PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12578910-2	2003	However, more recently PKA-independent pathways have been established through the exchange protein directly activated by cAMP (Epac), a guanine nucleotide exchange factor for the small GTPases Rap1 and Rap2.	Guanine Nucleotides	136-154	RAP2A, member of RAS oncogene family	Homo sapiens	202-206	
15525675-2	2005	Here we show that the Caenorhabditis elegans homologue of the mammalian guanine nucleotide exchange factors PDZ-GEFs, PXF-1, specifically activates Rap1 and Rap2.	Guanine Nucleotides	72-90	RAP2A, member of RAS oncogene family	Homo sapiens	157-161	
24231725-3	2014	The latter act as guanine-nucleotide exchange factors for the RAS-like small G proteins Rap1 and Rap2.	Guanine Nucleotides	18-36	RAP2A, member of RAS oncogene family	Homo sapiens	97-101	
12469113-2	2003	Recently, guanine nucleotide exchange factors specific for the small GTP-binding proteins Rap1 and Rap2 (Epacs) were described, which are also activated directly by cAMP.	Guanine Nucleotides	10-28	RAP2A, member of RAS oncogene family	Homo sapiens	99-103	
11158328-7	2001	The identification of novel cAMP-binding proteins that exhibit guanine nucleotide exchange (GEF) activity (cAMP-GEFS; Epacs) has open new doors for cAMP action that include activation of small GTPases such as Rap1a, Rap2, and possibly Ras.	Guanine Nucleotides	63-81	RAP2A, member of RAS oncogene family	Homo sapiens	216-220	
11235208-3	2001	In 293T cells, Rap2 was regulated by the same set of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs) as those which regulated Rap1.	Guanine Nucleotides	53-71	RAP2A, member of RAS oncogene family	Homo sapiens	15-19	
29111327-2	2018	EPAC has two isoforms (EPAC1 and EPAC2) and is a cAMP-dependent guanine nucleotide exchange factor for the small GTPases, Rap1 and Rap2.	Guanine Nucleotides	64-82	RAP2A, member of RAS oncogene family	Homo sapiens	131-135	
23364803-2	2013	The Epac family members, including Epac1 and Epac2, are guanine nucleotide exchange factors for the Ras-like small GTPases Rap1 and Rap2, and they function independently of protein kinase A.	Guanine Nucleotides	56-74	RAP2A, member of RAS oncogene family	Homo sapiens	132-136	
18391018-2	2008	We show that exchange protein directly activated by cAMP (Epac), which functions as a guanine nucleotide exchange factor for the Ras-like GTPases Rap1 and Rap2, was required for cAMP-dependent stimulation of adipocyte differentiation.	Guanine Nucleotides	86-104	RAP2A, member of RAS oncogene family	Homo sapiens	155-159	
17300802-1	2007	Rap1 and Rap2 are the only small guanine nucleotide-binding proteins of the Ras superfamily that do not use glutamine for GTP hydrolysis.	Guanine Nucleotides	33-51	RAP2A, member of RAS oncogene family	Homo sapiens	9-13	
19855995-2	2010	Epac family, including Epac1 and Epac2, are guanine nucleotide exchange factors for the Ras-like small GTPases Rap1 and Rap2 and function independently of protein kinase A.	Guanine Nucleotides	44-62	RAP2A, member of RAS oncogene family	Homo sapiens	120-124	
19210747-5	2009	EPACs are specific guanine nucleotide exchange factors for the Ras GTPase homologues, Rap1 and Rap2, which they activate independently of the classical routes for cAMP signalling, cyclic nucleotide-gated ion channels and protein kinase A.	Guanine Nucleotides	19-37	RAP2A, member of RAS oncogene family	Homo sapiens	95-99	
19645719-0	2009	RasGEF1A and RasGEF1B are guanine nucleotide exchange factors that discriminate between Rap GTP-binding proteins and mediate Rap2-specific nucleotide exchange.	Guanine Nucleotides	26-44	RAP2A, member of RAS oncogene family	Homo sapiens	125-129	
18411261-1	2008	Exchange proteins directly activated by cAMP (EPACs) are guanine nucleotide-exchange factors for the small GTPases Rap1 and Rap2 and represent a key receptor for the ubiquitous cAMP second messenger in eukaryotes.	Guanine Nucleotides	57-75	RAP2A, member of RAS oncogene family	Homo sapiens	124-128	
16213650-11	2006	This work demonstrates that Rap2C is a new member of the Rap2 subfamily of proteins, able to bind guanine nucleotides with peculiar properties, and differently expressed by various hematopoietic subsets.	Guanine Nucleotides	98-117	RAP2A, member of RAS oncogene family	Homo sapiens	28-32