PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18586382-0 2008 Involvement of Rho-kinase in prostaglandin F2alpha-stimulated interleukin-6 synthesis via p38 mitogen-activated protein kinase in osteoblasts. Dinoprost 29-50 mitogen-activated protein kinase 14 Mus musculus 90-93 29773555-0 2018 Prostaglandin F2alpha Facilitates Hepatic Glucose Production Through CaMKIIgamma/p38/FOXO1 Signaling Pathway in Fasting and Obesity. Dinoprost 0-21 mitogen-activated protein kinase 14 Mus musculus 81-84 16638579-0 2006 Differential involvement of ERK1-2 and p38MAPK activation on Swiss 3T3 cell proliferation induced by prostaglandin F2alpha. Dinoprost 101-122 mitogen-activated protein kinase 14 Mus musculus 39-46 16638579-3 2006 We demonstrate that PGF2alpha induces extracellular-signal-regulated kinase (ERK1-2) and p38MAPK activation, and inhibition of any of these signaling pathways completely blocks PGF2alpha-stimulated DNA synthesis. Dinoprost 20-29 mitogen-activated protein kinase 14 Mus musculus 89-96 10913228-6 2000 SB203580, an inhibitor of p38 MAP kinase, reduced the effect of sphingosine 1-phosphate on the formation of inositol phosphates by PGF2 alpha. Dinoprost 131-135 mitogen-activated protein kinase 14 Mus musculus 26-29 10913228-8 2000 SB203580 suppressed the phosphorylation of p38 MAP kinase by PGF2 alpha. Dinoprost 61-71 mitogen-activated protein kinase 14 Mus musculus 43-46 10913228-10 2000 These results strongly suggest that sphingosine 1-phosphate amplifies PGF2 alpha-induced phosphoinositide hydrolysis by phospholipase C through p38 MAP kinase in osteoblasts. Dinoprost 70-74 mitogen-activated protein kinase 14 Mus musculus 144-147 32904295-3 2020 We also found that Rho-kinase is involved in the signaling of PGF2alpha upstream of p38 MAPK in these cells. Dinoprost 62-71 mitogen-activated protein kinase 14 Mus musculus 84-92 32904295-12 2020 Tramadol upregulated the phosphorylation of SAPK/JNK and p38 MAPK stimulated by PGF2alpha but not that of p44/p42 MAPK or myosin phosphatase targeting protein (MYPT), a substrate of Rho-kinase. Dinoprost 80-89 mitogen-activated protein kinase 14 Mus musculus 57-65 32904295-13 2020 The inhibitors of both p38 MAPK and SAPK/JNK, SB203580 and SP600125, respectively, reduced the tramadol amplification of OPG release stimulated by PGF2alpha. Dinoprost 147-156 mitogen-activated protein kinase 14 Mus musculus 23-31 28849144-2 2017 We have previously demonstrated that prostaglandin F2alpha (PGF2alpha), a potent bone remodeling mediator, stimulates the synthesis of osteoprotegerin (OPG) through the activation of p44/p42 mitogen-activated protein kinase (MAPK), p38 MAPK and stress activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) in osteoblast-like MC3T3-E1 cells. Dinoprost 37-58 mitogen-activated protein kinase 14 Mus musculus 232-240 28849144-2 2017 We have previously demonstrated that prostaglandin F2alpha (PGF2alpha), a potent bone remodeling mediator, stimulates the synthesis of osteoprotegerin (OPG) through the activation of p44/p42 mitogen-activated protein kinase (MAPK), p38 MAPK and stress activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) in osteoblast-like MC3T3-E1 cells. Dinoprost 60-69 mitogen-activated protein kinase 14 Mus musculus 232-240 28542188-0 2017 HSP90 inhibitors potentiate PGF2alpha-induced IL-6 synthesis via p38 MAP kinase in osteoblasts. Dinoprost 28-37 mitogen-activated protein kinase 14 Mus musculus 65-68 28542188-6 2017 Geldanamycin, 17-AAG and onalespib markedly strengthened the PGF2alpha-induced phosphorylation of p38 MAP kinase. Dinoprost 61-70 mitogen-activated protein kinase 14 Mus musculus 98-101 28542188-8 2017 In addition, HSP90-siRNA enhanced the PGF2alpha-induced phosphorylation of p38 MAP kinase. Dinoprost 38-47 mitogen-activated protein kinase 14 Mus musculus 75-78 28542188-9 2017 Furthermore, SB203580, an inhibitor of p38 MAP kinase, significantly suppressed the amplification by geldanamycin, 17-AAG or 17-DMAG of the PGF2alpha-stimulated IL-6 release. Dinoprost 140-149 mitogen-activated protein kinase 14 Mus musculus 39-42 28542188-2 2017 We have previously reported that prostaglandin F2alpha (PGF2alpha), a potent bone remodeling mediator, stimulates the synthesis of interleukin-6 (IL-6) through p44/p42 mitogen-activated protein (MAP) kinase and p38 MAP kinase in osteoblast-like MC3T3-E1 cells, and that Rho-kinase acts at a point upstream of p38 MAP kinase. Dinoprost 33-54 mitogen-activated protein kinase 14 Mus musculus 211-214 28542188-2 2017 We have previously reported that prostaglandin F2alpha (PGF2alpha), a potent bone remodeling mediator, stimulates the synthesis of interleukin-6 (IL-6) through p44/p42 mitogen-activated protein (MAP) kinase and p38 MAP kinase in osteoblast-like MC3T3-E1 cells, and that Rho-kinase acts at a point upstream of p38 MAP kinase. Dinoprost 33-54 mitogen-activated protein kinase 14 Mus musculus 309-312 28542188-2 2017 We have previously reported that prostaglandin F2alpha (PGF2alpha), a potent bone remodeling mediator, stimulates the synthesis of interleukin-6 (IL-6) through p44/p42 mitogen-activated protein (MAP) kinase and p38 MAP kinase in osteoblast-like MC3T3-E1 cells, and that Rho-kinase acts at a point upstream of p38 MAP kinase. Dinoprost 56-65 mitogen-activated protein kinase 14 Mus musculus 211-214 28542188-2 2017 We have previously reported that prostaglandin F2alpha (PGF2alpha), a potent bone remodeling mediator, stimulates the synthesis of interleukin-6 (IL-6) through p44/p42 mitogen-activated protein (MAP) kinase and p38 MAP kinase in osteoblast-like MC3T3-E1 cells, and that Rho-kinase acts at a point upstream of p38 MAP kinase. Dinoprost 56-65 mitogen-activated protein kinase 14 Mus musculus 309-312 26744072-9 2016 The phosphorylation of p38 MAP kinase, p44/p42 MAP kinase or SAPK/JNK induced by PGF2alpha was not markedly affected by either mimosine or deferoxamine. Dinoprost 81-90 mitogen-activated protein kinase 14 Mus musculus 23-26 23814012-7 2013 Both in vitro and in vivo studies showed that PGF2 alpha significantly increases the expression of Slit2 and Robo1 during luteolysis through protein kinase C-dependent ERK1/2 and P38 MAPK signaling pathways, whereas an inhibitor of Slit/Robo signaling significantly decreases the stimulating effect of PGF2 alpha on luteolysis. Dinoprost 46-50 mitogen-activated protein kinase 14 Mus musculus 179-182 22614766-2 2012 We have previously shown that prostaglandin F2alpha (PGF2alpha) stimulates the synthesis of vascular endothelial growth factor (VEGF) and interleukin-6 (IL-6) via mitogen-activated protein (MAP) kinases, including p44/p42 MAP kinase, p38 MAP kinase and stress-activated protein kinase (SAPK)/c-Jun N-terminal kinase (JNK) in osteoblast-like MC3T3-E1 cells. Dinoprost 30-51 mitogen-activated protein kinase 14 Mus musculus 234-237 22614766-2 2012 We have previously shown that prostaglandin F2alpha (PGF2alpha) stimulates the synthesis of vascular endothelial growth factor (VEGF) and interleukin-6 (IL-6) via mitogen-activated protein (MAP) kinases, including p44/p42 MAP kinase, p38 MAP kinase and stress-activated protein kinase (SAPK)/c-Jun N-terminal kinase (JNK) in osteoblast-like MC3T3-E1 cells. Dinoprost 53-62 mitogen-activated protein kinase 14 Mus musculus 234-237 26744072-3 2016 We previously reported that prostaglandin F2alpha (PGF2alpha) induced osteoprotegerin synthesis through p38 mitogen-activated protein (MAP) kinase, p44/p42 MAP kinase and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) in osteoblast-like MC3T3-E1 cells. Dinoprost 28-49 mitogen-activated protein kinase 14 Mus musculus 104-107 26744072-3 2016 We previously reported that prostaglandin F2alpha (PGF2alpha) induced osteoprotegerin synthesis through p38 mitogen-activated protein (MAP) kinase, p44/p42 MAP kinase and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) in osteoblast-like MC3T3-E1 cells. Dinoprost 51-60 mitogen-activated protein kinase 14 Mus musculus 104-107 26744072-4 2016 We have also demonstrated that PGF2alpha induced the synthesis of interleukin-6 (IL-6) via p38 MAP kinase and p44/p42 MAP kinase but not SAPK/JNK in these cells. Dinoprost 31-40 mitogen-activated protein kinase 14 Mus musculus 91-94 23064268-0 2012 AMP-activated protein kinase inhibitor decreases prostaglandin F2alpha-stimulated interleukin-6 synthesis through p38 MAP kinase in osteoblasts. Dinoprost 49-70 mitogen-activated protein kinase 14 Mus musculus 126-129