PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32048687-3 2020 Translocation of the fused wildtype Rac1 effector permits its activation by GEFs (guanine nucleotide exchange factors) and consequent actin polymerization and lamellipodia formation, unlike in existing single-chain systems that operate by allosteric photo-switching of constitutively active Rac1 or the heterodimerization-based (i.e. two-component) membrane recruitment of a Rac1-activating GEF. Guanine Nucleotides 82-100 Rac family small GTPase 1 Homo sapiens 36-40 32456244-5 2020 Second, through interaction with a set of calmodulin binding proteins (CaMBPs), calmodulin can control the capacity of several guanine nucleotide exchange factors (GEFs) to promote the switch of inactive KRas and Rac1 to an active conformation. Guanine Nucleotides 127-145 Rac family small GTPase 1 Homo sapiens 213-217 32339198-8 2020 The 9 bp deletion reported in this study increases the RAC1-dependent guanine nucleotide exchange factors (GEF) activity. Guanine Nucleotides 70-88 Rac family small GTPase 1 Homo sapiens 55-59 31300985-14 2019 The binding of Rac1 with guanine nucleotide-dissociation inhibitor (GDI) is decreased, but its association with the guanine exchange factor, Vav2, is increased, resulting in Rac1 activation. Guanine Nucleotides 25-43 Rac family small GTPase 1 Homo sapiens 15-19 31300985-3 2019 Rac1 activation is regulated by guanine exchange factors and guanine nucleotide-dissociation inhibitors, and post-translational modifications assist in its association with exchange factors and dissociation inhibitors. Guanine Nucleotides 61-79 Rac family small GTPase 1 Homo sapiens 0-4 30853411-1 2019 The Dedicator Of CytoKinesis (DOCK) family of atypical guanine nucleotide exchange factors activates the Rho family GTPases Rac and/or Cdc42 through DOCK homology region 2 (DHR-2). Guanine Nucleotides 55-73 Rac family small GTPase 1 Homo sapiens 124-127 31089935-3 2019 Rho GTPase-specific guanine nucleotide exchange factors (RhoGEFs) are regulated by various extracellular stimuli and activates Rho GTPase such as RhoA, Rac1, and Cdc42. Guanine Nucleotides 20-38 Rac family small GTPase 1 Homo sapiens 152-156 28489964-1 2019 PLEKHG2 is a Gbetagamma- and Galphas-dependent guanine nucleotide exchange factor for Rac1 and Cdc42 small GTPases and has been shown to mediate signaling pathways such as those for actin cytoskeletal reorganization and serum response element (SRE)-dependent gene transcription. Guanine Nucleotides 47-65 Rac family small GTPase 1 Homo sapiens 86-90 30108175-6 2018 We further found that HGF also promotes the recruitment of ELMO2 and DOCK180, a bipartite guanine nucleotide exchange factor for RAC1, to the MET-AXL complex and thereby stimulates the RAC1-dependent cytoskeleton reorganization. Guanine Nucleotides 90-108 Rac family small GTPase 1 Homo sapiens 129-133 30108175-6 2018 We further found that HGF also promotes the recruitment of ELMO2 and DOCK180, a bipartite guanine nucleotide exchange factor for RAC1, to the MET-AXL complex and thereby stimulates the RAC1-dependent cytoskeleton reorganization. Guanine Nucleotides 90-108 Rac family small GTPase 1 Homo sapiens 185-189 27669437-1 2017 DOCK proteins are guanine nucleotide exchange factors for Rac and Cdc42 GTPases. Guanine Nucleotides 18-36 Rac family small GTPase 1 Homo sapiens 58-61 29130632-1 2018 Dedicator of cytokinesis (DOCK) family are evolutionary conserved guanine nucleotide exchange factors (GEFs) for the Rho GTPases, Rac, and Cdc42. Guanine Nucleotides 66-84 Rac family small GTPase 1 Homo sapiens 130-133 27267709-5 2017 RAC1/2 guanine nucleotide exchange factors harbouring polybasic stretches are recruited by PtdOH to sites of ruffle formation. Guanine Nucleotides 7-25 Rac family small GTPase 1 Homo sapiens 0-4 29967243-1 2018 Rac1 is a small guanine nucleotide binding protein that cycles between an inactive GDP-bound and active GTP-bound state to regulate cell motility and migration. Guanine Nucleotides 16-34 Rac family small GTPase 1 Homo sapiens 0-4 29844364-3 2018 Here, we demonstrate that STEF/TIAM2, a Rac1 selective guanine nucleotide exchange factor, localises at the nuclear envelope, co-localising with the key perinuclear proteins Nesprin-2G and Non-muscle myosin IIB (NMMIIB), where it regulates perinuclear Rac1 activity. Guanine Nucleotides 55-73 Rac family small GTPase 1 Homo sapiens 40-44 29178143-1 2017 Rac1 GTPase interaction with guanine nucleotide exchange factor Tiam1 is involved in several cancer types and cardiovascular diseases. Guanine Nucleotides 29-47 Rac family small GTPase 1 Homo sapiens 0-4 28807941-3 2017 This review examines the multiple mechanisms leading to Rac1 hyperactivation, particularly focusing on emerging paradigms that involve gain-of-function mutations in Rac and guanine nucleotide exchange factors, defects in Rac1 degradation, and mislocalization of Rac signaling components. Guanine Nucleotides 173-191 Rac family small GTPase 1 Homo sapiens 56-60 27152953-0 2016 Proteomic analysis of Rac1 signaling regulation by guanine nucleotide exchange factors. Guanine Nucleotides 51-69 Rac family small GTPase 1 Homo sapiens 22-26 27693992-10 2016 Glutathionylation of Rac1 on cysteine 81 and 157 located adjacent to guanine nucleotide binding site was required for the metabolic stress to inhibit Rac1 activity and promote endothelial hyperpermeability. Guanine Nucleotides 69-87 Rac family small GTPase 1 Homo sapiens 21-25 27693992-10 2016 Glutathionylation of Rac1 on cysteine 81 and 157 located adjacent to guanine nucleotide binding site was required for the metabolic stress to inhibit Rac1 activity and promote endothelial hyperpermeability. Guanine Nucleotides 69-87 Rac family small GTPase 1 Homo sapiens 150-154 27152953-3 2016 The diversity of Rac1 functioning in cells is mainly attributed to its ability to bind to a multitude of downstream effectors following activation by Guanine nucleotide Exchange Factors (GEFs). Guanine Nucleotides 150-168 Rac family small GTPase 1 Homo sapiens 17-21 25516960-2 2015 RhoGDI2 is a guanine nucleotide dissociation inhibitor (GDI) for the Rho family of GTPases thought to primarily bind to Rac1; however, Rac1 activation was not decreased by RhoGDI2 expression in bladder cancer cells. Guanine Nucleotides 13-31 Rac family small GTPase 1 Homo sapiens 120-124 27182061-2 2016 The PIX proteins, alpha-PIX and beta-PIX (also known as ARHGEF6 and ARHGEF7, respectively), are guanine nucleotide exchange factors (activators) for the Rho family small GTP-binding protein family members Rac1 and Cdc42. Guanine Nucleotides 96-114 Rac family small GTPase 1 Homo sapiens 205-209 26887924-0 2016 Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration. Guanine Nucleotides 32-50 Rac family small GTPase 1 Homo sapiens 13-17 26887924-0 2016 Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration. Guanine Nucleotides 32-50 Rac family small GTPase 1 Homo sapiens 98-102 25332238-4 2015 Elmo proteins are established to interact with Dock family guanine nucleotide exchange factors to control Rac-mediated cytoskeletal dynamics. Guanine Nucleotides 59-77 Rac family small GTPase 1 Homo sapiens 106-109 25635515-7 2015 Notably, S177D-Pdlim5, but not WT-Pdlim5, attenuates the association with Rac1-specific guanine nucleotide exchange factors at the cell periphery. Guanine Nucleotides 88-106 Rac family small GTPase 1 Homo sapiens 74-78 25289457-4 2015 Whereas much attention has been devoted to guanine nucleotide exchange factors that act on Rac1 to promote GTP loading and Rac1 activation, cellular oxidants may also regulate Rac1 activation by promoting guanine nucleotide exchange. Guanine Nucleotides 43-61 Rac family small GTPase 1 Homo sapiens 91-95 25289457-4 2015 Whereas much attention has been devoted to guanine nucleotide exchange factors that act on Rac1 to promote GTP loading and Rac1 activation, cellular oxidants may also regulate Rac1 activation by promoting guanine nucleotide exchange. Guanine Nucleotides 43-61 Rac family small GTPase 1 Homo sapiens 123-127 25289457-4 2015 Whereas much attention has been devoted to guanine nucleotide exchange factors that act on Rac1 to promote GTP loading and Rac1 activation, cellular oxidants may also regulate Rac1 activation by promoting guanine nucleotide exchange. Guanine Nucleotides 43-61 Rac family small GTPase 1 Homo sapiens 123-127 25289457-7 2015 Oxidation of Cys(18) by glutathione greatly perturbs Rac1 guanine nucleotide binding and promotes nucleotide exchange. Guanine Nucleotides 58-76 Rac family small GTPase 1 Homo sapiens 53-57 25655724-5 2015 Inhibition of the Trio-mediated Rac1 guanine nucleotide exchange activity with ITX3 partially blocked the SV4-mediated increase in Rac1-GTP. Guanine Nucleotides 37-55 Rac family small GTPase 1 Homo sapiens 32-36 25655724-5 2015 Inhibition of the Trio-mediated Rac1 guanine nucleotide exchange activity with ITX3 partially blocked the SV4-mediated increase in Rac1-GTP. Guanine Nucleotides 37-55 Rac family small GTPase 1 Homo sapiens 131-135 25655724-11 2015 Supervillin and Trio knockdowns, separately or together, inhibited cell spreading, suggesting that supervillin regulates the Rac1 guanine nucleotide exchange activity of Trio, and potentially also kalirin, during cell spreading and lamellipodia extension. Guanine Nucleotides 130-148 Rac family small GTPase 1 Homo sapiens 125-129 19933863-6 2009 Regarding the mechanism for this effect, we found that STAP-2 associates with Vav1, the guanine-nucleotide exchanging factor for Rac1, and enhances downstream Vav1/Rac1 signaling. Guanine Nucleotides 88-106 Rac family small GTPase 1 Homo sapiens 129-133 25014207-5 2014 In contrast to non-prenylated human Rac1 purified from Escherichia coli, prenylated Rac1 from insect cells was able to associate with synthetic liposomes and to bind Rho-specific guanine nucleotide dissociation inhibitor 1 (GDI1). Guanine Nucleotides 179-197 Rac family small GTPase 1 Homo sapiens 84-88 25014207-7 2014 The extraction was prevented when Rac1 was activated to its GTP-bound state by Rac-specific guanine nucleotide exchange factors (GEFs), such as Vav2, Dbl, Tiam1, P-Rex1 and TrioN, and bound by the downstream effector Pak1. Guanine Nucleotides 92-110 Rac family small GTPase 1 Homo sapiens 34-38 25014207-7 2014 The extraction was prevented when Rac1 was activated to its GTP-bound state by Rac-specific guanine nucleotide exchange factors (GEFs), such as Vav2, Dbl, Tiam1, P-Rex1 and TrioN, and bound by the downstream effector Pak1. Guanine Nucleotides 92-110 Rac family small GTPase 1 Homo sapiens 34-37 24607953-2 2014 In this review, we focus on RhoA and Rac1--2 Rho GTPases that are required for efficient adhesion and migration--and describe how specific guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs) regulate the extensive crosstalk that exists between them. Guanine Nucleotides 139-157 Rac family small GTPase 1 Homo sapiens 37-41 24043306-9 2013 T108 phosphorylation targets Rac1 to the nucleus, which isolates Rac1 from other guanine nucleotide exchange factors (GEFs) and hinders Rac1"s role in cell migration. Guanine Nucleotides 81-99 Rac family small GTPase 1 Homo sapiens 29-33 24043306-9 2013 T108 phosphorylation targets Rac1 to the nucleus, which isolates Rac1 from other guanine nucleotide exchange factors (GEFs) and hinders Rac1"s role in cell migration. Guanine Nucleotides 81-99 Rac family small GTPase 1 Homo sapiens 65-69 24043306-9 2013 T108 phosphorylation targets Rac1 to the nucleus, which isolates Rac1 from other guanine nucleotide exchange factors (GEFs) and hinders Rac1"s role in cell migration. Guanine Nucleotides 81-99 Rac family small GTPase 1 Homo sapiens 65-69 23014990-5 2012 The segregation of the ELMO clade from the larger ELMOD group is consistent with their contrasting functions as unconventional Rac1 guanine nucleotide exchange factors and the Arf family GTPase-activating proteins, respectively. Guanine Nucleotides 132-150 Rac family small GTPase 1 Homo sapiens 127-131 22238672-1 2012 The guanine-nucleotide exchange factor Trio encodes two DH-PH domains that catalyze nucleotide exchange on Rac1, RhoG and RhoA. Guanine Nucleotides 4-22 Rac family small GTPase 1 Homo sapiens 107-111 23718289-3 2013 Here we show that the guanine nucleotide exchange domain of DOCK7, DHR2 (for DOCK homology region 2), is a potent GEF for prenylated Cdc42 and Rac1 in a model liposome system, demonstrating that the prenylation and membrane localization of Cdc42 or Rac1 are necessary for their activation by DOCK7. Guanine Nucleotides 22-40 Rac family small GTPase 1 Homo sapiens 143-147 23718289-3 2013 Here we show that the guanine nucleotide exchange domain of DOCK7, DHR2 (for DOCK homology region 2), is a potent GEF for prenylated Cdc42 and Rac1 in a model liposome system, demonstrating that the prenylation and membrane localization of Cdc42 or Rac1 are necessary for their activation by DOCK7. Guanine Nucleotides 22-40 Rac family small GTPase 1 Homo sapiens 249-253 21943825-6 2011 Inactivation of Rac1 by using a Rac1 inhibitor NSC23766 or siRNA knocking down the expression of Tiam1, a guanine nucleotide exchange factor for Rac, significantly reduced Trastuzumab resistance in SKBR3 cells. Guanine Nucleotides 106-124 Rac family small GTPase 1 Homo sapiens 16-20 20444104-2 2010 In the human opportunistic pathogen Candida albicans, Rac1 and its activator Dck1, a member of the CED5, Dock180, myoblast city family of guanine nucleotide exchange factors, are required for the budding to filamentous transition during invasive growth. Guanine Nucleotides 138-156 Rac family small GTPase 1 Homo sapiens 54-58 20237902-2 2010 Dock180 was well known for the main target of signal adaptor protein Crk and acted as a guanine-nucleotide exchange factor for small GTPase Rac1. Guanine Nucleotides 88-106 Rac family small GTPase 1 Homo sapiens 140-144 19088377-5 2009 Furthermore, we found a similar novel phenotype in the absence of Vav1, Vav2, and Vav3, which function as guanine nucleotide exchange factors for Rac1 and Rac2. Guanine Nucleotides 106-124 Rac family small GTPase 1 Homo sapiens 146-150 19525225-4 2009 APC interacts with Asef and Asef2, Rac1- and Cdc42-specific guanine nucleotide exchange factors (GEFs), and stimulates their GEF activity; thereby regulating cell morphology, adhesion, and migration. Guanine Nucleotides 60-78 Rac family small GTPase 1 Homo sapiens 35-39 17686471-5 2007 To form these membrane protrusions, Rac1 is activated by guanine nucleotide exchange factors (GEFs) that catalyze the exchange of GDP for GTP. Guanine Nucleotides 57-75 Rac family small GTPase 1 Homo sapiens 36-40 18482007-0 2008 Activation of the small GTPase Rac1 by a specific guanine-nucleotide-exchange factor suffices to induce glucose uptake into skeletal-muscle cells. Guanine Nucleotides 50-68 Rac family small GTPase 1 Homo sapiens 31-35 18596235-1 2008 DOCK180 is the archetype of the DOCK180-family guanine nucleotide exchange factor for small GTPases Rac1 and Cdc42. Guanine Nucleotides 47-65 Rac family small GTPase 1 Homo sapiens 100-104 18267089-2 2008 PAR-3 directly interacts with Tiam1/Taim2 (STEF), Rac1-specific guanine nucleotide exchange factors, and forms a complex with aPKC-PAR-6-Cdc42*GTP, leading to Rac1 activation. Guanine Nucleotides 64-82 Rac family small GTPase 1 Homo sapiens 50-54 17932039-7 2007 Furthermore, our biochemical analyses with recombinant Rac proteins found that EHT 1864 possesses high affinity binding to Rac1, as well as the related Rac1b, Rac2, and Rac3 isoforms, and this association promoted the loss of bound nucleotide, inhibiting both guanine nucleotide association and Tiam1 Rac guanine nucleotide exchange factor-stimulated exchange factor activity in vitro. Guanine Nucleotides 260-278 Rac family small GTPase 1 Homo sapiens 55-58 17932039-7 2007 Furthermore, our biochemical analyses with recombinant Rac proteins found that EHT 1864 possesses high affinity binding to Rac1, as well as the related Rac1b, Rac2, and Rac3 isoforms, and this association promoted the loss of bound nucleotide, inhibiting both guanine nucleotide association and Tiam1 Rac guanine nucleotide exchange factor-stimulated exchange factor activity in vitro. Guanine Nucleotides 260-278 Rac family small GTPase 1 Homo sapiens 123-127 18589439-4 2008 These unique interactions stabilize the Vav1 DH domain for its intimate association with the Switch II region of Rac1 that is critical for the displacement of the guanine nucleotide. Guanine Nucleotides 163-181 Rac family small GTPase 1 Homo sapiens 113-117 18374160-5 2008 Our work suggests that EHT 1864 selectively inhibits Rac1 downstream signaling and cellular transformation by a novel mechanism involving guanine nucleotide displacement. Guanine Nucleotides 138-156 Rac family small GTPase 1 Homo sapiens 53-57 17932039-10 2007 Taken together, our results suggest that EHT 1864 selectively inhibits Rac downstream signaling and transformation by a novel mechanism involving guanine nucleotide displacement. Guanine Nucleotides 146-164 Rac family small GTPase 1 Homo sapiens 71-74 14506233-2 2003 Rac1 is activated by guanine nucleotide exchange factors and inactivated by GTPase-activating proteins. Guanine Nucleotides 21-39 Rac family small GTPase 1 Homo sapiens 0-4 17128987-1 2006 We have previously shown that redox agents including superoxide anion radical and nitrogen dioxide can react with GXXXXGK(S/T)C motif-containing GTPases (i.e., Rac1, Cdc42, and RhoA) to stimulate guanine nucleotide release. Guanine Nucleotides 196-214 Rac family small GTPase 1 Homo sapiens 160-164 16337026-1 2006 Alpha and betaPIX belong to the group of guanine nucleotide exchange factors (GEFs) that mediate activation of members of the Rho GTPase family, in particular Rac1 and Cdc42, by stimulating the exchange of GDP for GTP. Guanine Nucleotides 41-59 Rac family small GTPase 1 Homo sapiens 159-163 16289968-6 2005 Fluorescently labeled guanine nucleotides serve as fluorescence reporter groups to investigate the interactions of GTPases of the Rho family (e.g., RhoA, Rac1, and Cdc42). Guanine Nucleotides 22-41 Rac family small GTPase 1 Homo sapiens 154-158 17570359-5 2007 Previous studies have shown that RhoG activates Rac1 and induces several cellular functions including promotion of cell migration through its effector ELMO and the ELMO-binding protein Dock180 that function as a Rac-specific guanine nucleotide exchange factor. Guanine Nucleotides 225-243 Rac family small GTPase 1 Homo sapiens 48-52 17214551-1 2007 Asef is a member of the Dbl-family of guanine nucleotide exchange factors (GEFs) with a proposed specificity for the small GTPase Rac1. Guanine Nucleotides 38-56 Rac family small GTPase 1 Homo sapiens 130-134 15479739-2 2004 Here, we demonstrate that Rap1 regulates cell spreading by localizing guanine nucleotide exchange factors (GEFs) that act via the Rho family GTPase Rac1. Guanine Nucleotides 70-88 Rac family small GTPase 1 Homo sapiens 148-152 14973186-2 2004 We show that three guanosine 5"-triphosphate analogs with BODIPY fluorophores coupled via the gamma phosphate bind to the GTPases Cdc42, Rac1, RhoA, and Ras and displace guanosine 5"-diphosphate with high intrinsic exchange rates in the presence of Mg(2+) ions, thereby acting as synthetic, low molecular weight guanine nucleotide exchange factors. Guanine Nucleotides 312-330 Rac family small GTPase 1 Homo sapiens 137-141 14506233-7 2003 The regulation of both Rac1 and Rac1b activities is dependent on guanine nucleotide exchange factors and GTPase-activating proteins, but the difference in their activation is mainly determined by the inability of Rac1b to interact with Rho-GDI. Guanine Nucleotides 65-83 Rac family small GTPase 1 Homo sapiens 23-27 12626503-2 2003 Here we report a novel interaction between Shank and beta PIX, a guanine nucleotide exchange factor for the Rac1 and Cdc42 small GTPases. Guanine Nucleotides 65-83 Rac family small GTPase 1 Homo sapiens 108-112 13679059-8 2003 Guanine nucleotide exchange activities of the testis-expressed mouse Mcf-2 and human Dbl were analyzed using RhoA, Rac1, and Cdc42 as substrates. Guanine Nucleotides 0-18 Rac family small GTPase 1 Homo sapiens 115-119 12810717-5 2003 We further show that Vav2 and the ubiquitously expressed Rac1 guanine nucleotide exchange factor Tiam1 are phosphorylated in tyrosine residues in cells transfected with active and oncogenic Src. Guanine Nucleotides 62-80 Rac family small GTPase 1 Homo sapiens 57-61 12376551-4 2002 First, we determined that RhoG was regulated by guanine nucleotide exchange factors that also activate Rac and/or Cdc42. Guanine Nucleotides 48-66 Rac family small GTPase 1 Homo sapiens 103-106 12475976-12 2003 These results reveal the existence of a novel mechanism of Rac activation by a guanine nucleotide exchange factor and suggest that the induction by Trio of a conformational change in Rac1, in the absence of nucleotide exchange, is sufficient for enhancing its effector function. Guanine Nucleotides 79-97 Rac family small GTPase 1 Homo sapiens 183-187 12551911-1 2003 The armadillo protein SmgGDS promotes guanine nucleotide exchange by small GTPases containing a C-terminal polybasic region (PBR), such as Rac1 and RhoA. Guanine Nucleotides 38-56 Rac family small GTPase 1 Homo sapiens 139-143 10985780-1 2000 Guanine nucleotide dissociation stimulator (GDS) promotes the release of tightly bound GDP from various Ras superfamily proteins, including RhoA, Rac1, K-Ras, Rap1A, and Rap1B. Guanine Nucleotides 0-18 Rac family small GTPase 1 Homo sapiens 146-150 12192056-2 2002 We developed fluorescent resonance energy transfer-based probes which monitored the local balance between the activities of guanine nucleotide exchange factors and GTPase-activating proteins for Rac1 and Cdc42 at the membrane. Guanine Nucleotides 124-142 Rac family small GTPase 1 Homo sapiens 195-199 11595749-0 2001 Trp(56) of rac1 specifies interaction with a subset of guanine nucleotide exchange factors. Guanine Nucleotides 55-73 Rac family small GTPase 1 Homo sapiens 11-15 11590143-4 2001 FHOS interacted with the polybasic domain in the Rac1 C terminus in a guanine nucleotide-independent manner but did not interact with RhoA, Cdc42Hs, Rac2, or Rac3. Guanine Nucleotides 70-88 Rac family small GTPase 1 Homo sapiens 49-53 11130063-0 2000 Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1. Guanine Nucleotides 46-64 Rac family small GTPase 1 Homo sapiens 21-25 11130063-3 2000 The two switch regions of Rac1 are stabilized in conformations that disrupt both magnesium binding and guanine nucleotide interaction. Guanine Nucleotides 103-121 Rac family small GTPase 1 Homo sapiens 26-30 11130063-6 2000 The Tiam1/Rac1 structure highlights the interactions that catalyse nucleotide exchange on Rho family G proteins, and illustrates structural determinants dictating specificity between individual Rho family members and their associated Dbl-related guanine nucleotide exchange factors. Guanine Nucleotides 246-264 Rac family small GTPase 1 Homo sapiens 10-14 11685227-0 2001 Molecular basis for Rac1 recognition by guanine nucleotide exchange factors. Guanine Nucleotides 40-58 Rac family small GTPase 1 Homo sapiens 20-24 11728333-2 2001 Previously, the guanine nucleotide binding protein Rac-1 has been shown to control pre-T cell development. Guanine Nucleotides 16-34 Rac family small GTPase 1 Homo sapiens 51-56 11134022-8 2001 Furthermore, the oligomer-to-monomer transition of Rac1-GDP could be driven effectively by interaction with the Rho guanine nucleotide dissociation inhibitor. Guanine Nucleotides 116-134 Rac family small GTPase 1 Homo sapiens 51-55 10843989-2 2000 Here we have investigated the role of Mg(2+) cofactor in the guanine nucleotide binding and hydrolysis processes of the Rho family members, Cdc42, Rac1, and RhoA. Guanine Nucleotides 61-79 Rac family small GTPase 1 Homo sapiens 147-151 10725329-2 2000 Here, we show that the small guanine nucleotide (GTP)-binding protein, Rac1, can be activated upon HA binding to CD44. Guanine Nucleotides 29-47 Rac family small GTPase 1 Homo sapiens 71-75 35203342-4 2022 The p.Arg200Trp variant in mouse (Plekhg2-RW), which corresponds to the p.Arg204Trp variant in humans, showed decreased guanine nucleotide-exchange activity for Rac1, Rac3, and Cdc42. Guanine Nucleotides 120-138 Rac family small GTPase 1 Homo sapiens 161-165 10579713-4 1999 ECT2 catalyzes guanine nucleotide exchange on the small GTPases, RhoA, Rac1, and Cdc42. Guanine Nucleotides 15-33 Rac family small GTPase 1 Homo sapiens 71-75 10872457-1 1999 Members of the Rho family of small Ras-like GTPases--including RhoA, -B, and -C, Rac1 and -2, and Cdc42--exhibit guanine nucleotide-binding activity and function as molecular switches, cycling between an inactive GDP-bound state and an active GTP-bound state. Guanine Nucleotides 113-131 Rac family small GTPase 1 Homo sapiens 35-92 8760286-3 1996 Interestingly, DH domains are frequently found in guanine nucleotide-exchange factors for small GTP-binding proteins of the Ras and Rho families, and it has been recently shown that, whereas Ras controls the activation of mitogen activated kinases (MAPKs), two members of the Rho family of small GTPases, Rac 1 and Cdc42, regulate activity of stress activated protein kinases (SAPKs), also termed c-jun N-terminal kinases (JNKs). Guanine Nucleotides 50-68 Rac family small GTPase 1 Homo sapiens 305-310 8621595-3 1996 A second protein that interacts with p120Ras-GAP is P190Rac-GAP, which activates the GTPase of guanine nucleotide-binding proteins of the Rho family (including Rac1 and Rac2). Guanine Nucleotides 95-113 Rac family small GTPase 1 Homo sapiens 160-164 9285789-0 1997 Huntingtin-associated protein 1 (HAP1) binds to a Trio-like polypeptide, with a rac1 guanine nucleotide exchange factor domain. Guanine Nucleotides 85-103 Rac family small GTPase 1 Homo sapiens 80-84 33660564-2 2021 ELMO proteins form a tight complex with the DOCK1-5 guanine nucleotide exchange factors that regulate RAC1 spatiotemporal activation and signalling. Guanine Nucleotides 52-70 Rac family small GTPase 1 Homo sapiens 102-106 35174167-2 2021 ARHGEF3 or XPLN (exchange factor found in platelets, leukemic, and neuronal tissues) is a selective guanine nucleotide exchange factor for Rho GTPases (RhoGEFs) that activates RhoA and RhoB but not RhoC, RhoG, Rac1, or Cdc42. Guanine Nucleotides 100-118 Rac family small GTPase 1 Homo sapiens 210-214 2674130-4 1989 rac1 and rac2 possess four of the five conserved functional domains in ras associated with binding and hydrolysis of guanine nucleotides. Guanine Nucleotides 117-136 Rac family small GTPase 1 Homo sapiens 0-4 33284659-1 2021 BACKGROUND AND AIM: As a Rac1 guanine nucleotide exchange factor, T-cell lymphoma invasion and metastasis 2 (TIAM2) has been reported to be correlated with malignant phenotypes in several cancers, but its prognostic significance and function in pancreatic ductal adenocarcinoma (PDAC) was not investigated. Guanine Nucleotides 30-48 Rac family small GTPase 1 Homo sapiens 25-29 32978791-0 2020 The guanine nucleotide exchange factor FLJ00068 activates Rac1 in adipocyte insulin signaling. Guanine Nucleotides 4-22 Rac family small GTPase 1 Homo sapiens 58-62 33200195-1 2020 The Tiam family proteins - Tiam1 and Tiam2/STEF - are Rac1-specific Guanine Nucleotide Exchange Factors (GEFs) with important functions in epithelial, neuronal, immune and other cell types. Guanine Nucleotides 68-86 Rac family small GTPase 1 Homo sapiens 54-58 32978791-4 2020 Here, we show that knockdown of the guanine nucleotide exchange factor FLJ00068 inhibits Rac1 activation and GLUT4 translocation by insulin and a constitutively activated form of the protein kinase Akt2. Guanine Nucleotides 36-54 Rac family small GTPase 1 Homo sapiens 89-93