PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24178472-9 1996 This diphosphate has been shown to be the proximate effector binding to eIF-2B, the guanine nucleotide exchange factor (Singh, L. P. Arror, A. R. and Wahba, A. J. Guanine Nucleotides 84-102 eukaryotic translation initiation factor 2B subunit delta Homo sapiens 72-78 9032257-0 1997 Homologous segments in three subunits of the guanine nucleotide exchange factor eIF2B mediate translational regulation by phosphorylation of eIF2. Guanine Nucleotides 45-63 eukaryotic translation initiation factor 2B subunit delta Homo sapiens 80-85 9345299-0 1997 Catalysis of guanine nucleotide exchange on eIF-2 by eIF-2B: is it a sequential or substituted enzyme mechanism? Guanine Nucleotides 13-31 eukaryotic translation initiation factor 2B subunit delta Homo sapiens 53-59 9345299-1 1997 The mechanism of action of the eukaryotic initiation factor eIF-2B in catalyzing the exchange of guanine nucleotides bound to eIF-2 is uncertain--evidence having been adduced for a sequential mechanism and for a substituted enzyme mechanism. Guanine Nucleotides 97-116 eukaryotic translation initiation factor 2B subunit delta Homo sapiens 60-66 34877508-0 2021 GTP binding to translation factor eIF2B stimulates its guanine nucleotide exchange activity. Guanine Nucleotides 55-73 eukaryotic translation initiation factor 2B subunit delta Homo sapiens 34-39 8168527-4 1994 The anti-epsilon antibody inhibits both the guanine nucleotide exchange activity of eIF-2B and protein synthesis in the rabbit reticulocyte lysate at the level of initiation. Guanine Nucleotides 44-62 eukaryotic translation initiation factor 2B subunit delta Homo sapiens 84-90 8619603-2 1996 Phosphorylation of eIF-2alpha impairs the guanine nucleotide exchange activity of eIF-2B and thereby inhibits or shuts off protein synthesis. Guanine Nucleotides 42-60 eukaryotic translation initiation factor 2B subunit delta Homo sapiens 82-88 8336705-3 1993 Previous genetic and biochemical experiments led to the conclusion that GCD1, GCD2, and GCN3 are components of the GCD complex, recently shown to be the yeast equivalent of the mammalian guanine nucleotide exchange factor for eIF-2, known as eIF-2B. Guanine Nucleotides 187-205 eukaryotic translation initiation factor 2B subunit delta Homo sapiens 242-248 8336705-10 1993 The fact that all five subunits of yeast eIF-2B were first identified as translational regulators of GCN4 strongly suggests that regulation of guanine nucleotide exchange on eIF-2 is a key control point for translation in yeast cells just as in mammalian cells. Guanine Nucleotides 143-161 eukaryotic translation initiation factor 2B subunit delta Homo sapiens 41-47 8111971-3 1993 We identify here the translational initiation complex, eIF-4F, and the guanine nucleotide exchange factor for eIF-2, eIF-2B, as the rate controlling components of protein synthesis in immature oocytes of the starfish, Pisaster orchraceus. Guanine Nucleotides 71-89 eukaryotic translation initiation factor 2B subunit delta Homo sapiens 117-123 29489452-1 2018 eIF2B is a dedicated guanine nucleotide exchange factor for eIF2, the GTPase that is essential to initiate mRNA translation. Guanine Nucleotides 21-39 eukaryotic translation initiation factor 2B subunit delta Homo sapiens 0-5 29425030-1 2018 Eukaryotic translation initiation factor 2B (eIF2B) is the guanine nucleotide exchange factor of the GTPase eIF2, which brings the initiator Met-tRNAi to the ribosome in the form of the eIF2-GTP Met-tRNAi ternary complex (TC). Guanine Nucleotides 59-77 eukaryotic translation initiation factor 2B subunit delta Homo sapiens 0-43 29425030-1 2018 Eukaryotic translation initiation factor 2B (eIF2B) is the guanine nucleotide exchange factor of the GTPase eIF2, which brings the initiator Met-tRNAi to the ribosome in the form of the eIF2-GTP Met-tRNAi ternary complex (TC). Guanine Nucleotides 59-77 eukaryotic translation initiation factor 2B subunit delta Homo sapiens 45-50 28677085-1 2017 Eukaryotic initiation factor 2B (eIF2B) controls the first step of translation by catalyzing guanine nucleotide exchange on eukaryotic initiation factor 2 (eIF2). Guanine Nucleotides 93-111 eukaryotic translation initiation factor 2B subunit delta Homo sapiens 33-38 16378743-6 2006 Eukaryotic translation initiation factor 2B (eIF2B) mutations cause a decrease in guanine nucleotide exchange activity on eIF2-GDP, resulting in increased susceptibility to stress and enhanced ATF4 expression during endoplasmic reticulum stress. Guanine Nucleotides 82-100 eukaryotic translation initiation factor 2B subunit delta Homo sapiens 0-43 18631136-8 2008 In the present article, we review data from studies of representative G-protein-GEF pairs and compare these with observations from our research on eIF2 and eIF2B to propose a model for how interactions between eIF2B and eIF2 promote guanine nucleotide exchange. Guanine Nucleotides 233-251 eukaryotic translation initiation factor 2B subunit delta Homo sapiens 156-161 18631136-8 2008 In the present article, we review data from studies of representative G-protein-GEF pairs and compare these with observations from our research on eIF2 and eIF2B to propose a model for how interactions between eIF2B and eIF2 promote guanine nucleotide exchange. Guanine Nucleotides 233-251 eukaryotic translation initiation factor 2B subunit delta Homo sapiens 210-215 17512538-1 2007 In eukaryotic translation initiation, eIF2GTP-Met-tRNA(i)(Met) ternary complex (TC) interacts with eIF3-eIF1-eIF5 complex to form the multifactor complex (MFC), while eIF2GDP associates with eIF2B for guanine nucleotide exchange. Guanine Nucleotides 201-219 eukaryotic translation initiation factor 2B subunit delta Homo sapiens 191-196 16990799-8 2006 We propose that the eIF2/eIF5 complex represents a cytoplasmic reservoir for eIF2 that antagonizes eIF2B-promoted guanine nucleotide exchange, enabling coordinated regulation of translation initiation. Guanine Nucleotides 114-132 eukaryotic translation initiation factor 2B subunit delta Homo sapiens 99-104 26705305-4 2016 The suppression of eIF2alpha phosphorylation via MPT synthase and ATAC prevented sequestration of the guanine nucleotide exchange factor eIF2B, which recycles eIF2-GDP to eIF2-GTP, resulting in the promotion of translation initiation. Guanine Nucleotides 102-120 eukaryotic translation initiation factor 2B subunit delta Homo sapiens 137-142 20444979-9 2010 In yeast, eIF2B occupies a large cytoplasmic body where guanine nucleotide exchange on eIF2 can occur and be regulated. Guanine Nucleotides 56-74 eukaryotic translation initiation factor 2B subunit delta Homo sapiens 10-15 16990799-0 2006 An eIF5/eIF2 complex antagonizes guanine nucleotide exchange by eIF2B during translation initiation. Guanine Nucleotides 33-51 eukaryotic translation initiation factor 2B subunit delta Homo sapiens 64-69 16434554-7 2006 This is accompanied by inhibition of activity of the guanine nucleotide exchange factor eIF2B that is responsible for GDP-GTP exchange on eIF2. Guanine Nucleotides 53-71 eukaryotic translation initiation factor 2B subunit delta Homo sapiens 88-93 16378743-6 2006 Eukaryotic translation initiation factor 2B (eIF2B) mutations cause a decrease in guanine nucleotide exchange activity on eIF2-GDP, resulting in increased susceptibility to stress and enhanced ATF4 expression during endoplasmic reticulum stress. Guanine Nucleotides 82-100 eukaryotic translation initiation factor 2B subunit delta Homo sapiens 45-50 10852917-8 2000 In support of this model, our yeast eIF2B preparations bind guanine nucleotides, with an apparent dissociation constant for GTP in the low micromolar range. Guanine Nucleotides 60-79 eukaryotic translation initiation factor 2B subunit delta Homo sapiens 36-41 16157703-7 2005 Three different strategies to decrease the guanine nucleotide exchange function of eIF2B all inhibit eIF2 shuttling into the foci. Guanine Nucleotides 43-61 eukaryotic translation initiation factor 2B subunit delta Homo sapiens 83-88 16157703-8 2005 These results implicate a defined cytoplasmic center of eIF2B in the exchange of guanine nucleotides on the eIF2 translation initiation factor. Guanine Nucleotides 81-100 eukaryotic translation initiation factor 2B subunit delta Homo sapiens 56-61 16157703-9 2005 A focused core of eIF2B guanine nucleotide exchange might allow either greater activity or control of this elementary conserved step in the translation pathway. Guanine Nucleotides 24-42 eukaryotic translation initiation factor 2B subunit delta Homo sapiens 18-23 11726195-0 2001 Catalysis of guanine nucleotide exchange on eIF2 by eIF2B: can it be both a substituted enzyme and a sequential mechanism? Guanine Nucleotides 13-31 eukaryotic translation initiation factor 2B subunit delta Homo sapiens 52-57 11726195-1 2001 There are conflicting reports over the question of whether the displacement by GTP of GDP bound to eIF2 catalyzed by eIF2B follows a substituted enzyme mechanism, as is believed to be the case for other guanine nucleotide exchange factors, or is a sequential mechanism. Guanine Nucleotides 203-221 eukaryotic translation initiation factor 2B subunit delta Homo sapiens 117-122 12183515-6 2002 In contrast, insulin in combination with resistance exercise stimulates translation initiation and protein synthesis through enhanced activity of a guanine nucleotide exchange protein referred to as eIF2B. Guanine Nucleotides 148-166 eukaryotic translation initiation factor 2B subunit delta Homo sapiens 199-204