PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35242238-0 2022 Matrine exerts antitumor activity in cervical cancer by protective autophagy via the Akt/mTOR pathway in vitro and in vivo. matrine 0-7 mechanistic target of rapamycin kinase Homo sapiens 89-93 35242238-10 2022 These findings suggested that matrine inhibited the proliferation of cervical cancer cells and induced autophagy by inhibiting the Akt/mTOR signaling pathway. matrine 30-37 mechanistic target of rapamycin kinase Homo sapiens 135-139 33000249-0 2020 Matrine exerts anti-breast cancer activity by mediating apoptosis and protective autophagy via the AKT/mTOR pathway in MCF-7 cells. matrine 0-7 mechanistic target of rapamycin kinase Homo sapiens 103-107 33000249-7 2020 Additionally, matrine suppressed AKT and mammalian target of rapamycin (mTOR) phosphorylation, indicating that the AKT/mTOR pathway is involved in matrine-induced apoptosis and autophagy. matrine 14-21 mechanistic target of rapamycin kinase Homo sapiens 41-70 33000249-7 2020 Additionally, matrine suppressed AKT and mammalian target of rapamycin (mTOR) phosphorylation, indicating that the AKT/mTOR pathway is involved in matrine-induced apoptosis and autophagy. matrine 14-21 mechanistic target of rapamycin kinase Homo sapiens 72-76 33000249-7 2020 Additionally, matrine suppressed AKT and mammalian target of rapamycin (mTOR) phosphorylation, indicating that the AKT/mTOR pathway is involved in matrine-induced apoptosis and autophagy. matrine 14-21 mechanistic target of rapamycin kinase Homo sapiens 119-123 33000249-7 2020 Additionally, matrine suppressed AKT and mammalian target of rapamycin (mTOR) phosphorylation, indicating that the AKT/mTOR pathway is involved in matrine-induced apoptosis and autophagy. matrine 147-154 mechanistic target of rapamycin kinase Homo sapiens 119-123 33000249-8 2020 Overall, the results of the present study indicated that matrine possesses anti-breast cancer activity by providing protective autophagy via inhibition of the AKT/mTOR pathway. matrine 57-64 mechanistic target of rapamycin kinase Homo sapiens 163-167 31452769-11 2019 In addition, it was observed that matrine decreased the expression of phosphorylated (p)-PI3K, p-Akt and p-mTOR in a concentration-dependent manner. matrine 34-41 mechanistic target of rapamycin kinase Homo sapiens 107-111 31634459-0 2019 Matrine pre-treatment suppresses AGEs- induced HCSMCs fibrotic responses by regulating Poldip2/mTOR pathway. matrine 0-7 mechanistic target of rapamycin kinase Homo sapiens 95-99 31615459-0 2019 Autophagy inhibition enhances Matrine derivative MASM induced apoptosis in cancer cells via a mechanism involving reactive oxygen species-mediated PI3K/Akt/mTOR and Erk/p38 signaling. matrine 30-37 mechanistic target of rapamycin kinase Homo sapiens 156-160 31634459-9 2019 Matrine pre-treatment significantly reduced collagen content, increased smooth muscle myosin heavy chain 11 (MYH11) and Poldip2 expression, decreased expressions of collagen I, beta1-integrin, phsphoinositide-3-kinase (PI3K) and nuclear phosphorylated p70S6k, and reduced phosphorylation levels of protein kinase B (Akt) and mechanistic target of rapamycin (mTOR) in HCSMCs exposed to AGEs in a concentration dependent manner. matrine 0-7 mechanistic target of rapamycin kinase Homo sapiens 325-356 31634459-9 2019 Matrine pre-treatment significantly reduced collagen content, increased smooth muscle myosin heavy chain 11 (MYH11) and Poldip2 expression, decreased expressions of collagen I, beta1-integrin, phsphoinositide-3-kinase (PI3K) and nuclear phosphorylated p70S6k, and reduced phosphorylation levels of protein kinase B (Akt) and mechanistic target of rapamycin (mTOR) in HCSMCs exposed to AGEs in a concentration dependent manner. matrine 0-7 mechanistic target of rapamycin kinase Homo sapiens 358-362 31634459-11 2019 Matrine suppresses AGEs- induced fibrotic responses in HCSMCs via regulating Poldip2/mTOR signaling pathway. matrine 0-7 mechanistic target of rapamycin kinase Homo sapiens 85-89 31460901-17 2019 Compared with matrine or acitretin, matrine plus acitretin significantly down-regulated the phosphorylation of phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) pathway (P < 0.05) and its downstream p-p70S6K (P < 0.05). matrine 36-43 mechanistic target of rapamycin kinase Homo sapiens 167-196 31460901-17 2019 Compared with matrine or acitretin, matrine plus acitretin significantly down-regulated the phosphorylation of phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) pathway (P < 0.05) and its downstream p-p70S6K (P < 0.05). matrine 36-43 mechanistic target of rapamycin kinase Homo sapiens 198-202 31340906-8 2019 Treatment of the cells with 1.6 g/L matrine and 10 nmol/L LY294002 resulted in significantly lowered expressions of p-AKT and p-mTOR proteins and increased the expression of light chain 3B (LC 3B), an autophagy-related protein, as compared with those in the control cells (P &lt; 0.05). matrine 36-43 mechanistic target of rapamycin kinase Homo sapiens 128-132