mn2+ ions enhance substrate binding to wt IDH1 and R132H IDH1, but with the former manifesting lower Mg2+/Mn2+ KMs.	magnesium ion	0-4	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	47-51	
34725432-4	2021	Mg2+/Mn2+ ions enhance substrate binding to wt IDH1 and R132H IDH1, but with the former manifesting lower Mg2+/Mn2+ KMs.	magnesium ion	0-4	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	62-66	
34725432-4	2021	Mg2+/Mn2+ ions enhance substrate binding to wt IDH1 and R132H IDH1, but with the former manifesting lower Mg2+/Mn2+ KMs.	magnesium ion	106-110	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	47-51	
34725432-4	2021	Mg2+/Mn2+ ions enhance substrate binding to wt IDH1 and R132H IDH1, but with the former manifesting lower Mg2+/Mn2+ KMs.	magnesium ion	106-110	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	62-66	
34725432-5	2021	The isocitrate-Mg2+ complex is the preferred wt IDH1 substrate; with R132H IDH1, separate and weaker binding of 2-oxoglutarate and Mg2+ is preferred.	magnesium ion	131-135	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	48-52	
34725432-5	2021	The isocitrate-Mg2+ complex is the preferred wt IDH1 substrate; with R132H IDH1, separate and weaker binding of 2-oxoglutarate and Mg2+ is preferred.	magnesium ion	131-135	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	75-79	
34725432-6	2021	Binding of R132H IDH1 inhibitors at the dimer interface weakens binding of active site Mg2+ complexes; their potency is affected by the Mg2+ concentration.	magnesium ion	87-91	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	17-21	
34725432-6	2021	Binding of R132H IDH1 inhibitors at the dimer interface weakens binding of active site Mg2+ complexes; their potency is affected by the Mg2+ concentration.	magnesium ion	136-140	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	17-21	
34725432-7	2021	Inhibitor selectivity for R132H IDH1 over wt IDH1 substantially arises from different stabilities of wt and R132H IDH1 substrate-Mg2+ complexes.	magnesium ion	129-133	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	32-36	
34725432-7	2021	Inhibitor selectivity for R132H IDH1 over wt IDH1 substantially arises from different stabilities of wt and R132H IDH1 substrate-Mg2+ complexes.	magnesium ion	129-133	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	45-49	
34725432-7	2021	Inhibitor selectivity for R132H IDH1 over wt IDH1 substantially arises from different stabilities of wt and R132H IDH1 substrate-Mg2+ complexes.	magnesium ion	129-133	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	114-118	
9211842-2	1997	The reaction trajectory of IDH was modified (i) after the adenine moiety of nicotinamide adenine dinucleotide phosphate was changed to hypoxanthine (the 6-amino was changed to 6-hydroxyl), and (ii) by replacing Mg2+, which has six coordinating ligands, with Ca2+, which has eight coordinating ligands.	magnesium ion	211-215	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	27-30	
29923039-7	2018	Inactivation of IDH by Cd2+ is less effective when the enzyme is activated with Cd2+ than Mg2+.	magnesium ion	90-94	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	16-19	
11284679-0	2001	Structural basis for a change in substrate specificity: crystal structure of S113E isocitrate dehydrogenase in a complex with isopropylmalate, Mg2+, and NADP.	magnesium ion	143-147	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	83-107