PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
3456582-7	1986	The first step in the rescue of protein synthesis in inhibited lysates by hemin or MgGTP is the inhibition of heme-regulated eIF-2 alpha kinase, which enables endogenous phosphatase to dephosphorylate eIF-2(alpha P) and [RF .	Hemin	74-79	eukaryotic translation initiation factor 2 subunit beta	Homo sapiens	125-130	
7911326-5	1994	However, only hemin, and not p67, inhibited casein kinase catalyzed phosphorylation of eIF-2 beta-subunit.	Hemin	14-19	eukaryotic translation initiation factor 2 subunit beta	Homo sapiens	87-97	
3170604-1	1988	The inhibitions of protein synthesis initiation in heme-deficient reticulocyte lysates and in GSSG-treated hemin-supplemented lysates are both characterized by the activation of heme-regulated eIF-2 alpha kinase, which phosphorylates the alpha-subunit of eukaryotic initiation factor (eIF-2).	Hemin	107-112	eukaryotic translation initiation factor 2 subunit beta	Homo sapiens	193-198	
3170604-1	1988	The inhibitions of protein synthesis initiation in heme-deficient reticulocyte lysates and in GSSG-treated hemin-supplemented lysates are both characterized by the activation of heme-regulated eIF-2 alpha kinase, which phosphorylates the alpha-subunit of eukaryotic initiation factor (eIF-2).	Hemin	107-112	eukaryotic translation initiation factor 2 subunit beta	Homo sapiens	285-290	
3700391-10	1986	These results suggest that regulation of the protein kinase phosphorylating the alpha subunit of eIF-2 is not the only point at which hemin modulates protein synthesis in reticulocytes and reticulocyte lysates, since a correlation between inhibition of protein synthesis, inhibition of protein kinase activity, and phosphorylation of eIF-2 is not observed with all porphyrins.	Hemin	134-139	eukaryotic translation initiation factor 2 subunit beta	Homo sapiens	97-102	
223849-9	1979	Thus, hemin prevents the activation of eIF-2 kinase by inhibiting the cAMP-dependent protein kinase.	Hemin	6-11	eukaryotic translation initiation factor 2 subunit beta	Homo sapiens	39-44