PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34029971-3	2021	Conjugates were moderate inhibitors of equine and human BChE with negligible fluctuation in anti-BChE activity, whereas anti-AChE activity was substantially dependent on N4-substitution of the piperazine ring.	Piperazine	193-203	acetylcholinesterase (Cartwright blood group)	Homo sapiens	125-129	
32388435-2	2020	Conjugates with piperazine linked to the substituted salicylaldoxime emerged as efficient reactivators for VX inhibited hAChE.	Piperazine	16-26	acetylcholinesterase (Cartwright blood group)	Homo sapiens	120-125	
33743158-0	2021	Piperazine-substituted chalcones: a new class of MAO-B, AChE, and BACE-1 inhibitors for the treatment of neurological disorders.	Piperazine	0-10	acetylcholinesterase (Cartwright blood group)	Homo sapiens	56-60	
24591157-0	2013	Design, synthesis, biological evaluation, and molecular modeling of coumarin-piperazine derivatives as acetylcholinesterase inhibitors.	Piperazine	77-87	acetylcholinesterase (Cartwright blood group)	Homo sapiens	103-123	
30047333-0	2018	2D & 3D-QSAR Study on Novel Piperidine and Piperazine Derivatives as Acetylcholinesterase Enzyme Inhibitors.	Piperazine	43-53	acetylcholinesterase (Cartwright blood group)	Homo sapiens	69-96	
27721153-3	2017	In vitro studies showed that the majority of saccharin derivatives with piperazine moiety and one phthalimide derivative with 3-aminopiperidine fragment exhibited inhibitory potency toward acetylcholinesterase (AChE) with EeAChE IC50 values ranging from 0.83 muM to 19.18 muM.	Piperazine	72-82	acetylcholinesterase (Cartwright blood group)	Homo sapiens	211-215	
24591157-4	2013	Docking experiments of the designed coumarin-piperazine derivatives were carried out in order to compare the theoretical and experimental binding affinities toward hAChE, to delineate the inhibitory mechanism.	Piperazine	45-55	acetylcholinesterase (Cartwright blood group)	Homo sapiens	164-169	
24288651-0	2013	Virtual screening and biological evaluation of piperazine derivatives as human acetylcholinesterase inhibitors.	Piperazine	47-57	acetylcholinesterase (Cartwright blood group)	Homo sapiens	79-99	
24288651-1	2013	The piperazine derivatives have been shown to inhibit human acetylcholinesterase.	Piperazine	4-14	acetylcholinesterase (Cartwright blood group)	Homo sapiens	60-80