PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25014207-7 2014 The extraction was prevented when Rac1 was activated to its GTP-bound state by Rac-specific guanine nucleotide exchange factors (GEFs), such as Vav2, Dbl, Tiam1, P-Rex1 and TrioN, and bound by the downstream effector Pak1. Guanine Nucleotides 92-110 MCF.2 cell line derived transforming sequence Homo sapiens 150-153 30682817-1 2019 Dbl (B-cell lymphoma)-related guanine nucleotide exchange factors (GEFs), the largest family of GEFs, are directly responsible for the activation of Rho family GTPases and essential for a number of cellular events such as proliferation, differentiation and movement. Guanine Nucleotides 30-48 MCF.2 cell line derived transforming sequence Homo sapiens 0-3 29515755-5 2018 In this study, we demonstrate that CGEF-1, the C. elegans homolog of the human guanine nucleotide exchange factor Dbl, is a novel binding partner of RHEB-1 and activator of mTORC1 signaling in C. elegans. Guanine Nucleotides 79-97 MCF.2 cell line derived transforming sequence Homo sapiens 114-117 32322580-3 2020 Rac and Cdc42 are often dysregulated in cancer due to hyperactivation by guanine nucleotide exchange factors (GEFs), belonging to both the diffuse B-cell lymphoma (Dbl) and dedicator of cytokinesis (DOCK) families. Guanine Nucleotides 73-91 MCF.2 cell line derived transforming sequence Homo sapiens 164-167 26322553-0 2015 Catching Functional Modes and Structural Communication in Dbl Family Rho Guanine Nucleotide Exchange Factors. Guanine Nucleotides 73-91 MCF.2 cell line derived transforming sequence Homo sapiens 58-61 26322553-2 2015 In this study, these approaches have been coupled to the graph theory-based Protein Structure Network (PSN) analysis to dissect functional dynamics and structural communication in the Dbl family of Rho Guanine Nucleotide Exchange Factors (RhoGEFs). Guanine Nucleotides 202-220 MCF.2 cell line derived transforming sequence Homo sapiens 184-187 15544329-1 2004 Activation of many Rho family GTPase pathways involves the signaling module consisting of the Dbl-like guanine nucleotide exchange factors (GEFs), the Rho GTPases, and the Rho GTPase specific effectors. Guanine Nucleotides 103-121 MCF.2 cell line derived transforming sequence Homo sapiens 94-97 20713598-0 2010 Myosin II directly binds and inhibits Dbl family guanine nucleotide exchange factors: a possible link to Rho family GTPases. Guanine Nucleotides 49-67 MCF.2 cell line derived transforming sequence Homo sapiens 38-41 20713598-4 2010 Here, we show that MII interacts specifically with multiple Dbl family guanine nucleotide exchange factors (GEFs). Guanine Nucleotides 71-89 MCF.2 cell line derived transforming sequence Homo sapiens 60-63 17538024-4 2007 Mechanistically, we show that the recruitment of the ERM-interacting Rho/Cdc42-specific guanine nucleotide exchange factor Dbl to the plasma membrane and to lipid raft microdomains requires the phosphorylated, active conformer of ezrin, which serves to tether the plasma membrane or its subdomains to the cytoskeleton. Guanine Nucleotides 88-106 MCF.2 cell line derived transforming sequence Homo sapiens 123-126 17538024-5 2007 Together these data suggest a mechanism whereby precise spatial guanine nucleotide exchange of Cdc42 by Dbl is dependent on functional ERM proteins and is important for directional cell migration. Guanine Nucleotides 64-82 MCF.2 cell line derived transforming sequence Homo sapiens 104-107 15455375-1 2005 Several oncogenes isolated by the NIH/3T3 transformation assay, i.e., dbl, dbs, lbc, lfc, lsc, net, ost and tim, contain a Dbl homology (DH) and a pleckstrin-homology (PH) domain and act as GEFs (guanine nucleotide exchange factors) for Rho-like GTPases. Guanine Nucleotides 196-214 MCF.2 cell line derived transforming sequence Homo sapiens 123-126 23255595-1 2013 The diffuse B-cell lymphoma (Dbl) family of the guanine nucleotide exchange factors is a direct activator of the Rho family proteins. Guanine Nucleotides 48-66 MCF.2 cell line derived transforming sequence Homo sapiens 29-32 21372162-4 2011 In the present study, we examined the role of polyamines in the regulation of the guanine nucleotide exchange factor, diffuse B-cell lymphoma (Dbl), for Rho GTPases. Guanine Nucleotides 82-100 MCF.2 cell line derived transforming sequence Homo sapiens 143-146 19670212-1 2009 The DH-PH domain tandems of Dbl-homology guanine nucleotide exchange factors catalyze the exchange of GTP for GDP in Rho-family GTPases, and thus initiate a wide variety of cellular signaling cascades. Guanine Nucleotides 41-59 MCF.2 cell line derived transforming sequence Homo sapiens 28-31 17178836-1 2007 The dbl proto-oncogene product is a prototype of a growing family of guanine nucleotide exchange factors (GEFs) that stimulate the activation of small GTP-binding proteins from the Rho family. Guanine Nucleotides 69-87 MCF.2 cell line derived transforming sequence Homo sapiens 4-7 16201754-2 2005 Guanine nucleotide exchange factors of the Dbl family activate Cdc42 and other Rho GTPases by catalyzing the removal of bound GDP, allowing for GTP loading, and subsequent effector recognition ultimately leading to downstream signaling events. Guanine Nucleotides 0-18 MCF.2 cell line derived transforming sequence Homo sapiens 43-46 11889037-2 2002 While it is known that the DH domain is the principal catalytic subunit, recent biochemical data indicate that for some Dbl-family proteins, such as Dbs and Trio, PH domains may cooperate with their associated DH domains in promoting guanine nucleotide exchange of Rho GTPases. Guanine Nucleotides 234-252 MCF.2 cell line derived transforming sequence Homo sapiens 120-123 15274927-1 2004 Dbl proteins are guanine nucleotide exchange factors for Rho GTPases, containing adjacent Dbl homology (DH) and pleckstrin homology (PH) domains. Guanine Nucleotides 17-35 MCF.2 cell line derived transforming sequence Homo sapiens 0-3 13679059-8 2003 Guanine nucleotide exchange activities of the testis-expressed mouse Mcf-2 and human Dbl were analyzed using RhoA, Rac1, and Cdc42 as substrates. Guanine Nucleotides 0-18 MCF.2 cell line derived transforming sequence Homo sapiens 85-88 12006984-1 2002 Activation of Rho-family GTPases involves the removal of bound GDP and the subsequent loading of GTP, all catalyzed by guanine nucleotide exchange factors (GEFs) of the Dbl-family. Guanine Nucleotides 119-137 MCF.2 cell line derived transforming sequence Homo sapiens 169-172 15073184-1 2004 Ect2 was identified originally as a transforming protein and a member of the Dbl family of Rho guanine nucleotide exchange factors (GEFs). Guanine Nucleotides 95-113 MCF.2 cell line derived transforming sequence Homo sapiens 77-80 11911885-1 2002 The Dbl homology (DH) domain was first identified in the Dbl oncogene product as the limit region required for mediating guanine nucleotide exchange on the Rho family GTPase Cdc42. Guanine Nucleotides 121-139 MCF.2 cell line derived transforming sequence Homo sapiens 4-7 11911885-1 2002 The Dbl homology (DH) domain was first identified in the Dbl oncogene product as the limit region required for mediating guanine nucleotide exchange on the Rho family GTPase Cdc42. Guanine Nucleotides 121-139 MCF.2 cell line derived transforming sequence Homo sapiens 57-60 11911885-3 2002 In each case, a pleckstrin homology (PH) domain immediately follows the DH domain and this tandem DH-PH module is the signature motif of the Dbl family of guanine nucleotide exchange factors (GEFs). Guanine Nucleotides 155-173 MCF.2 cell line derived transforming sequence Homo sapiens 141-144 11911885-4 2002 Recent structural studies have provided significant insight into the molecular basis of guanine nucleotide exchange by Dbl family GEFs, opening the door for understanding the specificity of the DH/GTPase interaction as well as providing a starting point for understanding how the exchange activity of these proteins is modulated to achieve specific biological outcomes in the cell. Guanine Nucleotides 88-106 MCF.2 cell line derived transforming sequence Homo sapiens 119-122 11134331-1 2001 The dbl oncogene product (onco-Dbl) is the prototype member of a family of guanine nucleotide exchange factors (GEFs) for Rho GTPases. Guanine Nucleotides 75-93 MCF.2 cell line derived transforming sequence Homo sapiens 4-7 11577097-1 2001 Normally, Rho GTPases are activated by the removal of bound GDP and the concomitant loading of GTP catalyzed by members of the Dbl family of guanine nucleotide exchange factors (GEFs). Guanine Nucleotides 141-159 MCF.2 cell line derived transforming sequence Homo sapiens 127-130 11738596-1 2001 The Dbl family of guanine nucleotide exchange factors are multifunctional molecules that transduce diverse intracellular signals leading to the activation of Rho GTPases. Guanine Nucleotides 18-36 MCF.2 cell line derived transforming sequence Homo sapiens 4-7 11134331-1 2001 The dbl oncogene product (onco-Dbl) is the prototype member of a family of guanine nucleotide exchange factors (GEFs) for Rho GTPases. Guanine Nucleotides 75-93 MCF.2 cell line derived transforming sequence Homo sapiens 31-34 10523665-2 1999 Here we show that Dbs, like its rat homolog Ost and the closely related Dbl, exhibited guanine nucleotide exchange activity for the Rho family members RhoA and Cdc42, but not Rac1, in vitro. Guanine Nucleotides 87-105 MCF.2 cell line derived transforming sequence Homo sapiens 72-75 10835422-2 2000 Tiam1 is a member of the Dbl family of guanine nucleotide exchange factors that activate Rho family GTPases. Guanine Nucleotides 39-57 MCF.2 cell line derived transforming sequence Homo sapiens 25-28 10559246-1 1999 Guanine nucleotide exchange factors of the Dbl family regulate the actin cytoskeleton through activation of Rho-like GTPases. Guanine Nucleotides 0-18 MCF.2 cell line derived transforming sequence Homo sapiens 43-46 11130063-1 2000 The principal guanine nucleotide exchange factors for Rho family G proteins contain tandem Dbl-homology (DH) and pleckstrin-homology (PH) domains that catalyse nucleotide exchange and the activation of G proteins. Guanine Nucleotides 14-32 MCF.2 cell line derived transforming sequence Homo sapiens 91-94 11130063-6 2000 The Tiam1/Rac1 structure highlights the interactions that catalyse nucleotide exchange on Rho family G proteins, and illustrates structural determinants dictating specificity between individual Rho family members and their associated Dbl-related guanine nucleotide exchange factors. Guanine Nucleotides 246-264 MCF.2 cell line derived transforming sequence Homo sapiens 234-237 9030518-0 1997 Residues of the Rho family GTPases Rho and Cdc42 that specify sensitivity to Dbl-like guanine nucleotide exchange factors. Guanine Nucleotides 86-104 MCF.2 cell line derived transforming sequence Homo sapiens 77-80 9846881-1 1998 Guanine nucleotide exchange factors in the Dbl family activate Rho GTPases by accelerating dissociation of bound GDP, promoting acquisition of the GTP-bound state. Guanine Nucleotides 0-18 MCF.2 cell line derived transforming sequence Homo sapiens 43-46 9030518-1 1997 The Dbl-like guanine nucleotide exchange factor (GEF) Lbc oncoprotein specifically activates the small GTP-binding protein Rho in mammalian fibroblasts to induce transformation and actin stress fiber formation, whereas another Dbl-related molecule, Cdc24, stimulates guanine nucleotide exchange of the Rho family GTPase Cdc42 to elicit effects on both gene induction and actin-based cytoskeleton change in Saccharomyces cerevisiae. Guanine Nucleotides 13-31 MCF.2 cell line derived transforming sequence Homo sapiens 4-7 9030518-1 1997 The Dbl-like guanine nucleotide exchange factor (GEF) Lbc oncoprotein specifically activates the small GTP-binding protein Rho in mammalian fibroblasts to induce transformation and actin stress fiber formation, whereas another Dbl-related molecule, Cdc24, stimulates guanine nucleotide exchange of the Rho family GTPase Cdc42 to elicit effects on both gene induction and actin-based cytoskeleton change in Saccharomyces cerevisiae. Guanine Nucleotides 13-31 MCF.2 cell line derived transforming sequence Homo sapiens 227-230 8791419-2 1996 These putative guanine nucleotide exchange factors for Rho family small GTP-binding proteins (G proteins) all contain a Dbl homology domain in tandem with a pleckstrin homology domain, and seem to activate specific members of the Rho family of proteins to elicit various biological functions in cells. Guanine Nucleotides 15-33 MCF.2 cell line derived transforming sequence Homo sapiens 120-123 8702569-1 1996 The pleckstrin homology (PH) domain is an approximately 100 amino acid structural motif found in many cellular signaling molecules, including the Dbl oncoprotein and related, putative guanine nucleotide exchange factors (GEFs). Guanine Nucleotides 184-202 MCF.2 cell line derived transforming sequence Homo sapiens 146-149 8724692-6 1996 The presence of a putative guanine nucleotide exchange domain, the prototype of which is found in the dbl oncogene product, implies that Vav functions as a guanine nucleotide exchange factor (GEF) for one (or more) members of the Ras-like family of small GTP-binding proteins. Guanine Nucleotides 27-45 MCF.2 cell line derived transforming sequence Homo sapiens 102-105 9258606-1 1996 Certain p21GTPases (notably Ras) and some of their guanine nucleotide exchange factors (e.g., Ost, Dbl, Tiam) and downstream mediators (e.g., Raf, Myc) have the potential to promote the development of malignancies because they can enhance the transcription of genes that foster the tumorigenic and metastatic phenotype. Guanine Nucleotides 51-69 MCF.2 cell line derived transforming sequence Homo sapiens 99-102 7476457-0 1995 Guanine nucleotide exchange catalyzed by dbl oncogene product. Guanine Nucleotides 0-18 MCF.2 cell line derived transforming sequence Homo sapiens 41-44 7941732-2 1994 Cdc42p is a member of the Ras superfamily of GTPases and Cdc24p displays limited amino-acid sequence similarity with the Dbl proto-oncoprotein, which acts to stimulate guanine-nucleotide exchange on human Cdc42p. Guanine Nucleotides 168-186 MCF.2 cell line derived transforming sequence Homo sapiens 121-124 8276860-0 1994 Cellular transformation and guanine nucleotide exchange activity are catalyzed by a common domain on the dbl oncogene product. Guanine Nucleotides 28-46 MCF.2 cell line derived transforming sequence Homo sapiens 105-108