PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33494773-7 2021 Mechanistically, we reveal the miR-155 reprograms the prostaglandin metabolism by up-regulating PGE2-producing enzymes PTGES/PTGES2 while down-regulating PGD2-producing enzyme PTGDS. Dinoprostone 96-100 prostaglandin E synthase Homo sapiens 119-124 33527033-1 2021 Microsomal prostaglandin E synthase 1 (mPGES-1) is the terminal synthase of prostaglandin E2 (PGE2) which plays a crucial role in inflammatory diseases. Dinoprostone 76-92 prostaglandin E synthase Homo sapiens 0-37 33527033-1 2021 Microsomal prostaglandin E synthase 1 (mPGES-1) is the terminal synthase of prostaglandin E2 (PGE2) which plays a crucial role in inflammatory diseases. Dinoprostone 94-98 prostaglandin E synthase Homo sapiens 0-37 33441600-0 2021 Mechanism of action and potential applications of selective inhibition of microsomal prostaglandin E synthase-1-mediated PGE2 biosynthesis by sonlicromanol"s metabolite KH176m. Dinoprostone 121-125 prostaglandin E synthase Homo sapiens 74-111 33053444-3 2021 Prostaglandin E2 (PGE2) is robustly synthesized in the ischemic cortex by quickly induced COX-2 and microsomal prostaglandin E synthase-1 (mPGES-1) following cerebral ischemia. Dinoprostone 0-16 prostaglandin E synthase Homo sapiens 100-137 33053444-3 2021 Prostaglandin E2 (PGE2) is robustly synthesized in the ischemic cortex by quickly induced COX-2 and microsomal prostaglandin E synthase-1 (mPGES-1) following cerebral ischemia. Dinoprostone 18-22 prostaglandin E synthase Homo sapiens 100-137 33473256-3 2020 Researchers have identified multiple signaling pathways involved in lung cancer chemoresistance, including cyclooxygenase-2 (COX-2)/microsomal prostaglandin E synthase-1 (mPGES-1) derived prostaglandin E2 (PGE2). Dinoprostone 188-204 prostaglandin E synthase Homo sapiens 132-169 33473256-3 2020 Researchers have identified multiple signaling pathways involved in lung cancer chemoresistance, including cyclooxygenase-2 (COX-2)/microsomal prostaglandin E synthase-1 (mPGES-1) derived prostaglandin E2 (PGE2). Dinoprostone 206-210 prostaglandin E synthase Homo sapiens 132-169 32926636-4 2020 We now show that prostaglandin E synthase (PTGES), the final enzyme in the PGE2 biosynthetic pathway, is expressed at lower levels in the lungs of patients with IPF. Dinoprostone 75-79 prostaglandin E synthase Homo sapiens 17-41 32926636-4 2020 We now show that prostaglandin E synthase (PTGES), the final enzyme in the PGE2 biosynthetic pathway, is expressed at lower levels in the lungs of patients with IPF. Dinoprostone 75-79 prostaglandin E synthase Homo sapiens 43-48 32583353-10 2020 Lowering the PGE2 levels through inhibition of human microsomal prostaglandin E synthase-1 (mPGES-1) can enhance the host immune response against COVID-19. Dinoprostone 13-17 prostaglandin E synthase Homo sapiens 53-90 33028694-1 2020 BACKGROUND: 2,5-dimethylcelecoxib (DMC) is a targeted inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1), a key enzyme in the PGE2 synthesis pathway of inflammatory mediators. Dinoprostone 136-140 prostaglandin E synthase Homo sapiens 67-104 32655834-3 2020 One inflammatory pathway commonly dysregulated in cancer is the metabolism of arachidonic acid (AA) by Cyclooxygenase-2 (COX-2) and microsomal Prostaglandin E Synthase 1 (mPGES-1) into Prostaglandin E2 (PGE2). Dinoprostone 185-201 prostaglandin E synthase Homo sapiens 132-169 32655834-3 2020 One inflammatory pathway commonly dysregulated in cancer is the metabolism of arachidonic acid (AA) by Cyclooxygenase-2 (COX-2) and microsomal Prostaglandin E Synthase 1 (mPGES-1) into Prostaglandin E2 (PGE2). Dinoprostone 203-207 prostaglandin E synthase Homo sapiens 132-169 32231562-2 2020 However, miR-574-5p has recently been shown to positively regulate the expression of microsomal prostaglandin E-synthase-1 (mPGES-1), a key enzyme in the prostaglandin E2 (PGE2) biosynthesis, by acting as decoy to the RNA-binding protein CUG-RNA binding protein 1 (CUGBP1) in human lung cancer. Dinoprostone 154-170 prostaglandin E synthase Homo sapiens 85-122 32231562-2 2020 However, miR-574-5p has recently been shown to positively regulate the expression of microsomal prostaglandin E-synthase-1 (mPGES-1), a key enzyme in the prostaglandin E2 (PGE2) biosynthesis, by acting as decoy to the RNA-binding protein CUG-RNA binding protein 1 (CUGBP1) in human lung cancer. Dinoprostone 172-176 prostaglandin E synthase Homo sapiens 85-122 30814036-0 2019 MPGES-1 derived PGE2 inhibits cell migration by regulating ARP2/3 in the pathogenesis of Hirschsprung disease. Dinoprostone 16-20 prostaglandin E synthase Homo sapiens 0-7 30814036-1 2019 BACKGROUND: We previously studied the metabolomics, transcriptomics and proteomics of intestinal tissue of Hirschsprung disease (HSCR) patients; the results suggested that the expression of prostaglandin E2(PGE2), prostaglandin E receptor 2(PTGER2) and microsomal prostaglandin E synthase-1 (mPGES-1) notably increased in HSCR colon tissues. Dinoprostone 190-206 prostaglandin E synthase Homo sapiens 253-290 30814036-1 2019 BACKGROUND: We previously studied the metabolomics, transcriptomics and proteomics of intestinal tissue of Hirschsprung disease (HSCR) patients; the results suggested that the expression of prostaglandin E2(PGE2), prostaglandin E receptor 2(PTGER2) and microsomal prostaglandin E synthase-1 (mPGES-1) notably increased in HSCR colon tissues. Dinoprostone 207-211 prostaglandin E synthase Homo sapiens 253-290 30814036-10 2019 RESULTS: MPGES-1 derived PGE2 decreased the relative expression of EP2 and ARP2/3 and caused damage to cytoskeleton. Dinoprostone 25-29 prostaglandin E synthase Homo sapiens 9-16 30814036-13 2019 CONCLUSIONS: MPGES-1 derived PGE2 inhibits the cell migration by regulating ARP2/3 complex via prostaglandin E2 receptor. Dinoprostone 29-33 prostaglandin E synthase Homo sapiens 13-20 31320508-5 2019 Functional XBP1 transactivated the human PTGS2 and PTGES genes to enable optimal PGE2 production. Dinoprostone 81-85 prostaglandin E synthase Homo sapiens 51-56 31231223-1 2019 Pharmacological inhibition of microsomal prostaglandin E synthase (mPGES)-1 for selective reduction in prostaglandin E2 (PGE2) biosynthesis is protective in experimental models of cancer and inflammation. Dinoprostone 103-119 prostaglandin E synthase Homo sapiens 30-75 31231223-1 2019 Pharmacological inhibition of microsomal prostaglandin E synthase (mPGES)-1 for selective reduction in prostaglandin E2 (PGE2) biosynthesis is protective in experimental models of cancer and inflammation. Dinoprostone 121-125 prostaglandin E synthase Homo sapiens 30-75 31285948-0 2019 Stabilization of PTGES by deubiquitinase USP9X promotes metastatic features of lung cancer via PGE2 signaling. Dinoprostone 95-99 prostaglandin E synthase Homo sapiens 17-22 31285948-3 2019 In this study, we aimed to investigate the roles of the PTGES/PGE2 pathway in lung cancer progression. Dinoprostone 62-66 prostaglandin E synthase Homo sapiens 56-61 31285948-4 2019 We found that prostaglandin E synthase (PTGES), a key enzyme for PGE2 synthesis in the arachidonic acid pathway, was highly dysregulated in NSCLC. Dinoprostone 65-69 prostaglandin E synthase Homo sapiens 14-38 31285948-4 2019 We found that prostaglandin E synthase (PTGES), a key enzyme for PGE2 synthesis in the arachidonic acid pathway, was highly dysregulated in NSCLC. Dinoprostone 65-69 prostaglandin E synthase Homo sapiens 40-45 31285948-6 2019 Knockdown of PTGES in lung cancer cells resulted in suppressed cell migration, which was reversed by exogenous PGE2. Dinoprostone 111-115 prostaglandin E synthase Homo sapiens 13-18 31285948-11 2019 Taken together, our results show that the upregulated USP9X-PTGES-PGE2 axis contributes significantly to the metastatic features of NSCLC. Dinoprostone 66-70 prostaglandin E synthase Homo sapiens 60-65 30897501-1 2019 OBJECTIVES: Microsomal prostaglandin E synthase-1 (mPGES-1) catalyses the formation of PGE2 in inflammatory tissues. Dinoprostone 87-91 prostaglandin E synthase Homo sapiens 12-49 30894570-6 2019 RNAi knockdown of microsomal prostaglandin E synthase-1, the rate-limiting enzyme in PGE2 synthesis, sensitized OXR cells to oxaliplatin. Dinoprostone 85-89 prostaglandin E synthase Homo sapiens 18-55 31562624-8 2019 Arachidonic acid is first converted by cyclooxygenases into prostaglandin H2 and then further converted by microsomal prostaglandin E synthase-1 into prostaglandin E2. Dinoprostone 150-166 prostaglandin E synthase Homo sapiens 107-144 29891646-1 2018 mPGES-1 (microsomal prostaglandin E synthase-1), the downstream enzyme responsible for PGE2 (prostaglandin E2) synthesis in inflammatory conditions and oxidative stress are increased in vessels from hypertensive animals. Dinoprostone 87-91 prostaglandin E synthase Homo sapiens 9-46 29891646-1 2018 mPGES-1 (microsomal prostaglandin E synthase-1), the downstream enzyme responsible for PGE2 (prostaglandin E2) synthesis in inflammatory conditions and oxidative stress are increased in vessels from hypertensive animals. Dinoprostone 93-109 prostaglandin E synthase Homo sapiens 9-46 29804818-5 2018 By specifically targeting microsomal prostaglandin E synthase-1 (mPGES-1) activity with a small molecule inhibitor we could block CAF-derived PGE2 production leading to reduced tumor growth, impaired angiogenesis, inhibited CAF migration and infiltration, reduced tumor cell proliferation and a favorable shift in the M1/M2 macrophage ratio. Dinoprostone 142-146 prostaglandin E synthase Homo sapiens 26-63 29597170-2 2018 Here, we report on novel multi-target inhibitors that potently and dually interfere with 5-lipoxygenase-activating protein (FLAP) and microsomal prostaglandin E2 synthase (mPGES)-1 in LT and PGE2 biosynthesis, based on the previously identified selective FLAP inhibitor BRP-7 (8, IC50 = 0.31 muM). Dinoprostone 191-195 prostaglandin E synthase Homo sapiens 134-180 29226424-5 2018 Poly(I:C) induced the production of prostaglandin E2 in OHSCs by increasing cyclooxygenase (COX-2) and microsomal prostaglandin E synthase (mPGES)-1. Dinoprostone 36-52 prostaglandin E synthase Homo sapiens 103-148 29273868-4 2018 On the other hand, the toll like receptor 3 (TLR3) stimulant poly(I:C) increased expression of both COX-2 and PGES, resulting in a significant increase in PGE2 levels. Dinoprostone 155-159 prostaglandin E synthase Homo sapiens 110-114 29273868-8 2018 In summary, the present study reveals that upregulation of PGES via TLR3 is critical for BM-MSCs-mediated immunosuppression by PGE2 secretion via the COX-2/PGE2 pathway. Dinoprostone 127-131 prostaglandin E synthase Homo sapiens 59-63 29273868-8 2018 In summary, the present study reveals that upregulation of PGES via TLR3 is critical for BM-MSCs-mediated immunosuppression by PGE2 secretion via the COX-2/PGE2 pathway. Dinoprostone 156-160 prostaglandin E synthase Homo sapiens 59-63 29763932-9 2018 The downregulation of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 would lead to the decreased PGE2 production while the effect on NO could depend on the reduction of inducible nitric oxide synthase expression. Dinoprostone 109-113 prostaglandin E synthase Homo sapiens 43-80 28954232-5 2017 IFNgamma upregulated microsomal prostaglandin E synthase-1 (mPGES-1) alongside cyclo-oxygenase (COX-1) within macrophage populations, resulting in sustained prostaglandin (PG)E2 biosynthesis. Dinoprostone 157-177 prostaglandin E synthase Homo sapiens 21-58 28842681-4 2017 Inhibiting COX-2 or microsomal prostaglandin E synthase-1 suppressed the 6-OHDA-triggered PGE2 production in these cells. Dinoprostone 90-94 prostaglandin E synthase Homo sapiens 20-57 27611488-10 2017 PTGES, which encodes the prostaglandin E synthase, has also been linked to asthma, where deficient prostaglandin E2 synthesis has been associated with airway remodeling. Dinoprostone 99-115 prostaglandin E synthase Homo sapiens 0-5 27611488-10 2017 PTGES, which encodes the prostaglandin E synthase, has also been linked to asthma, where deficient prostaglandin E2 synthesis has been associated with airway remodeling. Dinoprostone 99-115 prostaglandin E synthase Homo sapiens 25-49 28458341-4 2017 Therefore, to elucidate the role of PGE2, studies of microsomal prostaglandin E synthase-1 (mPGES-1), an inducible terminal enzyme for PGE2 synthesis, have recently been an active area of research. Dinoprostone 135-139 prostaglandin E synthase Homo sapiens 53-90 28628921-7 2017 Albumin markedly activated cyclooxygenase-2 (COX-2)/ microsomal prostaglandin E synthase-1 (mPGES-1)/PGE2 pathway in this cell line, an effect largely abolished by NLRP3 silencing at both mRNA and protein levels. Dinoprostone 101-105 prostaglandin E synthase Homo sapiens 53-90 28854439-3 2017 Thus, the present study was undertaken to examine the role of microsomal prostaglandin E synthase-1 (mPGES-1)-derived Prostaglandin E2 (PGE2) in IS-induced MC proliferation. Dinoprostone 118-134 prostaglandin E synthase Homo sapiens 62-99 28854439-3 2017 Thus, the present study was undertaken to examine the role of microsomal prostaglandin E synthase-1 (mPGES-1)-derived Prostaglandin E2 (PGE2) in IS-induced MC proliferation. Dinoprostone 136-140 prostaglandin E synthase Homo sapiens 62-99 27159620-6 2016 Furthermore, pharmacological inhibition or siRNA-mediated knockdown of microsomal prostaglandin E synthase-1 (mPGES-1), the enzyme that functions downstream of COX-2 during the synthesis of PGE2, significantly increased expression of characteristics of the differentiated SMC phenotype. Dinoprostone 190-194 prostaglandin E synthase Homo sapiens 71-108 26791385-1 2016 Microsomal prostaglandin E2 synthase (mPGES)-1 is responsible for the massive prostaglandin E2 (PGE2) formation during inflammation. Dinoprostone 96-100 prostaglandin E synthase Homo sapiens 0-46 27012893-1 2016 Microsomal prostaglandin E synthase-1 (mPGES-1) is a membrane protein which plays crucial role in arachidonic acid metabolism, in the catalysis of PGH2 to PGE2. Dinoprostone 155-159 prostaglandin E synthase Homo sapiens 0-37 27033056-12 2016 The PGES-PGE2-EPs signaling pathway is a potential therapeutic strategy for treating neurodegeneration in patients. Dinoprostone 9-13 prostaglandin E synthase Homo sapiens 4-8 26195278-6 2015 RESULTS: Baseline PGE2 synthase (PGES) levels determined by PBL microarray gene expression and plasma PGE2 levels distinguished patients with symptomatic knee OA from non-OA controls (area under the receiver operating characteristic curve [AUC] 0.87 and 0.89, respectively, P < 0.0001). Dinoprostone 18-22 prostaglandin E synthase Homo sapiens 33-37 26123522-5 2015 The inducible microsomal PGE2 synthase (mPGES)-1 is considered mainly responsible for the excessive PGE2 synthesis during inflammation and was suggested as promising drug target for suppressing PGE2 biosynthesis. Dinoprostone 100-104 prostaglandin E synthase Homo sapiens 14-48 25905589-2 2015 Prostaglandin E2 (PGE2) is a pleiotropic lipid mediator that is synthesized from arachidonic acid by the sequential actions of cyclooxygenases (COX) and PGE synthases (PTGES). Dinoprostone 0-16 prostaglandin E synthase Homo sapiens 168-173 25905589-2 2015 Prostaglandin E2 (PGE2) is a pleiotropic lipid mediator that is synthesized from arachidonic acid by the sequential actions of cyclooxygenases (COX) and PGE synthases (PTGES). Dinoprostone 18-22 prostaglandin E synthase Homo sapiens 168-173 26150361-0 2015 Role of microsomal prostaglandin E synthase-1 (mPGES-1)-derived prostaglandin E2 in colon carcinogenesis. Dinoprostone 64-80 prostaglandin E synthase Homo sapiens 8-45 25817443-4 2015 The microsomal prostaglandin E synthase-1 (mPGES-1) gene product, mPGES-1, participates in prostaglandin E2 (PGE2) production. Dinoprostone 91-107 prostaglandin E synthase Homo sapiens 4-41 25817443-4 2015 The microsomal prostaglandin E synthase-1 (mPGES-1) gene product, mPGES-1, participates in prostaglandin E2 (PGE2) production. Dinoprostone 109-113 prostaglandin E synthase Homo sapiens 4-41 25961169-1 2015 Microsomal prostaglandin E synthase 1 (mPGES-1) is an alpha-helical homotrimeric integral membrane inducible enzyme that catalyzes the formation of prostaglandin E2 (PGE2) from prostaglandin H2 (PGH2). Dinoprostone 148-164 prostaglandin E synthase Homo sapiens 0-37 25961169-1 2015 Microsomal prostaglandin E synthase 1 (mPGES-1) is an alpha-helical homotrimeric integral membrane inducible enzyme that catalyzes the formation of prostaglandin E2 (PGE2) from prostaglandin H2 (PGH2). Dinoprostone 166-170 prostaglandin E synthase Homo sapiens 0-37 25314295-1 2015 OBJECTIVES: Microsomal prostaglandin E synthase-1 (mPGES-1) is a terminal enzyme in the production of prostaglandin E2 (PGE2) and its expression is upregulated during inflammation. Dinoprostone 102-118 prostaglandin E synthase Homo sapiens 12-49 25314295-1 2015 OBJECTIVES: Microsomal prostaglandin E synthase-1 (mPGES-1) is a terminal enzyme in the production of prostaglandin E2 (PGE2) and its expression is upregulated during inflammation. Dinoprostone 120-124 prostaglandin E synthase Homo sapiens 12-49 25108236-1 2014 Microsomal prostaglandin E synthase 1 (mPGES-1) is the terminal regulator of PGE2 synthesis. Dinoprostone 77-81 prostaglandin E synthase Homo sapiens 0-37 24852575-7 2014 Interestingly, following 1 or 6 h of MeHg exposure, Hsp90 binding to PGES/p23 or nNOS was significantly increased, resulting in increased prostaglandin E2 (PGE2) synthesis from MeHg-treated astrocytes. Dinoprostone 138-154 prostaglandin E synthase Homo sapiens 69-73 24852575-7 2014 Interestingly, following 1 or 6 h of MeHg exposure, Hsp90 binding to PGES/p23 or nNOS was significantly increased, resulting in increased prostaglandin E2 (PGE2) synthesis from MeHg-treated astrocytes. Dinoprostone 156-160 prostaglandin E synthase Homo sapiens 69-73 24886859-1 2014 INTRODUCTION: Microsomal prostaglandin E synthase 1 (mPGES-1) catalyzes the terminal step in the biosynthesis of PGE2, a critical mediator in the pathophysiology of osteoarthritis (OA). Dinoprostone 113-117 prostaglandin E synthase Homo sapiens 14-51 24138533-1 2014 Microsomal prostaglandin E synthase-1 (mPGES-1) is an inducible terminal synthase in PGE2 biosynthesis by inflammatory and cancer cells. Dinoprostone 85-89 prostaglandin E synthase Homo sapiens 0-37 23900502-2 2013 Cyclooxygenase-2 (COX-2) and microsomal prostaglandin E synthase-1 (mPGES-1) induced by inflammation are believed to mediate prostaglandin E2 (PGE2) production thereby promoting carcinogenesis. Dinoprostone 125-141 prostaglandin E synthase Homo sapiens 29-66 23900502-2 2013 Cyclooxygenase-2 (COX-2) and microsomal prostaglandin E synthase-1 (mPGES-1) induced by inflammation are believed to mediate prostaglandin E2 (PGE2) production thereby promoting carcinogenesis. Dinoprostone 143-147 prostaglandin E synthase Homo sapiens 29-66 23756023-2 2013 Among PG, PGE2 is produced by 3 isoforms of PGE synthase (PGES) and through activation of its cognate receptors (EP1-4), this PG is involved in the pathophysiology of vascular diseases. Dinoprostone 10-14 prostaglandin E synthase Homo sapiens 44-56 23756023-2 2013 Among PG, PGE2 is produced by 3 isoforms of PGE synthase (PGES) and through activation of its cognate receptors (EP1-4), this PG is involved in the pathophysiology of vascular diseases. Dinoprostone 10-14 prostaglandin E synthase Homo sapiens 58-62 23789712-1 2013 Microsomal prostaglandin E synthase-1 (mPGES-1) constitutes an inducible glutathione-dependent integral membrane protein that catalyzes the oxido-reduction of cyclooxygenase derived PGH2 into PGE2. Dinoprostone 192-196 prostaglandin E synthase Homo sapiens 0-37 23447581-0 2013 Inhibition of microsomal prostaglandin E synthase-1 by aminothiazoles decreases prostaglandin E2 synthesis in vitro and ameliorates experimental periodontitis in vivo. Dinoprostone 80-96 prostaglandin E synthase Homo sapiens 14-51 23447581-2 2013 The inducible enzyme microsomal prostaglandin E synthase-1 (mPGES-1), catalyzing the terminal step of PGE2 biosynthesis, is an attractive target for selective PGE2 inhibition. Dinoprostone 102-106 prostaglandin E synthase Homo sapiens 21-58 23447581-2 2013 The inducible enzyme microsomal prostaglandin E synthase-1 (mPGES-1), catalyzing the terminal step of PGE2 biosynthesis, is an attractive target for selective PGE2 inhibition. Dinoprostone 159-163 prostaglandin E synthase Homo sapiens 21-58 23439561-4 2013 The prostaglandin E synthase (PGES) responsible for acid-induced PGE2 production in BE, however, is not known. Dinoprostone 65-69 prostaglandin E synthase Homo sapiens 4-28 23439561-4 2013 The prostaglandin E synthase (PGES) responsible for acid-induced PGE2 production in BE, however, is not known. Dinoprostone 65-69 prostaglandin E synthase Homo sapiens 30-34 23488692-2 2013 Microsomal prostaglandin E synthase-1 (mPGES-1) is a terminal enzyme of the PGE2 pathway inducible by proinflammatory cytokines. Dinoprostone 76-80 prostaglandin E synthase Homo sapiens 0-37 22480456-5 2012 Conversely, prostaglandin E synthase, a cytokine produced during PGE(2) synthesis, gene expression was significantly reduced at 15 and 20 days (p<0.01 and 0.05 respectively). Dinoprostone 65-71 prostaglandin E synthase Homo sapiens 12-36 22268508-2 2012 In the present study, we describe a PGE2 positive feedback for COX (cyclo-oxygenase)-2 and mPGES-1 [microsomal PGES (PGE synthase)-1] expression in the macrophage cell line RAW 264.7. Dinoprostone 36-40 prostaglandin E synthase Homo sapiens 92-96 22356188-1 2012 Microsomal prostaglandin E synthase 1 (MPGES1) is an enzyme that produces the pro-inflammatory molecule prostaglandin E(2) (PGE(2)). Dinoprostone 104-122 prostaglandin E synthase Homo sapiens 0-37 22356188-1 2012 Microsomal prostaglandin E synthase 1 (MPGES1) is an enzyme that produces the pro-inflammatory molecule prostaglandin E(2) (PGE(2)). Dinoprostone 104-122 prostaglandin E synthase Homo sapiens 39-45 23166763-0 2012 Sulforaphane inhibits prostaglandin E2 synthesis by suppressing microsomal prostaglandin E synthase 1. Dinoprostone 22-38 prostaglandin E synthase Homo sapiens 64-101 22815767-1 2012 BACKGROUND: Blockade of Prostaglandin (PG) E(2) production via deletion of microsomal Prostaglandin E synthase-1 (mPGES-1) gene reduces tumor cell proliferation in vitro and in vivo on xenograft tumors. Dinoprostone 24-47 prostaglandin E synthase Homo sapiens 75-112 22038016-1 2011 Microsomal prostaglandin E synthase-1 (mPGES-1), an inducible enzyme that specifically catalyzes the conversion of prostaglandin H2 (PGH2) to prostaglandin E2 (PGE2), has been reported to be over-expressed in a variety of solid tumor cells and tissues, but not in normal tissues. Dinoprostone 142-158 prostaglandin E synthase Homo sapiens 0-37 22038016-1 2011 Microsomal prostaglandin E synthase-1 (mPGES-1), an inducible enzyme that specifically catalyzes the conversion of prostaglandin H2 (PGH2) to prostaglandin E2 (PGE2), has been reported to be over-expressed in a variety of solid tumor cells and tissues, but not in normal tissues. Dinoprostone 160-164 prostaglandin E synthase Homo sapiens 0-37 21801310-1 2011 Microsomal prostaglandin E synthase-1 (mPGES-1) is the key enzyme for prostaglandin E2 (PGE2) generation during inflammation and is a potential target for designing anti-inflammatory drugs. Dinoprostone 70-86 prostaglandin E synthase Homo sapiens 0-37 21801310-1 2011 Microsomal prostaglandin E synthase-1 (mPGES-1) is the key enzyme for prostaglandin E2 (PGE2) generation during inflammation and is a potential target for designing anti-inflammatory drugs. Dinoprostone 88-92 prostaglandin E synthase Homo sapiens 0-37 21341175-2 2011 In inflammation, bacterial products and cytokines enhance the expression of COX-2 and inducible microsomal prostaglandin E synthase-1 (mPGES-1) which are functionally coupled to result in increased PGE2 formation in macrophages and tissue cells. Dinoprostone 198-202 prostaglandin E synthase Homo sapiens 96-133 21570310-1 2011 5-Lipoxygenase (5-LO) and microsomal prostaglandin E2 synthase (mPGES)-1 are key enzymes in the biosynthesis of leukotrienes and prostaglandin (PG)E2, respectively, and are considered as valuable targets for the treatment of inflammatory diseases. Dinoprostone 129-149 prostaglandin E synthase Homo sapiens 26-72 21354147-1 2011 BACKGROUND & AIMS: Microsomal prostaglandin E synthase-1 (mPGES-1) is a rate-limiting enzyme that is coupled with cyclooxygenase (COX)-2 in the synthesis of prostaglandin E2. Dinoprostone 161-177 prostaglandin E synthase Homo sapiens 23-60 21298002-2 2011 In its turn, PGE(2) formed by cyclooxygenase (COX) and microsomal prostaglandin E(2) synthase 1 (MPGES1) contributes to the rheumatoid arthritis (RA) pathological process. Dinoprostone 13-19 prostaglandin E synthase Homo sapiens 97-103 20067770-1 2010 Inflammation-induced microsomal prostaglandin E synthase-1 (mPGES-1) is the terminal enzyme that synthesizes prostaglandin E(2) (PGE(2)) downstream of cyclooxygenase-2 (COX-2). Dinoprostone 109-127 prostaglandin E synthase Homo sapiens 21-58 20398340-3 2010 In this study we aimed to investigate the global gene expression profile of TNFalpha-stimulated primary human gingival fibroblasts, focusing on signal pathways related to the PGE2-synthesizing enzymes prostaglandin E synthases (PGES), as well as the upstream enzyme cyclooxygenase-2 (COX-2) and PGE2 production. Dinoprostone 175-179 prostaglandin E synthase Homo sapiens 228-232 20398340-3 2010 In this study we aimed to investigate the global gene expression profile of TNFalpha-stimulated primary human gingival fibroblasts, focusing on signal pathways related to the PGE2-synthesizing enzymes prostaglandin E synthases (PGES), as well as the upstream enzyme cyclooxygenase-2 (COX-2) and PGE2 production. Dinoprostone 295-299 prostaglandin E synthase Homo sapiens 228-232 20398340-4 2010 RESULTS: Microarray and western blot analyses showed that the mRNA and protein expression of the inflammatory induced microsomal prostaglandin E synthase-1 (mPGES-1) was up-regulated by the cytokine TNFalpha, accompanied by enhanced expression of COX-2 and increased production of PGE2. Dinoprostone 281-285 prostaglandin E synthase Homo sapiens 118-155 19820419-1 2010 OBJECTIVES: Prostaglandin E2 (PGE2) is a product of cyclooxygenase (COX) and PGE synthase (PGES) and deactivated by 15-hydroxyprostaglandin dehydrogenase (PGDH). Dinoprostone 12-28 prostaglandin E synthase Homo sapiens 77-89 19820419-1 2010 OBJECTIVES: Prostaglandin E2 (PGE2) is a product of cyclooxygenase (COX) and PGE synthase (PGES) and deactivated by 15-hydroxyprostaglandin dehydrogenase (PGDH). Dinoprostone 12-28 prostaglandin E synthase Homo sapiens 91-95 19820419-1 2010 OBJECTIVES: Prostaglandin E2 (PGE2) is a product of cyclooxygenase (COX) and PGE synthase (PGES) and deactivated by 15-hydroxyprostaglandin dehydrogenase (PGDH). Dinoprostone 30-34 prostaglandin E synthase Homo sapiens 77-89 19820419-1 2010 OBJECTIVES: Prostaglandin E2 (PGE2) is a product of cyclooxygenase (COX) and PGE synthase (PGES) and deactivated by 15-hydroxyprostaglandin dehydrogenase (PGDH). Dinoprostone 30-34 prostaglandin E synthase Homo sapiens 91-95 19820419-8 2010 CONCLUSIONS: These results suggest that enhanced PGE2 production proceeds through the expressions of COX-2 and microsomal PGES-1 and down-regulation of PGDH by SNAI2 in pancreatic tumors. Dinoprostone 49-53 prostaglandin E synthase Homo sapiens 122-126 20042640-7 2010 Prostaglandin E(2) (PGE(2)) biosynthesis was documented in transformed human esophageal cells by ectopic expression of PTGES as well as RNA interference directed against PTGES. Dinoprostone 0-18 prostaglandin E synthase Homo sapiens 119-124 20042640-7 2010 Prostaglandin E(2) (PGE(2)) biosynthesis was documented in transformed human esophageal cells by ectopic expression of PTGES as well as RNA interference directed against PTGES. Dinoprostone 0-18 prostaglandin E synthase Homo sapiens 170-175 20042640-7 2010 Prostaglandin E(2) (PGE(2)) biosynthesis was documented in transformed human esophageal cells by ectopic expression of PTGES as well as RNA interference directed against PTGES. Dinoprostone 20-26 prostaglandin E synthase Homo sapiens 119-124 20042640-7 2010 Prostaglandin E(2) (PGE(2)) biosynthesis was documented in transformed human esophageal cells by ectopic expression of PTGES as well as RNA interference directed against PTGES. Dinoprostone 20-26 prostaglandin E synthase Homo sapiens 170-175 19934399-1 2010 The microsomal prostaglandin E(2) synthase (mPGES)-1 is one of the terminal isoenzymes of prostaglandin (PG) E(2) biosynthesis. Dinoprostone 90-113 prostaglandin E synthase Homo sapiens 4-52 20133709-7 2010 These effects were achieved at least partly by repression of the expression of ADAMTS4, a physiological cartilage aggrecanase, and of cyclooxygenase-2 and microsomal prostaglandin E synthase-1, key enzymes in the PGE(2) synthesis pathway. Dinoprostone 213-219 prostaglandin E synthase Homo sapiens 155-192 19275907-6 2009 Recently, prostaglandin E synthases (PGES), which specifically catalyze the final step of PGE2 biosynthesis, were characterized. Dinoprostone 90-94 prostaglandin E synthase Homo sapiens 10-35 19275907-6 2009 Recently, prostaglandin E synthases (PGES), which specifically catalyze the final step of PGE2 biosynthesis, were characterized. Dinoprostone 90-94 prostaglandin E synthase Homo sapiens 37-41 19298395-1 2009 BACKGROUND AND PURPOSE: The selective inhibition of prostaglandin (PG)E(2) formation via interference with microsomal PGE(2) synthase (mPGES)-1 could have advantages in the treatment of PGE(2)-associated diseases, such as inflammation, fever and pain, compared with a general suppression of all PG biosynthesis, provided by inhibition of cyclooxygenase (COX)-1 and 2. Dinoprostone 52-74 prostaglandin E synthase Homo sapiens 107-143 19754418-4 2009 In order to minimize these side-effects, selective suppression of microsomal prostaglandin E(2) synthase (mPGES)-1 derived prostaglandin (PG)E(2) formation has been considered as alternative to general inhibition of prostanoid biosynthesis. Dinoprostone 123-145 prostaglandin E synthase Homo sapiens 66-114 18703630-2 2008 To study the link between estrogens and inflammation further, we examined the regulation of prostaglandin E synthase (PTGES), a key enzyme in the production of prostaglandin E2. Dinoprostone 160-176 prostaglandin E synthase Homo sapiens 92-116 18703630-2 2008 To study the link between estrogens and inflammation further, we examined the regulation of prostaglandin E synthase (PTGES), a key enzyme in the production of prostaglandin E2. Dinoprostone 160-176 prostaglandin E synthase Homo sapiens 118-123 18703630-8 2008 The synergistic up-regulation of PTGES may result in enhanced prostaglandin E2 production, which in turn may further enhance aromatase expression and production of local estrogens. Dinoprostone 62-78 prostaglandin E synthase Homo sapiens 33-38 18619641-2 2008 We found that most renomedullary interstitial cell tumors overexpressed cycloxygenase-2 (COX-2), with concomitant expression of microsomal prostaglandin E synthase-1 and the receptor for prostaglandin E2. Dinoprostone 187-203 prostaglandin E synthase Homo sapiens 128-165 18619641-3 2008 Prostaglandin E2 is the major prostaglandin product of COX-2/microsomal prostaglandin E synthase-1 enzymatic pathway in medullary interstitial cells, and concomitant expression of COX-2, microsomal prostaglandin E synthase-1, and prostaglandin E2 receptor on interstitial cell tumors implies the presence of an autocrine growth loop important in pathogenesis of these tumors. Dinoprostone 0-16 prostaglandin E synthase Homo sapiens 61-98 18619641-3 2008 Prostaglandin E2 is the major prostaglandin product of COX-2/microsomal prostaglandin E synthase-1 enzymatic pathway in medullary interstitial cells, and concomitant expression of COX-2, microsomal prostaglandin E synthase-1, and prostaglandin E2 receptor on interstitial cell tumors implies the presence of an autocrine growth loop important in pathogenesis of these tumors. Dinoprostone 0-16 prostaglandin E synthase Homo sapiens 187-224 17928629-13 2008 By coordinately regulating PTGS2 and PTGES, NFkappaB may contribute to an inducible PGE(2) biosynthesis pathway during human parturition. Dinoprostone 84-90 prostaglandin E synthase Homo sapiens 37-42 17403097-0 2007 Microsomal prostaglandin E synthase-1, which is not coupled to a particular cyclooxygenase isoenzyme, is essential for prostaglandin E(2) biosynthesis in vascular smooth muscle cells. Dinoprostone 119-137 prostaglandin E synthase Homo sapiens 0-37 17403097-12 2007 CONCLUSIONS: mPGES-1 is the main PGES responsible for PGE(2) biosynthesis by VSMC and its induction downregulates VSMC ability to produce PGI(2.) Dinoprostone 54-60 prostaglandin E synthase Homo sapiens 14-18 17374734-3 2007 In human lung cancer, prostacyclin synthase (PGIS) and PGI2 are down-regulated, whereas PGE2 synthase (PGES) and PGE2 are up-regulated. Dinoprostone 88-92 prostaglandin E synthase Homo sapiens 103-107 17439595-1 2007 The synthesis of prostaglandin E2 (PGE2) requires cyclooxygenase (COX) and prostaglandin E synthase (PGES). Dinoprostone 17-33 prostaglandin E synthase Homo sapiens 75-99 17439595-1 2007 The synthesis of prostaglandin E2 (PGE2) requires cyclooxygenase (COX) and prostaglandin E synthase (PGES). Dinoprostone 17-33 prostaglandin E synthase Homo sapiens 101-105 17439595-1 2007 The synthesis of prostaglandin E2 (PGE2) requires cyclooxygenase (COX) and prostaglandin E synthase (PGES). Dinoprostone 35-39 prostaglandin E synthase Homo sapiens 75-99 17439595-1 2007 The synthesis of prostaglandin E2 (PGE2) requires cyclooxygenase (COX) and prostaglandin E synthase (PGES). Dinoprostone 35-39 prostaglandin E synthase Homo sapiens 101-105 17105783-2 2007 Prostaglandin E(2) (PGE(2)) is synthesized by one of three enzymes, cytosolic prostaglandin E synthase (cPGES), microsomal PGES-1 (mPGES-1) and microsomal PGES-2 (mPGES-2). Dinoprostone 0-18 prostaglandin E synthase Homo sapiens 105-109 16766159-1 2006 Microsomal prostaglandin E synthase-1 (mPGES-1) is the terminal enzyme regulating the synthesis of prostaglandin E2 (PGE2) in inflammatory conditions. Dinoprostone 99-115 prostaglandin E synthase Homo sapiens 0-37 16766159-1 2006 Microsomal prostaglandin E synthase-1 (mPGES-1) is the terminal enzyme regulating the synthesis of prostaglandin E2 (PGE2) in inflammatory conditions. Dinoprostone 117-121 prostaglandin E synthase Homo sapiens 0-37 16807371-2 2006 PGE2 is produced from phospholipids by a cascade of enzymatic reactions involving phospholipase A2 (PLA2), cyclooxygenase (COX), and prostaglandin E synthase (PGES). Dinoprostone 0-4 prostaglandin E synthase Homo sapiens 133-157 16807371-2 2006 PGE2 is produced from phospholipids by a cascade of enzymatic reactions involving phospholipase A2 (PLA2), cyclooxygenase (COX), and prostaglandin E synthase (PGES). Dinoprostone 0-4 prostaglandin E synthase Homo sapiens 159-163 16891468-0 2006 Microsomal prostaglandin E synthase-1 regulates human glioma cell growth via prostaglandin E(2)-dependent activation of type II protein kinase A. Dysregulation of enzymes involved in prostaglandin biosynthesis plays a critical role in influencing the biological behavior and clinical outcome of several tumors. Dinoprostone 77-95 prostaglandin E synthase Homo sapiens 0-37 16891468-3 2006 We report that constitutive expression of the microsomal prostaglandin E synthase-1 (mPGES-1) is associated with increased prostaglandin E(2) (PGE(2)) production and stimulation of growth in the human astroglioma cell line U87-MG compared with human primary astrocytes. Dinoprostone 123-141 prostaglandin E synthase Homo sapiens 46-83 16540375-3 2006 In cells, arachidonic acid is transformed into PGE2 via cyclooxygenase (COX) enzymes and terminal prostaglandin E synthases (PGES). Dinoprostone 47-51 prostaglandin E synthase Homo sapiens 98-123 16540375-3 2006 In cells, arachidonic acid is transformed into PGE2 via cyclooxygenase (COX) enzymes and terminal prostaglandin E synthases (PGES). Dinoprostone 47-51 prostaglandin E synthase Homo sapiens 125-129 16540375-6 2006 In particular, we focus on the three isoforms of the terminal PGES, and discuss the potential of targeting PGES as a more precise strategy for inhibiting PGE2 production. Dinoprostone 154-158 prostaglandin E synthase Homo sapiens 107-111 16183115-2 2006 Biosynthesis of PGE2 is mediated by cyclooxygenases (COX) and prostaglandin E synthases (PGES). Dinoprostone 16-20 prostaglandin E synthase Homo sapiens 62-87 16183115-2 2006 Biosynthesis of PGE2 is mediated by cyclooxygenases (COX) and prostaglandin E synthases (PGES). Dinoprostone 16-20 prostaglandin E synthase Homo sapiens 89-93 16299051-3 2006 To explore other putative regulatory features we examined the role of phospholipase A2 (PLA2) and PGE synthase (PGES) enzymes in IL-1beta-induced PGE2 production. Dinoprostone 146-150 prostaglandin E synthase Homo sapiens 98-110 16299051-3 2006 To explore other putative regulatory features we examined the role of phospholipase A2 (PLA2) and PGE synthase (PGES) enzymes in IL-1beta-induced PGE2 production. Dinoprostone 146-150 prostaglandin E synthase Homo sapiens 112-116 16336776-0 2005 Prostaglandin E synthase, a terminal enzyme for prostaglandin E2 biosynthesis. Dinoprostone 48-64 prostaglandin E synthase Homo sapiens 0-24 16336776-2 2005 Prostaglandin E synthase (PGES), which isomerizes COX-derived PGH2 specifically to PGE2, occurs in multiple forms with distinct enzymatic properties, expressions, localizations and functions. Dinoprostone 83-87 prostaglandin E synthase Homo sapiens 0-24 16336776-2 2005 Prostaglandin E synthase (PGES), which isomerizes COX-derived PGH2 specifically to PGE2, occurs in multiple forms with distinct enzymatic properties, expressions, localizations and functions. Dinoprostone 83-87 prostaglandin E synthase Homo sapiens 26-30 15910650-1 2005 Prostaglandin E synthase (PGES) is a recently identified terminal enzyme that acts downstream of cyclooxygenase and catalyzes the conversion of prostaglandin (PG) H2 to PGE2. Dinoprostone 169-173 prostaglandin E synthase Homo sapiens 0-24 15910650-1 2005 Prostaglandin E synthase (PGES) is a recently identified terminal enzyme that acts downstream of cyclooxygenase and catalyzes the conversion of prostaglandin (PG) H2 to PGE2. Dinoprostone 169-173 prostaglandin E synthase Homo sapiens 26-30 15774546-10 2005 CONCLUSIONS: These data indicate that mPGES-1 is a gonadotropin-regulated PG synthesis enzyme expressed by granulosa cells of primate periovulatory follicles and suggest that mPGES-1 may be the primary PGES responsible for the increased follicular PGE2 levels necessary for primate ovulation. Dinoprostone 248-252 prostaglandin E synthase Homo sapiens 39-43 15458923-0 2005 Induced microsomal PGE synthase-1 is involved in cyclooxygenase-2-dependent PGE2 production in gastric fibroblasts. Dinoprostone 76-80 prostaglandin E synthase Homo sapiens 19-31 15899061-0 2005 Microsomal prostaglandin E synthase-1: the inducible synthase for prostaglandin E2. Dinoprostone 66-82 prostaglandin E synthase Homo sapiens 0-37 15899061-1 2005 Microsomal prostaglandin E synthase-1 (mPGES-1) is an inducible enzyme that catalyzes the conversion of prostaglandin (PG)H2 to PGE2. Dinoprostone 128-132 prostaglandin E synthase Homo sapiens 0-37 15372235-2 2004 Cyclooxygenase (COX) and prostaglandin E synthase (PGES) are involved in PGE2 synthesis. Dinoprostone 73-77 prostaglandin E synthase Homo sapiens 25-49 15372235-2 2004 Cyclooxygenase (COX) and prostaglandin E synthase (PGES) are involved in PGE2 synthesis. Dinoprostone 73-77 prostaglandin E synthase Homo sapiens 51-55 15457451-1 2004 OBJECTIVE: Microsomal prostaglandin E synthase 1 (mPGES-1) is the final enzyme of the cascade that produces prostaglandin E(2) (PGE(2)), a key actor in arthritis. Dinoprostone 108-126 prostaglandin E synthase Homo sapiens 11-48 15314505-3 2004 Little was known about the enzyme(s) involved in the isomerization of PGH2 into PGE2 synthesis until recent identification of PGE synthase (PGES). Dinoprostone 80-84 prostaglandin E synthase Homo sapiens 140-144 15379214-3 2004 In present study the involvement of microsomal prostaglandin E synthase-1 (mPGES-1) in relation to PGE2 production was investigated. Dinoprostone 99-103 prostaglandin E synthase Homo sapiens 36-73 15028417-1 2004 Increased prostaglandin E(2)(PGE(2)) synthesis involves multiple enzymes and two isoforms of the terminal enzyme of this biosynthetic pathway, PGE synthase (PGES), were recently identified. Dinoprostone 10-28 prostaglandin E synthase Homo sapiens 143-155 15028417-1 2004 Increased prostaglandin E(2)(PGE(2)) synthesis involves multiple enzymes and two isoforms of the terminal enzyme of this biosynthetic pathway, PGE synthase (PGES), were recently identified. Dinoprostone 10-28 prostaglandin E synthase Homo sapiens 157-161 15028417-1 2004 Increased prostaglandin E(2)(PGE(2)) synthesis involves multiple enzymes and two isoforms of the terminal enzyme of this biosynthetic pathway, PGE synthase (PGES), were recently identified. Dinoprostone 29-35 prostaglandin E synthase Homo sapiens 143-155 15028417-1 2004 Increased prostaglandin E(2)(PGE(2)) synthesis involves multiple enzymes and two isoforms of the terminal enzyme of this biosynthetic pathway, PGE synthase (PGES), were recently identified. Dinoprostone 29-35 prostaglandin E synthase Homo sapiens 157-161 15225371-2 2004 PGES converts prostaglandin (PG)H2 to PGE2 downstream of cyclooxygenase (COX). Dinoprostone 38-42 prostaglandin E synthase Homo sapiens 0-4 15225371-13 2004 Conversion of PGH2 to PGE2 (PGES activity) was significantly increased in the lysate from IL-1beta-stimulated chondrocytes and it was inhibited by MK-886, which has an inhibitory effect on mPGES-1 activity. Dinoprostone 22-26 prostaglandin E synthase Homo sapiens 28-32 12835322-1 2003 Current evidence suggests that two forms of prostaglandin (PG) E synthase (PGES), cytosolic PGES and membrane-bound PGES (mPGES) -1, preferentially lie downstream of cyclooxygenase (COX) -1 and -2, respectively, in the PGE2 biosynthetic pathway. Dinoprostone 219-223 prostaglandin E synthase Homo sapiens 44-73 12835322-1 2003 Current evidence suggests that two forms of prostaglandin (PG) E synthase (PGES), cytosolic PGES and membrane-bound PGES (mPGES) -1, preferentially lie downstream of cyclooxygenase (COX) -1 and -2, respectively, in the PGE2 biosynthetic pathway. Dinoprostone 219-223 prostaglandin E synthase Homo sapiens 75-79 12835322-1 2003 Current evidence suggests that two forms of prostaglandin (PG) E synthase (PGES), cytosolic PGES and membrane-bound PGES (mPGES) -1, preferentially lie downstream of cyclooxygenase (COX) -1 and -2, respectively, in the PGE2 biosynthetic pathway. Dinoprostone 219-223 prostaglandin E synthase Homo sapiens 101-131 12835322-7 2003 Collectively, mPGES-2 is a unique PGES that can be coupled with both COXs and may play a role in the production of the PGE2 involved in both tissue homeostasis and disease. Dinoprostone 119-123 prostaglandin E synthase Homo sapiens 15-19 12818365-1 2003 Increased production of prostaglandin E(2) (PGE(2)) by the combined activities of cyclooxygenase-2 (COX-2) and microsomal glutathione S-transferase 1-like 1 (MGST1-L1) enhances the progression of colorectal cancer. Dinoprostone 24-42 prostaglandin E synthase Homo sapiens 111-156 12818365-1 2003 Increased production of prostaglandin E(2) (PGE(2)) by the combined activities of cyclooxygenase-2 (COX-2) and microsomal glutathione S-transferase 1-like 1 (MGST1-L1) enhances the progression of colorectal cancer. Dinoprostone 24-42 prostaglandin E synthase Homo sapiens 158-166 12818365-1 2003 Increased production of prostaglandin E(2) (PGE(2)) by the combined activities of cyclooxygenase-2 (COX-2) and microsomal glutathione S-transferase 1-like 1 (MGST1-L1) enhances the progression of colorectal cancer. Dinoprostone 44-50 prostaglandin E synthase Homo sapiens 111-156 12818365-1 2003 Increased production of prostaglandin E(2) (PGE(2)) by the combined activities of cyclooxygenase-2 (COX-2) and microsomal glutathione S-transferase 1-like 1 (MGST1-L1) enhances the progression of colorectal cancer. Dinoprostone 44-50 prostaglandin E synthase Homo sapiens 158-166 12605868-1 2003 The measurement of prostaglandin E synthase (PGES) activity is cumbersome because the product of the reaction, PGE(2), is not readily quantitated by spectral means. Dinoprostone 111-117 prostaglandin E synthase Homo sapiens 19-43 12605868-1 2003 The measurement of prostaglandin E synthase (PGES) activity is cumbersome because the product of the reaction, PGE(2), is not readily quantitated by spectral means. Dinoprostone 111-117 prostaglandin E synthase Homo sapiens 45-49 12512699-6 2002 Functional expression of PGE-S was measured at the level of specific mRNA by semi-quantitative RT-PCR, PGE-S protein was detected by Western blot in HUVEC, while PGE2 was measured by immunoassay in the supernatant. Dinoprostone 162-166 prostaglandin E synthase Homo sapiens 25-30 12512699-11 2002 It means that IL-1beta-triggered-PGE2 biosynthesis in endothelial cells is probably regulated by induction of both COX-2 and PGE-S. Dinoprostone 33-37 prostaglandin E synthase Homo sapiens 125-130 12528468-2 2002 PGE2 synthase (PGES) catalyzes conversion of COX-derived PGH2 to PGE2. Dinoprostone 0-4 prostaglandin E synthase Homo sapiens 15-19 12233875-1 2002 OBJECTIVE: Recently, microsomal prostaglandin (PG) E synthase (mPGES) was cloned as a terminal enzyme catalyzing PGH2 to PGE2. Dinoprostone 121-125 prostaglandin E synthase Homo sapiens 32-61 12432931-1 2002 Prostaglandin E synthase (PGES), which converts cyclooxygenase (COX)-derived prostaglandin (PG)H2 to PGE2, occurs in multiple forms with distinct enzymatic properties, modes of expression, cellular and subcellular localizations and intracellular functions. Dinoprostone 101-105 prostaglandin E synthase Homo sapiens 0-24 12432931-1 2002 Prostaglandin E synthase (PGES), which converts cyclooxygenase (COX)-derived prostaglandin (PG)H2 to PGE2, occurs in multiple forms with distinct enzymatic properties, modes of expression, cellular and subcellular localizations and intracellular functions. Dinoprostone 101-105 prostaglandin E synthase Homo sapiens 26-30 11448962-1 2001 Prostaglandin E(2) (PGE(2)) is thought to be an ultimate prostaglandin effector during the ovulatory process, and the objectives of this study were to clone bovine PGE synthase (PGES) and to characterize its regulation by gonadotropins in preovulatory follicles in vivo. Dinoprostone 0-18 prostaglandin E synthase Homo sapiens 178-182 11448962-1 2001 Prostaglandin E(2) (PGE(2)) is thought to be an ultimate prostaglandin effector during the ovulatory process, and the objectives of this study were to clone bovine PGE synthase (PGES) and to characterize its regulation by gonadotropins in preovulatory follicles in vivo. Dinoprostone 20-26 prostaglandin E synthase Homo sapiens 178-182 11514380-0 2001 Overexpression of functionally coupled cyclooxygenase-2 and prostaglandin E synthase in symptomatic atherosclerotic plaques as a basis of prostaglandin E(2)-dependent plaque instability. Dinoprostone 138-156 prostaglandin E synthase Homo sapiens 60-84 11208485-29 2001 Moreover, acting as "microcytokine" Bk induces mRNAs for HO-1, COX-2 and PGE S, the isoenzymes responsible for a delayed endothelial biosynthesis of CO, PGI2 and PGE2. Dinoprostone 162-166 prostaglandin E synthase Homo sapiens 73-78 11029586-13 2000 In conclusion, it appears that PGES and cyclooxygenase-2 are functionally coupled in A549 cells and that a required coordinate expression of these enzymes allows for efficient biosynthesis of prostaglandin E2. Dinoprostone 192-208 prostaglandin E synthase Homo sapiens 31-35 34465013-0 2022 Upregulation of Prostaglandin E2 by Inducible Microsomal Prostaglandin E Synthase-1 in Colon Cancer. Dinoprostone 16-32 prostaglandin E synthase Homo sapiens 46-83 34465013-2 2022 Enzymes involved in the metabolism of PGE2 include cyclooxygenase (COX)-2, microsomal prostaglandin E synthase-1 (mPGES-1), and 15-prostaglandin dehydrogenase (15-PGDH). Dinoprostone 38-42 prostaglandin E synthase Homo sapiens 75-112 34405222-6 2021 Microsomal prostaglandin E synthase-1 (mPGES-1), the key terminal enzyme catalyzing the synthesis of inflammatory PGE2, and the four PGE2 receptors (EP1-4) have gained more attention as the promising alternative drug targets for the development of novel NSAIDs. Dinoprostone 114-118 prostaglandin E synthase Homo sapiens 0-37 34084773-1 2021 Background: Microsomal prostaglandin E synthase-1 (mPGES-1)-derived prostaglandin E2 (PGE2) is a chief mediator of inflammation. Dinoprostone 68-84 prostaglandin E synthase Homo sapiens 12-49 34084773-1 2021 Background: Microsomal prostaglandin E synthase-1 (mPGES-1)-derived prostaglandin E2 (PGE2) is a chief mediator of inflammation. Dinoprostone 86-90 prostaglandin E synthase Homo sapiens 12-49 35417776-5 2022 Microsomal prostaglandin E synthase 1 (mPGES-1) catalyzes the final step of PGE2 biosynthesis. Dinoprostone 76-80 prostaglandin E synthase Homo sapiens 0-37