PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12501628-5 2000 The two methods correlated significantly, the correlation coefficient between DCC and IHC being 0.565 for ER and 0.563 for PR (P < 0.05). DICYCLOHEXYLCARBODIIMIDE 78-81 estrogen receptor 1 Homo sapiens 106-108 12462082-6 2002 The correlation between DCC and ICC was 81% (82/101) for ER and 74% (66/101) for PR. DICYCLOHEXYLCARBODIIMIDE 24-27 estrogen receptor 1 Homo sapiens 57-59 12355945-2 2002 In DCC, ER was quantitated with competition of 16 alpha-125I-estradiol and diethyl stilbesterol, and PgR with 3H-R5020 and R5020. DICYCLOHEXYLCARBODIIMIDE 3-6 estrogen receptor 1 Homo sapiens 8-10 12355945-8 2002 In multiple regression analysis for consistency of DCC and EIA, for ER, there was an inconsistent trend for positive PgR and a consistent trend for patients in their fifties. DICYCLOHEXYLCARBODIIMIDE 51-54 estrogen receptor 1 Homo sapiens 68-70 10511809-1 1999 From March 1988 to December 1990, we detected estrogen receptor (ER) from breast cancer tissues with the dextran-coated charcoal (DCC) method. DICYCLOHEXYLCARBODIIMIDE 130-133 estrogen receptor 1 Homo sapiens 46-63 10511809-1 1999 From March 1988 to December 1990, we detected estrogen receptor (ER) from breast cancer tissues with the dextran-coated charcoal (DCC) method. DICYCLOHEXYLCARBODIIMIDE 130-133 estrogen receptor 1 Homo sapiens 65-67 10511809-6 1999 The positive rates of ER with DCC, H222, 6F11 and 1D5 were 49%, 53%, 53% and 52% respectively, which were within the reported range. DICYCLOHEXYLCARBODIIMIDE 30-33 estrogen receptor 1 Homo sapiens 22-24 9358857-7 1997 This immunostaining index showed a strong semilogarithmic correlation with biochemical receptor assessments of ER (DCC, r = 0.70, p < 0.001; EIA, r = 0.76, p < 0.001) and even better of PR (DCC, r = 0.86; p < 0.01; EIA, r = 0.80, p < 0.001). DICYCLOHEXYLCARBODIIMIDE 115-118 estrogen receptor 1 Homo sapiens 111-113 9358857-8 1997 A strong linear correlation of ER and PR quantification was also seen between DCC and EIA techniques (ER, r = 0.62, p < 0.001; PR, r = 0.92, p < 0.001). DICYCLOHEXYLCARBODIIMIDE 78-81 estrogen receptor 1 Homo sapiens 31-33 9358857-8 1997 A strong linear correlation of ER and PR quantification was also seen between DCC and EIA techniques (ER, r = 0.62, p < 0.001; PR, r = 0.92, p < 0.001). DICYCLOHEXYLCARBODIIMIDE 78-81 estrogen receptor 1 Homo sapiens 102-104 2721525-1 1989 In 25 cases of breast cancer occurring in perimenopausal age, estrogen receptor (ER) content was determined by the dextran-coated charcoal (DCC) assay and both endogenous-bound estradiol and nuclear DNA concentrations were measured by computerized quantitative analysis on formalin-fixed paraffin-embedded tissue samples. DICYCLOHEXYLCARBODIIMIDE 140-143 estrogen receptor 1 Homo sapiens 81-83 8904314-4 1995 Using the dextran coated charcoal (DCC) method, the level of total cytosolic ER measured was 204 (+/- 2) fmol/mg protein. DICYCLOHEXYLCARBODIIMIDE 35-38 estrogen receptor 1 Homo sapiens 77-79 7579486-2 1995 PATIENTS AND METHODS: ER were determined by both the dextran-coated charcoal (DCC) method and immunohistochemistry (ICA) in 699 patients with primary breast cancer; other parameters (age, pathological T-pT- and nodal status -pN-, progesterone receptors by DCC, proliferative index by ICA) were also recorded. DICYCLOHEXYLCARBODIIMIDE 78-81 estrogen receptor 1 Homo sapiens 22-24 1371912-3 1992 ER protein was estimated by a dextran coated charcoal (DCC) assay and by an ER-immunocytochemical (ER-ICA) assay using a specific monoclonal antibody. DICYCLOHEXYLCARBODIIMIDE 55-58 estrogen receptor 1 Homo sapiens 0-2 1852132-6 1991 These results indicate that ER protein can be readily detected in enzyme-treated paraffin tissue sections and that the IHC detection of ER protein correlates highly with the DCC assay. DICYCLOHEXYLCARBODIIMIDE 174-177 estrogen receptor 1 Homo sapiens 136-138 2137212-3 1990 The ER level by the DCC method was significantly decreased in the TMA, the MPA and the E2 groups. DICYCLOHEXYLCARBODIIMIDE 20-23 estrogen receptor 1 Homo sapiens 4-6 2462564-5 1988 Since the ER-ICA can be easily handled without radioactivity being involved and since it is more representative of the total tumor, we conclude (as other groups before us) that the ER-ICA is an easy-to-handle and reliable technique presenting many advantages over the DCC method. DICYCLOHEXYLCARBODIIMIDE 268-271 estrogen receptor 1 Homo sapiens 181-183 2480241-1 1989 The estrogen receptor content in 100 female breast carcinomas was determined using the biochemical dextran-coated charcoal (DCC) method and the monoclonal estrogen receptor immunocytochemical assay (ER-ICA). DICYCLOHEXYLCARBODIIMIDE 124-127 estrogen receptor 1 Homo sapiens 4-21 2529423-3 1989 The ER level by the DCC method significantly decreased in the TMA, the MPA and the E2 groups. DICYCLOHEXYLCARBODIIMIDE 20-23 estrogen receptor 1 Homo sapiens 4-6 11091756-5 1996 When the main carcinoma was small in size (less than 2.5 cm in diameter), and showed papillotubular carcinoma as the histological type or had estrogen receptor (ER) by the dextran-coated charcoal (DCC) method, the incidence of latent carcinoma was high. DICYCLOHEXYLCARBODIIMIDE 197-200 estrogen receptor 1 Homo sapiens 142-159 8640700-1 1996 BACKGROUND: Historically, estrogen receptor (ER) determinations have been made by the ligand-binding assay of tumor homogenates, primarily by the dextran-coated charcoal method (DCC). DICYCLOHEXYLCARBODIIMIDE 178-181 estrogen receptor 1 Homo sapiens 26-43 2482565-3 1989 The objective of the study was to characterize a low-cost and reliable working standard material for quality control of estrogen receptor (ER) determination with dextran-coated charcoal (DCC) and enzyme immunoassay (EIA) methods. DICYCLOHEXYLCARBODIIMIDE 187-190 estrogen receptor 1 Homo sapiens 139-141 2514309-1 1989 Estrogen receptor (ER) expression was investigated by ER-immunocytochemical assay (ICA) and the dextran coated charcoal (DCC) method in 10 recurrent or primary-advanced breast cancer patients treated with endocrine or chemo-endocrine therapy. DICYCLOHEXYLCARBODIIMIDE 121-124 estrogen receptor 1 Homo sapiens 19-21 2468075-5 1989 ER positive level of DCC method was seen in 62 percent of the cases. DICYCLOHEXYLCARBODIIMIDE 21-24 estrogen receptor 1 Homo sapiens 0-2 2845868-2 1988 Using the DCC method, estrogen receptor activity was detected in 6 of 26 cases (23.1%) with gastric carcinoma, 3 of 16 hepatocellular carcinoma cases (18.8%), 1 of 3 gallbladder carcinoma cases (33.3%), and both of the 2 cases (100%) with normal liver tissue. DICYCLOHEXYLCARBODIIMIDE 10-13 estrogen receptor 1 Homo sapiens 22-39 2417397-5 1986 The concomitant increase in estradiol binding and decrease in protein concentration in both homogenate or cytosol after DCC treatment indicate the possible removal of some protein(s) which inactivate(s) the estradiol receptor. DICYCLOHEXYLCARBODIIMIDE 120-123 estrogen receptor 1 Homo sapiens 207-225 2830006-9 1988 A statistically significant higher number of ER-positive carcinomas in ER-ICA and dextran-coated charcoal assay (DCC) occurred when elastic tissue was present. DICYCLOHEXYLCARBODIIMIDE 113-116 estrogen receptor 1 Homo sapiens 45-47 3064778-6 1988 The results show that the qualitative detection of ER, obtained by the ERICA-assay and the DCC-assay has a concordance of about 90% for all the participating departments. DICYCLOHEXYLCARBODIIMIDE 91-94 estrogen receptor 1 Homo sapiens 51-53 3276143-4 1988 The semiquantitative degree of ERICA positivity correlated with the concentration of estrogen receptor by DCC. DICYCLOHEXYLCARBODIIMIDE 106-109 estrogen receptor 1 Homo sapiens 85-102 2428544-2 1986 We first documented that ER so measured agreed with results by established radioligand-based assays [dextran-coated charcoal (DCC) and hydroxylapatite (HAP)] for in-house breast carcinomas and for proficiency testing specimens. DICYCLOHEXYLCARBODIIMIDE 126-129 estrogen receptor 1 Homo sapiens 25-27 2426418-1 1986 We developed an immunoperoxidase technique using a monoclonal antibody to the estradiol receptor (ER) to identify immunoreactive ER (iER) in breast carcinomas and compared this with the conventional dextran-coated charcoal (DCC) steroid binding assay. DICYCLOHEXYLCARBODIIMIDE 224-227 estrogen receptor 1 Homo sapiens 98-100 3708571-7 1986 A series of human breast tumor biopsies assayed by MCG at 0.1 mg protein per ml gave about the same ER values (fmol/mg) as at 1 mg/ml, while the DCC efficiency for ER at the lower concentration averaged only 32%. DICYCLOHEXYLCARBODIIMIDE 145-148 estrogen receptor 1 Homo sapiens 164-166 2884137-2 1987 The method utilized to determine the presence of estrogen receptor was cytosol protein-counting and Dextran coated charcoal (DCC) saturation analysis. DICYCLOHEXYLCARBODIIMIDE 125-128 estrogen receptor 1 Homo sapiens 49-66 2435857-5 1987 Measurement of immunoreactive ER by monoclonal antibody method provides certain advantages over the conventional dextran-coated charcoal (DCC) method, especially in ER-/PR+ tumors. DICYCLOHEXYLCARBODIIMIDE 138-141 estrogen receptor 1 Homo sapiens 30-32 3539025-2 1986 The rates of coincidence of positivity and negativity of ER between the DCC method and EIA or RIA in 30 human breast tumors were 96.7% (29/30) and 86.7% (26/30), respectively. DICYCLOHEXYLCARBODIIMIDE 72-75 estrogen receptor 1 Homo sapiens 57-59 3539025-3 1986 A highly significant positive correlation was observed between ER values obtained by the DCC method and those by EIA (r = 0.87, P less than 0.001). DICYCLOHEXYLCARBODIIMIDE 89-92 estrogen receptor 1 Homo sapiens 63-65 3539025-4 1986 On the other hand, the correlation between ER values obtained by the DCC method and those by RIA was less significant (r = 0.41, P less than 0.05). DICYCLOHEXYLCARBODIIMIDE 69-72 estrogen receptor 1 Homo sapiens 43-45 3708571-3 1986 For estrogen receptor (ER), as for progesterone receptor, the efficiency of the standard dextran-coated charcoal (DCC) assay drops rapidly as samples are diluted much below 1 mg protein per ml. DICYCLOHEXYLCARBODIIMIDE 114-117 estrogen receptor 1 Homo sapiens 4-21 3708571-3 1986 For estrogen receptor (ER), as for progesterone receptor, the efficiency of the standard dextran-coated charcoal (DCC) assay drops rapidly as samples are diluted much below 1 mg protein per ml. DICYCLOHEXYLCARBODIIMIDE 114-117 estrogen receptor 1 Homo sapiens 23-25 6311560-4 1983 The [3H]-water and the ring-substituted radiolabeled products possessed several characteristics of a genuine estrogen receptor protein in that they were resistant to dextran-coated charcoal (DCC) adsorption and their enzymatic formation was inhibited with non-steroidal estrogens like diethylstilbestrol. DICYCLOHEXYLCARBODIIMIDE 191-194 estrogen receptor 1 Homo sapiens 109-126 17380454-2 2007 METHODS: ER was measured in fresh colorectal cancer tissues by Dextran-coated charcoal (DCC) assay. DICYCLOHEXYLCARBODIIMIDE 88-91 estrogen receptor 1 Homo sapiens 9-11 16317583-2 2006 More precisely, analytical methods for ER determination have changed over the last two decades from ligand binding assay (LBA) dextran-coated charcoal (DCC) to enzyme immuno-assay (EIA) and more recently immunohistochemistry (IHC). DICYCLOHEXYLCARBODIIMIDE 152-155 estrogen receptor 1 Homo sapiens 39-41 16317583-6 2006 ER negativity was 20, 13 and 10% in LBA-DCC, EIA, IHC, respectively. DICYCLOHEXYLCARBODIIMIDE 40-43 estrogen receptor 1 Homo sapiens 0-2