PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31932645-3 2020 Our research reveals a novel DNA response mechanism different from general DNA-damaging agents, and that sophoridine derivate inhibits the phosphorylation of Tyr694 and Ser780 of STAT5a to induce the lessened shuttle from the cytoplasm to the nucleus, and leads to the decreased nuclear STAT5a and subsequently inhibits the expression of STAT5a target gene RAD51 that contributes to the checkpoint activation, thus inhibiting ATR activation. matrine 105-116 RAD51 recombinase Homo sapiens 357-362