PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28255536-3 2016 Furthermore, Rac has two guanine nucleotide exchange factors, Vav and Sos, whose role in activating Rac is not well understood. Guanine Nucleotides 25-43 vav guanine nucleotide exchange factor 1 Homo sapiens 62-65 22203994-5 2012 Computational modeling suggests that the NCF2 H389Q mutation reduces the binding efficiency of NCF2 with the guanine nucleotide exchange factor Vav1. Guanine Nucleotides 109-127 vav guanine nucleotide exchange factor 1 Homo sapiens 144-148 24501217-4 2014 We found decreased transcription of the Rac guanine nucleotide exchange factors Tiam1 and Vav1 in unstimulated peripheral blood CLL cells with almost complete loss of Tiam1 but increased transcription of the potential Rac antagonist RhoH. Guanine Nucleotides 44-62 vav guanine nucleotide exchange factor 1 Homo sapiens 90-94 22692505-2 2012 In the present study, we present the cellular and molecular roles of the Rho GTPase guanine nucleotide exchange factor Vav in lymphoid leukemogenesis and explore the roles of Vav proteins in BCR-ABL-dependent signaling. Guanine Nucleotides 84-102 vav guanine nucleotide exchange factor 1 Homo sapiens 119-122 22467863-8 2012 Analysis of Rac guanine nucleotide exchange factors (GEFs) suggests that radixin affects the activity of Vav GEFs. Guanine Nucleotides 16-34 vav guanine nucleotide exchange factor 1 Homo sapiens 105-108 22432082-1 2012 The Vav family of proteins are guanine nucleotide exchange factors which have been shown to be deregulated in several types of human cancer. Guanine Nucleotides 31-49 vav guanine nucleotide exchange factor 1 Homo sapiens 4-7 17275330-2 2007 Vav1 is also a unique member of the GEF family in that it contains a cysteine-rich domain (CRD) that is critical for Rac1 binding and maximal guanine nucleotide exchange activity, and thus may provide a unique protein-protein interface compared to other GEF/GTPase pairs. Guanine Nucleotides 142-160 vav guanine nucleotide exchange factor 1 Homo sapiens 0-4 21606197-1 2011 Activated Syk, an essential tyrosine kinase in B cell signaling, interacts with Vav guanine nucleotide exchange factors and regulates Vav activity through tyrosine phosphorylation. Guanine Nucleotides 84-102 vav guanine nucleotide exchange factor 1 Homo sapiens 80-83 20140013-1 2010 Vav proteins are guanine nucleotide exchange factors for Rho GTPases that regulate cell adhesion, motility, spreading and proliferation in response to growth factor signalling. Guanine Nucleotides 17-35 vav guanine nucleotide exchange factor 1 Homo sapiens 0-3 19672294-0 2009 Vav links the T cell antigen receptor to the actin cytoskeleton and T cell activation independently of intrinsic Guanine nucleotide exchange activity. Guanine Nucleotides 113-131 vav guanine nucleotide exchange factor 1 Homo sapiens 0-3 19672294-2 2009 The Vav family of guanine nucleotide exchange factors (GEF) has been implicated in generation of TCR signals and immune synapse formation, however, it is currently not known if Vav"s GEF activity is required in T cell activation by the TCR in general, and in actin polymerization downstream of the TCR in particular. Guanine Nucleotides 18-36 vav guanine nucleotide exchange factor 1 Homo sapiens 4-7 19088377-5 2009 Furthermore, we found a similar novel phenotype in the absence of Vav1, Vav2, and Vav3, which function as guanine nucleotide exchange factors for Rac1 and Rac2. Guanine Nucleotides 106-124 vav guanine nucleotide exchange factor 1 Homo sapiens 66-70 22043008-6 2011 Loss of PTEN in macrophage leads to activation of the pleckstrin homology domain-containing guanine-nucleotide exchange factor Vav1 and subsequent activation of Rac1 GTPase, resulting in increased amounts of F-actin upon engulfment of apoptotic cells. Guanine Nucleotides 92-110 vav guanine nucleotide exchange factor 1 Homo sapiens 127-131 21151158-11 2011 The guanine nucleotide exchange activity of Vav1 was required for enhancing Bcl-2 promoter activity, and the Vav1 downstream substrate, small GTPase Rac2, was likely involved in the control of Bcl-2 expression. Guanine Nucleotides 4-22 vav guanine nucleotide exchange factor 1 Homo sapiens 44-48 19933863-6 2009 Regarding the mechanism for this effect, we found that STAP-2 associates with Vav1, the guanine-nucleotide exchanging factor for Rac1, and enhances downstream Vav1/Rac1 signaling. Guanine Nucleotides 88-106 vav guanine nucleotide exchange factor 1 Homo sapiens 78-82 19435813-1 2009 Vav guanine nucleotide exchange factors modulate changes in cytoskeletal organization through activation of Rho, Rac, and Cdc42 small GTPases. Guanine Nucleotides 4-22 vav guanine nucleotide exchange factor 1 Homo sapiens 0-3 18925966-3 2008 One group of activators which regulate the Rho-GTPases is the guanine nucleotide exchange factors (GEFs), and this study looked at three such GEFs, Trio, Vav1 and TIAM-1. Guanine Nucleotides 62-80 vav guanine nucleotide exchange factor 1 Homo sapiens 154-158 18589439-0 2008 Structural basis of guanine nucleotide exchange mediated by the T-cell essential Vav1. Guanine Nucleotides 20-38 vav guanine nucleotide exchange factor 1 Homo sapiens 81-85 18589439-4 2008 These unique interactions stabilize the Vav1 DH domain for its intimate association with the Switch II region of Rac1 that is critical for the displacement of the guanine nucleotide. Guanine Nucleotides 163-181 vav guanine nucleotide exchange factor 1 Homo sapiens 40-44 18589439-6 2008 Further, mutational analyses confirms that the atypical CRD is critical for maintaining both optimal guanine nucleotide exchange activity and broader specificity of Vav family GEFs. Guanine Nucleotides 101-119 vav guanine nucleotide exchange factor 1 Homo sapiens 165-168 17550897-2 2007 Vav1 consists of multiple structural domains so as to facilitate both its guanine nucleotide exchange activity and scaffold function following T cell antigen receptor (TCR) engagement. Guanine Nucleotides 74-92 vav guanine nucleotide exchange factor 1 Homo sapiens 0-4 17339487-7 2007 In contrast, phosphorylation of the Rho/Rac guanine nucleotide exchange factor Vav1 and the Rac target p21-activated kinases were markedly reduced in both hck-/-fgr-/- neutrophils and human neutrophils incubated with a PP2. Guanine Nucleotides 44-62 vav guanine nucleotide exchange factor 1 Homo sapiens 79-83 16397238-4 2006 Vav proteins are guanine-nucleotide exchange factors for Rho GTPases that regulate actin dynamics and gene expression. Guanine Nucleotides 17-35 vav guanine nucleotide exchange factor 1 Homo sapiens 0-3 16684890-7 2006 The adaptor protein, Src homology 2 domain-containing leukocyte phosphoprotein of 76 kDa, which relays signals to downstream signaling components, also showed reduced phosphorylation, which correlated with reduced VAV guanine nucleotide exchange factors association. Guanine Nucleotides 218-236 vav guanine nucleotide exchange factor 1 Homo sapiens 214-217 17060455-0 2007 The Rac effector p67phox regulates phagocyte NADPH oxidase by stimulating Vav1 guanine nucleotide exchange activity. Guanine Nucleotides 79-97 vav guanine nucleotide exchange factor 1 Homo sapiens 74-78 12616499-2 2003 Vav1 is a guanine nucleotide exchange factor for members of the Rho/Rac family of GTPases which is activated following TCR stimulation, suggesting that it may transduce TCR signals to the activation of some or all actin-controlled processes. Guanine Nucleotides 10-28 vav guanine nucleotide exchange factor 1 Homo sapiens 0-4 15249579-2 2004 Vav proteins are Rho family guanine nucleotide exchange factors that become tyrosine phosphorylated in response to adhesion. Guanine Nucleotides 28-46 vav guanine nucleotide exchange factor 1 Homo sapiens 0-3 14764585-5 2004 Furthermore, we show that Vav1 transduces TCR signals to Ras by controlling the membrane recruitment of two guanine nucleotide exchange factors. Guanine Nucleotides 108-126 vav guanine nucleotide exchange factor 1 Homo sapiens 26-30 14709332-4 2004 These ATRA-induced events are independent on the guanine nucleotide exchange activity of Vav. Guanine Nucleotides 49-67 vav guanine nucleotide exchange factor 1 Homo sapiens 89-92 14607270-5 2004 We will also cover how the Vav proteins succeed in controlling these processes by their function as guanine nucleotide exchange factors (GEFs) for the Rho/Rac family of GTPases. Guanine Nucleotides 100-118 vav guanine nucleotide exchange factor 1 Homo sapiens 27-30 16213217-5 2005 Here, we show that the C. elegans Rho/Rac-family guanine nucleotide exchange factor, VAV-1, which is homologous to the mammalian Vav proto-oncogene, has a crucial role in all three behaviors. Guanine Nucleotides 49-67 vav guanine nucleotide exchange factor 1 Homo sapiens 129-132 15618286-2 2005 This event activates multimeric signaling pathways, including the activation of the Vav family of guanine nucleotide exchange factors. Guanine Nucleotides 98-116 vav guanine nucleotide exchange factor 1 Homo sapiens 84-87 15661896-4 2005 Reduction of Itk expression via small interfering RNA treatment of the Jurkat human T lymphoma cell line or human peripheral blood T cells disrupted TCR-induced actin polarization, a defect that correlated with decreased recruitment of the Vav guanine nucleotide exchange factor to the site of Ag contact. Guanine Nucleotides 244-262 vav guanine nucleotide exchange factor 1 Homo sapiens 240-243 15456756-1 2004 Vav family proteins are guanine nucleotide exchange factors for the Rho/Rac family of small GTP-binding proteins. Guanine Nucleotides 24-42 vav guanine nucleotide exchange factor 1 Homo sapiens 0-3 12386169-2 2002 One well studied regulator of Rho GTPases is Vav1; a hematopoietic cell-specific guanine nucleotide exchange factor critical for signaling in T cells, including stimulation of the nuclear factor of activated T cells (NFAT). Guanine Nucleotides 81-99 vav guanine nucleotide exchange factor 1 Homo sapiens 45-49 12386169-3 2002 Surprisingly, Vav1 associates with Ly-GDI, a hematopoietic cell-specific guanine nucleotide dissociation inhibitor of Rac. Guanine Nucleotides 73-91 vav guanine nucleotide exchange factor 1 Homo sapiens 14-18 11859076-1 2002 The Vav family of guanine nucleotide exchange factors for Rho family GTPases plays a critical role in lymphocyte proliferation, gene transcription, and cytoskeleton reorganization following immunoreceptor stimulation. Guanine Nucleotides 18-36 vav guanine nucleotide exchange factor 1 Homo sapiens 4-7 12177050-1 2002 Vav family proteins are members of the Dbl family of guanine nucleotide exchange factors and activators of Rho family small GTPases. Guanine Nucleotides 53-71 vav guanine nucleotide exchange factor 1 Homo sapiens 0-3 11716957-0 2002 In vitro, Vav is a regulated guanine nucleotide dissociation inhibitor for Ras. Guanine Nucleotides 29-47 vav guanine nucleotide exchange factor 1 Homo sapiens 10-13 11813163-3 2002 Searching for molecules that couple TCR and CD28 to MEKK1, we found that the guanine nucleotide exchange factor Vav synergized with CD28 stimulation in Jurkat cells to induce NF-kappaB transcriptional activity through the activation of IKKalpha and IKKbeta. Guanine Nucleotides 77-95 vav guanine nucleotide exchange factor 1 Homo sapiens 112-115 10748082-6 2000 We also show Vav activation in cells, as monitored by phosphorylation of Vav, Vav association with phosphatidylinositol 3,4,5-trisphosphate, and Vav guanine nucleotide exchange activity, is blocked by the phosphatidylinositol 3-kinase inhibitor wortmannin. Guanine Nucleotides 149-167 vav guanine nucleotide exchange factor 1 Homo sapiens 13-16 10938113-1 2000 Vav proteins are guanine nucleotide exchange factors for Rho family GTPases which activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. Guanine Nucleotides 17-35 vav guanine nucleotide exchange factor 1 Homo sapiens 0-3 11470914-4 2001 The expression of Vav (Delta1-187), a constitutively active guanine nucleotide exchange factor for the Rho GTPases, or activated forms of Ras or Rho family members, leads to STAT3-specific activation. Guanine Nucleotides 60-78 vav guanine nucleotide exchange factor 1 Homo sapiens 18-21 11262396-1 2001 Vav1 and Vav2 are members of the Dbl family of guanine nucleotide exchange factors for the Rho family of small GTPases. Guanine Nucleotides 47-65 vav guanine nucleotide exchange factor 1 Homo sapiens 0-4 10022833-6 1999 In order to define the mechanism by which Socs1-mediated suppression of Kit-dependent mitogenesis occurs, we demonstrate that Socs1 binds to the signalling proteins Grb-2 and the Rho-family guanine nucleotide exchange factors Vav. Guanine Nucleotides 190-208 vav guanine nucleotide exchange factor 1 Homo sapiens 226-229 10760587-1 2000 Vav and vav2 are members of the dbl family of guanine nucleotide exchange factors (GEF) for the rho/rac family of GTP binding proteins. Guanine Nucleotides 46-64 vav guanine nucleotide exchange factor 1 Homo sapiens 0-3 10713454-0 2000 Major transcript variants of VAV3, a new member of the VAV family of guanine nucleotide exchange factors. Guanine Nucleotides 69-87 vav guanine nucleotide exchange factor 1 Homo sapiens 29-32 8677749-3 1996 The product of the vav proto-oncogene (Vav) is expressed exclusively in hematopoietic cells and has guanine nucleotide exchange activity. Guanine Nucleotides 100-118 vav guanine nucleotide exchange factor 1 Homo sapiens 19-22 9209406-13 1997 It has been reported that Vav has guanine nucleotide exchange activity and activates Ras in vitro and in vivo. Guanine Nucleotides 34-52 vav guanine nucleotide exchange factor 1 Homo sapiens 26-29 8724692-6 1996 The presence of a putative guanine nucleotide exchange domain, the prototype of which is found in the dbl oncogene product, implies that Vav functions as a guanine nucleotide exchange factor (GEF) for one (or more) members of the Ras-like family of small GTP-binding proteins. Guanine Nucleotides 27-45 vav guanine nucleotide exchange factor 1 Homo sapiens 137-140 8677749-3 1996 The product of the vav proto-oncogene (Vav) is expressed exclusively in hematopoietic cells and has guanine nucleotide exchange activity. Guanine Nucleotides 100-118 vav guanine nucleotide exchange factor 1 Homo sapiens 39-42 7535775-2 1995 One possible mediator in such signaling is the vav proto-oncogene product (p95vav), which is specifically expressed in cells of hematopoietic origin and contains domains typical of guanine nucleotide exchange factors as well as Src homology 2 and Src homology 3 domains. Guanine Nucleotides 181-199 vav guanine nucleotide exchange factor 1 Homo sapiens 47-50 7539782-1 1995 The vav proto-oncogene product (Vav) is expressed exclusively in hematopoietic cells and is reported to have guanine nucleotide exchange activity. Guanine Nucleotides 109-127 vav guanine nucleotide exchange factor 1 Homo sapiens 4-7 7539782-1 1995 The vav proto-oncogene product (Vav) is expressed exclusively in hematopoietic cells and is reported to have guanine nucleotide exchange activity. Guanine Nucleotides 109-127 vav guanine nucleotide exchange factor 1 Homo sapiens 32-35 8484124-0 1993 Tyrosine kinase-stimulated guanine nucleotide exchange activity of Vav in T cell activation. Guanine Nucleotides 27-45 vav guanine nucleotide exchange factor 1 Homo sapiens 67-70 7524075-6 1994 This tyrosine phosphorylation of p72ITK/EMT is rapid (within 30 sec), occurs in the absence of LCK activation, and precedes tyrosine phosphorylation of the guanine nucleotide exchange factor VAV. Guanine Nucleotides 156-174 vav guanine nucleotide exchange factor 1 Homo sapiens 191-194 34252536-1 2021 Vav1 exhibits two signal transducing properties as an adaptor protein and a regulator of cytoskeleton organization through its Guanine nucleotide Exchange Factor module. Guanine Nucleotides 127-145 vav guanine nucleotide exchange factor 1 Homo sapiens 0-4 8489524-4 1993 Vav may play a role in hematopoietic cell signaling by coupling tyrosine kinase pathways to ras-like GTPases through the regulation of guanine nucleotide exchange. Guanine Nucleotides 135-153 vav guanine nucleotide exchange factor 1 Homo sapiens 0-3 31974114-1 2020 Vav family guanine nucleotide exchange factors (GEFs) are essential regulators of immune function. Guanine Nucleotides 11-29 vav guanine nucleotide exchange factor 1 Homo sapiens 0-3 35237130-1 2021 Vav proteins belong to the class of guanine nucleotide exchange factors (GEFs) that catalyze the exchange of guanosine diphosphate (GDP) by guanosine triphosphate (GTP) on their target proteins. Guanine Nucleotides 36-54 vav guanine nucleotide exchange factor 1 Homo sapiens 0-3 31548614-4 2020 Among the identified genes shared by the two cell types are proto-oncogenes ERK2, a component of the ERK/MAPK pathway, and VAV1, a guanine nucleotide exchange factor for Rho family GTPases that also activates the ERK/MAPK pathway. Guanine Nucleotides 131-149 vav guanine nucleotide exchange factor 1 Homo sapiens 123-127