PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7651382-6 1995 Radioligand binding of [125I] angiotensin II to the angiotensin II receptor was specific, saturable, reversible and modulated by guanine nucleotides. Guanine Nucleotides 129-148 angiotensinogen Rattus norvegicus 30-44 16698001-8 2006 AngII altered neither expression nor tyrosine phosphorylation of GTPase activating protein GAP-p190 and the guanine nucleotide exchange factors Vav and Tiam. Guanine Nucleotides 108-126 angiotensinogen Rattus norvegicus 0-5 16698001-9 2006 Transaortic constriction as well as AngII increased the binding of Rho guanine nucleotide dissociation inhibitor (RhoGDIalpha) to Rac1. Guanine Nucleotides 71-89 angiotensinogen Rattus norvegicus 36-41 15927708-6 2005 However, the guanine nucleotide had no effect on the binding of 125I-[Sar1,Ile8]angiotensin II as has also been reported elsewhere, and may suggest that Sar1-Ile8-angiotensin II, being a partial agonist, binds to both the G-protein coupled and uncoupled states of the angiotensin receptors. Guanine Nucleotides 13-31 angiotensinogen Rattus norvegicus 163-177 8967472-4 1996 The sensitivity of 125I-ANG II binding to AT1a and AT1b receptors to guanine nucleotides was unaffected by pertussis toxin treatment. Guanine Nucleotides 69-88 angiotensinogen Rattus norvegicus 24-30 7651382-6 1995 Radioligand binding of [125I] angiotensin II to the angiotensin II receptor was specific, saturable, reversible and modulated by guanine nucleotides. Guanine Nucleotides 129-148 angiotensinogen Rattus norvegicus 52-66 7977700-2 1994 Here we have shown that the AT2-receptor-mediated stimulation of neuronal IK by ANG II (100 nM) was abolished by pretreatment of cultures with pertussis toxin (PTX; 200 ng/ml) and by intracellular application of an antibody against the inhibitory guanine nucleotide (GTP) binding protein (anti-Gi alpha, 1:200). Guanine Nucleotides 247-265 angiotensinogen Rattus norvegicus 80-86 7929124-1 1994 Angiotensin II (AII) receptors are known to interact with two distinct guanine nucleotide binding proteins, Gq/11 and Gi, in rat adrenal glomerulosa cells to activate phospholipase C and to inhibit adenylate cyclase, respectively. Guanine Nucleotides 71-89 angiotensinogen Rattus norvegicus 0-14 1667760-4 1991 The stable guanine nucleotide GTP gamma S inhibited binding of [125I][Sar1]angiotensin II in young and adult rats by approximately 50% with IC50 values of 105 and 120 nM, respectively, suggesting that the angiotensin receptor is G-protein linked. Guanine Nucleotides 11-29 angiotensinogen Rattus norvegicus 75-89 7525030-15 1994 These data indicate a reversal of control by AII in the hypertrophic Dahl S heart in response to forskolin, which activates adenylyl cyclase directly on the catalytic subunit, converting the substrate, ATP, to cAMP, independent of the guanine nucleotide activated protein, and in response to isoproterenol, which activates adenylyl cyclase through G protein mechanisms. Guanine Nucleotides 235-253 angiotensinogen Rattus norvegicus 45-48 1698055-9 1990 In crude WB lysates, angiotensin II, [Arg8]vasopressin and adrenaline each stimulated inositol phosphate formation in a guanine-nucleotide-dependent manner. Guanine Nucleotides 120-138 angiotensinogen Rattus norvegicus 21-35 1649188-9 1991 The effect of angiotensin II on [alpha-32P]GDP dissociation was blocked by the angiotensin II receptor antagonist [Sar1,Ile8]angiotensin II, demonstrating that the guanine nucleotide binding was receptor-mediated. Guanine Nucleotides 164-182 angiotensinogen Rattus norvegicus 14-28 1649188-9 1991 The effect of angiotensin II on [alpha-32P]GDP dissociation was blocked by the angiotensin II receptor antagonist [Sar1,Ile8]angiotensin II, demonstrating that the guanine nucleotide binding was receptor-mediated. Guanine Nucleotides 164-182 angiotensinogen Rattus norvegicus 79-93 1649188-9 1991 The effect of angiotensin II on [alpha-32P]GDP dissociation was blocked by the angiotensin II receptor antagonist [Sar1,Ile8]angiotensin II, demonstrating that the guanine nucleotide binding was receptor-mediated. Guanine Nucleotides 164-182 angiotensinogen Rattus norvegicus 79-93 1649738-0 1991 Angiotensin-II receptor subtypes in fetal tissue of the rat: autoradiography, guanine nucleotide sensitivity, and association with phosphoinositide hydrolysis. Guanine Nucleotides 78-96 angiotensinogen Rattus norvegicus 0-14 2826911-5 1987 The adrenal AII receptor, like that in other tissues, is coupled to the inhibitory guanine nucleotide inhibitory protein (Ni). Guanine Nucleotides 83-101 angiotensinogen Rattus norvegicus 12-15 2826911-8 1987 The actions of AII on adrenal cortical function are thus regulated by at least two guanine nucleotide regulatory proteins that are selectively activated by increasing AII concentrations. Guanine Nucleotides 83-101 angiotensinogen Rattus norvegicus 15-18 2826911-8 1987 The actions of AII on adrenal cortical function are thus regulated by at least two guanine nucleotide regulatory proteins that are selectively activated by increasing AII concentrations. Guanine Nucleotides 83-101 angiotensinogen Rattus norvegicus 167-170 23233801-1 2012 PURPOSE: Studies to explore angiotensin II (Ang II) and its downstream signaling pathways via Rho guanine nucleotide exchange factors (RhoGEFs) and RhoA signaling are crucial to understanding the mechanisms of smooth muscle contraction leading to hypertension. Guanine Nucleotides 98-116 angiotensinogen Rattus norvegicus 28-42 6318757-4 1983 Guanine nucleotides such as GTP or GMP-P (NH)P were also required to elicit the inhibition by angiotensin II. Guanine Nucleotides 0-19 angiotensinogen Rattus norvegicus 94-108 6279654-3 1982 Guanine nucleotides were observed to modify the binding of 125I-angiotensin II to rat hepatic plasma membrane receptors. Guanine Nucleotides 0-19 angiotensinogen Rattus norvegicus 64-78 6279654-7 1982 In analogous experiments using the angiotensin II antagonist, 125I-sarcosine1,Ala8-angiotensin II (125I-saralasin), guanine nucleotides minimally affected the interaction of 125I-saralasin with its receptor, increasing the dissociation rate 1.9-fold and the Kd 1.4-fold. Guanine Nucleotides 116-135 angiotensinogen Rattus norvegicus 35-49 6279654-7 1982 In analogous experiments using the angiotensin II antagonist, 125I-sarcosine1,Ala8-angiotensin II (125I-saralasin), guanine nucleotides minimally affected the interaction of 125I-saralasin with its receptor, increasing the dissociation rate 1.9-fold and the Kd 1.4-fold. Guanine Nucleotides 116-135 angiotensinogen Rattus norvegicus 83-97 6279654-13 1982 The ability of angiotensin II to inhibit cyclic AMP synthesis may provide an explanation for the observed effects of guanine nucleotides on 125I-angiotensin II binding to plasma membranes. Guanine Nucleotides 117-136 angiotensinogen Rattus norvegicus 15-29 6279654-13 1982 The ability of angiotensin II to inhibit cyclic AMP synthesis may provide an explanation for the observed effects of guanine nucleotides on 125I-angiotensin II binding to plasma membranes. Guanine Nucleotides 117-136 angiotensinogen Rattus norvegicus 145-159 23233801-1 2012 PURPOSE: Studies to explore angiotensin II (Ang II) and its downstream signaling pathways via Rho guanine nucleotide exchange factors (RhoGEFs) and RhoA signaling are crucial to understanding the mechanisms of smooth muscle contraction leading to hypertension. Guanine Nucleotides 98-116 angiotensinogen Rattus norvegicus 44-50