PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32251425-2 2020 betaPix (ARHGEF7) is a guanine nucleotide exchange factor for the small GTPases Rac1 and Cdc42, which modulate the organization of actin filaments and microtubules. Guanine Nucleotides 23-41 cell division cycle 42 Mus musculus 89-94 7957046-5 1994 Purified Ost protein catalyzed guanine nucleotide exchange on RhoA and Cdc42 among the Rho and Ras family members tested, indicating that Ost can activate these small GTP-binding proteins. Guanine Nucleotides 31-49 cell division cycle 42 Mus musculus 71-76 33247143-2 2020 Here we show that mesoderm organization in mouse embryos depends on beta-Pix (Arhgef7), a guanine nucleotide exchange factor for Rac1 and Cdc42. Guanine Nucleotides 90-108 cell division cycle 42 Mus musculus 138-143 31402636-1 2019 betaPix is a guanine nucleotide exchange factor for the Rho family small GTPases, Rac1 and Cdc42. Guanine Nucleotides 13-31 cell division cycle 42 Mus musculus 91-96 16784226-8 2006 We showed that expression of the limit functional domain of Cdc42GAP inhibited Cdc42[F28L]-induced transformation, as well as selectively reversed the transformed phenotypes caused by the hyperactivation of wild-type Cdc42 in cells expressing the oncogenic version of Dbl (for Diffuse B cell lymphoma), a guanine nucleotide exchange factor for Cdc42 and the related Rac and Rho GTPases. Guanine Nucleotides 305-323 cell division cycle 42 Mus musculus 60-65 30254339-4 2019 Here we rationally identified a Cdc42 activity-specific inhibitor (CASIN) that can bind to Cdc42 with submicromolar affinity and competitively interfere with guanine nucleotide exchange activity. Guanine Nucleotides 158-176 cell division cycle 42 Mus musculus 32-37 30254339-4 2019 Here we rationally identified a Cdc42 activity-specific inhibitor (CASIN) that can bind to Cdc42 with submicromolar affinity and competitively interfere with guanine nucleotide exchange activity. Guanine Nucleotides 158-176 cell division cycle 42 Mus musculus 91-96 19995334-2 2010 The activity of Rho GTPases, such as Rac1, Cdc42, and RhoA, is regulated by GTPase-activating proteins (GAPs), guanine nucleotide exchange factors (GEFs), and guanine nucleotide dissociation inhibitor (GDI). Guanine Nucleotides 111-129 cell division cycle 42 Mus musculus 43-48 19995334-2 2010 The activity of Rho GTPases, such as Rac1, Cdc42, and RhoA, is regulated by GTPase-activating proteins (GAPs), guanine nucleotide exchange factors (GEFs), and guanine nucleotide dissociation inhibitor (GDI). Guanine Nucleotides 159-177 cell division cycle 42 Mus musculus 43-48 16714282-0 2006 Caveolin-1 functions as a novel Cdc42 guanine nucleotide dissociation inhibitor in pancreatic beta-cells. Guanine Nucleotides 38-56 cell division cycle 42 Mus musculus 32-37 30333726-1 2018 ARHGEF6 belongs to the family of guanine nucleotide exchange factors (GEFs) for Rho GTPases, and it specifically activates Rho GTPases CDC42 and RAC1. Guanine Nucleotides 33-51 cell division cycle 42 Mus musculus 135-140 20568994-2 2010 Zizimin2 was revealed that it is a new family member of Dock (dedicator of cytokinesis), Dock11, which was the guanine nucleotide exchange factor for Cdc42, the Rho family of low molecular weight GTPases. Guanine Nucleotides 111-129 cell division cycle 42 Mus musculus 150-155 17196961-0 2007 Dock6, a Dock-C subfamily guanine nucleotide exchanger, has the dual specificity for Rac1 and Cdc42 and regulates neurite outgrowth. Guanine Nucleotides 26-44 cell division cycle 42 Mus musculus 94-99 16714282-5 2006 Analyses of the Cav-1 scaffolding domain revealed a motif conserved in guanine nucleotide dissociation inhibitors (GDIs), which suggested a novel role for Cav-1 as a Cdc42 GDI in beta-cells. Guanine Nucleotides 71-89 cell division cycle 42 Mus musculus 166-171 16784226-8 2006 We showed that expression of the limit functional domain of Cdc42GAP inhibited Cdc42[F28L]-induced transformation, as well as selectively reversed the transformed phenotypes caused by the hyperactivation of wild-type Cdc42 in cells expressing the oncogenic version of Dbl (for Diffuse B cell lymphoma), a guanine nucleotide exchange factor for Cdc42 and the related Rac and Rho GTPases. Guanine Nucleotides 305-323 cell division cycle 42 Mus musculus 79-84 16784226-8 2006 We showed that expression of the limit functional domain of Cdc42GAP inhibited Cdc42[F28L]-induced transformation, as well as selectively reversed the transformed phenotypes caused by the hyperactivation of wild-type Cdc42 in cells expressing the oncogenic version of Dbl (for Diffuse B cell lymphoma), a guanine nucleotide exchange factor for Cdc42 and the related Rac and Rho GTPases. Guanine Nucleotides 305-323 cell division cycle 42 Mus musculus 79-84 14506284-5 2003 The EGF-stimulated activation of Cdc42 does require activated Src, as well as the Vav2 protein, a member of the Dbl family of guanine nucleotide exchange factors. Guanine Nucleotides 126-144 cell division cycle 42 Mus musculus 33-38 15723051-4 2005 Here, we found that PAR-3 directly interacted with STEF/Tiam1, which are Rac-specific guanine nucleotide-exchange factors, and that STEF formed a complex with PAR-3-aPKC-PAR-6-Cdc42-GTP. Guanine Nucleotides 86-104 cell division cycle 42 Mus musculus 176-181 12799088-1 2003 Dbl-family guanine nucleotide exchange factors (Dbl-GEFs) act as activators of Rho-like small G proteins such as Rac1, Cdc42 and RhoA. Guanine Nucleotides 11-29 cell division cycle 42 Mus musculus 119-124 12913069-2 2003 FGD1 and Fgd1, the mouse FGD1 ortholog, encode guanine nucleotide exchange factors (GEF) that specifically activate Cdc42, a Rho GTPase that controls the organization of the actin cytoskeleton. Guanine Nucleotides 47-65 cell division cycle 42 Mus musculus 116-121 11266127-1 2001 BetaPix, a Pak-interacting guanine nucleotide exchange factor is known to be involved in the regulation of Cdc42/Rac GTPases and Pak kinase activity. Guanine Nucleotides 27-45 cell division cycle 42 Mus musculus 107-112