PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22360559-7 2012 Small molecule CA IX inhibitors, of sulfonamide and coumarin type are in advanced preclinical evaluation, both for imaging and treatment of solid tumors and metastases in which CA IX/XII are present. coumarin 52-60 carbonic anhydrase 9 Homo sapiens 15-20 22360559-7 2012 Small molecule CA IX inhibitors, of sulfonamide and coumarin type are in advanced preclinical evaluation, both for imaging and treatment of solid tumors and metastases in which CA IX/XII are present. coumarin 52-60 carbonic anhydrase 9 Homo sapiens 177-182 33602041-0 2021 Selective inhibition of carbonic anhydrase IX and XII by coumarin and psoralen derivatives. coumarin 57-65 carbonic anhydrase 9 Homo sapiens 24-45 33640442-1 2021 With an aim to develop novel potential anti-cancer agents we have designed a series of novel 4,7-disubstituted coumarin hybrids synthesis and evaluated for their inhibitory activity against the human carbonic anhydrase isoforms namely CA I, CA II, CA IX and CA XII. coumarin 111-119 carbonic anhydrase 9 Homo sapiens 248-253 33640442-2 2021 The results of CA inhibition clearly showed that the novel 4, 7-disubstituted coumarin hybrids (7a-i & 8a-j) exhibited selective inhibition towards tumor associated isoforms, CA IX and CA XII without inhibiting CA I and CA II isoforms. coumarin 78-86 carbonic anhydrase 9 Homo sapiens 175-180 33346945-0 2021 Coumarin-Thiourea Hybrids Show Potent Carbonic Anhydrase IX and XIII Inhibitory Action. coumarin 0-8 carbonic anhydrase 9 Homo sapiens 38-59 32744806-3 2020 On the other hand, coumarin derivatives showed weak potency but high selectivity against the tumor-associated isoform CA IX. coumarin 19-27 carbonic anhydrase 9 Homo sapiens 118-123 32961467-0 2020 Synthesis and biological evaluation of some coumarin hybrids as selective carbonic anhydrase IX and XII inhibitors. coumarin 44-52 carbonic anhydrase 9 Homo sapiens 74-95 32193032-0 2020 Design, synthesis and biological evaluation of coumarin linked 1,2,4-oxadiazoles as selective carbonic anhydrase IX and XII inhibitors. coumarin 47-55 carbonic anhydrase 9 Homo sapiens 94-115 32044580-2 2020 Most sulfonamide derivatives efficiently inhibit the target CA IX (KIs in the range 0.47-44.7 nM) and CA XII (KIs in the range 2.9-83.1 nM), while the 5-FU coumarin derivatives showed a potent and totally selective inhibitory action against the target CA IX/XII over off-target CA I/II. coumarin 156-164 carbonic anhydrase 9 Homo sapiens 60-65 31810330-3 2019 The elucidation of the crystal structure of the catalytic domains of CAIX/XII provided the basis for the generation of CAIX/XII selective inhibitors based on the sulfonamide, sulfamate and coumarins chemical structures. coumarin 189-198 carbonic anhydrase 9 Homo sapiens 69-73 31810330-3 2019 The elucidation of the crystal structure of the catalytic domains of CAIX/XII provided the basis for the generation of CAIX/XII selective inhibitors based on the sulfonamide, sulfamate and coumarins chemical structures. coumarin 189-198 carbonic anhydrase 9 Homo sapiens 119-123 30857344-3 2019 Therefore, the synthesized coumarin ligands demonstrated to be potent and selective hCA IX/XII inhibitors, and were shown to be as potent as the reference inhibitor acetazolamide against hCA XII, with single-digit nanomolar Ki values. coumarin 27-35 carbonic anhydrase 9 Homo sapiens 84-90 30258546-1 2018 We have synthesized a new series of coumarin-based compounds demonstrating high selectivity and potent effects with low nanomolar affinity against the tumor associated carbonic anhydrase (CA, EC 4.2.1.1) isoforms hCA IX and XII. coumarin 36-44 carbonic anhydrase 9 Homo sapiens 213-227 29197732-0 2018 Inhibitory effects and structural insights for a novel series of coumarin-based compounds that selectively target human CA IX and CA XII carbonic anhydrases. coumarin 65-73 carbonic anhydrase 9 Homo sapiens 120-125 29197732-3 2018 By decorating the natural compound umbelliferone (1) we have identified a new series of coumarin-based compounds demonstrating high CA inhibitory effects with nanomolar affinity for hCA IX and hCA XII isoforms that were considered a target amenable to develop antitumor agents. coumarin 88-96 carbonic anhydrase 9 Homo sapiens 182-188