PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28761141-3 2017 The aim of the present study was to investigate the role of prostaglandin E2 (PGE2) in dentine repair by examining the localisation and mRNA expression levels of its transporter (Pgt) and two of its receptors (Ep2 and Ep4) in a rat model of pulpotomy with MTA capping. Dinoprostone 60-76 prostaglandin E receptor 2 Rattus norvegicus 210-213 28761141-3 2017 The aim of the present study was to investigate the role of prostaglandin E2 (PGE2) in dentine repair by examining the localisation and mRNA expression levels of its transporter (Pgt) and two of its receptors (Ep2 and Ep4) in a rat model of pulpotomy with MTA capping. Dinoprostone 78-82 prostaglandin E receptor 2 Rattus norvegicus 210-213 28349234-5 2017 We here showed that treatment of rat trigeminal ganglion (TG) explants with PGE2 significantly upregulated the mRNA and protein expressions of Nav1.7 through PGE2 receptor EP2. Dinoprostone 76-80 prostaglandin E receptor 2 Rattus norvegicus 172-175 27973680-10 2017 These results indicate that PGE2 potentiates IFN-gamma-induced nitric oxide production in microglia through the EP2 receptor, which may shed light on one of the pro-inflammatory aspects of PGE2 . Dinoprostone 28-32 prostaglandin E receptor 2 Rattus norvegicus 112-115 27973680-10 2017 These results indicate that PGE2 potentiates IFN-gamma-induced nitric oxide production in microglia through the EP2 receptor, which may shed light on one of the pro-inflammatory aspects of PGE2 . Dinoprostone 189-193 prostaglandin E receptor 2 Rattus norvegicus 112-115 27111625-5 2016 RESULTS: PGE2 concentration-dependently increased the accumulation of cAMP in cells expressing rat EP2 (EC50 value = 1.3 nmol/L) and EP4 receptors (EC50 value = 17 nmol/L). Dinoprostone 9-13 prostaglandin E receptor 2 Rattus norvegicus 99-102 27973680-1 2017 Prostaglandin E2 (PGE2 ) plays crucial roles in managing microglial activation through the prostanoid EP2 receptor, a PGE2 receptor subtype. Dinoprostone 0-16 prostaglandin E receptor 2 Rattus norvegicus 91-114 27973680-1 2017 Prostaglandin E2 (PGE2 ) plays crucial roles in managing microglial activation through the prostanoid EP2 receptor, a PGE2 receptor subtype. Dinoprostone 18-22 prostaglandin E receptor 2 Rattus norvegicus 91-114 27400965-9 2016 The sensitizing actions of PGE2 after acute and long-term exposure were attenuated by EP2, EP3, and EP4 receptor antagonists, but not by an EP1 antagonist. Dinoprostone 27-31 prostaglandin E receptor 2 Rattus norvegicus 86-89 27435772-8 2016 PGE2 are essential to corpus luteum formation by stimulating macrophages to induce angiogenesis through EP2/EP4. Dinoprostone 0-4 prostaglandin E receptor 2 Rattus norvegicus 104-107 26051129-6 2015 All subtypes of prostaglandin E2 (PGE2) receptors (EP1-EP4) were expressed in ileum, and PGE2 and selective EP2 or EP4 agonist inhibited CCh-mediated contraction. Dinoprostone 16-32 prostaglandin E receptor 2 Rattus norvegicus 108-111 26051129-10 2015 In conclusion, LPS induces COX-2 to produce PGE2, which initially activates EP2 and/or EP4 on smooth muscle cells to inhibit the contractility in early phase of LPS exposure. Dinoprostone 44-48 prostaglandin E receptor 2 Rattus norvegicus 76-79 26311764-11 2015 Using multidisciplinary approaches from single-cell reverse transcriptase-PCR, mass spectrometry, to ex vivo and in vivo pharmacology and optogenetics, we provide compelling evidence identifying PgE2 as the main prostaglandin in NVC, pyramidal neurons as their main cellular source and the vasodilatory EP2 and EP4 receptors as their main targets. Dinoprostone 195-199 prostaglandin E receptor 2 Rattus norvegicus 303-306 26445960-16 2015 Moreover, RT-PCR showed that expressions of EP2 and EP4, which are the receptors of PGE2, were also up-regulated. Dinoprostone 84-88 prostaglandin E receptor 2 Rattus norvegicus 44-47 26445960-17 2015 Increased expressions of apoptotic pathway factors, including P53 and FasL, might be induced by the binding of PGE2 with EP2/4. Dinoprostone 111-115 prostaglandin E receptor 2 Rattus norvegicus 121-126 26445960-21 2015 Expressions of EP2 and EP4 receptors also decreased, suggesting that PGE2-mediated apoptosis was inhibited by QSYQ. Dinoprostone 69-73 prostaglandin E receptor 2 Rattus norvegicus 15-18 25047516-7 2014 In addition, this glutamate release-inhibiting effect of celecoxib was mediated through the PGE2 subtype 2 receptor (EP2) because it was not observed in the presence of butaprost (an EP2 agonist) or PF04418948 [1-(4-fluorobenzoyl)-3-[[6-methoxy-2-naphthalenyl)methyl]-3-azetidinecarboxylic acid; an EP2 antagonist]. Dinoprostone 92-96 prostaglandin E receptor 2 Rattus norvegicus 117-120 25715797-5 2015 We show here that activation of the E prostanoid receptor 2 (EP2, PTGER2) for prostaglandin E2 mediates microglial death induced by LPS/IL-13, and that EP2 activation by agonist alone kills microglia. Dinoprostone 78-94 prostaglandin E receptor 2 Rattus norvegicus 36-59 25715797-5 2015 We show here that activation of the E prostanoid receptor 2 (EP2, PTGER2) for prostaglandin E2 mediates microglial death induced by LPS/IL-13, and that EP2 activation by agonist alone kills microglia. Dinoprostone 78-94 prostaglandin E receptor 2 Rattus norvegicus 61-64 25715797-5 2015 We show here that activation of the E prostanoid receptor 2 (EP2, PTGER2) for prostaglandin E2 mediates microglial death induced by LPS/IL-13, and that EP2 activation by agonist alone kills microglia. Dinoprostone 78-94 prostaglandin E receptor 2 Rattus norvegicus 66-72 24845544-1 2014 Prostaglandin E2 (PGE2) plays a critical role in the modulation of microglial function including migration and phagocytosis through EP2, which increases intracellular cyclic adenosine monophosphate (AMP) concentration. Dinoprostone 0-16 prostaglandin E receptor 2 Rattus norvegicus 132-135 24845544-1 2014 Prostaglandin E2 (PGE2) plays a critical role in the modulation of microglial function including migration and phagocytosis through EP2, which increases intracellular cyclic adenosine monophosphate (AMP) concentration. Dinoprostone 18-22 prostaglandin E receptor 2 Rattus norvegicus 132-135 23404506-1 2013 Activation of EP2 receptors by prostaglandin E2 (PGE2) promotes brain inflammation in neurodegenerative diseases, but the pathways responsible are unclear. Dinoprostone 31-47 prostaglandin E receptor 2 Rattus norvegicus 14-17 23404506-1 2013 Activation of EP2 receptors by prostaglandin E2 (PGE2) promotes brain inflammation in neurodegenerative diseases, but the pathways responsible are unclear. Dinoprostone 49-53 prostaglandin E receptor 2 Rattus norvegicus 14-17 22546206-0 2012 Synthesis and evaluation of gamma-lactam analogs of PGE2 as EP4 and EP2/EP4 agonists. Dinoprostone 52-56 prostaglandin E receptor 2 Rattus norvegicus 68-71 22789984-1 2013 STUDY DESIGN: This study implemented immunohistochemistry to assay prostaglandin E2 (PGE2) receptor EP2 expression in the dorsal root ganglion (DRG) of rats after painful cervical facet joint injury. Dinoprostone 67-83 prostaglandin E receptor 2 Rattus norvegicus 100-103 21490976-4 2011 We have previously shown that PGE2 activates EP2 and EP4 receptors which increases protein kinase A (PKA) activity and that masculinized dendritic spine density and sex behavior are both dependent upon PKA as well as activation of AMPA type glutamate receptors. Dinoprostone 30-34 prostaglandin E receptor 2 Rattus norvegicus 45-48 22257560-2 2012 Prostaglandin-E2 acts via four different receptor subtypes, EP1, EP2, EP3 and EP4 whereas prostaglandin-F2alpha acts through FP. Dinoprostone 0-16 prostaglandin E receptor 2 Rattus norvegicus 65-68 21436889-0 2011 Prostaglandin E2 signals through PTGER2 to regulate sclerostin expression. Dinoprostone 0-16 prostaglandin E receptor 2 Rattus norvegicus 33-39 19233324-0 2009 EP2 and EP4 receptors differentially mediate MAPK pathways underlying anabolic actions of prostaglandin E2 on bone formation in rat calvaria cell cultures. Dinoprostone 90-106 prostaglandin E receptor 2 Rattus norvegicus 0-3 18726914-6 2008 In female rats, neonatal treatment with antisense oligonucleotides against EP2 or EP4 but not EP1 or EP3 completely prevented the expression of adult behavior organized by PGE2 exposure. Dinoprostone 172-176 prostaglandin E receptor 2 Rattus norvegicus 75-78 19138674-0 2009 EP2 receptor activation by prostaglandin E2 leads to induction of HO-1 via PKA and PI3K pathways in C6 cells. Dinoprostone 27-43 prostaglandin E receptor 2 Rattus norvegicus 0-3 18726914-10 2008 The body of evidence suggests that EP2 and EP4 are both necessary and sufficient for PGE2-induced masculinization of sex behavior, whereas EP1 and EP3 provide redundant roles. Dinoprostone 85-89 prostaglandin E receptor 2 Rattus norvegicus 35-38 17408863-7 2007 Use of antisense oligonucleotides against the mRNA for each receptor reveals that either EP2 or EP3 receptor knockdown reduces spinophilin in PGE2- or estradiol-treated females, whereas reducing EP1 or EP4 receptor levels by the same means has a smaller but also significant effect. Dinoprostone 142-146 prostaglandin E receptor 2 Rattus norvegicus 89-92 18565497-7 2008 These findings indicate that ATP-induced microglial migration is reduced by PGE(2) through EP2 and adenylate cyclase. Dinoprostone 76-82 prostaglandin E receptor 2 Rattus norvegicus 91-94 15821755-0 2005 Prostaglandin E2-induced modification of tetrodotoxin-resistant Na+ currents involves activation of both EP2 and EP4 receptors in neonatal rat nodose ganglion neurones. Dinoprostone 0-16 prostaglandin E receptor 2 Rattus norvegicus 105-108 16309709-0 2006 Prostaglandin E2 deteriorates N-methyl-D-aspartate receptor-mediated cytotoxicity possibly by activating EP2 receptors in cultured cortical neurons. Dinoprostone 0-16 prostaglandin E receptor 2 Rattus norvegicus 105-108 16309709-10 2006 These results suggest that PGE2, acting via EP2 receptors, aggravates excitotoxic neurodegeneration by a cAMP-dependent mechanism. Dinoprostone 27-31 prostaglandin E receptor 2 Rattus norvegicus 44-47 15914318-12 2005 CONCLUSIONS: The effect of PGE2 to prolong the survival of skin transplant requires the action of a combination of three receptors, i.e., EP2+EP3+EP4. Dinoprostone 27-31 prostaglandin E receptor 2 Rattus norvegicus 138-141 17091492-0 2007 TNF-alpha/IFN-gamma-induced iNOS expression increased by prostaglandin E2 in rat primary astrocytes via EP2-evoked cAMP/PKA and intracellular calcium signaling. Dinoprostone 57-73 prostaglandin E receptor 2 Rattus norvegicus 104-107 17091492-4 2007 Pharmacological and RNA interference approaches further indicated the involvement of the receptor EP2 in PGE(2)-induced iNOS upregulation in T/I-treated astrocytes. Dinoprostone 105-111 prostaglandin E receptor 2 Rattus norvegicus 98-101 17091492-5 2007 Quantitative real-time polymerase chain reaction and gel mobility shift assays also demonstrated that PGE(2) increased iNOS transcription through EP2-induced cAMP/protein kinase A (PKA)-dependent pathway. Dinoprostone 102-108 prostaglandin E receptor 2 Rattus norvegicus 146-149 17091492-8 2007 By analyzing the expression of astrocytic glial fibrillary acidic protein (GFAP), we found that PGE(2) alone only triggered the EP2-induced cAMP/PKA/p38MAPK signaling pathway in astrocytes. Dinoprostone 96-102 prostaglandin E receptor 2 Rattus norvegicus 128-131 16437207-1 2006 We investigated the distribution and time course of expression of two subtypes of prostaglandin E(2) (PGE(2)) receptors, EP2 and EP4, in a rat model of cerebral ischemia and ischemic tolerance. Dinoprostone 82-99 prostaglandin E receptor 2 Rattus norvegicus 121-124 15944932-2 2005 UNLABELLED: This study was conducted to elucidate the role of three of prostaglandin E2 (PGE2) receptor subtype (EP2, EP3, and EP4) agonists in the process of follicular growth. Dinoprostone 71-87 prostaglandin E receptor 2 Rattus norvegicus 113-116 15914318-2 2005 There have been recognized four receptors for PGE2 (EP1-EP4 receptor) so far, and EP2 and EP4 receptors are mainly involved in the immunosuppressive effect of PGE2 in vitro. Dinoprostone 159-163 prostaglandin E receptor 2 Rattus norvegicus 82-85 15821755-11 2005 7 These results suggest that the PGE2-induced modification of I(NaR) is mainly mediated by activation of both EP2 and EP4 receptors. Dinoprostone 33-37 prostaglandin E receptor 2 Rattus norvegicus 110-113 12954235-0 2003 Simultaneous stimulation of EP2 and EP4 is essential to the effect of prostaglandin E2 in chondrocyte differentiation. Dinoprostone 70-86 prostaglandin E receptor 2 Rattus norvegicus 28-31 16280600-2 2005 PGE2 exerts its effects by activating four specific E-type prostanoid receptors (EP1, EP2, EP3, and EP4). Dinoprostone 0-4 prostaglandin E receptor 2 Rattus norvegicus 86-89 15210817-1 2004 Prostaglandin E(2) is a potent lipid mediator of inflammation that effects changes in cell functions through ligation of four distinct G protein-coupled receptors (E-prostanoid (EP)1, EP2, EP3, and EP4). Dinoprostone 0-18 prostaglandin E receptor 2 Rattus norvegicus 184-187 15210817-11 2004 Additionally, the EP2 antagonist AH-6809 abrogated the inhibitory effects of both PGE(2) and butaprost. Dinoprostone 82-88 prostaglandin E receptor 2 Rattus norvegicus 18-21 14606517-0 2003 A novel, non-prostanoid EP2 receptor-selective prostaglandin E2 agonist stimulates local bone formation and enhances fracture healing. Dinoprostone 47-63 prostaglandin E receptor 2 Rattus norvegicus 13-36 15560120-0 2004 PGE2 exerts its effect on the LPS-induced release of TNF-alpha, ET-1, IL-1alpha, IL-6 and IL-10 via the EP2 and EP4 receptor in rat liver macrophages. Dinoprostone 0-4 prostaglandin E receptor 2 Rattus norvegicus 104-107 15560120-3 2004 This effect of PGE2 is mimicked by specific agonists for the PGE2 receptors EP2 and EP4; whereas, agonists for the PGE2 receptors EP1 and EP3 are inactive. Dinoprostone 15-19 prostaglandin E receptor 2 Rattus norvegicus 76-79 15560120-5 2004 These data suggest that PGE2 exerts its anti-fibrogenic effect through the EP2 and EP4 receptor by inhibiting the release of the fibrogenic mediators TNF-alpha, ET-1 and IL-1alpha, and by enhancing the release of the anti-fibrogenic mediators IL-6 and IL-10 in liver macrophages. Dinoprostone 24-28 prostaglandin E receptor 2 Rattus norvegicus 75-78 15481309-0 2004 Prostaglandin E2 inhibits platelet-derived growth factor-stimulated cell proliferation through a prostaglandin E receptor EP2 subtype in rat hepatic stellate cells. Dinoprostone 0-16 prostaglandin E receptor 2 Rattus norvegicus 122-125 15044156-11 2004 Our results show that PGE(2) stimulates rat osteoclast Cl(-) current by activation of a cAMP-dependent pathway through EP2 and, to a lesser degree, EP4 receptors and reduces osteoclast motility. Dinoprostone 22-28 prostaglandin E receptor 2 Rattus norvegicus 119-122 12954235-13 2003 CONCLUSION: These results suggest that simultaneous stimulation of EP2 and EP4 is necessary and sufficient to elicit the effect of PGE(2)on rat primary chondrocyte differentiation. Dinoprostone 131-137 prostaglandin E receptor 2 Rattus norvegicus 67-70 12535167-6 2003 The effects of PGE2 to suppress [Ca2+]i were mimicked by the selective EP3 agonist, ONO-AE-248, whereas three other EP agonists, ONO-DI-004 (EP1), ONO-AE1-259 (EP2) and ONO-AE1-329 (EP4), had little or no effect on [Ca2+]i. Dinoprostone 15-19 prostaglandin E receptor 2 Rattus norvegicus 160-163 12218705-1 2002 Prostaglandin E(2)(PGE(2)) elicits a variety of effects by activating four subtypes of receptors, EP1, EP2, EP3 and EP4. Dinoprostone 0-18 prostaglandin E receptor 2 Rattus norvegicus 103-106 12218705-1 2002 Prostaglandin E(2)(PGE(2)) elicits a variety of effects by activating four subtypes of receptors, EP1, EP2, EP3 and EP4. Dinoprostone 19-25 prostaglandin E receptor 2 Rattus norvegicus 103-106 11352840-0 2001 Localization of prostaglandin E(2) EP2 and EP4 receptors in the rat kidney. Dinoprostone 16-34 prostaglandin E receptor 2 Rattus norvegicus 35-38 11403359-1 2001 OBJECTIVE: Prostaglandin (PG) E2, a major arachidonic acid metabolite in the kidney, acts on four receptor subtypes (EP1, EP2, EP3 and EP4). Dinoprostone 11-32 prostaglandin E receptor 2 Rattus norvegicus 122-125 10520139-6 1999 The inhibitory effects of PGE2 on the frequency of IPSCs were mimicked by the EP1/EP3 agonists, 17PT-PGE2 and sulprostone, and the EP2/EP3 agonist, misoprostol, whereas the EP2 agonist, butaprost, or the FP agonist, fluprostenol, had little effect. Dinoprostone 26-30 prostaglandin E receptor 2 Rattus norvegicus 131-134 11207665-7 2001 Our results suggest that prostaglandin E2 regulates the functions of synovial macrophages and fibroblasts through EP2 and EP4, which are induced by inflammatory stimuli in rats with adjuvant arthritis. Dinoprostone 25-41 prostaglandin E receptor 2 Rattus norvegicus 114-117 11248657-9 2001 Northern blot analysis failed to detect both basal and PGE(2)-induced EP(2) mRNA in the bone samples or cell lines tested. Dinoprostone 55-61 prostaglandin E receptor 2 Rattus norvegicus 70-75 11222664-8 2001 These results suggest that PGE2, acting via an EP2-like receptor, directly depolarizes spinal neurons. Dinoprostone 27-31 prostaglandin E receptor 2 Rattus norvegicus 47-50 10520139-6 1999 The inhibitory effects of PGE2 on the frequency of IPSCs were mimicked by the EP1/EP3 agonists, 17PT-PGE2 and sulprostone, and the EP2/EP3 agonist, misoprostol, whereas the EP2 agonist, butaprost, or the FP agonist, fluprostenol, had little effect. Dinoprostone 26-30 prostaglandin E receptor 2 Rattus norvegicus 173-176 9950799-3 1999 PGE2 increased both parameters, peaking at 100 nM, an effect that was mimicked by forskolin and was abolished by 2",3"-dideoxyadenosine (an adenylate cyclase inhibitor) and was thus cAMP dependent, pointing to the involvement of EP2 or EP4. Dinoprostone 0-4 prostaglandin E receptor 2 Rattus norvegicus 229-232 10468708-9 1999 CONCLUSIONS: These results suggest that PGE2 dilated both arterioles and venules in the rat gastric mucosa through the EP2 receptors and constricted the venules through the EP3 receptors. Dinoprostone 40-44 prostaglandin E receptor 2 Rattus norvegicus 119-122 9950799-5 1999 Furthermore, butaprost (EP2 agonist) was inactive, 11-deoxy-PGE1 (EP4/EP2 agonist) was as effective as PGE2, and the PGE2 effect was abolished dose dependently by the selective EP4 antagonist AH-23848B, suggesting the involvement of EP4. Dinoprostone 103-107 prostaglandin E receptor 2 Rattus norvegicus 70-73 9893949-9 1998 On the other hand, COX-2 expression was up-regulated by the macrophage-deactivating cytokine TGF-beta 1, by exogenous PGE2 itself, which acted through EP2 receptors linked to cyclic AMP generation, and by non steroidal anti-inflammatory drugs. Dinoprostone 118-122 prostaglandin E receptor 2 Rattus norvegicus 151-154 9950799-5 1999 Furthermore, butaprost (EP2 agonist) was inactive, 11-deoxy-PGE1 (EP4/EP2 agonist) was as effective as PGE2, and the PGE2 effect was abolished dose dependently by the selective EP4 antagonist AH-23848B, suggesting the involvement of EP4. Dinoprostone 117-121 prostaglandin E receptor 2 Rattus norvegicus 24-27 9950799-5 1999 Furthermore, butaprost (EP2 agonist) was inactive, 11-deoxy-PGE1 (EP4/EP2 agonist) was as effective as PGE2, and the PGE2 effect was abolished dose dependently by the selective EP4 antagonist AH-23848B, suggesting the involvement of EP4. Dinoprostone 117-121 prostaglandin E receptor 2 Rattus norvegicus 70-73 9930728-13 1999 Thus, the inhibitory effects of PGE2 on microglia are mediated by the EP2 receptor subtype, and the signaling mechanism of this effect is likely via cAMP. Dinoprostone 32-36 prostaglandin E receptor 2 Rattus norvegicus 70-73 9893949-10 1998 Interestingly, PGE2 utilized the same EP2 receptor-mediated signal transduction mechanism to down-regulate the expression of the inducible NO synthase and the production of NO. Dinoprostone 15-19 prostaglandin E receptor 2 Rattus norvegicus 38-41 9779823-3 1998 We now report that these actions by PGE2 are routed through cAMP via the PGE2, EP2 receptor. Dinoprostone 36-40 prostaglandin E receptor 2 Rattus norvegicus 79-82 9779823-3 1998 We now report that these actions by PGE2 are routed through cAMP via the PGE2, EP2 receptor. Dinoprostone 73-77 prostaglandin E receptor 2 Rattus norvegicus 79-82 9779823-15 1998 Overall, these results illustrate that much of the PGE2 action on the expression of COL, LO, and COX1 genes is mediated through the EP2 receptor and a subsequent increase in intracellular cAMP. Dinoprostone 51-55 prostaglandin E receptor 2 Rattus norvegicus 132-135 9537820-4 1997 The KD values obtained with prostaglandin E2 for the prostanoid receptor subtypes EP1, EP2, EP3alpha and EP4 were approximately 24, 5, 1 and 1 nM, respectively. Dinoprostone 28-44 prostaglandin E receptor 2 Rattus norvegicus 87-90 9537820-5 1997 The rank order of affinities for various prostanoids at the prostanoid receptor subtypes EP2, EP3alpha and EP4 receptor subtypes was prostaglandin E2 = prostaglandin E1 > iloprost > prostaglandin F2alpha > prostaglandin D2 > U46619. Dinoprostone 133-149 prostaglandin E receptor 2 Rattus norvegicus 89-92 32832866-1 2020 Prostaglandin E2 (PGE2) is elevated in the brain by excitotoxic insults and, in turn, aggravates the neurotoxicity mainly through acting on its Galphas-coupled receptor EP2, inspiring a therapeutic strategy of targeting this key proinflammatory pathway. Dinoprostone 0-16 prostaglandin E receptor 2 Rattus norvegicus 169-172 9440134-2 1997 The receptors for PGE2 have been classified into four pharmacological subtypes, EP1, EP2, EP3, and EP4, based on the responses to selective agonists and antagonists. Dinoprostone 18-22 prostaglandin E receptor 2 Rattus norvegicus 85-88 9440134-5 1997 In COS-7 cells transfected with rat EP2 cDNA, specific [3H]PGE2 binding was found with a dissociation constant of 14.9 nM, and this binding was inhibited by unlabeled PGE2 and PGE2 alpha. Dinoprostone 59-63 prostaglandin E receptor 2 Rattus norvegicus 36-39 9440134-5 1997 In COS-7 cells transfected with rat EP2 cDNA, specific [3H]PGE2 binding was found with a dissociation constant of 14.9 nM, and this binding was inhibited by unlabeled PGE2 and PGE2 alpha. Dinoprostone 167-171 prostaglandin E receptor 2 Rattus norvegicus 36-39 9440134-5 1997 In COS-7 cells transfected with rat EP2 cDNA, specific [3H]PGE2 binding was found with a dissociation constant of 14.9 nM, and this binding was inhibited by unlabeled PGE2 and PGE2 alpha. Dinoprostone 167-171 prostaglandin E receptor 2 Rattus norvegicus 36-39 9440134-6 1997 PGE2 and butaprost, an EP2 selective agonist, were effective in increasing the cAMP level in the COS-7 cell transfectants. Dinoprostone 0-4 prostaglandin E receptor 2 Rattus norvegicus 23-26 9182946-5 1997 The observations that the lipopolysaccharide-induced prostanoid production was specifically increased by 11-deoxy-16,16-dm PGE2, a selective agonist at the PGE2 receptor EP2 coupled to the activation of adenylyl cyclase, and that the enhancing effect of PGE2 was partially prevented by specific inhibitors of adenylyl cyclase and protein kinase A, suggest that the up-regulation of cyclooxygenase-2 expression by PGE2 is mediated by cAMP, through a putative microglial EP2 receptor. Dinoprostone 123-127 prostaglandin E receptor 2 Rattus norvegicus 170-173 9182946-5 1997 The observations that the lipopolysaccharide-induced prostanoid production was specifically increased by 11-deoxy-16,16-dm PGE2, a selective agonist at the PGE2 receptor EP2 coupled to the activation of adenylyl cyclase, and that the enhancing effect of PGE2 was partially prevented by specific inhibitors of adenylyl cyclase and protein kinase A, suggest that the up-regulation of cyclooxygenase-2 expression by PGE2 is mediated by cAMP, through a putative microglial EP2 receptor. Dinoprostone 123-127 prostaglandin E receptor 2 Rattus norvegicus 469-472 9182946-5 1997 The observations that the lipopolysaccharide-induced prostanoid production was specifically increased by 11-deoxy-16,16-dm PGE2, a selective agonist at the PGE2 receptor EP2 coupled to the activation of adenylyl cyclase, and that the enhancing effect of PGE2 was partially prevented by specific inhibitors of adenylyl cyclase and protein kinase A, suggest that the up-regulation of cyclooxygenase-2 expression by PGE2 is mediated by cAMP, through a putative microglial EP2 receptor. Dinoprostone 156-160 prostaglandin E receptor 2 Rattus norvegicus 170-173 9182946-5 1997 The observations that the lipopolysaccharide-induced prostanoid production was specifically increased by 11-deoxy-16,16-dm PGE2, a selective agonist at the PGE2 receptor EP2 coupled to the activation of adenylyl cyclase, and that the enhancing effect of PGE2 was partially prevented by specific inhibitors of adenylyl cyclase and protein kinase A, suggest that the up-regulation of cyclooxygenase-2 expression by PGE2 is mediated by cAMP, through a putative microglial EP2 receptor. Dinoprostone 156-160 prostaglandin E receptor 2 Rattus norvegicus 469-472 9182946-5 1997 The observations that the lipopolysaccharide-induced prostanoid production was specifically increased by 11-deoxy-16,16-dm PGE2, a selective agonist at the PGE2 receptor EP2 coupled to the activation of adenylyl cyclase, and that the enhancing effect of PGE2 was partially prevented by specific inhibitors of adenylyl cyclase and protein kinase A, suggest that the up-regulation of cyclooxygenase-2 expression by PGE2 is mediated by cAMP, through a putative microglial EP2 receptor. Dinoprostone 156-160 prostaglandin E receptor 2 Rattus norvegicus 170-173 9182946-5 1997 The observations that the lipopolysaccharide-induced prostanoid production was specifically increased by 11-deoxy-16,16-dm PGE2, a selective agonist at the PGE2 receptor EP2 coupled to the activation of adenylyl cyclase, and that the enhancing effect of PGE2 was partially prevented by specific inhibitors of adenylyl cyclase and protein kinase A, suggest that the up-regulation of cyclooxygenase-2 expression by PGE2 is mediated by cAMP, through a putative microglial EP2 receptor. Dinoprostone 156-160 prostaglandin E receptor 2 Rattus norvegicus 469-472 9182946-7 1997 In conclusion, while the strong up-regulation of cyclooxygenase-2 expression by exogenous PGE2 appears to be mediated by EP2 receptors and cAMP, the limited down-regulation caused by anti-inflammatory drug treatments may be either due to arachidonic acid metabolites other than PGE2, or to PGE2 itself, acting through a distinct cAMP-independent signalling pathway. Dinoprostone 90-94 prostaglandin E receptor 2 Rattus norvegicus 121-124 9034831-6 1997 Second, the inhibitory effect of PGE2 was mimicked by 11-deoxy-16,16-dm PGE2, a selective agonist at the PGE2 receptor subtype EP2, coupled to the activation of adenylyl cyclase, but not by sulprostone, a potent agonist at receptor subtypes EP3 and EP1, associated with an inhibition of adenylyl cyclase activity and intracellular Ca2+ elevation, respectively. Dinoprostone 33-37 prostaglandin E receptor 2 Rattus norvegicus 127-130 8679543-1 1996 Cell surface expression of multiple structurally and functionally distinct prostaglandin E2 (PGE2) receptors (Rs), designated the EP1, EP2, EP3, and EP4 Rs, is a principal determinant of the diverse cellular effects of PGE2. Dinoprostone 93-97 prostaglandin E receptor 2 Rattus norvegicus 135-138 7874506-9 1994 These findings indicate that PGE2 protects cultured cortical neurons against NMDA receptor-mediated glutamate neurotoxicity via EP2 receptors. Dinoprostone 29-33 prostaglandin E receptor 2 Rattus norvegicus 128-131 33822473-4 2021 The result showed that EP2 and EP4 receptors were both up-regulated in the PGE2-treated cardiomyocyte cells. Dinoprostone 75-79 prostaglandin E receptor 2 Rattus norvegicus 23-26 33822473-5 2021 PGE2 treatment enhanced active beta-catenin (non-phosphorylated) signalling through mediating EP2 and EP4 receptors. Dinoprostone 0-4 prostaglandin E receptor 2 Rattus norvegicus 94-97 32832866-1 2020 Prostaglandin E2 (PGE2) is elevated in the brain by excitotoxic insults and, in turn, aggravates the neurotoxicity mainly through acting on its Galphas-coupled receptor EP2, inspiring a therapeutic strategy of targeting this key proinflammatory pathway. Dinoprostone 18-22 prostaglandin E receptor 2 Rattus norvegicus 169-172 10617145-0 2000 Protein kinase C activation reduces microglial cyclic AMP response to prostaglandin E2 by interfering with EP2 receptors. Dinoprostone 70-86 prostaglandin E receptor 2 Rattus norvegicus 107-110 10617145-8 2000 These results indicated EP2 receptors as a possible target of PKC and suggest that PKC-activating agents present in the pathological brain may prevent the cAMP-mediated microglia-deactivating function of PGE2. Dinoprostone 204-208 prostaglandin E receptor 2 Rattus norvegicus 24-27 33410110-1 2021 Prostaglandin-E2 (PGE2), an important mediator of inflammation, achieves its functions via four different G protein-coupled receptors (EP1, EP2, EP3, and EP4). Dinoprostone 0-16 prostaglandin E receptor 2 Rattus norvegicus 140-143 35550162-2 2022 Among the four subtypes of PGE2 receptors (EP1, EP2, EP3, and EP4), EP3 receptor is crucially involved in the febrile effects of PGE2. Dinoprostone 129-133 prostaglandin E receptor 2 Rattus norvegicus 48-51 33370588-1 2021 BACKGROUND: Prostaglandin E2 (PGE2) binds to four receptor subtypes (EP1, EP2, EP3 and EP4) and plays an important role in response to stress. Dinoprostone 12-28 prostaglandin E receptor 2 Rattus norvegicus 74-77 33370588-1 2021 BACKGROUND: Prostaglandin E2 (PGE2) binds to four receptor subtypes (EP1, EP2, EP3 and EP4) and plays an important role in response to stress. Dinoprostone 30-34 prostaglandin E receptor 2 Rattus norvegicus 74-77 33410110-1 2021 Prostaglandin-E2 (PGE2), an important mediator of inflammation, achieves its functions via four different G protein-coupled receptors (EP1, EP2, EP3, and EP4). Dinoprostone 18-22 prostaglandin E receptor 2 Rattus norvegicus 140-143 31490357-4 2020 In this study, we evaluate the effect of blockade of the low affinity pro-inflammatory receptors EP1 and EP2 on expression of COX-2, the rate limiting enzyme in PGE2 biosynthesis, and on gut barrier permeability using cultured enterocytes and three different models of intestinal injury. Dinoprostone 161-165 prostaglandin E receptor 2 Rattus norvegicus 105-108 33049240-13 2021 These results suggest that in neuropathic pain condition, endothelial cell-derived PGE2 may act on EP2 and EP4 receptors on spinal neurons and modulate pain sensitivity. Dinoprostone 83-87 prostaglandin E receptor 2 Rattus norvegicus 99-102 31490357-5 2020 PGE2 upregulated COX-2 in IEC-6 enterocytes, and this response was blocked by the EP2 antagonist PF-04418948, but not by the EP1 antagonist ONO-8711 or EP4 antagonist E7046. Dinoprostone 0-4 prostaglandin E receptor 2 Rattus norvegicus 82-85 29792868-0 2018 AH6809 decreases production of inflammatory mediators by PGE2 - EP2 - cAMP signaling pathway in an experimentally induced pure cerebral concussion in rats. Dinoprostone 57-61 prostaglandin E receptor 2 Rattus norvegicus 64-67 29792868-12 2018 AH6809 improves the recovery of injured neurons in the hippocampal CA1 area and downregulates the inflammatory mediators by PGE2 - EP2 - cAMP signaling pathway. Dinoprostone 124-128 prostaglandin E receptor 2 Rattus norvegicus 131-134 32913950-8 2020 Our findings suggest that COX-2 via the PGE2/EP2 pathway regulates hippocampal BDNF/TrkB activity following prolonged seizures. Dinoprostone 40-44 prostaglandin E receptor 2 Rattus norvegicus 45-48 30818067-1 2020 This review describes an adult rat model of status epilepticus (SE) induced by diisopropyl fluorophosphate (DFP), and the beneficial outcomes of transient inhibition of the prostaglandin-E2 receptor EP2 with a small molecule antagonist, delayed by 2-4 h after SE onset. Dinoprostone 173-189 prostaglandin E receptor 2 Rattus norvegicus 199-202 29792868-3 2018 More specifically, it remains to be ascertained whether AH6809 (an EP2 receptor antagonist) would interfere with the downstream of the PGE2, regulate the inflammatory mediators and improve neuronal damage in the hippocampus by PGE2 - EP2 - cAMP signaling pathway. Dinoprostone 135-139 prostaglandin E receptor 2 Rattus norvegicus 67-70 29792868-3 2018 More specifically, it remains to be ascertained whether AH6809 (an EP2 receptor antagonist) would interfere with the downstream of the PGE2, regulate the inflammatory mediators and improve neuronal damage in the hippocampus by PGE2 - EP2 - cAMP signaling pathway. Dinoprostone 227-231 prostaglandin E receptor 2 Rattus norvegicus 67-70