PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25329472-6	2014	AGEF-1 is homologous to the mammalian BIG1 and BIG2 Arf GTPase guanine nucleotide exchange factors (GEFs), which regulate secretory traffic between the Trans-Golgi network, endosomes and the plasma membrane via activation of Arf GTPases and recruitment of the AP-1 clathrin adaptor complex.	Guanine Nucleotides	63-81	ADP ribosylation factor guanine nucleotide exchange factor 1	Homo sapiens	38-42	
16413268-1	2005	BIG1 and BIG2 are large (approximately 200 kDa) guanine nucleotide-exchange proteins for ADP-ribosylation factors, or ARFs, that were isolated based on sensitivity of their guanine nucleotide-exchange activity to inhibition by brefeldin A.	Guanine Nucleotides	48-66	ADP ribosylation factor guanine nucleotide exchange factor 1	Homo sapiens	0-4	
23918382-1	2013	Brefeldin A-inhibited guanine nucleotide-exchange factors BIG1 and BIG2 activate, through their Sec7 domains, ADP ribosylation factors (Arfs) by accelerating the replacement of Arf-bound GDP with GTP for initiation of vesicular transport or activation of specific enzymes that modify important phospholipids.	Guanine Nucleotides	22-40	ADP ribosylation factor guanine nucleotide exchange factor 1	Homo sapiens	58-62	
23386609-0	2013	The Sec7 guanine nucleotide exchange factor GBF1 regulates membrane recruitment of BIG1 and BIG2 guanine nucleotide exchange factors to the trans-Golgi network (TGN).	Guanine Nucleotides	9-27	ADP ribosylation factor guanine nucleotide exchange factor 1	Homo sapiens	83-87	
23220274-10	2013	This novel function of BIG1 was dependent on the guanine nucleotide-exchange activity and achieved through activation of ADP-ribosylation factor 1.	Guanine Nucleotides	49-67	ADP ribosylation factor guanine nucleotide exchange factor 1	Homo sapiens	23-27	
19651892-4	2009	The TGN targeting of mDpy-30 is mediated by BIG1, a TGN-localized guanine nucleotide exchange factor for adenosine diphosphate ribosylation factor GTPases.	Guanine Nucleotides	66-84	ADP ribosylation factor guanine nucleotide exchange factor 1	Homo sapiens	44-48	
24835460-4	2014	RESULTS: Here we report that the endosomal Rab protein Rab4 orchestrates a GTPase cascade that results in the sequential recruitment of the ADP-ribosylation factor (Arf)-like protein Arl1; the Arf-specific guanine nucleotide exchange factors BIG1 and BIG2; and the class I Arfs, Arf1 and Arf3.	Guanine Nucleotides	206-224	ADP ribosylation factor guanine nucleotide exchange factor 1	Homo sapiens	242-246	
19332778-0	2009	Interaction of phosphodiesterase 3A with brefeldin A-inhibited guanine nucleotide-exchange proteins BIG1 and BIG2 and effect on ARF1 activity.	Guanine Nucleotides	63-81	ADP ribosylation factor guanine nucleotide exchange factor 1	Homo sapiens	100-104	
16413268-1	2005	BIG1 and BIG2 are large (approximately 200 kDa) guanine nucleotide-exchange proteins for ADP-ribosylation factors, or ARFs, that were isolated based on sensitivity of their guanine nucleotide-exchange activity to inhibition by brefeldin A.	Guanine Nucleotides	173-191	ADP ribosylation factor guanine nucleotide exchange factor 1	Homo sapiens	0-4	
16413268-2	2005	The intracellular distributions of BIG1 and BIG2 differ from those of other ARF guanine nucleotide-exchange proteins.	Guanine Nucleotides	80-98	ADP ribosylation factor guanine nucleotide exchange factor 1	Homo sapiens	35-39	
10393931-2	1999	Here, we investigated the cellular localization and BFA sensitivity of human p200 ARF-GEP1 (p200), a ubiquitously expressed guanine nucleotide exchange factor of the Sec7 domain family.	Guanine Nucleotides	124-142	ADP ribosylation factor guanine nucleotide exchange factor 1	Homo sapiens	77-81	
10393931-2	1999	Here, we investigated the cellular localization and BFA sensitivity of human p200 ARF-GEP1 (p200), a ubiquitously expressed guanine nucleotide exchange factor of the Sec7 domain family.	Guanine Nucleotides	124-142	ADP ribosylation factor guanine nucleotide exchange factor 1	Homo sapiens	92-96	
29112323-3	2018	Here, we used brefeldin A (BFA) that blocks the activity of the cellular Arf guanine nucleotide exchange factors GBF1, BIG1, and BIG2, which play a major role in reshuffling of cellular membranes.	Guanine Nucleotides	77-95	ADP ribosylation factor guanine nucleotide exchange factor 1	Homo sapiens	119-123	
7708740-3	1995	The p200 protein is dissociated from Golgi membranes in the presence of brefeldin A and it is induced to bind to Golgi membranes by activation of guanine nucleotide binding proteins (G proteins) with guanosine 5"-[gamma-thio]triphosphate or aluminum fluoride.	Guanine Nucleotides	146-164	ADP ribosylation factor guanine nucleotide exchange factor 1	Homo sapiens	4-8