PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26674084-11	2015	The phosphorylations of the IRbeta and the downstream insulin signaling factors including AKT and ERK1/2 significantly increase in adipose, skeletal muscle, and liver tissue of the honokiol-treated mice.	honokiol	181-189	mitogen-activated protein kinase 3	Mus musculus	98-104	
33902432-13	2021	Meanwhile, the inhibitory effect of miR-27a-3p inhibitor on osteogenic differentiation was reversed by knockdown of CRY2 or using honokiol (ERK1/2 signal activator).	honokiol	130-138	mitogen-activated protein kinase 3	Mus musculus	140-146	
31115492-11	2019	Using Honokiol and FR180204, the activator and inhibitor of ERK1/2, respectively, it was then revealed that Honokiol partially eliminated the decrease in HGF expression, whereas FR180204 further promoted the reduction in HGF caused by NMDA.	honokiol	108-116	mitogen-activated protein kinase 3	Mus musculus	60-66	
26454217-0	2016	Honokiol induces autophagy of neuroblastoma cells through activating the PI3K/Akt/mTOR and endoplasmic reticular stress/ERK1/2 signaling pathways and suppressing cell migration.	honokiol	0-8	mitogen-activated protein kinase 3	Mus musculus	120-126	
26454217-10	2016	Consequently, honokiol stimulated phosphorylation of extracellular signal-regulated kinase (ERK)1/2.	honokiol	14-22	mitogen-activated protein kinase 3	Mus musculus	53-99	
26454217-11	2016	However, pretreatment of neuro-2a cells with PD98059, an inhibitor of ERK1/2, lowered honokiol-induced autophagy.	honokiol	86-94	mitogen-activated protein kinase 3	Mus musculus	70-76	
26454217-14	2016	Taken together, this study showed that honokiol can induce autophagy of neuroblastoma cells and consequent apoptosis through activating the PI3K/Akt/mTOR and ERS/ROS/ERK1/2 signaling pathways and suppressing cell migration.	honokiol	39-47	mitogen-activated protein kinase 3	Mus musculus	166-172	
26674084-12	2015	Moreover, honokiol enhanced the insulin-stimulated phosphorylations of IRbeta, AKT, and ERK1/2 in a dose-dependent manner in C2C12 myotube cells.	honokiol	10-18	mitogen-activated protein kinase 3	Mus musculus	88-94	
20192217-3	2010	At the same time, honokiol not only inhibited nitric oxide expression in LPS-stimulated murine macrophages but also inhibited the LPS-induced phosphorylation of ERK1/2, JNK1/2, and p38.	honokiol	18-26	mitogen-activated protein kinase 3	Mus musculus	161-167	
25912802-8	2015	Mechanistic investigations revealed that honokiol could markedly reverse the amount of phosphorylated Akt and extracellular regulated kinases 1/2 (ERK1/2) changes in the brain of the SCOP-treated mice.	honokiol	41-49	mitogen-activated protein kinase 3	Mus musculus	147-153