PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31083300-0 2019 3-Methylcholanthrene Induces Chylous Ascites in TCDD-Inducible Poly-ADP-Ribose Polymerase (Tiparp) Knockout Mice. Methylcholanthrene 0-20 TCDD-inducible poly(ADP-ribose) polymerase Mus musculus 48-89 31083300-0 2019 3-Methylcholanthrene Induces Chylous Ascites in TCDD-Inducible Poly-ADP-Ribose Polymerase (Tiparp) Knockout Mice. Methylcholanthrene 0-20 TCDD-inducible poly(ADP-ribose) polymerase Mus musculus 91-97 31083300-4 2019 In this study, we treated male Tiparp-/- or wild type (WT) mice with a single injection of 100 mg/kg 3-methylcholanthrene (3MC). Methylcholanthrene 101-121 TCDD-inducible poly(ADP-ribose) polymerase Mus musculus 31-37 31083300-5 2019 Consistent with TIPARP"s role as a repressor of AHR signaling, 3MC-treated Tiparp-/- mice exhibited increased hepatic Cyp1a1 and Cyp1b1 levels compared with WT mice. Methylcholanthrene 63-66 TCDD-inducible poly(ADP-ribose) polymerase Mus musculus 16-22 31083300-5 2019 Consistent with TIPARP"s role as a repressor of AHR signaling, 3MC-treated Tiparp-/- mice exhibited increased hepatic Cyp1a1 and Cyp1b1 levels compared with WT mice. Methylcholanthrene 63-66 TCDD-inducible poly(ADP-ribose) polymerase Mus musculus 75-81 31083300-11 2019 Our study reveals that Tiparp-/- mice have increased sensitivity to 3MC-induced liver toxicity, but unlike with TCDD, lethality is due to chylous ascites rather than wasting syndrome. Methylcholanthrene 68-71 TCDD-inducible poly(ADP-ribose) polymerase Mus musculus 23-29