PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
3756145-6	1986	Simultaneous fusion of the liposomes containing IgG-B1 and -B2 proteins with guanine nucleotide binding stimulatory (G/F) protein/Fc gamma 2aR-deficient cyc- cells resulted in the formation of the hybrid membrane whose adenylate cyclase responds to immune complex formed with IgG2a-subclass antibody (IC2a) by about a 2.7-fold increase in the activity over the control (hybrid membrane between cyc- cells and liposome containing no protein).	Guanine Nucleotides	77-95	peptidylprolyl isomerase A, pseudogene 1	Mus musculus	153-156	
1329904-4	1992	Forskolin-stimulated adenylate cyclase activity in the presence of Mn2+ was also increased in membranes prepared from SMS-treated cyc- cells; however, guanine nucleotide-mediated inhibition of adenylate cyclase activity was not changed despite a small decrease in inhibitory Gi alpha subunits detected by immunoblotting.	Guanine Nucleotides	151-169	peptidylprolyl isomerase A, pseudogene 1	Mus musculus	31-34	
3118356-3	1987	It is shown that cholate extracts from cholera toxin-treated brush border membranes can efficiently reconstitute adenylyl cyclase activity in the guanine nucleotide-binding regulatory component (Gs)-deficient cyc- variant of the S49 mouse lymphoma cell line (cyc- cells lack the alpha subunit of Gs needed to activate the catalytic subunit of adenylyl cyclase).	Guanine Nucleotides	146-164	peptidylprolyl isomerase A, pseudogene 1	Mus musculus	122-125	
3118356-3	1987	It is shown that cholate extracts from cholera toxin-treated brush border membranes can efficiently reconstitute adenylyl cyclase activity in the guanine nucleotide-binding regulatory component (Gs)-deficient cyc- variant of the S49 mouse lymphoma cell line (cyc- cells lack the alpha subunit of Gs needed to activate the catalytic subunit of adenylyl cyclase).	Guanine Nucleotides	146-164	peptidylprolyl isomerase A, pseudogene 1	Mus musculus	209-212	
3022802-9	1986	Stimulation of adenylyl cyclase with fluoride, guanylyl 5"-imidodiphosphate, glucagon, or isoproterenol was observed after fusion of cyc- S49 cells [which lack the stimulatory, guanine nucleotide binding, regulatory protein of adenylyl cyclase (Ns)] with liver membranes alkylated with 1.5 mM NEM.	Guanine Nucleotides	177-195	peptidylprolyl isomerase A, pseudogene 1	Mus musculus	24-27	
3756145-6	1986	Simultaneous fusion of the liposomes containing IgG-B1 and -B2 proteins with guanine nucleotide binding stimulatory (G/F) protein/Fc gamma 2aR-deficient cyc- cells resulted in the formation of the hybrid membrane whose adenylate cyclase responds to immune complex formed with IgG2a-subclass antibody (IC2a) by about a 2.7-fold increase in the activity over the control (hybrid membrane between cyc- cells and liposome containing no protein).	Guanine Nucleotides	77-95	peptidylprolyl isomerase A, pseudogene 1	Mus musculus	229-232	
2997214-1	1985	Interaction of receptors with a guanine nucleotide-binding protein in membranes prepared from L6 myoblasts and from wild-type and cyc- S49 lymphoma cells.	Guanine Nucleotides	32-50	peptidylprolyl isomerase A, pseudogene 1	Mus musculus	130-133	
6434354-1	1984	The relationship between the assay values of the activities of the stimulatory guanine nucleotide-binding regulatory component (N-protein) of adenylate cyclase by two different methods: reconstitution of plasma membranes of cyc- S49 cells and ADP ribosylation catalyzed by cholera toxin, have not been fully elucidated yet.	Guanine Nucleotides	79-97	peptidylprolyl isomerase A, pseudogene 1	Mus musculus	152-155	
6297910-0	1983	Occurrence of an inhibitory guanine nucleotide-binding regulatory component of the adenylate cyclase system in cyc- variants of S49 lymphoma cells.	Guanine Nucleotides	28-46	peptidylprolyl isomerase A, pseudogene 1	Mus musculus	93-96	
6142891-7	1984	There are several similarities between inhibition of forskolin-stimulated adenylate cyclase by guanine nucleotides and somatostatin in cyc- and wild type membranes.	Guanine Nucleotides	95-114	peptidylprolyl isomerase A, pseudogene 1	Mus musculus	84-87	
6309843-15	1983	The beta subunit activity in extracts of cyc- membranes is expressed after incubation with guanine nucleotide analogs, implying association of the beta subunit with a GTP-binding protein.	Guanine Nucleotides	91-109	peptidylprolyl isomerase A, pseudogene 1	Mus musculus	41-44	
6134642-1	1983	cyc--Variants of S49 lymphoma cells are defective in the stimulatory guanine nucleotide site of the adenylate cyclase but contain an inhibitory site.	Guanine Nucleotides	69-87	peptidylprolyl isomerase A, pseudogene 1	Mus musculus	0-3	
6135205-9	1983	The data indicate that membranes of cyc- variants contain a regulatory site that mediates both guanine nucleotide and hormone-induced inhibition of the adenylate cyclase and suggest that the mechanisms of activation and inactivation of this inhibitory site are similar to those of the stimulatory component missing in cyc-membranes.	Guanine Nucleotides	95-113	peptidylprolyl isomerase A, pseudogene 1	Mus musculus	36-39	
6135205-9	1983	The data indicate that membranes of cyc- variants contain a regulatory site that mediates both guanine nucleotide and hormone-induced inhibition of the adenylate cyclase and suggest that the mechanisms of activation and inactivation of this inhibitory site are similar to those of the stimulatory component missing in cyc-membranes.	Guanine Nucleotides	95-113	peptidylprolyl isomerase A, pseudogene 1	Mus musculus	162-165	
6133220-1	1983	The cyc- variants of S49 lymphoma cells have served as powerful tools for studying the components and mechanisms of hormone-induced adenylate cyclase stimulation, as these cells are deficient in the guanine nucleotide regulatory site (Ns) mediating hormone, guanine nucleotide, cholera toxin and fluoride-induced stimulations of the enzyme.	Guanine Nucleotides	199-217	peptidylprolyl isomerase A, pseudogene 1	Mus musculus	4-7	
6133220-10	1983	The data strongly suggest that both the hormone- and guanine nucleotide-induced adenylate cyclase inhibitions in cyc- cells are mediated by Ni and that the mechanisms of activation and inactivation of Ni are similar to those established for Ns.	Guanine Nucleotides	53-71	peptidylprolyl isomerase A, pseudogene 1	Mus musculus	90-93	
6685126-1	1983	Requirements and kinetics of guanine nucleotide-induced inhibition of the cyc- S49 adenylyl cyclase.	Guanine Nucleotides	29-47	peptidylprolyl isomerase A, pseudogene 1	Mus musculus	74-77	
6757248-0	1982	Guanine nucleotide inhibition of cyc- S49 mouse lymphoma cell membrane adenylyl cyclase.	Guanine Nucleotides	0-18	peptidylprolyl isomerase A, pseudogene 1	Mus musculus	33-36	
6757248-1	1982	Cyc- S49 mouse lymphoma cell membranes contain an adenylyl cyclase system which is deficient in the regulatory properties characteristic of a stimulatory guanine nucleotide-binding regulatory component (Ns), such as enhancement of activity in the presence of GTP, GTP analogues, and NaF.	Guanine Nucleotides	154-172	peptidylprolyl isomerase A, pseudogene 1	Mus musculus	0-3	
6757248-7	1982	Our results indicate the presence in cyc- S49 cell membranes of a guanine nucleotide-binding component which is inhibitory to adenylyl cyclase activity (Ni).	Guanine Nucleotides	66-84	peptidylprolyl isomerase A, pseudogene 1	Mus musculus	37-40