PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19196702-4 2009 Using a novel fluorescence polarization guanine nucleotide-binding assay using BODIPY-Texas Red-GTPgammaS (BODIPY-TR-GTPgammaS), the authors performed a 10,000-compound high-throughput screen for inhibitors of LARG-stimulated RhoA nucleotide binding. Guanine Nucleotides 40-58 Rho guanine nucleotide exchange factor 12 Homo sapiens 210-214 19196702-5 2009 Five compounds identified from the high-throughput screen were confirmed in a nonfluorescent radioactive guanine nucleotide-binding assay measuring LARG-stimulated [( 35)S] GTPgammaS binding to RhoA, thus ruling out nonspecific fluorescent effects. Guanine Nucleotides 105-123 Rho guanine nucleotide exchange factor 12 Homo sapiens 148-152 17575049-5 2007 The FH2 domain stimulates the guanine nucleotide exchange activity of LARG in vitro. Guanine Nucleotides 30-48 Rho guanine nucleotide exchange factor 12 Homo sapiens 70-74 11799111-0 2002 Regulation of G protein-linked guanine nucleotide exchange factors for Rho, PDZ-RhoGEF, and LARG by tyrosine phosphorylation: evidence of a role for focal adhesion kinase. Guanine Nucleotides 31-49 Rho guanine nucleotide exchange factor 12 Homo sapiens 92-96 16652149-5 2006 Using siRNA to suppress expression of the three known G-protein alpha-subunit-associated RhoA guanine nucleotide exchange factors (GEFs), we also show that two of these RhoA GEFs, PDZ-RhoGEF and leukemia-associated RhoGEF (LARG), link bombesin receptors to RhoA in a non-redundant manner in PC cells. Guanine Nucleotides 94-112 Rho guanine nucleotide exchange factor 12 Homo sapiens 195-221 16652149-5 2006 Using siRNA to suppress expression of the three known G-protein alpha-subunit-associated RhoA guanine nucleotide exchange factors (GEFs), we also show that two of these RhoA GEFs, PDZ-RhoGEF and leukemia-associated RhoGEF (LARG), link bombesin receptors to RhoA in a non-redundant manner in PC cells. Guanine Nucleotides 94-112 Rho guanine nucleotide exchange factor 12 Homo sapiens 223-227 15485891-1 2004 The alpha-subunit of G proteins of the G(12/13) family stimulate Rho by their direct binding to the RGS-like (RGL) domain of a family of Rho guanine nucleotide exchange factors (RGL-RhoGEFs) that includes PDZ-RhoGEF (PRG), p115RhoGEF, and LARG, thereby regulating cellular functions as diverse as shape and movement, gene expression, and normal and aberrant cell growth. Guanine Nucleotides 141-159 Rho guanine nucleotide exchange factor 12 Homo sapiens 239-243 15210733-3 2004 Plexin-B1 has recently been shown to mediate activation of RhoA through a stable interaction with the Rho guanine nucleotide exchange factors PDZ-RhoGEF and LARG. Guanine Nucleotides 106-124 Rho guanine nucleotide exchange factor 12 Homo sapiens 157-161 14712228-1 2004 PDZ-RhoGEF, LARG, and p115RhoGEF are members of a newly identified family of Rho-guanine nucleotide exchange factors (GEFs) exhibiting a unique structural feature consisting of the presence of an area of similarity to regulators of G protein signaling (RGS). Guanine Nucleotides 81-99 Rho guanine nucleotide exchange factor 12 Homo sapiens 12-16 15488183-1 2004 The regulator of G-protein signaling (RGS)-containing RhoGEFs, including p115RhoGEF, PDZ-RhoGEF, and LARG, represent a novel family of guanine nucleotide exchange factors for RhoA that are regulated by the Galpha(12/13) family of heterotrimeric G proteins. Guanine Nucleotides 135-153 Rho guanine nucleotide exchange factor 12 Homo sapiens 101-105 15488184-1 2004 Three mammalian Rho guanine nucleotide exchange factors (RhoGEFs), leukemia-associated RhoGEF (LARG), p115RhoGEF, and PDZ-RhoGEF, contain regulator of G-protein signaling (RGS) domains within their amino-terminal regions. Guanine Nucleotides 20-38 Rho guanine nucleotide exchange factor 12 Homo sapiens 67-93 12123608-3 2002 Here, we demonstrate that plexin-B family members associate through their C termini with the Rho guanine nucleotide exchange factors PDZ-RhoGEF and LARG. Guanine Nucleotides 97-115 Rho guanine nucleotide exchange factor 12 Homo sapiens 148-152 11799111-1 2002 A recently identified family of guanine nucleotide exchange factors for Rho that includes PDZ-RhoGEF, LARG, and p115RhoGEF exhibits a unique structural feature consisting in the presence of area of similarity to regulators of G protein signaling (RGS). Guanine Nucleotides 32-50 Rho guanine nucleotide exchange factor 12 Homo sapiens 102-106 33419897-1 2021 BACKGROUND/AIM: Fusion of histone-lysine N-methyltransferase 2A gene (KMT2A) with the Rho guanine nucleotide exchange factor 12 gene (ARHGEF12), both located in 11q23, was reported in some leukemic patients. Guanine Nucleotides 90-108 Rho guanine nucleotide exchange factor 12 Homo sapiens 134-142 26627240-4 2015 Two related guanine nucleotide exchange factors (GEFs), PDZ-RhoGEF and leukemia-associated RhoGEF (LARG), use their PDZ domains to bind class B plexins and play critical roles in signaling. Guanine Nucleotides 12-30 Rho guanine nucleotide exchange factor 12 Homo sapiens 71-97 31704028-5 2019 When binding to its agonist glycine or D-serine, GluD1 elicits non-ionotropic postsynaptic signaling involving the guanine nucleotide exchange factor ARHGEF12 and the regulatory subunit of protein phosphatase 1 PPP1R12A. Guanine Nucleotides 115-133 Rho guanine nucleotide exchange factor 12 Homo sapiens 150-158 26627240-4 2015 Two related guanine nucleotide exchange factors (GEFs), PDZ-RhoGEF and leukemia-associated RhoGEF (LARG), use their PDZ domains to bind class B plexins and play critical roles in signaling. Guanine Nucleotides 12-30 Rho guanine nucleotide exchange factor 12 Homo sapiens 99-103 23993968-10 2013 Furthermore, suppression of the activity of G proteins of the Galpha12/13 subfamily by adenoviral overexpression of the regulator of G protein signaling domain of LSC as well as siRNA-mediated knockdown of the Rho specific guanine nucleotide exchange factor leukemia associated RhoGEF (LARG) inhibited the S1P-induced activation of RhoC and concomitantly increased sprouting of HUVEC with similar efficacy. Guanine Nucleotides 223-241 Rho guanine nucleotide exchange factor 12 Homo sapiens 258-284 20844236-3 2010 HGAL enhances activation of RhoA and its down-stream effectors by a novel mechanism - direct binding to the catalytic DH-domain of the RhoA-specific guanine nucleotide exchange factors (RhoGEFs) PDZ-RhoGEF and LARG that stimulate the GDP-GTP exchange rate of RhoA. Guanine Nucleotides 149-167 Rho guanine nucleotide exchange factor 12 Homo sapiens 210-214 20348106-2 2010 Here we show that the Rho guanine nucleotide exchange factors PDZ-RhoGEF and LARG bind to the C terminus of ABCA1 by a PDZ-PDZ interaction and prevent ABCA1 protein degradation by activating RhoA. Guanine Nucleotides 26-44 Rho guanine nucleotide exchange factor 12 Homo sapiens 77-81