PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23601311-4 2013 We show that only the immobilized state of RCC1 interacts with Ran and conclude that its guanine nucleotide exchange activity is restricted to specific sites on chromatin. Guanine Nucleotides 89-107 regulator of chromosome condensation 1 Homo sapiens 43-47 28284242-4 2017 RCC1 is the major nuclear guanine nucleotide exchange factor for the small GTPase Ran enzyme. Guanine Nucleotides 26-44 regulator of chromosome condensation 1 Homo sapiens 0-4 15807788-2 2005 In vertebrates, these functions are controlled by a three-dimensional gradient of Ran-GTP to Ran-GDP, established by the spatial separation of Ran GTPase-activating protein (RanGAP) and the Ran guanine nucleotide exchange factor RCC1. Guanine Nucleotides 194-212 regulator of chromosome condensation 1 Homo sapiens 229-233 16449645-6 2006 Inactivation of the Ran guanine nucleotide exchange factor RCC1 inhibited Smad3 export and led to nuclear accumulation of phosphorylated Smad3. Guanine Nucleotides 24-42 regulator of chromosome condensation 1 Homo sapiens 59-63 15937128-1 2005 Yeast Gtr1p and its human homolog RRAG A belong to the Ras-like small G-protein superfamily and genetically interact with RCC1, a guanine nucleotide exchange factor for Ran GTPase. Guanine Nucleotides 130-148 regulator of chromosome condensation 1 Homo sapiens 122-126 10471274-9 1999 In the presence of nucleotide, the ternary complex of Ran.nucleotide.RCC1, an intermediate in the guanine nucleotide exchange reaction, could be observed. Guanine Nucleotides 98-116 regulator of chromosome condensation 1 Homo sapiens 69-73 11336674-0 2001 Structural basis for guanine nucleotide exchange on Ran by the regulator of chromosome condensation (RCC1). Guanine Nucleotides 21-39 regulator of chromosome condensation 1 Homo sapiens 101-105 15203004-3 2004 Ran-GTP is generated by the guanine nucleotide exchange factor RCC1, the localization of which to chromosomes is necessary for the fidelity of mitosis in human cells. Guanine Nucleotides 28-46 regulator of chromosome condensation 1 Homo sapiens 63-67 9933584-5 1999 The cell line tsBN2 contains a temperature-sensitive point mutation in the RCC1 gene, which encodes a guanine nucleotide exchange factor of Ran. Guanine Nucleotides 102-120 regulator of chromosome condensation 1 Homo sapiens 75-79 8861955-0 1996 p619, a giant protein related to the chromosome condensation regulator RCC1, stimulates guanine nucleotide exchange on ARF1 and Rab proteins. Guanine Nucleotides 88-106 regulator of chromosome condensation 1 Homo sapiens 71-75 9843686-4 1998 In this study, we show that mammalian p10/NTF2 dramatically inhibits the dissociation of [3H]GDP from Ran and the binding of [35S]GTPgammaS to Ran following the dissociation of non-radioactive GDP by RCC1, the only known mammalian guanine nucleotide exchange factor for Ran (Ran-GEF) [7]. Guanine Nucleotides 231-249 regulator of chromosome condensation 1 Homo sapiens 200-204 9233772-2 1997 This protein, designated p532 based on its predicted molecular weight (EMBO J 15: 5738, 1996), contains multiple structural domains including two regions of seven internal repeats highly related to the cell cycle regulator RCC1, a guanine nucleotide exchange factor for the small GTP-binding protein Ran, seven beta-repeat domains characteristic of the beta subunit of heterotrimeric G proteins, three putative SH3 binding sites, a putative leucine-zipper and a carboxy-terminal HECT domain characteristic of E3 ubiquitin-protein ligases. Guanine Nucleotides 231-249 regulator of chromosome condensation 1 Homo sapiens 223-227 8861955-8 1996 Moreover, the second RCC1-like motif located at the amino-terminus of p619 stimulates guanine nucleotide exchange on ARF1 and on members of the related Rab proteins, but not on other small GTP binding proteins such as Ran or R-Ras2/TC21. Guanine Nucleotides 86-104 regulator of chromosome condensation 1 Homo sapiens 21-25 8583915-0 1995 Catalysis of guanine nucleotide exchange of Ran by RCC1 and stimulation of hydrolysis of Ran-bound GTP by Ran-GAP1. Guanine Nucleotides 13-31 regulator of chromosome condensation 1 Homo sapiens 51-55 7548002-1 1995 The interaction of Ran, a Ras-related nuclear GTP-binding protein, with its guanine nucleotide exchange factor RCC1 has been studied by equilibrium and transient kinetic measurements using fluorescent nucleotides. Guanine Nucleotides 76-94 regulator of chromosome condensation 1 Homo sapiens 111-115 7603572-1 1995 Ran/TC4 is a small nuclear G protein that forms a complex with the chromatin-bound guanine nucleotide release factor RCC1 (ref. Guanine Nucleotides 83-101 regulator of chromosome condensation 1 Homo sapiens 117-121 7616957-4 1995 Partially purified, GST-fused RanBP1 inhibited RCC1-stimulated guanine nucleotide release from Ran in vitro. Guanine Nucleotides 63-81 regulator of chromosome condensation 1 Homo sapiens 47-51 7882974-1 1995 RCC1 (the regulator of chromosome condensation) stimulates guanine nucleotide dissociation on the Ras-related nuclear protein Ran. Guanine Nucleotides 59-77 regulator of chromosome condensation 1 Homo sapiens 0-4 7819259-1 1995 The guanine nucleotide dissociation and GTPase reactions of Ran, a Ras-related nuclear protein, have been investigated using different fluorescence techniques to determine how these reactions are stimulated by the guanine nucleotide exchange factor RCC1 and the other regulatory protein, RanGAP1 (GTPase-activating protein). Guanine Nucleotides 4-22 regulator of chromosome condensation 1 Homo sapiens 249-253 7819259-1 1995 The guanine nucleotide dissociation and GTPase reactions of Ran, a Ras-related nuclear protein, have been investigated using different fluorescence techniques to determine how these reactions are stimulated by the guanine nucleotide exchange factor RCC1 and the other regulatory protein, RanGAP1 (GTPase-activating protein). Guanine Nucleotides 214-232 regulator of chromosome condensation 1 Homo sapiens 249-253 7819259-4 1995 The intrinsic guanine nucleotide dissociation rates of Ran are also very low and are likewise increased 10(5)-fold by the exchange factor RCC1. Guanine Nucleotides 14-32 regulator of chromosome condensation 1 Homo sapiens 138-142 7819259-8 1995 The combination of these properties leads to stabilization of the Ran(T24N)-RCC1 complex and may result in vivo in depletion of RCC1 available for stimulating guanine nucleotide exchange. Guanine Nucleotides 159-177 regulator of chromosome condensation 1 Homo sapiens 76-80 7819259-8 1995 The combination of these properties leads to stabilization of the Ran(T24N)-RCC1 complex and may result in vivo in depletion of RCC1 available for stimulating guanine nucleotide exchange. Guanine Nucleotides 159-177 regulator of chromosome condensation 1 Homo sapiens 128-132 1944575-0 1991 Catalysis of guanine nucleotide exchange on Ran by the mitotic regulator RCC1. Guanine Nucleotides 13-31 regulator of chromosome condensation 1 Homo sapiens 73-77 8255297-3 1993 One known regulator, the protein RCC1 (refs 12, 13), interacts with Ran to catalyse guanine nucleotide exchange, and both RCC1 and Ran are components of an intrinsic checkpoint control that prevents the premature initiation of mitosis. Guanine Nucleotides 84-102 regulator of chromosome condensation 1 Homo sapiens 33-37 1944575-9 1991 Here we show that RCC1 specifically catalyses the exchange of guanine nucleotides on the Ran protein but not on the protein c-Ha-ras p21 (p21ras). Guanine Nucleotides 62-81 regulator of chromosome condensation 1 Homo sapiens 18-22 35549614-3 2022 Our recent work indicates that it interacts with and stimulates RCC1, the sole guanine nucleotide exchange factor for the GTPase Ran. Guanine Nucleotides 79-97 regulator of chromosome condensation 1 Homo sapiens 64-68