PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23814014-6	2013	11beta-HSD1 activity in microsomes from rat mesenteric adipose depots and 3T3-L1 adipocytes was determined in the presence of 11-dehydrocorticosterone with or without varying concentrations of resveratrol.	11-dehydrocorticosterone	126-150	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	0-11	
32229097-5	2020	Tissue glucocorticoid levels are regulated by 11beta-hydroxysteroid dehydrogenase type1 (11betaHSD1), which increases the local concentration of active glucocorticoids by the production of corticosterone from 11-dehydrocorticosterone.	11-dehydrocorticosterone	209-233	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	46-87	
32229097-5	2020	Tissue glucocorticoid levels are regulated by 11beta-hydroxysteroid dehydrogenase type1 (11betaHSD1), which increases the local concentration of active glucocorticoids by the production of corticosterone from 11-dehydrocorticosterone.	11-dehydrocorticosterone	209-233	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	89-99	
26859423-7	2016	Ziram exerted competitive inhibition of rat HSD11B1 when 11-dehydrocorticosterone was used and mixed inhibition when NADPH was supplied.	11-dehydrocorticosterone	57-81	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	44-51	
11751610-0	2002	11Beta-hydroxysteroid dehydrogenase 1 transforms 11-dehydrocorticosterone into transcriptionally active glucocorticoid in neonatal rat heart.	11-dehydrocorticosterone	49-73	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	0-37	
18826995-5	2008	11 beta-Hydroxysteroid dehydrogenase type 1 is known to convert inactive 11-dehydrocorticosterone to active corticosterone.	11-dehydrocorticosterone	73-97	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	0-43	
17218963-2	2006	In vivo, hepatic 11beta-hydroxysteroid dehydrogenase 1 (HSD1) stimulates the shift of 11-dehydrocorticosterone to corticosterone, enhancing active glucocorticoids at tissue level.	11-dehydrocorticosterone	86-110	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	17-54	
17218963-2	2006	In vivo, hepatic 11beta-hydroxysteroid dehydrogenase 1 (HSD1) stimulates the shift of 11-dehydrocorticosterone to corticosterone, enhancing active glucocorticoids at tissue level.	11-dehydrocorticosterone	86-110	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	56-60	
12210834-2	2002	11beta-HSD1 converts biologically inactive 11-dehydrocorticosterone into active corticosterone.	11-dehydrocorticosterone	43-67	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	0-11	
22792090-7	2012	As for 11beta-HSD1 is a regulating enzyme, converting the inactive 11-dehydrocorticosterone into the active glucocorticoid corticosterone, thus amplifying GC action in local tissues.	11-dehydrocorticosterone	67-91	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	7-18	
21879473-1	2011	BACKGROUND: 11-beta-hydroxysteroid dehydrogenase type I (11-beta-HSD1) in the white adipose tissue (WAT) of rats catalyses the conversion of 11-dehydrocorticosterone to corticosterone, a more active glucocorticosteroid.	11-dehydrocorticosterone	141-165	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	57-69	
11751610-5	2002	Enzyme activity studies demonstrated that 11betaHSD1 acted as a reductase only, converting biologically inactive 11-dehydrocorticosterone to corticosterone, which then stimulated serum and glucocorticoid-induced kinase gene transcription via GR.	11-dehydrocorticosterone	113-137	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	42-52	
8938587-1	1996	11 beta-Hydroxysteroid dehydrogenase (11 beta-HSD) catalyses the interconversion of biologically active cortisol to inactive cortisone in man, and corticosterone to 11-dehydrocorticosterone in rodents.	11-dehydrocorticosterone	165-189	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	0-7	
10828853-10	2000	The substantial concentrations of plasma 11-DHC as substrate suggest that 11 beta-HSD-1 activity and its potential selective inhibition could modify glucocorticoid action in vivo.	11-dehydrocorticosterone	41-47	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	74-87	
10567193-2	1999	Abnormal activity of 11beta-hydroxysteroid dehydrogenase enzymes (11beta-HSD1 and 11beta-HSD2), which interconvert corticosterone and inactive 11-dehydrocorticosterone, might contribute to the LH phenotype by regulating corticosteroid hormone access to receptors.	11-dehydrocorticosterone	143-167	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	66-77	
10567193-4	1999	11beta-HSD1 (expressed in liver and kidney) favors active glucocorticoid formation from 11-dehydrocorticosterone.	11-dehydrocorticosterone	88-112	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	0-11	
11576624-1	2001	The 11beta-hydroxysteroid dehydrogenase types 1 and 2 enzymes (11beta-HSD1 and 11beta-HSD2), modulate glucocorticoid occupation of the mineralocorticoid and glucocorticoid receptors by interconverting corticosterone and cortisol to the inactive metabolites 11-dehydrocorticosterone and cortisone within the target cells.	11-dehydrocorticosterone	257-281	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	63-74	
8969940-1	1996	11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) catalyzes the interconversion of cortisol (F) to inactive cortisone (E) in man (corticosterone (B) to 11-dehydrocorticosterone (A) in rodents) and plays a crucial role in regulating corticosteroid hormone action.	11-dehydrocorticosterone	153-177	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	0-7	
8969940-1	1996	11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) catalyzes the interconversion of cortisol (F) to inactive cortisone (E) in man (corticosterone (B) to 11-dehydrocorticosterone (A) in rodents) and plays a crucial role in regulating corticosteroid hormone action.	11-dehydrocorticosterone	153-177	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	38-45	
8938587-1	1996	11 beta-Hydroxysteroid dehydrogenase (11 beta-HSD) catalyses the interconversion of biologically active cortisol to inactive cortisone in man, and corticosterone to 11-dehydrocorticosterone in rodents.	11-dehydrocorticosterone	165-189	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	38-45	
8938587-6	1996	Consistent with this, 11 beta-dehydrogenase activity (pmol 11-dehydrocorticosterone formed/mg protein per h, mean +/- S.E.M.)	11-dehydrocorticosterone	59-83	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	22-29	
7848528-9	1994	In contrast, intact cells did not convert corticosterone to 11-dehydrocorticosterone over 24 h, but showed a clear dose-related 11 beta-reductase activity, apparent within 4 h of addition of 11-dehydrocorticosterone to the medium.	11-dehydrocorticosterone	191-215	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	128-135	
7848528-1	1994	11 beta-Hydroxysteroid dehydrogenase (11 beta-HSD) catalyses the metabolism of corticosterone to inert 11-dehydrocorticosterone, thus preventing glucocorticoid access to otherwise non-selective renal mineralocorticoid receptors (MRs), producing aldosterone selectivity in vivo.	11-dehydrocorticosterone	103-127	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	0-7	
7848528-1	1994	11 beta-Hydroxysteroid dehydrogenase (11 beta-HSD) catalyses the metabolism of corticosterone to inert 11-dehydrocorticosterone, thus preventing glucocorticoid access to otherwise non-selective renal mineralocorticoid receptors (MRs), producing aldosterone selectivity in vivo.	11-dehydrocorticosterone	103-127	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	38-45	
7848528-4	1994	Transfection of rat 11 beta-HSD1 cDNA into amphibian cells with a mineralocorticoid phenotype encodes 11 beta-reductase activity (activation of inert 11-dehydrocorticosterone) suggesting that 11 beta-HSD1 does not have the necessary properties to protect renal MRs from exposure to glucocorticoids.	11-dehydrocorticosterone	150-174	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	20-32	
7848528-4	1994	Transfection of rat 11 beta-HSD1 cDNA into amphibian cells with a mineralocorticoid phenotype encodes 11 beta-reductase activity (activation of inert 11-dehydrocorticosterone) suggesting that 11 beta-HSD1 does not have the necessary properties to protect renal MRs from exposure to glucocorticoids.	11-dehydrocorticosterone	150-174	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	20-27