PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7816803-0 1995 Expression of the wild-type p53 antioncogene induces guanine nucleotide-dependent stem cell division kinetics. Guanine Nucleotides 53-71 tumor protein p53 Homo sapiens 28-31 9436988-1 1998 We have proposed that reduced activity of inosine-5"-monophosphate dehydrogenase (IMPD; IMP:NAD oxidoreductase, EC 1.2.1.14), the rate-limiting enzyme for guanine nucleotide biosynthesis, in response to wild-type p53 expression, is essential for p53-dependent growth suppression. Guanine Nucleotides 155-173 tumor protein p53 Homo sapiens 213-216 9436988-1 1998 We have proposed that reduced activity of inosine-5"-monophosphate dehydrogenase (IMPD; IMP:NAD oxidoreductase, EC 1.2.1.14), the rate-limiting enzyme for guanine nucleotide biosynthesis, in response to wild-type p53 expression, is essential for p53-dependent growth suppression. Guanine Nucleotides 155-173 tumor protein p53 Homo sapiens 246-249 7816803-5 1995 We show that through a guanine nucleotide-dependent mechanism, the p53 antioncogene can induce exponentially dividing cells to switch to an asymmetric stem cell growth pattern. Guanine Nucleotides 23-41 tumor protein p53 Homo sapiens 67-70 8106638-13 1994 As p53 protein is a regulator of guanine nucleotide synthesis, the loss of normal inhibitory regulation by the p53 mutation would serve to increase the availability of GTP for the transduction of signals essential for increased cell growth and hormone expression in the adrenal tumors. Guanine Nucleotides 33-51 tumor protein p53 Homo sapiens 3-6 8106638-13 1994 As p53 protein is a regulator of guanine nucleotide synthesis, the loss of normal inhibitory regulation by the p53 mutation would serve to increase the availability of GTP for the transduction of signals essential for increased cell growth and hormone expression in the adrenal tumors. Guanine Nucleotides 33-51 tumor protein p53 Homo sapiens 111-114