PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32513570-2 2020 The synaptic Ras homologous (Rho) guanine nucleotide exchange factors (GEFs) Kalirin and Trio have emerged as central regulators of actin dynamics at the synapse. Guanine Nucleotides 34-52 trio Rho guanine nucleotide exchange factor Homo sapiens 89-93 29207149-1 2018 Triple functional domain protein (Trio) is an evolutionarily conserved protein with guanine nucleotide exchange factors that regulate different physiological processes in some types of cancer. Guanine Nucleotides 84-102 trio Rho guanine nucleotide exchange factor Homo sapiens 0-32 29207149-1 2018 Triple functional domain protein (Trio) is an evolutionarily conserved protein with guanine nucleotide exchange factors that regulate different physiological processes in some types of cancer. Guanine Nucleotides 84-102 trio Rho guanine nucleotide exchange factor Homo sapiens 34-38 25655724-5 2015 Inhibition of the Trio-mediated Rac1 guanine nucleotide exchange activity with ITX3 partially blocked the SV4-mediated increase in Rac1-GTP. Guanine Nucleotides 37-55 trio Rho guanine nucleotide exchange factor Homo sapiens 18-22 27907191-4 2016 This interacting protein, Trio, is a member of the Dbl family of guanine nucleotide exchange factors (GEFs) known to regulate the dynamic assembly of actin and growth factor dependent axon guidance and synaptic growth. Guanine Nucleotides 65-83 trio Rho guanine nucleotide exchange factor Homo sapiens 26-30 25655724-11 2015 Supervillin and Trio knockdowns, separately or together, inhibited cell spreading, suggesting that supervillin regulates the Rac1 guanine nucleotide exchange activity of Trio, and potentially also kalirin, during cell spreading and lamellipodia extension. Guanine Nucleotides 130-148 trio Rho guanine nucleotide exchange factor Homo sapiens 16-20 25655724-11 2015 Supervillin and Trio knockdowns, separately or together, inhibited cell spreading, suggesting that supervillin regulates the Rac1 guanine nucleotide exchange activity of Trio, and potentially also kalirin, during cell spreading and lamellipodia extension. Guanine Nucleotides 130-148 trio Rho guanine nucleotide exchange factor Homo sapiens 170-174 22966858-2 2012 Previous work has identified roles for the Rho family guanine nucleotide exchange factors Trio and Vav3 in glioblastoma invasion. Guanine Nucleotides 54-72 trio Rho guanine nucleotide exchange factor Homo sapiens 90-94 23177739-3 2013 Using a synthetic-biology approach and a genome-wide RNAi screen, we found that a highly conserved guanine nucleotide exchange factor, Trio, is essential for activating Rho- and Rac-regulated signaling pathways acting on JNK and p38, and thereby transducing proliferative signals from Galpha(q) to the nucleus independently of phospholipase C-beta. Guanine Nucleotides 99-117 trio Rho guanine nucleotide exchange factor Homo sapiens 135-139 22238672-1 2012 The guanine-nucleotide exchange factor Trio encodes two DH-PH domains that catalyze nucleotide exchange on Rac1, RhoG and RhoA. Guanine Nucleotides 4-22 trio Rho guanine nucleotide exchange factor Homo sapiens 39-43 9464532-1 1998 Trio contains two functional guanine nucleotide exchange factors (GEF) domains for the Rho-like GTPases and a serine/threonine kinase domain. Guanine Nucleotides 29-47 trio Rho guanine nucleotide exchange factor Homo sapiens 0-4 18925966-3 2008 One group of activators which regulate the Rho-GTPases is the guanine nucleotide exchange factors (GEFs), and this study looked at three such GEFs, Trio, Vav1 and TIAM-1. Guanine Nucleotides 62-80 trio Rho guanine nucleotide exchange factor Homo sapiens 148-152 17881726-0 2007 Kalirin/Trio Rho guanine nucleotide exchange factors regulate a novel step in secretory granule maturation. Guanine Nucleotides 17-35 trio Rho guanine nucleotide exchange factor Homo sapiens 8-12 14597635-0 2004 Mechanisms of guanine nucleotide exchange and Rac-mediated signaling revealed by a dominant negative trio mutant. Guanine Nucleotides 14-32 trio Rho guanine nucleotide exchange factor Homo sapiens 101-105 12475976-12 2003 These results reveal the existence of a novel mechanism of Rac activation by a guanine nucleotide exchange factor and suggest that the induction by Trio of a conformational change in Rac1, in the absence of nucleotide exchange, is sufficient for enhancing its effector function. Guanine Nucleotides 79-97 trio Rho guanine nucleotide exchange factor Homo sapiens 148-152 11889037-2 2002 While it is known that the DH domain is the principal catalytic subunit, recent biochemical data indicate that for some Dbl-family proteins, such as Dbs and Trio, PH domains may cooperate with their associated DH domains in promoting guanine nucleotide exchange of Rho GTPases. Guanine Nucleotides 234-252 trio Rho guanine nucleotide exchange factor Homo sapiens 157-161 22155786-4 2011 Binding of proNGF to the p75NTR-SorCS2 complex induced growth cone retraction by initiating the dissociation of the guanine nucleotide exchange factor Trio from the p75NTR-SorCS2 complex, resulting in decreased Rac activity and, consequently, growth cone collapse. Guanine Nucleotides 116-134 trio Rho guanine nucleotide exchange factor Homo sapiens 151-155 35290799-8 2022 We also identify putative guanine nucleotide exchange factors for Rac and Cdc42, Trio and Fgd1, respectively, whose phosphorylation states increase upon mitochondrial depolarization and whose suppression inhibits ADA. Guanine Nucleotides 26-44 trio Rho guanine nucleotide exchange factor Homo sapiens 81-85