PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30085093-0 2018 The cAMP-EPAC Pathway Mediates PGE2-Induced FGF2 in Bovine Granulosa Cells. Dinoprostone 31-35 fibroblast growth factor 2 Bos taurus 44-48 30085093-1 2018 During the periovulatory period, the profile of fibroblast growth factor 2 (FGF2) coincides with elevated prostaglandin E2 (PGE2) levels. Dinoprostone 106-122 fibroblast growth factor 2 Bos taurus 48-74 30085093-1 2018 During the periovulatory period, the profile of fibroblast growth factor 2 (FGF2) coincides with elevated prostaglandin E2 (PGE2) levels. Dinoprostone 106-122 fibroblast growth factor 2 Bos taurus 76-80 30085093-1 2018 During the periovulatory period, the profile of fibroblast growth factor 2 (FGF2) coincides with elevated prostaglandin E2 (PGE2) levels. Dinoprostone 124-128 fibroblast growth factor 2 Bos taurus 48-74 30085093-1 2018 During the periovulatory period, the profile of fibroblast growth factor 2 (FGF2) coincides with elevated prostaglandin E2 (PGE2) levels. Dinoprostone 124-128 fibroblast growth factor 2 Bos taurus 76-80 30085093-3 2018 PGE2 temporally stimulated FGF2. Dinoprostone 0-4 fibroblast growth factor 2 Bos taurus 27-31 30085093-4 2018 Accordingly, endoperoxide-synthase2-silenced cells, exhibiting low endogenous PGE2 levels, had reduced FGF2. Dinoprostone 78-82 fibroblast growth factor 2 Bos taurus 103-107 30085093-5 2018 Furthermore, elevation of viable granulosa cell numbers by PGE2 was abolished with FGF2 receptor 1 inhibitor, suggesting that FGF2 mediates this action of PGE2. Dinoprostone 59-63 fibroblast growth factor 2 Bos taurus 83-87 30085093-5 2018 Furthermore, elevation of viable granulosa cell numbers by PGE2 was abolished with FGF2 receptor 1 inhibitor, suggesting that FGF2 mediates this action of PGE2. Dinoprostone 59-63 fibroblast growth factor 2 Bos taurus 126-130 30085093-5 2018 Furthermore, elevation of viable granulosa cell numbers by PGE2 was abolished with FGF2 receptor 1 inhibitor, suggesting that FGF2 mediates this action of PGE2. Dinoprostone 155-159 fibroblast growth factor 2 Bos taurus 83-87 30085093-5 2018 Furthermore, elevation of viable granulosa cell numbers by PGE2 was abolished with FGF2 receptor 1 inhibitor, suggesting that FGF2 mediates this action of PGE2. Dinoprostone 155-159 fibroblast growth factor 2 Bos taurus 126-130 30085093-9 2018 Whereas FGF2 upregulated by PGE2, PTGER2 agonist, or forskolin was unaffected by the protein kinase A (PKA) inhibitor H89, EREG was significantly inhibited. Dinoprostone 28-32 fibroblast growth factor 2 Bos taurus 8-12 30085093-12 2018 These findings ascribe a novel autocrine role for PGE2, namely, elevating FGF2 production in granulosa cells. Dinoprostone 50-54 fibroblast growth factor 2 Bos taurus 74-78 30085093-13 2018 This study also reveals that cAMP-activated EPAC1, rather than PKA, mediates the effect of PGE2/PTGER2 on the expression of FGF2. Dinoprostone 91-95 fibroblast growth factor 2 Bos taurus 124-128 30085093-15 2018 PGE2-stimulated FGF2 can act to maintain granulosa cell survival; it can also act on ovarian endothelial cells to promote angiogenesis. Dinoprostone 0-4 fibroblast growth factor 2 Bos taurus 16-20 25219846-9 2014 PGE1 or PGE2 increased (P < 0.05) FGF-2 in luteal tissue of Angus cows compared with Day-13 and Day-19 Angus controls but decreased (P < 0.05) FGF-2 in luteal tissue of Brahman cows when compared w Day-13 or Day-19 Angus controls. Dinoprostone 8-12 fibroblast growth factor 2 Bos taurus 37-42 29080298-5 2018 The results indicated that PGE2 at concentration about 10-7 to 10-5 M could up-regulate CTGF, FGF-2, IL-8, MMP-2, TGF-beta1, VEGFA mRNA and protein expression, and could induce the proliferation of epithelial and fibroblast cells and reduce the proapoptotic factor (caspase-3) expression in bovine endometrial explants in vitro. Dinoprostone 27-31 fibroblast growth factor 2 Bos taurus 95-100 25219846-9 2014 PGE1 or PGE2 increased (P < 0.05) FGF-2 in luteal tissue of Angus cows compared with Day-13 and Day-19 Angus controls but decreased (P < 0.05) FGF-2 in luteal tissue of Brahman cows when compared w Day-13 or Day-19 Angus controls. Dinoprostone 8-12 fibroblast growth factor 2 Bos taurus 149-154 25219846-13 2014 PGE1 or PGE2 may alter cow luteal FGF-2, ANG-1, or ANG-2 but not VEGF to prevent luteolysis; however, species or breed differences may exist. Dinoprostone 8-12 fibroblast growth factor 2 Bos taurus 34-39