PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24835460-4 2014 RESULTS: Here we report that the endosomal Rab protein Rab4 orchestrates a GTPase cascade that results in the sequential recruitment of the ADP-ribosylation factor (Arf)-like protein Arl1; the Arf-specific guanine nucleotide exchange factors BIG1 and BIG2; and the class I Arfs, Arf1 and Arf3. Guanine Nucleotides 206-224 ADP ribosylation factor 1 Homo sapiens 279-283 31270230-9 2019 In this work, we show that the guanine nucleotide exchange factor GBF1, relevant for COPI/Arf1-mediated cellular vesicular transport, participates in the replication cycle of the virus, influencing the correct processing of viral glycoproteins VP7 and NSP4 and the assembly of the virus surface proteins VP7 and VP4. Guanine Nucleotides 31-49 ADP ribosylation factor 1 Homo sapiens 90-94 30151872-1 2018 Cytohesin-2 is a member of the guanine nucleotide exchange factors for ADP ribosylation factor 1 (Arf1) and Arf6, which are small GTPases that regulate membrane traffic and actin dynamics. Guanine Nucleotides 31-49 ADP ribosylation factor 1 Homo sapiens 71-96 30151872-1 2018 Cytohesin-2 is a member of the guanine nucleotide exchange factors for ADP ribosylation factor 1 (Arf1) and Arf6, which are small GTPases that regulate membrane traffic and actin dynamics. Guanine Nucleotides 31-49 ADP ribosylation factor 1 Homo sapiens 98-102 27500526-6 2016 Furthermore, we reveal for first time that Rab1b localization time at ERES depended on GBF1, a Rab1b effector that acts as the guanine nucleotide exchange factor of Arf1, and that Rab1b membrane association/dissociation dynamics at ERES was dependent on the GBF1 membrane association and activity, which strongly suggests that GBF1 activity modulates Rab1b membrane cycling dynamic. Guanine Nucleotides 127-145 ADP ribosylation factor 1 Homo sapiens 165-169 33405949-0 2021 Modeling the dynamic behaviors of the COPI vesicle formation regulators, the small GTPase Arf1 and its activating Sec7 guanine nucleotide exchange factor GBF1 on Golgi membranes. Guanine Nucleotides 119-137 ADP ribosylation factor 1 Homo sapiens 90-94 33405949-2 2021 The coating cascade is initiated after the small GTPase Arf1 is activated by the Sec7 domain-containing guanine nucleotide exchange factor GBF1. Guanine Nucleotides 104-122 ADP ribosylation factor 1 Homo sapiens 56-60 23220274-10 2013 This novel function of BIG1 was dependent on the guanine nucleotide-exchange activity and achieved through activation of ADP-ribosylation factor 1. Guanine Nucleotides 49-67 ADP ribosylation factor 1 Homo sapiens 121-146 23943872-2 2013 The spatiotemporal regulation of Arf1 activation is mediated by guanine nucleotide exchange factors (GEFs) of the GBF and BIG families, but the mechanisms of their localization to multiple sites within cells are poorly understood. Guanine Nucleotides 64-82 ADP ribosylation factor 1 Homo sapiens 33-37 25332841-2 2013 COPI recruitment is triggered by guanine nucleotide exchange activating the Arf1 GTPase, but the key exchange factor, GBF1, is a peripheral membrane component whose membrane association is dependent on another GTPase, Rab1. Guanine Nucleotides 33-51 ADP ribosylation factor 1 Homo sapiens 76-80 19669794-0 2009 Large Arf1 guanine nucleotide exchange factors: evolution, domain structure, and roles in membrane trafficking and human disease. Guanine Nucleotides 11-29 ADP ribosylation factor 1 Homo sapiens 6-10 22996016-3 2012 Arf1 is activated at the TGN by Sec7, the founding member of the Sec7 family of guanine nucleotide exchange factors (GEFs) and a close homolog of the human ARFGEF2 implicated in congenital defects in cerebral cortex development. Guanine Nucleotides 80-98 ADP ribosylation factor 1 Homo sapiens 0-4 22573891-3 2012 Here we show that GBF1, a guanine nucleotide exchanging factor for Arf-GTPases, is primarily responsible for Arf1 activation upon GPCR stimulation and is important for neutrophil chemotaxis and superoxide production. Guanine Nucleotides 26-44 ADP ribosylation factor 1 Homo sapiens 109-113 11320245-7 2001 Some aptamers inhibit guanine-nucleotide exchange on ARF1, thereby preventing ARF activation in vitro. Guanine Nucleotides 22-40 ADP ribosylation factor 1 Homo sapiens 53-57 18451304-4 2008 This asymmetric tethering relied on motifs that sensed membrane curvature both in the N terminus of GMAP-210 and in ArfGAP1, which controlled the interaction of the C terminus of GMAP-210 with the small guanine nucleotide-binding protein Arf1. Guanine Nucleotides 203-221 ADP ribosylation factor 1 Homo sapiens 238-242 11342560-0 2001 Specificities for the small G proteins ARF1 and ARF6 of the guanine nucleotide exchange factors ARNO and EFA6. Guanine Nucleotides 60-78 ADP ribosylation factor 1 Homo sapiens 39-43 19039328-6 2009 Here, we propose a molecular mechanism of this specificity for the COPI coat by showing a direct and specific interaction between a COPI subunit and a cis-Golgi localized subfamily of Arf guanine nucleotide exchange factors (GEFs) that takes place independently of Arf1 activation. Guanine Nucleotides 188-206 ADP ribosylation factor 1 Homo sapiens 265-269 15642342-2 2005 Previously, it has been shown that the RCC1-like domain 1 (RLD1) of HERC1 stimulates guanine nucleotide dissociation on ARF1 and Rab proteins. Guanine Nucleotides 85-103 ADP ribosylation factor 1 Homo sapiens 120-124 14690595-0 2003 Crystal structure of ARF1*Sec7 complexed with Brefeldin A and its implications for the guanine nucleotide exchange mechanism. Guanine Nucleotides 87-105 ADP ribosylation factor 1 Homo sapiens 21-25 10881192-7 2000 Altogether, our results provide a structural basis for understanding how Arf1 and Arf6 can be distinguished by their guanine nucleotide exchange factors and suggest a model for the nucleotide/membrane cycle of Arf6. Guanine Nucleotides 117-135 ADP ribosylation factor 1 Homo sapiens 73-77 10212218-3 1999 Cytohesin-1 and its Sec7 domain (C-1Sec7) exhibit guanine nucleotide exchange protein activity with ARF1 but not ARF-like protein 1 (ARL1), which is 57% identical in amino acid sequence. Guanine Nucleotides 50-68 ADP ribosylation factor 1 Homo sapiens 100-104 10608818-0 1999 Dual interaction of ADP ribosylation factor 1 with Sec7 domain and with lipid membranes during catalysis of guanine nucleotide exchange. Guanine Nucleotides 108-126 ADP ribosylation factor 1 Homo sapiens 20-45 9020126-4 1997 Agents that inhibit the Golgi membrane guanine nucleotide exchange factor (the fungal metabolite brefeldin A and trypsin treatment) selectively inhibited the guanine nucleotide exchange on mammalian ARF1. Guanine Nucleotides 158-176 ADP ribosylation factor 1 Homo sapiens 199-203 9679139-4 1998 Association of AP-3 with membranes in vitro was enhanced by GTPgammaS and inhibited by brefeldin A (BFA), an inhibitor of ARF1 guanine nucleotide exchange. Guanine Nucleotides 127-145 ADP ribosylation factor 1 Homo sapiens 122-126 9649435-0 1998 A glutamic finger in the guanine nucleotide exchange factor ARNO displaces Mg2+ and the beta-phosphate to destabilize GDP on ARF1. Guanine Nucleotides 25-43 ADP ribosylation factor 1 Homo sapiens 125-129 9233772-0 1997 A giant protein that stimulates guanine nucleotide exchange on ARF1 and Rab proteins forms a cytosolic ternary complex with clathrin and Hsp70. Guanine Nucleotides 32-50 ADP ribosylation factor 1 Homo sapiens 63-67 9233772-1 1997 We have recently identified an unusually large human protein that stimulates guanine nucleotide exchange on ARF1 and Rab proteins (EMBO J 15: 4262-4273, 1996). Guanine Nucleotides 77-95 ADP ribosylation factor 1 Homo sapiens 108-112 9020126-4 1997 Agents that inhibit the Golgi membrane guanine nucleotide exchange factor (the fungal metabolite brefeldin A and trypsin treatment) selectively inhibited the guanine nucleotide exchange on mammalian ARF1. Guanine Nucleotides 39-57 ADP ribosylation factor 1 Homo sapiens 199-203 9020126-9 1997 These data indicate that the specificity for ARF action on the Golgi membranes is primarily determined by the Golgi guanine nucleotide exchange factor, which has a strong preference for myristoylated mammalian ARF1. Guanine Nucleotides 116-134 ADP ribosylation factor 1 Homo sapiens 210-214 8922375-8 1996 Vesicles bound coatomer in a physiological fashion requiring an ARF1-guanine nucleotide exchange activity. Guanine Nucleotides 69-87 ADP ribosylation factor 1 Homo sapiens 64-68 8861955-0 1996 p619, a giant protein related to the chromosome condensation regulator RCC1, stimulates guanine nucleotide exchange on ARF1 and Rab proteins. Guanine Nucleotides 88-106 ADP ribosylation factor 1 Homo sapiens 119-123 8861955-8 1996 Moreover, the second RCC1-like motif located at the amino-terminus of p619 stimulates guanine nucleotide exchange on ARF1 and on members of the related Rab proteins, but not on other small GTP binding proteins such as Ran or R-Ras2/TC21. Guanine Nucleotides 86-104 ADP ribosylation factor 1 Homo sapiens 117-121 1577740-0 1992 Characterization of the human gene encoding ADP-ribosylation factor 1, a guanine nucleotide-binding activator of cholera toxin. Guanine Nucleotides 73-91 ADP ribosylation factor 1 Homo sapiens 44-69 1448152-7 1992 Here we report the discovery of an enzyme in a Golgi-enriched fraction that catalyses guanine nucleotide (GDP-GTP) exchange on ARF-1 protein, and which is inhibited by brefeldin A. Guanine Nucleotides 86-104 ADP ribosylation factor 1 Homo sapiens 127-132