PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9052892-0 1997 Bradykinin B2 receptor modulates renal prostaglandin E2 and nitric oxide. Dinoprostone 39-55 kininogen 1 Canis lupus familiaris 0-10 9117112-6 1997 Bradykinin (10(-8) M to 3 x 10(-6) M) caused a three fold stimulation in the release of the vasodilator prostaglandin E2 (PGE2) and a two fold stimulation of that of the vasodilator prostacyclin, measured by the production of 6-keto-PGF1 alpha (its stable breakdown product). Dinoprostone 104-120 kininogen 1 Canis lupus familiaris 0-10 9117112-6 1997 Bradykinin (10(-8) M to 3 x 10(-6) M) caused a three fold stimulation in the release of the vasodilator prostaglandin E2 (PGE2) and a two fold stimulation of that of the vasodilator prostacyclin, measured by the production of 6-keto-PGF1 alpha (its stable breakdown product). Dinoprostone 122-126 kininogen 1 Canis lupus familiaris 0-10 8793749-0 1996 EP receptor subtypes implicated in the PGE2-induced sensitization of polymodal receptors in response to bradykinin and heat. Dinoprostone 39-43 kininogen 1 Canis lupus familiaris 104-114 8866513-7 1996 Possible involvement of intracellular cAMP in the facilitatory effects of PGE2 on both responses was discussed in connection with the PGE receptor subtypes involved in the sensitization of the bradykinin and heat responses. Dinoprostone 74-78 kininogen 1 Canis lupus familiaris 193-203 8793749-2 1996 Our previous studies, in which we used in vitro canine testispermatic nerve preparations, showed that prostaglandin E2 (PGE2) augments both bradykinin (BK)- and heat-induced discharges of polymodal receptors. Dinoprostone 102-118 kininogen 1 Canis lupus familiaris 140-150 8793749-2 1996 Our previous studies, in which we used in vitro canine testispermatic nerve preparations, showed that prostaglandin E2 (PGE2) augments both bradykinin (BK)- and heat-induced discharges of polymodal receptors. Dinoprostone 102-118 kininogen 1 Canis lupus familiaris 152-154 8793749-2 1996 Our previous studies, in which we used in vitro canine testispermatic nerve preparations, showed that prostaglandin E2 (PGE2) augments both bradykinin (BK)- and heat-induced discharges of polymodal receptors. Dinoprostone 120-124 kininogen 1 Canis lupus familiaris 140-150 8793749-2 1996 Our previous studies, in which we used in vitro canine testispermatic nerve preparations, showed that prostaglandin E2 (PGE2) augments both bradykinin (BK)- and heat-induced discharges of polymodal receptors. Dinoprostone 120-124 kininogen 1 Canis lupus familiaris 152-154 8793749-3 1996 However, the PGE2 concentration required to augment the BK responses were 100 times lower than those necessary for the heat responses, suggesting that different receptors are involved in these phenomena. Dinoprostone 13-17 kininogen 1 Canis lupus familiaris 56-58 8793749-6 1996 PGE2-induced augmentation of the BK responses was unaffected when treated with an antagonist for the EP1 receptor, AH6809. Dinoprostone 0-4 kininogen 1 Canis lupus familiaris 33-35 8793749-8 1996 An agonist for the EP3 receptor, M&B28767, at > or = 10 nM, significantly augmented the BK responses in a concentration-dependent manner that mimics the PGE2-induced effect. Dinoprostone 160-164 kininogen 1 Canis lupus familiaris 95-97 8793749-16 1996 These results indicate that the EP3 and EP2 receptor subtypes are differentially implicated in the respective PGE2-induced augmentation of BK responses and heat responses of polymodal receptors. Dinoprostone 110-114 kininogen 1 Canis lupus familiaris 139-141 1550682-6 1992 Bradykinin (BK) stimulation caused substantial secretion in less than or equal to 20 min of PGE2 and 6-keto-PGF1 alpha from PM but not CM cells: after stimulation with 10(-6) M BK, 6-keto-PGF1 alpha secretion was 348 +/- 74% in PM cells versus 157 +/- 18% of baseline secretion in CM cells (P less than 0.005); PGE2 secretion was 310 +/- 53% in PM cells versus 163 +/- 15% of baseline secretion in CM cells (P less than 0.001). Dinoprostone 92-96 kininogen 1 Canis lupus familiaris 0-10 8741527-3 1996 The release of PGE2 was increased by bradykinin and was decreased by two NO synthase inhibitors: NG-nitro-L-arginine methyl ester and NG-monomethyl-L-arginine. Dinoprostone 15-19 kininogen 1 Canis lupus familiaris 37-47 8177499-1 1994 In clarifying the possible involvement of cyclic AMP (cAMP) in prostaglandin (PG) E2-induced sensitization of the bradykinin response of canine testicular polymodal receptors, the effects of forskolin, an activator of adenylyl cyclase, were studied in the presence and absence of acetylsalicylic acid (ASA, 550 microM) which blocks PG production. Dinoprostone 63-84 kininogen 1 Canis lupus familiaris 114-124 8177499-5 1994 These results suggest that intracellular cAMP may be related with PG E2-induced sensitization of the bradykinin response through its decrease. Dinoprostone 66-71 kininogen 1 Canis lupus familiaris 101-111 1550682-6 1992 Bradykinin (BK) stimulation caused substantial secretion in less than or equal to 20 min of PGE2 and 6-keto-PGF1 alpha from PM but not CM cells: after stimulation with 10(-6) M BK, 6-keto-PGF1 alpha secretion was 348 +/- 74% in PM cells versus 157 +/- 18% of baseline secretion in CM cells (P less than 0.005); PGE2 secretion was 310 +/- 53% in PM cells versus 163 +/- 15% of baseline secretion in CM cells (P less than 0.001). Dinoprostone 92-96 kininogen 1 Canis lupus familiaris 12-14 1550682-6 1992 Bradykinin (BK) stimulation caused substantial secretion in less than or equal to 20 min of PGE2 and 6-keto-PGF1 alpha from PM but not CM cells: after stimulation with 10(-6) M BK, 6-keto-PGF1 alpha secretion was 348 +/- 74% in PM cells versus 157 +/- 18% of baseline secretion in CM cells (P less than 0.005); PGE2 secretion was 310 +/- 53% in PM cells versus 163 +/- 15% of baseline secretion in CM cells (P less than 0.001). Dinoprostone 311-315 kininogen 1 Canis lupus familiaris 0-10 1550682-6 1992 Bradykinin (BK) stimulation caused substantial secretion in less than or equal to 20 min of PGE2 and 6-keto-PGF1 alpha from PM but not CM cells: after stimulation with 10(-6) M BK, 6-keto-PGF1 alpha secretion was 348 +/- 74% in PM cells versus 157 +/- 18% of baseline secretion in CM cells (P less than 0.005); PGE2 secretion was 310 +/- 53% in PM cells versus 163 +/- 15% of baseline secretion in CM cells (P less than 0.001). Dinoprostone 311-315 kininogen 1 Canis lupus familiaris 12-14 2504507-9 1989 When stimulated with the calcium ionophore, free exogenous arachidonate, bradykinin, or histamine the cells produced prostaglandin E2 and prostaglandin I2. Dinoprostone 117-133 kininogen 1 Canis lupus familiaris 73-83 2121048-7 1990 BK increased PGE2 production in PMA-treated cells, suggesting a protein kinase C-independent mechanism of action as well. Dinoprostone 13-17 kininogen 1 Canis lupus familiaris 0-2 2114944-12 1990 When epidermal growth factor in combination with either TPA or bradykinin was used, at least additive effects were observed with respect to release of [3H]arachidonic acid, 3H-prostaglandins, and radioimmunoassayable PGE2. Dinoprostone 217-221 kininogen 1 Canis lupus familiaris 63-73 2514604-2 1989 In both species, bradykinin, platelet-activating factor (PAF), and A23187 (a calcium ionophore) caused increases in the rate of release of prostaglandin (PG) E2 and smaller increases in PGF2 alpha, 6-keto-PGF1 alpha, and thromboxane B2 output. Dinoprostone 139-160 kininogen 1 Canis lupus familiaris 17-27 1351697-3 1992 We present evidence indicating that these BK-induced reflex phenomena are 1) mediated by the activation of B2 receptors; 2) potentiated by prostaglandin E2 (PGE2) and serotonin (5-HT) the latter acting via sub-type 5-HT3 receptors; 3) reduced by indomethacin and/or NG-nitroarginine, and 4) abolished by methylene blue. Dinoprostone 139-155 kininogen 1 Canis lupus familiaris 42-44 1351697-3 1992 We present evidence indicating that these BK-induced reflex phenomena are 1) mediated by the activation of B2 receptors; 2) potentiated by prostaglandin E2 (PGE2) and serotonin (5-HT) the latter acting via sub-type 5-HT3 receptors; 3) reduced by indomethacin and/or NG-nitroarginine, and 4) abolished by methylene blue. Dinoprostone 157-161 kininogen 1 Canis lupus familiaris 42-44 2735424-10 1989 In contrast to complete blockade by 10(-8) PMA of the PGE2 (10(-5) M)-elicited Ca2+ transient, this concentration of PMA inhibited the Ca2+ transient evoked by 10(-9) M bradykinin (BK) by 50%. Dinoprostone 54-58 kininogen 1 Canis lupus familiaris 169-179 2742591-0 1989 Bradykinin stimulated PGE2 production is independent of changes in intracellular calcium in MDCK cells. Dinoprostone 22-26 kininogen 1 Canis lupus familiaris 0-10 2742591-1 1989 In order to assess whether changes in intracellular Ca2+ are necessary for bradykinin stimulated activation of phospholipase A2 and PGE2 production, MDCK cells were treated with phorbol myristate acetate (PMA) and Lanthanum (La3+). Dinoprostone 132-136 kininogen 1 Canis lupus familiaris 75-85 2528913-1 1989 Like arachidonic acid (AA) and bradykinin (BK), the intrarenal administration of atrial natriuretic peptide (ANP) has been shown to increase the urinary excretion of prostaglandin E2 (PGE2). Dinoprostone 166-182 kininogen 1 Canis lupus familiaris 31-41 2528913-1 1989 Like arachidonic acid (AA) and bradykinin (BK), the intrarenal administration of atrial natriuretic peptide (ANP) has been shown to increase the urinary excretion of prostaglandin E2 (PGE2). Dinoprostone 166-182 kininogen 1 Canis lupus familiaris 43-45 2528913-5 1989 Although the rate of PGE2 production was significantly increased 11-fold with AA and threefold with BK, it was unaffected by four different doses of ANP (10(-5) to 10(-11) M). Dinoprostone 21-25 kininogen 1 Canis lupus familiaris 100-102 2528913-6 1989 Furthermore, the production of PGE2 during basal and stimulated (BK or AA) conditions was significantly blocked by indomethacin but not by ANP. Dinoprostone 31-35 kininogen 1 Canis lupus familiaris 65-67 2754465-12 1989 Prostaglandin E2, which has been known to be released by BK and to augment the BK response, failed to restore the suppressed response by either preapplication (2.8 X 10(-7) M) or simultaneous application in high concentration (1.4 X 10(-5) M). Dinoprostone 0-16 kininogen 1 Canis lupus familiaris 57-59 2754465-12 1989 Prostaglandin E2, which has been known to be released by BK and to augment the BK response, failed to restore the suppressed response by either preapplication (2.8 X 10(-7) M) or simultaneous application in high concentration (1.4 X 10(-5) M). Dinoprostone 0-16 kininogen 1 Canis lupus familiaris 79-81 2735424-10 1989 In contrast to complete blockade by 10(-8) PMA of the PGE2 (10(-5) M)-elicited Ca2+ transient, this concentration of PMA inhibited the Ca2+ transient evoked by 10(-9) M bradykinin (BK) by 50%. Dinoprostone 54-58 kininogen 1 Canis lupus familiaris 181-183 3038198-4 1987 Bradykinin (0.1-10 microM) also inhibited the stimulatory effect of vasopressin on cAMP synthesis in a concentration-dependent manner, but affected neither basal cAMP content, nor its stimulation by glucagon, prostaglandin E2 and forskolin. Dinoprostone 209-225 kininogen 1 Canis lupus familiaris 0-10 2753447-4 1989 Bradykinin (10(-5) M) applied to the luminal surface increased PGE2 output markedly. Dinoprostone 63-67 kininogen 1 Canis lupus familiaris 0-10 2753447-5 1989 Indomethacin (10(-5) M) decreased PGE2 and prevented the usual increase in PGE2 caused by bradykinin. Dinoprostone 75-79 kininogen 1 Canis lupus familiaris 90-100 3202451-9 1988 This factor is likely to be prostaglandin E2, which is generated by the epithelial cells in response to bradykinin stimulation and inhibits smooth muscle contraction induced by electrical field stimulation. Dinoprostone 28-44 kininogen 1 Canis lupus familiaris 104-114 3284391-4 1988 Bradykinin (10(-7) M) produced significant stimulation of both PGE2 and 6-keto-PGF1 alpha production in superficial (PGE2 from 0.44 +/- 0.32 to 5.46 +/- 3.77 pg/period and 6-keto-PGF1 alpha from 6.5 +/- 5.0 to 104.5 +/- 25.5 pg/period) and juxtamedullary afferent arterioles (PGE2 from 0.31 +/- 0.06 to 7.47 +/- 1.55 pg/period and 6-keto-PGF1 alpha from 12.0 +/- 0.01 to 184.4 +/- 14.8 pg/period). Dinoprostone 63-67 kininogen 1 Canis lupus familiaris 0-10 3284391-4 1988 Bradykinin (10(-7) M) produced significant stimulation of both PGE2 and 6-keto-PGF1 alpha production in superficial (PGE2 from 0.44 +/- 0.32 to 5.46 +/- 3.77 pg/period and 6-keto-PGF1 alpha from 6.5 +/- 5.0 to 104.5 +/- 25.5 pg/period) and juxtamedullary afferent arterioles (PGE2 from 0.31 +/- 0.06 to 7.47 +/- 1.55 pg/period and 6-keto-PGF1 alpha from 12.0 +/- 0.01 to 184.4 +/- 14.8 pg/period). Dinoprostone 117-121 kininogen 1 Canis lupus familiaris 0-10 3284391-4 1988 Bradykinin (10(-7) M) produced significant stimulation of both PGE2 and 6-keto-PGF1 alpha production in superficial (PGE2 from 0.44 +/- 0.32 to 5.46 +/- 3.77 pg/period and 6-keto-PGF1 alpha from 6.5 +/- 5.0 to 104.5 +/- 25.5 pg/period) and juxtamedullary afferent arterioles (PGE2 from 0.31 +/- 0.06 to 7.47 +/- 1.55 pg/period and 6-keto-PGF1 alpha from 12.0 +/- 0.01 to 184.4 +/- 14.8 pg/period). Dinoprostone 117-121 kininogen 1 Canis lupus familiaris 0-10 3028834-3 1986 During indomethacin infusion, the reflex hypertensive response to low doses of bradykinin was potentiated dose dependently by the following arachidonic acid metabolites (ED50): prostaglandin (PG)I2 (2.9 nmol) greater than or equal to PGH2 (4.4) greater than PGE2 (14) = thromboxane (TX)A2(15) greater than PGD2 (greater than 100). Dinoprostone 258-262 kininogen 1 Canis lupus familiaris 79-89 2439985-5 1987 Concentrations of PG-E2 of 1.4 X 10(-8) M or greater augmented BK responses; higher concentrations and/or longer applications were needed to enhance responses to algesic salt solutions. Dinoprostone 18-23 kininogen 1 Canis lupus familiaris 63-65 2439985-8 1987 The ASA effect on the BK response was largely restored by an addition of PG-E2. Dinoprostone 73-78 kininogen 1 Canis lupus familiaris 22-24 3812104-6 1986 On the other hand, the activity of bradykinin in plasma leakage was potentiated by simultaneous injection of PGE2, when tested in rabbit skin. Dinoprostone 109-113 kininogen 1 Canis lupus familiaris 35-45 3812104-10 1986 On the basis of the bradykinin release in the pleural cavity, once the PGE2 release was superimposed, the maximal plasma leakage was observed, indicating that PGE2 was released independently from bradykinin, and potentiated the plasma leakage by bradykinin. Dinoprostone 159-163 kininogen 1 Canis lupus familiaris 20-30 3079968-4 1986 Both urinary and renal venous PGE2 outflows increased during AA or BK infusion. Dinoprostone 30-34 kininogen 1 Canis lupus familiaris 67-69 3924453-4 1985 The reflex effects of bradykinin could be temporarily restored by treatment of the pericardium with either prostacyclin (0.1 microgram/min) or PGE2 (0.1 microgram/min). Dinoprostone 143-147 kininogen 1 Canis lupus familiaris 22-32 3918456-0 1985 Bradykinin stimulates Cl secretion and prostaglandin E2 release by canine tracheal epithelium. Dinoprostone 39-55 kininogen 1 Canis lupus familiaris 0-10 3918456-8 1985 Finally, prostaglandin E2 release was significantly increased by submucosal addition of bradykinin, and this effect was abolished by pretreatment with indomethacin. Dinoprostone 9-25 kininogen 1 Canis lupus familiaris 88-98 3925124-11 1985 These data indicate that PGs, presumably PGI2 and PGE2, play a permissive role in the vasodilator effect of bradykinin in the pancreas of anesthetized dogs. Dinoprostone 50-54 kininogen 1 Canis lupus familiaris 108-118 3924453-7 1985 The results indicate that locally formed prostanoids, specifically prostacyclin and PGE2, can facilitate activation of the pericardial pressor reflex by bradykinin. Dinoprostone 84-88 kininogen 1 Canis lupus familiaris 153-163 6588055-9 1984 In contrast to the results observed with AVP, bradykinin caused PGE2 release only when added to the apical surface of CCCT cells, which suggested that urinary but not blood borne kinins elicit PGE2 formation by the canine collecting tubule. Dinoprostone 64-68 kininogen 1 Canis lupus familiaris 46-56 6588055-9 1984 In contrast to the results observed with AVP, bradykinin caused PGE2 release only when added to the apical surface of CCCT cells, which suggested that urinary but not blood borne kinins elicit PGE2 formation by the canine collecting tubule. Dinoprostone 193-197 kininogen 1 Canis lupus familiaris 46-56 6588055-10 1984 PGE2 was released in comparable amounts on each side of the monolayer in response both to AVP and to bradykinin. Dinoprostone 0-4 kininogen 1 Canis lupus familiaris 101-111 6346852-3 1983 The reflex pressor effects evoked by bradykinin are reduced after inhibition of prostaglandins biosynthesis with indomethacin and potentiated by concomitant topical application of low doses (0.1 to 0.3 microgram/min) of PGE1 or PGE2 and prostacyclin (PGI2). Dinoprostone 228-232 kininogen 1 Canis lupus familiaris 37-47 6346852-7 1983 Also, intracoronary infusion of PGE2 (0.1 to 0.3 microgram/min), which enhanced the pressor reflex effects of bradykinin, was without effect on nicotine-induced depressor reflex. Dinoprostone 32-36 kininogen 1 Canis lupus familiaris 110-120 6189405-3 1983 These agents inhibited basal-, calcium ionophore (A23187)-, or bradykinin-stimulated PGE2 biosynthesis by MDCK cells. Dinoprostone 85-89 kininogen 1 Canis lupus familiaris 63-73 6799988-1 1981 Supplementation of growing MDCK canine kidney tubular epithelial cultures with linoleic acid produced a 3.6- to 4.9-fold increase in bradykinin-stimulated PGE2 release as measured by radioimmunoassay. Dinoprostone 155-159 kininogen 1 Canis lupus familiaris 133-143 6309869-10 1983 The results support the concept that prostaglandin E2 is an endogenous cellular mediator that acts between an extracellular effector such as bradykinin and a second endogenous mediator of hormone action: cyclic AMP. Dinoprostone 37-53 kininogen 1 Canis lupus familiaris 141-151 7027322-2 1981 Prostacyclin (PGI2) or prostaglandin E2 (PGE2), when applied epicardially, had no effects by themselves but potentiated the reflex pressor changes to bradykinin; the depressor responses to nicotine were not changed. Dinoprostone 23-39 kininogen 1 Canis lupus familiaris 150-160 7027322-2 1981 Prostacyclin (PGI2) or prostaglandin E2 (PGE2), when applied epicardially, had no effects by themselves but potentiated the reflex pressor changes to bradykinin; the depressor responses to nicotine were not changed. Dinoprostone 41-45 kininogen 1 Canis lupus familiaris 150-160 25505603-7 2014 In separate experiments using Madin-Darby Canine Kidney cells engineered to express the PGE2 receptor EP4, bradykinin again induced autocrine PGE2 signaling, as judged by an abrupt increase in intracellular cAMP. Dinoprostone 88-92 kininogen 1 Canis lupus familiaris 107-117