PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33081556-0 2020 Honokiol ameliorates radiation-induced brain injury via the activation of SIRT3. honokiol 0-8 sirtuin 3 Mus musculus 74-79 33081556-6 2020 Furthermore, HKL treatment increased the expression of SIRT3 and decreased the expression of COX-2. honokiol 13-16 sirtuin 3 Mus musculus 55-60 33081556-7 2020 The radioprotective effects of HKL were achieved via SIRT3 activation. honokiol 31-34 sirtuin 3 Mus musculus 53-58 32439965-4 2020 Honokiol is a natural biphenolic compound that, by activating mitochondrial SIRT3, can carry out anti-oxidant, anti-inflammatory and anti-fibrotic activities. honokiol 0-8 sirtuin 3 Mus musculus 76-81 32439965-9 2020 Selective activation of SIRT3 through honokiol administration translated into the attenuation of albuminuria, amelioration of glomerular damage, and a reduction in podocyte injury. honokiol 38-46 sirtuin 3 Mus musculus 24-29 32281286-8 2020 The activation of Sirt3 by honokiol could improve FAO and renal function and reduced fatty acid deposition in wide-type mice, but not Sirt3-defective mice. honokiol 27-35 sirtuin 3 Mus musculus 18-23 32281286-10 2020 Also, the activation of Sirt3 by honokiol increased ATP production as well as reduced ROS and lipid peroxidation through improving mitochondrial function. honokiol 33-41 sirtuin 3 Mus musculus 24-29 32922930-6 2020 The pharmacological agonist of SIRT3, Honokiol (HKL), was injected in an intraperitoneal manner (10 mg/kg) immediately after the operation. honokiol 38-46 sirtuin 3 Mus musculus 31-36 32922930-6 2020 The pharmacological agonist of SIRT3, Honokiol (HKL), was injected in an intraperitoneal manner (10 mg/kg) immediately after the operation. honokiol 48-51 sirtuin 3 Mus musculus 31-36 32922930-11 2020 Result: SIRT3 was downregulated after SAH, and additional treatment of SIRT3 agonist HKL alleviated brain edema and neurobehavioral deficits after SAH. honokiol 85-88 sirtuin 3 Mus musculus 8-13 32922930-11 2020 Result: SIRT3 was downregulated after SAH, and additional treatment of SIRT3 agonist HKL alleviated brain edema and neurobehavioral deficits after SAH. honokiol 85-88 sirtuin 3 Mus musculus 71-76 29865070-0 2018 Honokiol Alleviates Cognitive Deficits of Alzheimer"s Disease (PS1V97L) Transgenic Mice by Activating Mitochondrial SIRT3. honokiol 0-8 sirtuin 3 Mus musculus 116-121 30296006-0 2019 SIRT3 activator honokiol ameliorates surgery/anesthesia-induced cognitive decline in mice through anti-oxidative stress and anti-inflammatory in hippocampus. honokiol 16-24 sirtuin 3 Mus musculus 0-5 30296006-2 2019 Honokiol (HNK), as an activator of Sirtuin3 (SIRT3), has potential multiple biological functions. honokiol 0-8 sirtuin 3 Mus musculus 35-43 30296006-2 2019 Honokiol (HNK), as an activator of Sirtuin3 (SIRT3), has potential multiple biological functions. honokiol 0-8 sirtuin 3 Mus musculus 45-50 30296006-13 2019 CONCLUSIONS: These results suggested that activation of SIRT3 by honokiol may attenuate surgery/anesthesia-induced cognitive impairment in mice through regulation of oxidative stress and neuroinflammatory in hippocampus. honokiol 65-73 sirtuin 3 Mus musculus 56-61 30523227-0 2018 [Honokiol attenuates lipopolysaccharide-induced acute respiratory distress syndrome via activation of mitochondrion-dependent Sirt3/AMPK pathway]. honokiol 1-9 sirtuin 3 Mus musculus 126-131 30036533-0 2018 Honokiol protects hepatocytes from oxidative injury through mitochondrial deacetylase SIRT3. honokiol 0-8 sirtuin 3 Mus musculus 86-91 30036533-4 2018 This study aims to evaluate the hepatoprotective potential of honokiol against oxidative injury in tert-butyl hydroperoxide (t-BHP)-injured AML12 hepatocytes in vitro and carbon tetrachloride (CCl4)-stimulated liver damaged mice in vivo and to determine whether or not this effect occurs by activating SIRT3. honokiol 62-70 sirtuin 3 Mus musculus 302-307 30036533-5 2018 The results showed honokiol protects t-BHP-injured AML12 hepatocytes and CCl4-stimulated liver damage in mice by activating SIRT3. honokiol 19-27 sirtuin 3 Mus musculus 124-129 30036533-9 2018 These results suggest that honokiol can ameliorate oxidative damage in hepatocytes by activating SIRT3, which might be a potential therapeutic agent for liver oxidative injury. honokiol 27-35 sirtuin 3 Mus musculus 97-102 34202229-6 2021 Further, pharmacologic SIRT3 inducers (i.e., resveratrol, viniferin, and honokiol) each diminish oxidant-induced AEC mtDNA damage in vitro and, in the case of honokiol, protection occurs in a SIRT3-dependent manner. honokiol 73-81 sirtuin 3 Mus musculus 23-28 28465484-7 2017 In addition, honokiol (HKL), a major bioactive compound isolated from Magnolia officinalis (Houpo), suppressed AngII-induced renal fibrosis through activating SIRT3-KLF15 signaling. honokiol 13-21 sirtuin 3 Mus musculus 159-164 28465484-7 2017 In addition, honokiol (HKL), a major bioactive compound isolated from Magnolia officinalis (Houpo), suppressed AngII-induced renal fibrosis through activating SIRT3-KLF15 signaling. honokiol 23-26 sirtuin 3 Mus musculus 159-164 28423723-0 2017 Honokiol, an activator of Sirtuin-3 (SIRT3) preserves mitochondria and protects the heart from doxorubicin-induced cardiomyopathy in mice. honokiol 0-8 sirtuin 3 Mus musculus 26-35 28423723-0 2017 Honokiol, an activator of Sirtuin-3 (SIRT3) preserves mitochondria and protects the heart from doxorubicin-induced cardiomyopathy in mice. honokiol 0-8 sirtuin 3 Mus musculus 37-42 28423723-4 2017 We have recently identified honokiol (HKL) as an activator of SIRT3, which protects the heart from developing pressure overload hypertrophy. honokiol 28-36 sirtuin 3 Mus musculus 62-67 28423723-4 2017 We have recently identified honokiol (HKL) as an activator of SIRT3, which protects the heart from developing pressure overload hypertrophy. honokiol 38-41 sirtuin 3 Mus musculus 62-67 34752757-6 2022 Meanwhile, HKL-treated mice displayed much higher hippocampal expression and activity of mitochondrial sirtuin 3 (SIRT3). honokiol 11-14 sirtuin 3 Mus musculus 103-112 34752757-6 2022 Meanwhile, HKL-treated mice displayed much higher hippocampal expression and activity of mitochondrial sirtuin 3 (SIRT3). honokiol 11-14 sirtuin 3 Mus musculus 114-119 34518519-8 2021 The activation of SIRT3 by honokiol ameliorated acetylation and prevented renal fibrosis. honokiol 27-35 sirtuin 3 Mus musculus 18-23 25871545-0 2015 Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3. honokiol 0-8 sirtuin 3 Mus musculus 85-90 25871545-3 2015 Our data suggest that the anti-hypertrophic effects of HKL depend on activation of the deacetylase Sirt3. honokiol 55-58 sirtuin 3 Mus musculus 99-104 25871545-7 2015 Moreover, HKL-treatment blocks cardiac fibroblast proliferation and differentiation to myofibroblasts in a Sirt3-dependent manner. honokiol 10-13 sirtuin 3 Mus musculus 107-112 25871545-8 2015 These results suggest that HKL is a pharmacological activator of Sirt3 capable of blocking, and even reversing, the cardiac hypertrophic response. honokiol 27-30 sirtuin 3 Mus musculus 65-70 34758848-0 2021 Honokiol attenuates lipotoxicity in hepatocytes via activating SIRT3-AMPK mediated lipophagy. honokiol 0-8 sirtuin 3 Mus musculus 63-68 34287090-8 2021 Pharmacological activation of Sirt3, both invitro and in vivo, by Honokiol (HK), a known activator of Sirt3, abrogated the inhibitory effect of iron overload on active beta-catenin expression and prevented the iron induced upregulation of alphaSMA and TGFbeta expression. honokiol 66-74 sirtuin 3 Mus musculus 30-35 34287090-8 2021 Pharmacological activation of Sirt3, both invitro and in vivo, by Honokiol (HK), a known activator of Sirt3, abrogated the inhibitory effect of iron overload on active beta-catenin expression and prevented the iron induced upregulation of alphaSMA and TGFbeta expression. honokiol 66-74 sirtuin 3 Mus musculus 102-107 34202229-6 2021 Further, pharmacologic SIRT3 inducers (i.e., resveratrol, viniferin, and honokiol) each diminish oxidant-induced AEC mtDNA damage in vitro and, in the case of honokiol, protection occurs in a SIRT3-dependent manner. honokiol 73-81 sirtuin 3 Mus musculus 192-197 34202229-6 2021 Further, pharmacologic SIRT3 inducers (i.e., resveratrol, viniferin, and honokiol) each diminish oxidant-induced AEC mtDNA damage in vitro and, in the case of honokiol, protection occurs in a SIRT3-dependent manner. honokiol 159-167 sirtuin 3 Mus musculus 192-197 35264952-2 2022 Honokiol (HK) has previously been reported to improve myocardial ischemia/reperfusion injury and reverse myocardial hypertrophy by activating Sirt1 and Sirt3. honokiol 0-8 sirtuin 3 Mus musculus 152-157