PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 1329904-4 1992 Forskolin-stimulated adenylate cyclase activity in the presence of Mn2+ was also increased in membranes prepared from SMS-treated cyc- cells; however, guanine nucleotide-mediated inhibition of adenylate cyclase activity was not changed despite a small decrease in inhibitory Gi alpha subunits detected by immunoblotting. Guanine Nucleotides 151-169 peptidylprolyl isomerase A, pseudogene 1 Mus musculus 31-34 3756145-6 1986 Simultaneous fusion of the liposomes containing IgG-B1 and -B2 proteins with guanine nucleotide binding stimulatory (G/F) protein/Fc gamma 2aR-deficient cyc- cells resulted in the formation of the hybrid membrane whose adenylate cyclase responds to immune complex formed with IgG2a-subclass antibody (IC2a) by about a 2.7-fold increase in the activity over the control (hybrid membrane between cyc- cells and liposome containing no protein). Guanine Nucleotides 77-95 peptidylprolyl isomerase A, pseudogene 1 Mus musculus 153-156 3118356-3 1987 It is shown that cholate extracts from cholera toxin-treated brush border membranes can efficiently reconstitute adenylyl cyclase activity in the guanine nucleotide-binding regulatory component (Gs)-deficient cyc- variant of the S49 mouse lymphoma cell line (cyc- cells lack the alpha subunit of Gs needed to activate the catalytic subunit of adenylyl cyclase). Guanine Nucleotides 146-164 peptidylprolyl isomerase A, pseudogene 1 Mus musculus 122-125 3118356-3 1987 It is shown that cholate extracts from cholera toxin-treated brush border membranes can efficiently reconstitute adenylyl cyclase activity in the guanine nucleotide-binding regulatory component (Gs)-deficient cyc- variant of the S49 mouse lymphoma cell line (cyc- cells lack the alpha subunit of Gs needed to activate the catalytic subunit of adenylyl cyclase). Guanine Nucleotides 146-164 peptidylprolyl isomerase A, pseudogene 1 Mus musculus 209-212 3022802-9 1986 Stimulation of adenylyl cyclase with fluoride, guanylyl 5"-imidodiphosphate, glucagon, or isoproterenol was observed after fusion of cyc- S49 cells [which lack the stimulatory, guanine nucleotide binding, regulatory protein of adenylyl cyclase (Ns)] with liver membranes alkylated with 1.5 mM NEM. Guanine Nucleotides 177-195 peptidylprolyl isomerase A, pseudogene 1 Mus musculus 24-27 3756145-6 1986 Simultaneous fusion of the liposomes containing IgG-B1 and -B2 proteins with guanine nucleotide binding stimulatory (G/F) protein/Fc gamma 2aR-deficient cyc- cells resulted in the formation of the hybrid membrane whose adenylate cyclase responds to immune complex formed with IgG2a-subclass antibody (IC2a) by about a 2.7-fold increase in the activity over the control (hybrid membrane between cyc- cells and liposome containing no protein). Guanine Nucleotides 77-95 peptidylprolyl isomerase A, pseudogene 1 Mus musculus 229-232 6434354-1 1984 The relationship between the assay values of the activities of the stimulatory guanine nucleotide-binding regulatory component (N-protein) of adenylate cyclase by two different methods: reconstitution of plasma membranes of cyc- S49 cells and ADP ribosylation catalyzed by cholera toxin, have not been fully elucidated yet. Guanine Nucleotides 79-97 peptidylprolyl isomerase A, pseudogene 1 Mus musculus 152-155 2997214-1 1985 Interaction of receptors with a guanine nucleotide-binding protein in membranes prepared from L6 myoblasts and from wild-type and cyc- S49 lymphoma cells. Guanine Nucleotides 32-50 peptidylprolyl isomerase A, pseudogene 1 Mus musculus 130-133 6142891-7 1984 There are several similarities between inhibition of forskolin-stimulated adenylate cyclase by guanine nucleotides and somatostatin in cyc- and wild type membranes. Guanine Nucleotides 95-114 peptidylprolyl isomerase A, pseudogene 1 Mus musculus 84-87 6685126-1 1983 Requirements and kinetics of guanine nucleotide-induced inhibition of the cyc- S49 adenylyl cyclase. Guanine Nucleotides 29-47 peptidylprolyl isomerase A, pseudogene 1 Mus musculus 74-77 6309843-15 1983 The beta subunit activity in extracts of cyc- membranes is expressed after incubation with guanine nucleotide analogs, implying association of the beta subunit with a GTP-binding protein. Guanine Nucleotides 91-109 peptidylprolyl isomerase A, pseudogene 1 Mus musculus 41-44 6134642-1 1983 cyc--Variants of S49 lymphoma cells are defective in the stimulatory guanine nucleotide site of the adenylate cyclase but contain an inhibitory site. Guanine Nucleotides 69-87 peptidylprolyl isomerase A, pseudogene 1 Mus musculus 0-3 6135205-9 1983 The data indicate that membranes of cyc- variants contain a regulatory site that mediates both guanine nucleotide and hormone-induced inhibition of the adenylate cyclase and suggest that the mechanisms of activation and inactivation of this inhibitory site are similar to those of the stimulatory component missing in cyc-membranes. Guanine Nucleotides 95-113 peptidylprolyl isomerase A, pseudogene 1 Mus musculus 36-39 6135205-9 1983 The data indicate that membranes of cyc- variants contain a regulatory site that mediates both guanine nucleotide and hormone-induced inhibition of the adenylate cyclase and suggest that the mechanisms of activation and inactivation of this inhibitory site are similar to those of the stimulatory component missing in cyc-membranes. Guanine Nucleotides 95-113 peptidylprolyl isomerase A, pseudogene 1 Mus musculus 162-165 6133220-1 1983 The cyc- variants of S49 lymphoma cells have served as powerful tools for studying the components and mechanisms of hormone-induced adenylate cyclase stimulation, as these cells are deficient in the guanine nucleotide regulatory site (Ns) mediating hormone, guanine nucleotide, cholera toxin and fluoride-induced stimulations of the enzyme. Guanine Nucleotides 199-217 peptidylprolyl isomerase A, pseudogene 1 Mus musculus 4-7 6133220-10 1983 The data strongly suggest that both the hormone- and guanine nucleotide-induced adenylate cyclase inhibitions in cyc- cells are mediated by Ni and that the mechanisms of activation and inactivation of Ni are similar to those established for Ns. Guanine Nucleotides 53-71 peptidylprolyl isomerase A, pseudogene 1 Mus musculus 90-93 6297910-0 1983 Occurrence of an inhibitory guanine nucleotide-binding regulatory component of the adenylate cyclase system in cyc- variants of S49 lymphoma cells. Guanine Nucleotides 28-46 peptidylprolyl isomerase A, pseudogene 1 Mus musculus 93-96 6757248-0 1982 Guanine nucleotide inhibition of cyc- S49 mouse lymphoma cell membrane adenylyl cyclase. Guanine Nucleotides 0-18 peptidylprolyl isomerase A, pseudogene 1 Mus musculus 33-36 6757248-1 1982 Cyc- S49 mouse lymphoma cell membranes contain an adenylyl cyclase system which is deficient in the regulatory properties characteristic of a stimulatory guanine nucleotide-binding regulatory component (Ns), such as enhancement of activity in the presence of GTP, GTP analogues, and NaF. Guanine Nucleotides 154-172 peptidylprolyl isomerase A, pseudogene 1 Mus musculus 0-3 6757248-7 1982 Our results indicate the presence in cyc- S49 cell membranes of a guanine nucleotide-binding component which is inhibitory to adenylyl cyclase activity (Ni). Guanine Nucleotides 66-84 peptidylprolyl isomerase A, pseudogene 1 Mus musculus 37-40