PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10376804-4 1999 Calphostin C, a highly potent and specific inhibitor of PKC, inhibited the PGF2alpha-induced p42/p44 MAP kinase activity. Dinoprost 75-84 mitogen-activated protein kinase 3 Mus musculus 97-100 10376804-0 1999 p42/p44 mitogen-activated protein kinase activation is involved in prostaglandin F2alpha-induced interleukin-6 synthesis in osteoblasts. Dinoprost 67-88 mitogen-activated protein kinase 3 Mus musculus 4-7 10376804-1 1999 Prostaglandin F2alpha (PGF2alpha) significantly induced p42/p44 mitogen-activated protein (MAP) kinase activity in osteoblast-like MC3T3-E1 cells. Dinoprost 0-21 mitogen-activated protein kinase 3 Mus musculus 60-63 10376804-1 1999 Prostaglandin F2alpha (PGF2alpha) significantly induced p42/p44 mitogen-activated protein (MAP) kinase activity in osteoblast-like MC3T3-E1 cells. Dinoprost 23-32 mitogen-activated protein kinase 3 Mus musculus 60-63 10376804-2 1999 PD98059, a selective inhibitor of MAP kinase kinase, inhibited PGF2alpha-induced interleukin-6 (IL-6) synthesis as well as PGF2alpha-induced p42/p44 MAP kinase activation. Dinoprost 123-132 mitogen-activated protein kinase 3 Mus musculus 145-148 10376804-5 1999 These results strongly suggest that PKC-dependent p42/p44 MAP kinase activatioin is involved in PGF2alpha-induced IL-6 synthesis in osteoblasts. Dinoprost 96-105 mitogen-activated protein kinase 3 Mus musculus 54-57 32904295-2 2020 We previously showed that the synthesis of OPG is stimulated by prostaglandin F2alpha (PGF2alpha) in the involvement of p38 mitogen-activated protein kinase (MAPK), stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) and p44/p42 MAPK in osteoblast-like MC3T3-E1 cells. Dinoprost 87-96 mitogen-activated protein kinase 3 Mus musculus 236-239 34986499-7 2022 However, the phosphorylation of p44/p42 MAP kinase, p38 MAP kinase, or JNK induced by PGF2alpha was not affected by GIP or GLP-1. Dinoprost 86-95 mitogen-activated protein kinase 3 Mus musculus 32-50 33840687-5 2021 We have previously reported that prostaglandin (PG) E2 and PGF2alpha induce osteoprotegerin synthesis through p38 mitogen-activated protein kinase (MAPK), p44/p42 MAPK and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) in osteoblast-like MC3T3-E1 cells. Dinoprost 59-68 mitogen-activated protein kinase 3 Mus musculus 155-167 32904295-2 2020 We previously showed that the synthesis of OPG is stimulated by prostaglandin F2alpha (PGF2alpha) in the involvement of p38 mitogen-activated protein kinase (MAPK), stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) and p44/p42 MAPK in osteoblast-like MC3T3-E1 cells. Dinoprost 64-85 mitogen-activated protein kinase 3 Mus musculus 236-239 28542188-2 2017 We have previously reported that prostaglandin F2alpha (PGF2alpha), a potent bone remodeling mediator, stimulates the synthesis of interleukin-6 (IL-6) through p44/p42 mitogen-activated protein (MAP) kinase and p38 MAP kinase in osteoblast-like MC3T3-E1 cells, and that Rho-kinase acts at a point upstream of p38 MAP kinase. Dinoprost 33-54 mitogen-activated protein kinase 3 Mus musculus 160-163 28849144-2 2017 We have previously demonstrated that prostaglandin F2alpha (PGF2alpha), a potent bone remodeling mediator, stimulates the synthesis of osteoprotegerin (OPG) through the activation of p44/p42 mitogen-activated protein kinase (MAPK), p38 MAPK and stress activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) in osteoblast-like MC3T3-E1 cells. Dinoprost 37-58 mitogen-activated protein kinase 3 Mus musculus 183-186 28849144-2 2017 We have previously demonstrated that prostaglandin F2alpha (PGF2alpha), a potent bone remodeling mediator, stimulates the synthesis of osteoprotegerin (OPG) through the activation of p44/p42 mitogen-activated protein kinase (MAPK), p38 MAPK and stress activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) in osteoblast-like MC3T3-E1 cells. Dinoprost 60-69 mitogen-activated protein kinase 3 Mus musculus 183-186 29245902-2 2017 Using human TauP301S transgenic (Tg) mice as in vivo model, our results demonstrated that PGI2 and PGF2alpha mediated the effects of tumor necrosis factor alpha (TNF-alpha) and Zinc ions (Zn2+) on upregulating the phosphorylation of tau via the PI3-K/AKT, ERK1/2 and JNK/c-Jun signaling pathways. Dinoprost 99-108 mitogen-activated protein kinase 3 Mus musculus 256-262 29701904-8 2018 Enzyme immunoassay showed that GSK1016790A or ACh triggered the release of PGF2alpha (prostaglandin F2alpha ) was reduced by inhibition of PKC or ERK1/2. Dinoprost 75-84 mitogen-activated protein kinase 3 Mus musculus 146-152 29701904-8 2018 Enzyme immunoassay showed that GSK1016790A or ACh triggered the release of PGF2alpha (prostaglandin F2alpha ) was reduced by inhibition of PKC or ERK1/2. Dinoprost 86-107 mitogen-activated protein kinase 3 Mus musculus 146-152 28542188-2 2017 We have previously reported that prostaglandin F2alpha (PGF2alpha), a potent bone remodeling mediator, stimulates the synthesis of interleukin-6 (IL-6) through p44/p42 mitogen-activated protein (MAP) kinase and p38 MAP kinase in osteoblast-like MC3T3-E1 cells, and that Rho-kinase acts at a point upstream of p38 MAP kinase. Dinoprost 56-65 mitogen-activated protein kinase 3 Mus musculus 160-163 26744072-9 2016 The phosphorylation of p38 MAP kinase, p44/p42 MAP kinase or SAPK/JNK induced by PGF2alpha was not markedly affected by either mimosine or deferoxamine. Dinoprost 81-90 mitogen-activated protein kinase 3 Mus musculus 39-42 26744072-3 2016 We previously reported that prostaglandin F2alpha (PGF2alpha) induced osteoprotegerin synthesis through p38 mitogen-activated protein (MAP) kinase, p44/p42 MAP kinase and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) in osteoblast-like MC3T3-E1 cells. Dinoprost 28-49 mitogen-activated protein kinase 3 Mus musculus 148-151 26744072-3 2016 We previously reported that prostaglandin F2alpha (PGF2alpha) induced osteoprotegerin synthesis through p38 mitogen-activated protein (MAP) kinase, p44/p42 MAP kinase and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) in osteoblast-like MC3T3-E1 cells. Dinoprost 51-60 mitogen-activated protein kinase 3 Mus musculus 148-151 26744072-4 2016 We have also demonstrated that PGF2alpha induced the synthesis of interleukin-6 (IL-6) via p38 MAP kinase and p44/p42 MAP kinase but not SAPK/JNK in these cells. Dinoprost 31-40 mitogen-activated protein kinase 3 Mus musculus 110-113 17980568-1 2007 We have reported that prostaglandin F2alpha (PGF2alpha) stimulates the synthesis of vascular endothelial growth factor (VEGF) via p44/p42 mitogen-activated protein (MAP) kinase in osteoblast-like MC3T3-E1 cells. Dinoprost 22-43 mitogen-activated protein kinase 3 Mus musculus 130-133 26090777-7 2015 Furthermore Gly-Pro analog 3 potentiated the effect of PGF2alpha on Galphaq mediated ERK1/2 activation. Dinoprost 55-64 mitogen-activated protein kinase 3 Mus musculus 85-91 23814012-7 2013 Both in vitro and in vivo studies showed that PGF2 alpha significantly increases the expression of Slit2 and Robo1 during luteolysis through protein kinase C-dependent ERK1/2 and P38 MAPK signaling pathways, whereas an inhibitor of Slit/Robo signaling significantly decreases the stimulating effect of PGF2 alpha on luteolysis. Dinoprost 46-50 mitogen-activated protein kinase 3 Mus musculus 168-174 22614766-2 2012 We have previously shown that prostaglandin F2alpha (PGF2alpha) stimulates the synthesis of vascular endothelial growth factor (VEGF) and interleukin-6 (IL-6) via mitogen-activated protein (MAP) kinases, including p44/p42 MAP kinase, p38 MAP kinase and stress-activated protein kinase (SAPK)/c-Jun N-terminal kinase (JNK) in osteoblast-like MC3T3-E1 cells. Dinoprost 30-51 mitogen-activated protein kinase 3 Mus musculus 214-217 22614766-2 2012 We have previously shown that prostaglandin F2alpha (PGF2alpha) stimulates the synthesis of vascular endothelial growth factor (VEGF) and interleukin-6 (IL-6) via mitogen-activated protein (MAP) kinases, including p44/p42 MAP kinase, p38 MAP kinase and stress-activated protein kinase (SAPK)/c-Jun N-terminal kinase (JNK) in osteoblast-like MC3T3-E1 cells. Dinoprost 53-62 mitogen-activated protein kinase 3 Mus musculus 214-217 17980568-1 2007 We have reported that prostaglandin F2alpha (PGF2alpha) stimulates the synthesis of vascular endothelial growth factor (VEGF) via p44/p42 mitogen-activated protein (MAP) kinase in osteoblast-like MC3T3-E1 cells. Dinoprost 45-54 mitogen-activated protein kinase 3 Mus musculus 130-133 17980568-8 2007 PDGF-BB itself induced the phosphorylation of p44/p42 MAP kinase in these cells, and the effects of PDGF-BB and PGF2alpha on the phosphorylation of p44/p42 MAP kinase were additive. Dinoprost 112-121 mitogen-activated protein kinase 3 Mus musculus 148-151 17980568-10 2007 These results strongly suggest that PGF2alpha-stimulated VEGF synthesis is amplified by PI3-kinase-mediating PDGF-BB signaling in osteoblasts, and that the effect is exerted at a point downstream from p44/p42 MAP kinase. Dinoprost 36-45 mitogen-activated protein kinase 3 Mus musculus 201-204 16638579-0 2006 Differential involvement of ERK1-2 and p38MAPK activation on Swiss 3T3 cell proliferation induced by prostaglandin F2alpha. Dinoprost 101-122 mitogen-activated protein kinase 3 Mus musculus 28-34 16638579-3 2006 We demonstrate that PGF2alpha induces extracellular-signal-regulated kinase (ERK1-2) and p38MAPK activation, and inhibition of any of these signaling pathways completely blocks PGF2alpha-stimulated DNA synthesis. Dinoprost 20-29 mitogen-activated protein kinase 3 Mus musculus 77-83 16638579-3 2006 We demonstrate that PGF2alpha induces extracellular-signal-regulated kinase (ERK1-2) and p38MAPK activation, and inhibition of any of these signaling pathways completely blocks PGF2alpha-stimulated DNA synthesis. Dinoprost 177-186 mitogen-activated protein kinase 3 Mus musculus 77-83 11968002-4 2002 L-CAZ suppressed the PGF2alpha-induced p44/p42 MAP kinase phosphorylation. Dinoprost 21-30 mitogen-activated protein kinase 3 Mus musculus 39-42 15922088-1 2005 We have previously reported that prostaglandin F2alpha (PGF2alpha) activates p44/p42 mitogen-activated protein (MAP) kinase through protein kinase C (PKC), resulting in the synthesis of vascular endothelial growth factor (VEGF) in osteoblast-like MC3T3-E1 cells, and that incadronate, a bisphosphonate, amplifies the VEGF synthesis. Dinoprost 33-54 mitogen-activated protein kinase 3 Mus musculus 77-80 15922088-1 2005 We have previously reported that prostaglandin F2alpha (PGF2alpha) activates p44/p42 mitogen-activated protein (MAP) kinase through protein kinase C (PKC), resulting in the synthesis of vascular endothelial growth factor (VEGF) in osteoblast-like MC3T3-E1 cells, and that incadronate, a bisphosphonate, amplifies the VEGF synthesis. Dinoprost 56-65 mitogen-activated protein kinase 3 Mus musculus 77-80 15062846-1 2004 We have reported that prostaglandin F2(alpha) (PGF2(alpha)) activates p44/p42 mitogen-activated protein (MAP) kinase in osteoblast-like MC3T3-E1 cells, and that p44/p42 MAP kinase plays a role in the PGF2(alpha)-induced heat shock protein 27 (HSP27). Dinoprost 22-38 mitogen-activated protein kinase 3 Mus musculus 70-73 15062846-1 2004 We have reported that prostaglandin F2(alpha) (PGF2(alpha)) activates p44/p42 mitogen-activated protein (MAP) kinase in osteoblast-like MC3T3-E1 cells, and that p44/p42 MAP kinase plays a role in the PGF2(alpha)-induced heat shock protein 27 (HSP27). Dinoprost 22-38 mitogen-activated protein kinase 3 Mus musculus 161-164 15062846-1 2004 We have reported that prostaglandin F2(alpha) (PGF2(alpha)) activates p44/p42 mitogen-activated protein (MAP) kinase in osteoblast-like MC3T3-E1 cells, and that p44/p42 MAP kinase plays a role in the PGF2(alpha)-induced heat shock protein 27 (HSP27). Dinoprost 47-51 mitogen-activated protein kinase 3 Mus musculus 70-73 15062846-1 2004 We have reported that prostaglandin F2(alpha) (PGF2(alpha)) activates p44/p42 mitogen-activated protein (MAP) kinase in osteoblast-like MC3T3-E1 cells, and that p44/p42 MAP kinase plays a role in the PGF2(alpha)-induced heat shock protein 27 (HSP27). Dinoprost 47-51 mitogen-activated protein kinase 3 Mus musculus 161-164 15062846-1 2004 We have reported that prostaglandin F2(alpha) (PGF2(alpha)) activates p44/p42 mitogen-activated protein (MAP) kinase in osteoblast-like MC3T3-E1 cells, and that p44/p42 MAP kinase plays a role in the PGF2(alpha)-induced heat shock protein 27 (HSP27). Dinoprost 200-204 mitogen-activated protein kinase 3 Mus musculus 70-73 15062846-1 2004 We have reported that prostaglandin F2(alpha) (PGF2(alpha)) activates p44/p42 mitogen-activated protein (MAP) kinase in osteoblast-like MC3T3-E1 cells, and that p44/p42 MAP kinase plays a role in the PGF2(alpha)-induced heat shock protein 27 (HSP27). Dinoprost 200-204 mitogen-activated protein kinase 3 Mus musculus 161-164 12646577-17 2003 Incadronate markedly enhanced the phosphorylation of Raf-1, MEK1/2, and p44/p42 MAPK induced by PGF2 alpha or 12-O-tetradecanoylphorbol-13-acetate, a PKC activator. Dinoprost 96-106 mitogen-activated protein kinase 3 Mus musculus 72-75 12646577-19 2003 These results strongly suggest that PGF2 alpha stimulates VEGF synthesis through the PKC-dependent activation of p44/p42 MAPK in osteoblasts and that the incadronate enhances the VEGF synthesis at the point between PKC and Raf-1. Dinoprost 36-40 mitogen-activated protein kinase 3 Mus musculus 113-116 16291739-4 2006 However, LIF and PGF2alpha can trigger increases in ERK1/2 activity, which are required for their mitogenic responses because U0126, a MEK1/2 inhibitor, prevents both ERK1/2 activation and induction of DNA synthesis by LIF or PGF2alpha treatment. Dinoprost 17-26 mitogen-activated protein kinase 3 Mus musculus 52-58 16291739-4 2006 However, LIF and PGF2alpha can trigger increases in ERK1/2 activity, which are required for their mitogenic responses because U0126, a MEK1/2 inhibitor, prevents both ERK1/2 activation and induction of DNA synthesis by LIF or PGF2alpha treatment. Dinoprost 17-26 mitogen-activated protein kinase 3 Mus musculus 167-173 16291739-4 2006 However, LIF and PGF2alpha can trigger increases in ERK1/2 activity, which are required for their mitogenic responses because U0126, a MEK1/2 inhibitor, prevents both ERK1/2 activation and induction of DNA synthesis by LIF or PGF2alpha treatment. Dinoprost 226-235 mitogen-activated protein kinase 3 Mus musculus 52-58 16673205-1 2006 In our previous study, we showed that prostaglandin F2alpha (PGF2alpha) stimulates vascular endothelial growth factor (VEGF) synthesis via activation of p44/p42 mitogen-activated protein (MAP) kinase via protein kinase C (PKC) in osteoblast-like MC3T3-E1 cells. Dinoprost 38-59 mitogen-activated protein kinase 3 Mus musculus 153-156 16673205-1 2006 In our previous study, we showed that prostaglandin F2alpha (PGF2alpha) stimulates vascular endothelial growth factor (VEGF) synthesis via activation of p44/p42 mitogen-activated protein (MAP) kinase via protein kinase C (PKC) in osteoblast-like MC3T3-E1 cells. Dinoprost 61-70 mitogen-activated protein kinase 3 Mus musculus 153-156 16673205-5 2006 PGF2alpha-stimulated phosphorylation of Raf-1, MEK1/2 and p44/p42 MAP kinase were suppressed by minodronate. Dinoprost 0-9 mitogen-activated protein kinase 3 Mus musculus 58-61 15062846-8 2004 On the other hand, PD98059, a specific inhibitor of the upstream kinase of p44/p42 MAP kinase, which reduced the phosphorylation of p44/p42 MAP kinase stimulated by PGF2(alpha), had little effect on the PGF2(alpha)-induced phosphorylation of SAPK/JNK. Dinoprost 165-169 mitogen-activated protein kinase 3 Mus musculus 75-78 15062846-8 2004 On the other hand, PD98059, a specific inhibitor of the upstream kinase of p44/p42 MAP kinase, which reduced the phosphorylation of p44/p42 MAP kinase stimulated by PGF2(alpha), had little effect on the PGF2(alpha)-induced phosphorylation of SAPK/JNK. Dinoprost 165-169 mitogen-activated protein kinase 3 Mus musculus 132-135 15062846-8 2004 On the other hand, PD98059, a specific inhibitor of the upstream kinase of p44/p42 MAP kinase, which reduced the phosphorylation of p44/p42 MAP kinase stimulated by PGF2(alpha), had little effect on the PGF2(alpha)-induced phosphorylation of SAPK/JNK. Dinoprost 203-207 mitogen-activated protein kinase 3 Mus musculus 75-78 15062846-8 2004 On the other hand, PD98059, a specific inhibitor of the upstream kinase of p44/p42 MAP kinase, which reduced the phosphorylation of p44/p42 MAP kinase stimulated by PGF2(alpha), had little effect on the PGF2(alpha)-induced phosphorylation of SAPK/JNK. Dinoprost 203-207 mitogen-activated protein kinase 3 Mus musculus 132-135 12646577-2 2003 We have previously reported that prostaglandin F2 alpha (PGF2 alpha) activates p44/p42 mitogen-activated protein kinase (MAPK) through protein kinase C (PKC) in osteoblast-like MC3T3-E1 cells. Dinoprost 33-49 mitogen-activated protein kinase 3 Mus musculus 79-82 12646577-2 2003 We have previously reported that prostaglandin F2 alpha (PGF2 alpha) activates p44/p42 mitogen-activated protein kinase (MAPK) through protein kinase C (PKC) in osteoblast-like MC3T3-E1 cells. Dinoprost 57-61 mitogen-activated protein kinase 3 Mus musculus 79-82