PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21372002-2 2011 In the current study, the immune characteristics of MPO-NAA and MPO-ANCA were examined and compared with the aim to investigate the pathogenesis of MPO-ANCA. 1-naphthaleneacetic acid 56-59 myeloperoxidase Homo sapiens 52-55 21372002-7 2011 The MPO-NAA-induced production of reactive oxygen species was assessed using oxidation of dihydrorhodamine (DHR) to rhodamine. 1-naphthaleneacetic acid 8-11 myeloperoxidase Homo sapiens 4-7 21372002-8 2011 RESULTS: MPO-NAA recognized epitope(s) in the heavy chains of MPO with conformation-dependent structure, the same as MPO-ANCA. 1-naphthaleneacetic acid 13-16 myeloperoxidase Homo sapiens 9-12 21372002-8 2011 RESULTS: MPO-NAA recognized epitope(s) in the heavy chains of MPO with conformation-dependent structure, the same as MPO-ANCA. 1-naphthaleneacetic acid 13-16 myeloperoxidase Homo sapiens 62-65 21372002-8 2011 RESULTS: MPO-NAA recognized epitope(s) in the heavy chains of MPO with conformation-dependent structure, the same as MPO-ANCA. 1-naphthaleneacetic acid 13-16 myeloperoxidase Homo sapiens 62-65 21372002-9 2011 The median titre of MPO-NAA was lower than that of MPO-ANCA (1 : 40 vs 1 : 4800, P < 0.001). 1-naphthaleneacetic acid 24-27 myeloperoxidase Homo sapiens 20-23 21372002-10 2011 The median avidity of MPO-NAA was lower than that of MPO-ANCA (2.2 x 10(7) vs 8.7 x 10(7)/M, P = 0.014). 1-naphthaleneacetic acid 26-29 myeloperoxidase Homo sapiens 22-25 21372002-11 2011 The IgG subclasses of MPO-NAA were mainly restricted to IgG1 (100%) and lack of IgG3. 1-naphthaleneacetic acid 26-29 myeloperoxidase Homo sapiens 22-25 21372002-12 2011 The inhibition effect on the binding between ceruloplasmin and MPO was lower for MPO-NAA than MPO-ANCA (P = 0.046). 1-naphthaleneacetic acid 85-88 myeloperoxidase Homo sapiens 63-66 21372002-12 2011 The inhibition effect on the binding between ceruloplasmin and MPO was lower for MPO-NAA than MPO-ANCA (P = 0.046). 1-naphthaleneacetic acid 85-88 myeloperoxidase Homo sapiens 81-84 21372002-12 2011 The inhibition effect on the binding between ceruloplasmin and MPO was lower for MPO-NAA than MPO-ANCA (P = 0.046). 1-naphthaleneacetic acid 85-88 myeloperoxidase Homo sapiens 81-84 21372002-13 2011 The MPO-NAA-induced respiratory burst of neutrophils was significantly weaker than that of MPO-ANCA (P = 0.036). 1-naphthaleneacetic acid 8-11 myeloperoxidase Homo sapiens 4-7 21372002-14 2011 CONCLUSION: The lower titre, lower avidity and lack of IgG3 subclass compared with MPO-ANCA may contribute to the non-pathogenic co-existence of MPO-NAA with MPO in serum. 1-naphthaleneacetic acid 149-152 myeloperoxidase Homo sapiens 145-148 21372002-14 2011 CONCLUSION: The lower titre, lower avidity and lack of IgG3 subclass compared with MPO-ANCA may contribute to the non-pathogenic co-existence of MPO-NAA with MPO in serum. 1-naphthaleneacetic acid 149-152 myeloperoxidase Homo sapiens 145-148