PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11327082-0	2001	Prostaglandin F2alpha upregulates interleukin-6 production in human gingival fibroblasts.	Dinoprost	0-21	interleukin 6	Homo sapiens	34-47	
30827352-11	2019	PGF2alpha increased mRNA content and protein activity of MMP9, and gene and protein expression of interleukin-6 (P < 0.05).	Dinoprost	0-9	interleukin 6	Homo sapiens	98-111	
25882540-4	2015	Confirmatory enzyme-linked immunosorbent assays (ELISAs) showed that PGF2alpha stimulated increased output of interleukin (IL) 1beta, IL6, IL8 (CXCL8) and monocyte chemotactic protein-1 (MCP1, also known as chemokine (c-c motif) ligand 2, CCL2) by HUSMCs isolated from both upper and lower uterine segments.	Dinoprost	69-78	interleukin 6	Homo sapiens	134-137	
25882540-10	2015	Inhibition of ERK reversed PGF2alpha-induced IL1beta, IL6 and CCL2 output, while inhibition of PI3K blocked the effect of PGF2alpha on IL6, CXCL8 and CCL2 output and inhibition of NF-kappaB reversed PGF2alpha-induced IL1beta and CCL2 output.	Dinoprost	27-36	interleukin 6	Homo sapiens	54-57	
25882540-10	2015	Inhibition of ERK reversed PGF2alpha-induced IL1beta, IL6 and CCL2 output, while inhibition of PI3K blocked the effect of PGF2alpha on IL6, CXCL8 and CCL2 output and inhibition of NF-kappaB reversed PGF2alpha-induced IL1beta and CCL2 output.	Dinoprost	122-131	interleukin 6	Homo sapiens	135-138	
25882540-10	2015	Inhibition of ERK reversed PGF2alpha-induced IL1beta, IL6 and CCL2 output, while inhibition of PI3K blocked the effect of PGF2alpha on IL6, CXCL8 and CCL2 output and inhibition of NF-kappaB reversed PGF2alpha-induced IL1beta and CCL2 output.	Dinoprost	122-131	interleukin 6	Homo sapiens	135-138	
11327082-9	2001	TMB-8 significantly suppressed PGF2alpha-induced IL-6 production, whereas calphostin C showed a stimulatory effect on PGF2alpha-induced IL-6 production.	Dinoprost	118-127	interleukin 6	Homo sapiens	136-140	
11327082-10	2001	From these data, we suggest that PGF2alpha upregulates IL-6 production through FP receptors in HGF, that PGF2alpha synergistically enhances IL-6 production in IL-1beta- and TNFalpha-stimulated HGF, and that PGF2alpha-induced IL-6 production may be dependent on intracellular Ca2+ mobilization and be downregulated by PKC activation.	Dinoprost	33-42	interleukin 6	Homo sapiens	55-59	
11327082-10	2001	From these data, we suggest that PGF2alpha upregulates IL-6 production through FP receptors in HGF, that PGF2alpha synergistically enhances IL-6 production in IL-1beta- and TNFalpha-stimulated HGF, and that PGF2alpha-induced IL-6 production may be dependent on intracellular Ca2+ mobilization and be downregulated by PKC activation.	Dinoprost	105-114	interleukin 6	Homo sapiens	140-144	
11327082-10	2001	From these data, we suggest that PGF2alpha upregulates IL-6 production through FP receptors in HGF, that PGF2alpha synergistically enhances IL-6 production in IL-1beta- and TNFalpha-stimulated HGF, and that PGF2alpha-induced IL-6 production may be dependent on intracellular Ca2+ mobilization and be downregulated by PKC activation.	Dinoprost	105-114	interleukin 6	Homo sapiens	140-144	
11327082-10	2001	From these data, we suggest that PGF2alpha upregulates IL-6 production through FP receptors in HGF, that PGF2alpha synergistically enhances IL-6 production in IL-1beta- and TNFalpha-stimulated HGF, and that PGF2alpha-induced IL-6 production may be dependent on intracellular Ca2+ mobilization and be downregulated by PKC activation.	Dinoprost	105-114	interleukin 6	Homo sapiens	140-144	
11327082-10	2001	From these data, we suggest that PGF2alpha upregulates IL-6 production through FP receptors in HGF, that PGF2alpha synergistically enhances IL-6 production in IL-1beta- and TNFalpha-stimulated HGF, and that PGF2alpha-induced IL-6 production may be dependent on intracellular Ca2+ mobilization and be downregulated by PKC activation.	Dinoprost	105-114	interleukin 6	Homo sapiens	140-144	
11327082-11	2001	PGF2alpha may be involved in the pathogenesis of periodontal disease by enhancing IL-6 levels in periodontal lesions.	Dinoprost	0-9	interleukin 6	Homo sapiens	82-86	
30794283-0	2019	Cooperative effects of sequential PGF2alpha and IL-1beta on IL-6 and COX-2 expression in human myometrial cells .	Dinoprost	34-43	interleukin 6	Homo sapiens	60-64	
30794283-5	2019	Sequential stimulation of HMSMC by PGF2alpha and IL-1beta in either order results in amplified upregulation of IL-6 and COX-2 mRNA and protein, compared to their effects individually.	Dinoprost	35-44	interleukin 6	Homo sapiens	111-115	
30794283-7	2019	These results suggest that PGF2alpha and IL-1beta act cooperatively upstream in the birth cascade to maximize amplification of IL-6 and COX-2, to build inflammatory load and thereby promote uterine transition.	Dinoprost	27-36	interleukin 6	Homo sapiens	127-131	
30794283-8	2019	Targeting PGF2alpha or IL-1beta, their actions, or intermediates (e.g. IL-6) would be an effective therapeutic intervention for preterm birth prevention or delay.	Dinoprost	10-19	interleukin 6	Homo sapiens	71-75	
11327082-4	2001	PGF2alpha stimulated IL-6 production in a time- and concentration-dependent fashion.	Dinoprost	0-9	interleukin 6	Homo sapiens	21-25	
11327082-5	2001	IL-1beta and tumor necrosis factor alpha (TNFalpha), proinflammatory cytokines, induced IL-6 production in a time-dependent manner, and PGF2alpha synergistically enhanced IL-6 production induced by IL-1beta and TNFalpha.	Dinoprost	136-145	interleukin 6	Homo sapiens	171-175	
11327082-6	2001	IL-6 mRNA was expressed in PGF2alpha-stimulated HGF, and PGF2alpha increased IL-6 mRNA levels induced by IL-1beta and TNFalpha.	Dinoprost	27-36	interleukin 6	Homo sapiens	0-4	
11327082-6	2001	IL-6 mRNA was expressed in PGF2alpha-stimulated HGF, and PGF2alpha increased IL-6 mRNA levels induced by IL-1beta and TNFalpha.	Dinoprost	57-66	interleukin 6	Homo sapiens	77-81	
11327082-7	2001	Fluprostenol, a selective FP receptor agonist, could mimic PGF2alpha-induced IL-6 production.	Dinoprost	59-68	interleukin 6	Homo sapiens	77-81	
11327082-8	2001	Since FP receptors are coupled to elevation of intracellular calcium and activation of protein kinase C (PKC), the mechanism of IL-6 production by PGF2alpha was investigated using TMB-8, an inhibitor of Ca2+ mobilization from intracellular stores, and calphostin C, an inhibitor of PKC.	Dinoprost	147-156	interleukin 6	Homo sapiens	128-132	
11327082-9	2001	TMB-8 significantly suppressed PGF2alpha-induced IL-6 production, whereas calphostin C showed a stimulatory effect on PGF2alpha-induced IL-6 production.	Dinoprost	31-40	interleukin 6	Homo sapiens	49-53	
2107353-7	1990	However, when PDGF-BB or -AB was combined with IL-1 beta or IL-6, prostanoid generation by HMC was synergistically increased up to 222-fold (IL-1 beta) or 12-fold (IL-6) above the control values, with the induction of PGE2 greater than 6-keto-PGF1 alpha greater than PGF2 alpha much greater than TXB2.	Dinoprost	267-271	interleukin 6	Homo sapiens	60-64	
9581864-2	1998	In the present study, we investigated the effect of tiludronate, a bisphosphonate known to inhibit bone resorption, on the PGF2alpha- and PGE1-induced IL-6 synthesis in these cells.	Dinoprost	123-132	interleukin 6	Homo sapiens	151-155	
9581864-10	1998	These results strongly suggest that tiludronate inhibits PGF2alpha-induced IL-6 synthesis via suppression of phosphatidylcholine-hydrolyzing phospholipase D activation in osteoblasts, and that the inhibitory effect is exerted at the point between heterotrimeric GTP-binding protein and phospholipase D.	Dinoprost	57-66	interleukin 6	Homo sapiens	75-79