PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 3456582-7 1986 The first step in the rescue of protein synthesis in inhibited lysates by hemin or MgGTP is the inhibition of heme-regulated eIF-2 alpha kinase, which enables endogenous phosphatase to dephosphorylate eIF-2(alpha P) and [RF . Hemin 74-79 eukaryotic translation initiation factor 2 subunit beta Homo sapiens 125-130 7911326-5 1994 However, only hemin, and not p67, inhibited casein kinase catalyzed phosphorylation of eIF-2 beta-subunit. Hemin 14-19 eukaryotic translation initiation factor 2 subunit beta Homo sapiens 87-97 3170604-1 1988 The inhibitions of protein synthesis initiation in heme-deficient reticulocyte lysates and in GSSG-treated hemin-supplemented lysates are both characterized by the activation of heme-regulated eIF-2 alpha kinase, which phosphorylates the alpha-subunit of eukaryotic initiation factor (eIF-2). Hemin 107-112 eukaryotic translation initiation factor 2 subunit beta Homo sapiens 193-198 3170604-1 1988 The inhibitions of protein synthesis initiation in heme-deficient reticulocyte lysates and in GSSG-treated hemin-supplemented lysates are both characterized by the activation of heme-regulated eIF-2 alpha kinase, which phosphorylates the alpha-subunit of eukaryotic initiation factor (eIF-2). Hemin 107-112 eukaryotic translation initiation factor 2 subunit beta Homo sapiens 285-290 3700391-10 1986 These results suggest that regulation of the protein kinase phosphorylating the alpha subunit of eIF-2 is not the only point at which hemin modulates protein synthesis in reticulocytes and reticulocyte lysates, since a correlation between inhibition of protein synthesis, inhibition of protein kinase activity, and phosphorylation of eIF-2 is not observed with all porphyrins. Hemin 134-139 eukaryotic translation initiation factor 2 subunit beta Homo sapiens 97-102 223849-9 1979 Thus, hemin prevents the activation of eIF-2 kinase by inhibiting the cAMP-dependent protein kinase. Hemin 6-11 eukaryotic translation initiation factor 2 subunit beta Homo sapiens 39-44