PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28938488-10	2017	BRCA mutations were associated with increased DNA DSBs in primordial follicle oocytes (62% +- 5.2% vs 36% +- 3.4%; P = 0.0005).	1,2-di-(4-sulfamidophenyl)-4-butylpyrazolidine-3,5-dione	50-54	BRCA1 DNA repair associated	Homo sapiens	0-4	
23122415-5	2012	H2A.Z exchange at DSBs shifts the chromatin to an open conformation and is required for acetylation and ubiquitination of histones and for loading of the brca1 complex.	1,2-di-(4-sulfamidophenyl)-4-butylpyrazolidine-3,5-dione	18-22	BRCA1 DNA repair associated	Homo sapiens	154-159	
21135055-9	2011	CONCLUSION: BRCA1 loss as assessed by CGH analysis can identify patients with substantially improved outcome after adjuvant DSB-inducing chemotherapy when compared with standard anthracycline-based chemotherapy in our series.	1,2-di-(4-sulfamidophenyl)-4-butylpyrazolidine-3,5-dione	124-127	BRCA1 DNA repair associated	Homo sapiens	12-17	
34419699-4	2021	In particular, sensitivity characterized cells harboring mutations in the hereditary breast/ovarian cancer genes, BRCA1 or BRCA2, that function in the repair of DSBs by homologous recombination (HR).	1,2-di-(4-sulfamidophenyl)-4-butylpyrazolidine-3,5-dione	161-165	BRCA1 DNA repair associated	Homo sapiens	114-119	
34419699-5	2021	Along with functions in HR, BRCA proteins were found to prevent DSBs by protecting stalled replication forks from nuclease degradation.	1,2-di-(4-sulfamidophenyl)-4-butylpyrazolidine-3,5-dione	64-68	BRCA1 DNA repair associated	Homo sapiens	28-32	
34419699-6	2021	Coming full-circle, BRCA mutant cancer cells that gained resistance to genotoxic chemotherapy often displayed restored DNA repair by HR and/or restored fork protection (FP) implicating that the therapy was tolerated when DSB repair was intact or DSBs were prevented.	1,2-di-(4-sulfamidophenyl)-4-butylpyrazolidine-3,5-dione	246-250	BRCA1 DNA repair associated	Homo sapiens	20-24	
34998176-5	2022	Wwox deficiency, instead, leads to early formation of the Brca1-CtIP/MRN complex at induced DSBs, stimulating immediate post-IR end-resection.	1,2-di-(4-sulfamidophenyl)-4-butylpyrazolidine-3,5-dione	92-96	BRCA1 DNA repair associated	Homo sapiens	58-63	
32041954-4	2020	Here we show that depleting 53BP1 in BRCA1-null cells restores PALB2 accrual at resected DSBs.	1,2-di-(4-sulfamidophenyl)-4-butylpyrazolidine-3,5-dione	89-93	BRCA1 DNA repair associated	Homo sapiens	37-42	
31447348-3	2019	Mechanistically, LMO2 inhibits BRCA1 recruitment to DSBs by interacting with 53BP1 during repair.	1,2-di-(4-sulfamidophenyl)-4-butylpyrazolidine-3,5-dione	52-56	BRCA1 DNA repair associated	Homo sapiens	31-36	
34224374-6	2021	In this issue of Cancer Research, Zhou and colleagues revealed a novel synthetic lethal approach in which the greater dependency on HR to repair clustered DSBs induced by protons is exploited to enhance killing of tumor cells and tumor xenografts by suppressing HR with an ATM inhibitor or mutant BRCA1.	1,2-di-(4-sulfamidophenyl)-4-butylpyrazolidine-3,5-dione	155-159	BRCA1 DNA repair associated	Homo sapiens	297-302	
31822904-10	2020	In both women with BRCA mutations and BRCA-mutant mice, primordial follicle numbers are reduced and there is accelerated accumulation of DNA DSBs in oocytes.	1,2-di-(4-sulfamidophenyl)-4-butylpyrazolidine-3,5-dione	141-145	BRCA1 DNA repair associated	Homo sapiens	19-23	
31822904-10	2020	In both women with BRCA mutations and BRCA-mutant mice, primordial follicle numbers are reduced and there is accelerated accumulation of DNA DSBs in oocytes.	1,2-di-(4-sulfamidophenyl)-4-butylpyrazolidine-3,5-dione	141-145	BRCA1 DNA repair associated	Homo sapiens	38-42	
26383678-5	2015	Given that DSBs represent the most biologically significant lesions induced by ionizing radiation and that impaired DSB repair leads to radiation sensitivity, it has been expected that cancer patients with BRCA1 mutations should benefit from radiation therapy.	1,2-di-(4-sulfamidophenyl)-4-butylpyrazolidine-3,5-dione	11-15	BRCA1 DNA repair associated	Homo sapiens	206-211	
27655732-8	2016	In p53-deficient cells, diminished localization of 53BP1 is accompanied by a reciprocal increase in BRCA1 recruitment to DSBs.	1,2-di-(4-sulfamidophenyl)-4-butylpyrazolidine-3,5-dione	121-125	BRCA1 DNA repair associated	Homo sapiens	100-105	
24413181-10	2014	These results suggest that triapine augments the sensitivity of BRCA wild-type EOC cells to drug-induced DSBs by disrupting CtIP-mediated HRR.	1,2-di-(4-sulfamidophenyl)-4-butylpyrazolidine-3,5-dione	105-109	BRCA1 DNA repair associated	Homo sapiens	64-68