PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9575890-2 1998 In our current studies, we determine whether insulin and IGF-I are involved in the signal transduction mechanisms resulting in IL-1 beta-induced NO and PGE2 biosynthesis in renal mesangial cells. Dinoprostone 152-156 insulin like growth factor 1 Homo sapiens 57-62 10404828-5 1999 We found that both IGF-I and IGF-II were able to stimulate PGE2 synthesis in a time- and dose-dependent way, whereas they both inhibited PGF2alpha production. Dinoprostone 59-63 insulin like growth factor 1 Homo sapiens 19-24 10187857-9 1999 We also found that prostaglandin E2-induced expression of reporter genes containing human IGF-I promoter 1 or four tandem copies of the human HS3D element fused to a minimal promoter and show that these effects were enhanced by a co-transfected C/EBPdelta expression plasmid. Dinoprostone 19-35 insulin like growth factor 1 Homo sapiens 90-95 10614631-3 2000 One important bone growth factor, insulin-like growth factor I (IGF-I), is induced in osteoblasts by hormones such as PGE2 that increase intracellular cAMP levels. Dinoprostone 118-122 insulin like growth factor 1 Homo sapiens 34-62 10614631-3 2000 One important bone growth factor, insulin-like growth factor I (IGF-I), is induced in osteoblasts by hormones such as PGE2 that increase intracellular cAMP levels. Dinoprostone 118-122 insulin like growth factor 1 Homo sapiens 64-69 10614631-4 2000 In this way, PGE2 activates transcription factor CCAAT/enhancer-binding protein-delta (C/EBPdelta) and enhances its binding to a specific control element found in exon 1 in the IGF-I gene. Dinoprostone 13-17 insulin like growth factor 1 Homo sapiens 177-182 10614631-5 2000 Our current studies show that preexposure to glucocorticoid enhanced C/EBPdelta and C/EBPbeta expression by osteoblasts and thereby potentiated IGF-I gene promoter activation in response to PGE2. Dinoprostone 190-194 insulin like growth factor 1 Homo sapiens 144-149 9575890-3 1998 We demonstrate that both insulin and IGF-I increase IL-1 beta-induced Cox-2 and iNOS protein expression, which in turn enhance PGE2 and NO production. Dinoprostone 127-131 insulin like growth factor 1 Homo sapiens 37-42 9138096-2 1997 Prostaglandin E2 (PGE2) stimulates collagen and proteoglycan synthesis in cartilage via an autocrine feedback loop involving IGF-1. Dinoprostone 0-16 insulin like growth factor 1 Homo sapiens 125-130 9138096-2 1997 Prostaglandin E2 (PGE2) stimulates collagen and proteoglycan synthesis in cartilage via an autocrine feedback loop involving IGF-1. Dinoprostone 18-22 insulin like growth factor 1 Homo sapiens 125-130 9138096-12 1997 PGE2 activation of the IGF-1/IGFBP axis may play a pivotal role in the metabolism of cartilage and possibly connective tissues in general. Dinoprostone 0-4 insulin like growth factor 1 Homo sapiens 23-28 8913883-10 1996 Taken together, our results suggest that PGE2 modulates IGFBP-3 expression, protein synthesis, and secretion, and that such regulation may modify human chondrocyte responsiveness to IGF-1 and influence cartilage metabolism. Dinoprostone 41-45 insulin like growth factor 1 Homo sapiens 182-187 8912808-3 1996 Since our preliminary data suggested that PGE2 can stimulate IGF-1 release from human articular chondrocytes, we examined whether the eicosanoid could influence collagen synthesis and whether the effect was mediated by IGF-1. Dinoprostone 42-46 insulin like growth factor 1 Homo sapiens 61-66 8912808-4 1996 Incubation of primary cultures of human articular chondrocytes with increasing concentrations of PGE2 resulted in a dose-dependent (ANOVA, F= 51.62, P < 0.0001, n = 5) and saturable increase in the synthesis and release of IGF-1 and expression of IGF-1 mRNA. Dinoprostone 97-101 insulin like growth factor 1 Homo sapiens 226-231 8912808-4 1996 Incubation of primary cultures of human articular chondrocytes with increasing concentrations of PGE2 resulted in a dose-dependent (ANOVA, F= 51.62, P < 0.0001, n = 5) and saturable increase in the synthesis and release of IGF-1 and expression of IGF-1 mRNA. Dinoprostone 97-101 insulin like growth factor 1 Homo sapiens 250-255 8912808-6 1996 Human IGF-1 mimicked the effects of low PGE2 concentrations by stimulating in a dose-dependent (ANOVA, F= 31.65, P < 0.001, n = 3) and saturable fashion the incorporation of [3H]proline into CDP although the magnitude of the response induced by IGF-1 was far greater (3.5-fold). Dinoprostone 40-44 insulin like growth factor 1 Homo sapiens 6-11 8912808-6 1996 Human IGF-1 mimicked the effects of low PGE2 concentrations by stimulating in a dose-dependent (ANOVA, F= 31.65, P < 0.001, n = 3) and saturable fashion the incorporation of [3H]proline into CDP although the magnitude of the response induced by IGF-1 was far greater (3.5-fold). Dinoprostone 40-44 insulin like growth factor 1 Homo sapiens 248-253 8912808-8 1996 Furthermore, the PGE2-induced increase in [3H]proline incorporation into CDP was inhibited (63%, P < 0.001, n = 7) by the addition to the culture medium of an anti-IGF-1 antibody. Dinoprostone 17-21 insulin like growth factor 1 Homo sapiens 167-172 8912808-9 1996 We conclude that PGE2 may act as a secretagogue of IGF-1 and that the latter growth factor may mediate, via an autocrine loop and the IGF-1 receptor, at least some of the anabolic effects of the eicosanoid on cartilage metabolism. Dinoprostone 17-21 insulin like growth factor 1 Homo sapiens 51-56 26187065-2 2015 Here we show that IGF-I gene promoter activity in prostaglandin E2 (PGE2) induced osteoblasts is suppressed by dihydrotestosterone (DHT) through an essential C/EBP response element (RE) in exon 1 of the igf1 gene. Dinoprostone 50-66 insulin like growth factor 1 Homo sapiens 18-23 8404598-0 1993 Insulin-like growth factor-I inhibits parathyroid hormone-stimulated and enhances prostaglandin E2-stimulated adenosine 3",5"-monophosphate production by human osteoblast-like SaOS-2 cells. Dinoprostone 82-98 insulin like growth factor 1 Homo sapiens 0-28 8404598-9 1993 We conclude that physiologically relevant concentrations of IGF-I specifically inhibited PTH-stimulated and enhanced PGE2-stimulated production of cAMP by an action at the level of PTH and PGE2 receptors and/or coupling of the receptors to Gs alpha. Dinoprostone 117-121 insulin like growth factor 1 Homo sapiens 60-65 8461541-9 1993 However, at high concentrations or in the presence of IGF-I, PGE2 inhibits collagen synthesis. Dinoprostone 61-65 insulin like growth factor 1 Homo sapiens 54-59 2788408-5 1989 The increased production of prostaglandin E2, which is initiated when IL1 or TNF bind to the chondrocytes, was the same in the presence or absence of IGF 1. Dinoprostone 28-44 insulin like growth factor 1 Homo sapiens 150-155 31217077-1 2019 Inhibition of prostaglandin E2 signaling via EP2/EP4 prostanoid receptors suppresses Insulin-like growth factor (IGF)-1-induced proliferation of pancreatic cancer BxPC-3 cells. Dinoprostone 14-30 insulin like growth factor 1 Homo sapiens 85-119 8913883-0 1996 Prostaglandin E2 up-regulates insulin-like growth factor binding protein-3 expression and synthesis in human articular chondrocytes by a c-AMP-independent pathway: role of calcium and protein kinase A and C. Insulin-like growth factor-1, IGF-1, is believed to be an important anabolic modulator of cartilage metabolism and its bioactivity and bioavailability is regulated, in part, by IGF-1 binding protein 3 (IGFBP-3). Dinoprostone 0-16 insulin like growth factor 1 Homo sapiens 208-236 8913883-0 1996 Prostaglandin E2 up-regulates insulin-like growth factor binding protein-3 expression and synthesis in human articular chondrocytes by a c-AMP-independent pathway: role of calcium and protein kinase A and C. Insulin-like growth factor-1, IGF-1, is believed to be an important anabolic modulator of cartilage metabolism and its bioactivity and bioavailability is regulated, in part, by IGF-1 binding protein 3 (IGFBP-3). Dinoprostone 0-16 insulin like growth factor 1 Homo sapiens 238-243 8913883-1 1996 Prostaglandin E2 (PGE2) stimulates IGF-1 production by articular chondrocytes and we determined whether the eicosanoid could regulate IGFBP-3 and, as such, act as a modifier of IGF-1 action at a different level. Dinoprostone 0-16 insulin like growth factor 1 Homo sapiens 35-40 8913883-1 1996 Prostaglandin E2 (PGE2) stimulates IGF-1 production by articular chondrocytes and we determined whether the eicosanoid could regulate IGFBP-3 and, as such, act as a modifier of IGF-1 action at a different level. Dinoprostone 0-16 insulin like growth factor 1 Homo sapiens 177-182 8913883-1 1996 Prostaglandin E2 (PGE2) stimulates IGF-1 production by articular chondrocytes and we determined whether the eicosanoid could regulate IGFBP-3 and, as such, act as a modifier of IGF-1 action at a different level. Dinoprostone 18-22 insulin like growth factor 1 Homo sapiens 35-40 26187065-2 2015 Here we show that IGF-I gene promoter activity in prostaglandin E2 (PGE2) induced osteoblasts is suppressed by dihydrotestosterone (DHT) through an essential C/EBP response element (RE) in exon 1 of the igf1 gene. Dinoprostone 50-66 insulin like growth factor 1 Homo sapiens 203-207 26187065-2 2015 Here we show that IGF-I gene promoter activity in prostaglandin E2 (PGE2) induced osteoblasts is suppressed by dihydrotestosterone (DHT) through an essential C/EBP response element (RE) in exon 1 of the igf1 gene. Dinoprostone 68-72 insulin like growth factor 1 Homo sapiens 18-23 26187065-2 2015 Here we show that IGF-I gene promoter activity in prostaglandin E2 (PGE2) induced osteoblasts is suppressed by dihydrotestosterone (DHT) through an essential C/EBP response element (RE) in exon 1 of the igf1 gene. Dinoprostone 68-72 insulin like growth factor 1 Homo sapiens 203-207 26187065-9 2015 Finally, although the PGE2 sensitive C/EBP RE in the igf1 gene is not essential for basal TGF-beta induction, C/EBPdelta activity through this site is potently enhanced by TGF-beta. Dinoprostone 22-26 insulin like growth factor 1 Homo sapiens 53-57 25804855-8 2015 Prostaglandin E2 (PGE2) and Wnt3a, which are secreted by osteocytes, osteocalcin (OCN) and IGF-1, which are produced by osteoblasts and sclerostin which is secreted by both cell types, might impact skeletal muscle cells. Dinoprostone 0-16 insulin like growth factor 1 Homo sapiens 91-96 25804855-8 2015 Prostaglandin E2 (PGE2) and Wnt3a, which are secreted by osteocytes, osteocalcin (OCN) and IGF-1, which are produced by osteoblasts and sclerostin which is secreted by both cell types, might impact skeletal muscle cells. Dinoprostone 18-22 insulin like growth factor 1 Homo sapiens 91-96 17341442-4 2007 Herein we showed that IGF-I efficiently induced COX-2 expression and PGE(2) biosynthesis at physiologically relevant concentrations in human ovarian cancer cells. Dinoprostone 69-75 insulin like growth factor 1 Homo sapiens 22-27 25575814-4 2015 PGE2 or growth factors such as EGF, HGF and IGF-1 increased complex formation of phospho-PHBT258 with Ras, phospho-AktS473, phospho-Raf-1S338, MEKK1 and IKKalpha/betaS176/180 in the raft domain transiently within 1 hour and MIG-7 in the cytosol 12-24 hours later. Dinoprostone 0-4 insulin like growth factor 1 Homo sapiens 44-49 24440782-2 2014 Here we show that hypoxia and the stress hormones PGE2 and glucocorticoid interact in complex ways in osteoblasts, converging on insulin like growth factor I (IGF-I) expression. Dinoprostone 50-54 insulin like growth factor 1 Homo sapiens 129-157 24440782-2 2014 Here we show that hypoxia and the stress hormones PGE2 and glucocorticoid interact in complex ways in osteoblasts, converging on insulin like growth factor I (IGF-I) expression. Dinoprostone 50-54 insulin like growth factor 1 Homo sapiens 159-164 24440782-4 2014 Notably, hypoxia increased expression of the acute phase response transcription factor C/EBPdelta which can induce IGF-I in response to PGE2, but conversely prevented the stimulatory effect of PGE2 on IGF-I mRNA. Dinoprostone 136-140 insulin like growth factor 1 Homo sapiens 115-120 24440782-4 2014 Notably, hypoxia increased expression of the acute phase response transcription factor C/EBPdelta which can induce IGF-I in response to PGE2, but conversely prevented the stimulatory effect of PGE2 on IGF-I mRNA. Dinoprostone 193-197 insulin like growth factor 1 Homo sapiens 201-206 16257278-4 2006 A linear relationship was observed between endogenous PGE2 levels and insulin-like growth factor 1 (IGF-1) levels in OA Ob. Dinoprostone 54-58 insulin like growth factor 1 Homo sapiens 70-98 16257278-4 2006 A linear relationship was observed between endogenous PGE2 levels and insulin-like growth factor 1 (IGF-1) levels in OA Ob. Dinoprostone 54-58 insulin like growth factor 1 Homo sapiens 100-105 16257278-5 2006 As parathyroid hormone (PTH) and PGE2 are known stimulators of IGF-1 production in Ob, we next evaluated their effect in OA Ob. Dinoprostone 33-37 insulin like growth factor 1 Homo sapiens 63-68 16257278-6 2006 Both subgroups increased their IGF-1 production similarly in response to PGE2, while the high OA subgroup showed a blunted response to PTH compared to the low OA group. Dinoprostone 73-77 insulin like growth factor 1 Homo sapiens 31-36 16257278-7 2006 Conversely, only the high OA group showed a significant inhibition of IGF-1 production when PGE2 synthesis was reduced with Naproxen, a non-steroidal antiinflammatory drug (NSAID) that inhibits cyclooxygenases (COX). Dinoprostone 92-96 insulin like growth factor 1 Homo sapiens 70-75 16257278-8 2006 The PGE2-dependent stimulation of IGF-1 synthesis was due in part to the cAMP/protein kinase A pathway since both the direct inhibition of this pathway with H-89 and the inhibition of EP2 or EP4 receptors, linked to cAMP production, reduced IGF-1 synthesis. Dinoprostone 4-8 insulin like growth factor 1 Homo sapiens 34-39 16257278-8 2006 The PGE2-dependent stimulation of IGF-1 synthesis was due in part to the cAMP/protein kinase A pathway since both the direct inhibition of this pathway with H-89 and the inhibition of EP2 or EP4 receptors, linked to cAMP production, reduced IGF-1 synthesis. Dinoprostone 4-8 insulin like growth factor 1 Homo sapiens 241-246 16257278-10 2006 Under basal condition, OA Ob expressed similar IGF-1 mRNA to normal Ob; however, PGE2 stimulated IGF-1 mRNA expression more in OA than normal Ob. Dinoprostone 81-85 insulin like growth factor 1 Homo sapiens 97-102 16257278-11 2006 These data suggest that increased IGF-1 levels correlate with elevated endogenous PGE2 levels in OA Ob and that higher IGF-1 levels in OA Ob could be important for bone sclerosis in OA. Dinoprostone 82-86 insulin like growth factor 1 Homo sapiens 34-39