PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21870251-2 2011 Since PARP-1 gene is expressed constitutively, its activation cannot be surmised from increased expression of its mRNA or protein, but by demonstrating the consequences of its catalytic -reaction which results in consumption of the substrate nicotinamide adenine dinucleotide (NAD(+)) and formation of three products, namely, polymer of ADP-ribose (pADPr or PAR), nicotinamide, and protons. Niacinamide 242-254 jumping translocation breakpoint Homo sapiens 6-9