PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34243065-1	2021	ALS2, a product of the causative gene for familial amyotrophic lateral sclerosis (ALS) type 2, plays a pivotal role in the regulation of endosome dynamics by activating small GTPase Rab5 via its intrinsic guanine nucleotide-exchange factor activity.	Guanine Nucleotides	205-223	alsin Rho guanine nucleotide exchange factor ALS2	Homo sapiens	0-4	
16085057-5	2005	Our results further demonstrate the requirement of the Alsin VPS9 domain for occurrence of the vacuolation process and the role of Alsin as a guanine nucleotide exchange factor for Rab5.	Guanine Nucleotides	142-160	alsin Rho guanine nucleotide exchange factor ALS2	Homo sapiens	131-136	
33339852-3	2020	Here, we identified ALS2, a guanine nucleotide exchange factor that is upregulated in cancer, as responsible for increased Rab5-GTP loading, cell migration and metastasis in hypoxia.	Guanine Nucleotides	28-46	alsin Rho guanine nucleotide exchange factor ALS2	Homo sapiens	20-24	
17239822-1	2007	ALS2, the causative gene product for a number of recessive motor neuron diseases, is a guanine-nucleotide exchange factor for Rab5, and acts as a modulator for endosome dynamics.	Guanine Nucleotides	87-105	alsin Rho guanine nucleotide exchange factor ALS2	Homo sapiens	0-4	
15247254-0	2004	Homo-oligomerization of ALS2 through its unique carboxyl-terminal regions is essential for the ALS2-associated Rab5 guanine nucleotide exchange activity and its regulatory function on endosome trafficking.	Guanine Nucleotides	116-134	alsin Rho guanine nucleotide exchange factor ALS2	Homo sapiens	24-28	
15247254-0	2004	Homo-oligomerization of ALS2 through its unique carboxyl-terminal regions is essential for the ALS2-associated Rab5 guanine nucleotide exchange activity and its regulatory function on endosome trafficking.	Guanine Nucleotides	116-134	alsin Rho guanine nucleotide exchange factor ALS2	Homo sapiens	95-99	
12837691-5	2003	The carboxy-terminus of ALS2 protein carrying a VPS9 domain mediates not only the activation of Rab5 via a guanine-nucleotide exchanging reaction but also the endosomal localization of the ALS2 protein, while the amino-terminal half containing RLD acts suppressive in its membranous localization.	Guanine Nucleotides	107-125	alsin Rho guanine nucleotide exchange factor ALS2	Homo sapiens	24-28	
15033976-4	2004	We found that the Vps9p domain of alsin has Rab5 guanine nucleotide exchange activity.	Guanine Nucleotides	49-67	alsin Rho guanine nucleotide exchange factor ALS2	Homo sapiens	34-39