PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31527829-9 2020 In WT mice, PGE2 increased chloride reabsorption via EP1 in isolated perfused thick ascending limb (TAL), but PGE2 or EP1 deletion did not affect vasopressin-mediated chloride reabsorption. Dinoprostone 12-16 prostaglandin E receptor 1 (subtype EP1) Mus musculus 53-56 32502905-0 2020 Manganese exposure caused reproductive toxicity of male mice involving activation of GnRH secretion in the hypothalamus by prostaglandin E2 receptors EP1 and EP2. Dinoprostone 123-139 prostaglandin E receptor 1 (subtype EP1) Mus musculus 150-153 32502905-3 2020 Astrocytes can indirectly regulate the secretion of GnRH by binding paracrine prostaglandin E2 (PGE2) specifically to the EP1 and EP2 receptors on GnRH neurons. Dinoprostone 78-94 prostaglandin E receptor 1 (subtype EP1) Mus musculus 122-125 32502905-3 2020 Astrocytes can indirectly regulate the secretion of GnRH by binding paracrine prostaglandin E2 (PGE2) specifically to the EP1 and EP2 receptors on GnRH neurons. Dinoprostone 96-100 prostaglandin E receptor 1 (subtype EP1) Mus musculus 122-125 32502905-6 2020 Our data demonstrate that antagonizing the EP1 and EP2 receptors of PGE2 can restore abnormal levels of GnRH caused by Mn exposure. Dinoprostone 68-72 prostaglandin E receptor 1 (subtype EP1) Mus musculus 43-46 32502905-8 2020 These findings suggest that EP1 and EP2, the receptors of PGE2, may be the key to abnormal GnRH secretion caused by Mn exposure. Dinoprostone 58-62 prostaglandin E receptor 1 (subtype EP1) Mus musculus 28-31 32636414-0 2020 Prostaglandin E2 breaks down pericyte-endothelial cell interaction via EP1 and EP4-dependent downregulation of pericyte N-cadherin, connexin-43, and R-Ras. Dinoprostone 0-16 prostaglandin E receptor 1 (subtype EP1) Mus musculus 71-74 32432758-1 2020 OBJECTIVE: This study aimed to investigate the effects of prostaglandin E2 receptor subtypes 1 (EP1) and 2 (EP2) on endoplasmic reticulum (ER) stress induced by TGF-beta1 in mouse mesangial cells (MCs) and to explore its potential mechanisms. Dinoprostone 58-74 prostaglandin E receptor 1 (subtype EP1) Mus musculus 96-99 32059846-6 2020 In addition, we showed that the expression profile of PGE2 receptors (EP1-EP4) and PGE2 effects on matrix mineralization derived from it changed during cell differentiation. Dinoprostone 54-58 prostaglandin E receptor 1 (subtype EP1) Mus musculus 70-73 31617678-0 2020 Role of the PGE2 receptor subtypes EP1, EP2, and EP3 in repetitive traumatic brain injury. Dinoprostone 12-16 prostaglandin E receptor 1 (subtype EP1) Mus musculus 35-38 31527829-11 2020 Overall, EP1 mediated TAL and IMCD transport in response to PGE2 is unaltered in Htn, and EP1 is protective in HKD. Dinoprostone 60-64 prostaglandin E receptor 1 (subtype EP1) Mus musculus 9-12 31679420-10 2019 Further, in vitro experiments indicated that PGE2 also acts directly on DCs via its EP1 receptors to stimulate intracellular isoLG formation. Dinoprostone 45-49 prostaglandin E receptor 1 (subtype EP1) Mus musculus 84-87 31985468-2 2020 One of the most recognized pathways in mediating neuroinflammation is the prostaglandin E2-EP1 receptor pathway. Dinoprostone 74-90 prostaglandin E receptor 1 (subtype EP1) Mus musculus 91-94 29488342-6 2018 The levels of PGE2 and its 4 distinct receptors (EP1-4) were assessed by biochemical analysis. Dinoprostone 14-18 prostaglandin E receptor 1 (subtype EP1) Mus musculus 49-54 30926983-2 2019 Prostaglandin E2 (PGE2), which is the most abundantly detected PG in various tissues, exerts versatile physiological and pathological actions via four receptor subtypes (EP1-4). Dinoprostone 0-16 prostaglandin E receptor 1 (subtype EP1) Mus musculus 170-173 30926983-2 2019 Prostaglandin E2 (PGE2), which is the most abundantly detected PG in various tissues, exerts versatile physiological and pathological actions via four receptor subtypes (EP1-4). Dinoprostone 18-22 prostaglandin E receptor 1 (subtype EP1) Mus musculus 170-173 30883354-5 2019 Elevated levels of PGE2 were responsible for phosphorylating tau in an EP-1, -2, and -3 but not EP4-dependent glycogen synthase kinase 3-activating manner. Dinoprostone 19-23 prostaglandin E receptor 1 (subtype EP1) Mus musculus 71-87 30027346-2 2018 We hypothesized that an increase of renal EP2 or EP4 receptors and/or a downregulation of renal EP1 and EP3 receptors enhances PGE2-induced renal vasodilatation. Dinoprostone 127-131 prostaglandin E receptor 1 (subtype EP1) Mus musculus 96-99 28444901-3 2017 PGE2 binds four different receptors EP1-4. Dinoprostone 0-4 prostaglandin E receptor 1 (subtype EP1) Mus musculus 36-41 30038227-2 2018 PGE2 and PGF2alpha were topically applied to induce transient OH in Wild-type (WT) and FP-, EP1-, EP2-, and EP3-deficient (knockout [KO]) mice. Dinoprostone 0-4 prostaglandin E receptor 1 (subtype EP1) Mus musculus 92-95 30038227-4 2018 PGE2 and PGF2alpha induced significant OH in the WT, FPKO, and EP1-3KO mice compared to the control 30 min after instillation, and the increase in IOP at 30 or 60 min after instillation in FPKO mice was significantly higher than that in the WT mice. Dinoprostone 0-4 prostaglandin E receptor 1 (subtype EP1) Mus musculus 63-66 30038227-7 2018 Transient OH was induced by PGE2 and PGF2alpha in WT, FPKO, and EP1-3KO mice, which was enhanced in FPKO mice. Dinoprostone 28-32 prostaglandin E receptor 1 (subtype EP1) Mus musculus 64-67 29735520-9 2018 These findings indicate that COX-1 and the EP1 and EP3 receptors mediate the downstream pathological effects of PGE2 during polymicrobial IAI and may serve as effective therapeutic targets. Dinoprostone 112-116 prostaglandin E receptor 1 (subtype EP1) Mus musculus 43-46 28966102-1 2017 Prostaglandin E2 (PGE2) exerts various biological effects by binding to E-prostanoid receptors (EP1-4). Dinoprostone 0-16 prostaglandin E receptor 1 (subtype EP1) Mus musculus 96-101 28966102-1 2017 Prostaglandin E2 (PGE2) exerts various biological effects by binding to E-prostanoid receptors (EP1-4). Dinoprostone 18-22 prostaglandin E receptor 1 (subtype EP1) Mus musculus 96-101 28955904-1 2016 Prostaglandin E2 (PGE2) is a lipid mediator released from the phospholipid membranes that mediates important physiological functions in the nervous system via activation of four EP receptors (EP1-4). Dinoprostone 0-16 prostaglandin E receptor 1 (subtype EP1) Mus musculus 192-197 28918839-14 2017 CONCLUSIONS: Our results suggest that PGE2 induces biphasic regulation of COX-2 through renin-dependent PRR activation via EP1 and EP4 receptors. Dinoprostone 38-42 prostaglandin E receptor 1 (subtype EP1) Mus musculus 123-126 28580285-2 2017 The effects of PGE2 are mediated by its four receptors, E-Prostanoid Receptors 1-4 (EP1-4). Dinoprostone 15-19 prostaglandin E receptor 1 (subtype EP1) Mus musculus 84-89 27512093-11 2016 These findings suggest that PGE2 has an important role in the progression of kidney disease via the EP1/EP3 receptor, whereas EP2 and EP4 receptors are equally important in preserving the progression of chronic kidney failure. Dinoprostone 28-32 prostaglandin E receptor 1 (subtype EP1) Mus musculus 100-116 27657726-11 2016 These findings indicate that the hypercapnic vasodilatation depends on COX-1-derived PGE2 acting on EP1 receptors and highlight the critical role that COX-1-derived PGE2 and EP1 receptors play in the hypercapnic regulation of the cerebral circulation. Dinoprostone 85-89 prostaglandin E receptor 1 (subtype EP1) Mus musculus 100-103 27657726-11 2016 These findings indicate that the hypercapnic vasodilatation depends on COX-1-derived PGE2 acting on EP1 receptors and highlight the critical role that COX-1-derived PGE2 and EP1 receptors play in the hypercapnic regulation of the cerebral circulation. Dinoprostone 85-89 prostaglandin E receptor 1 (subtype EP1) Mus musculus 174-177 28955904-1 2016 Prostaglandin E2 (PGE2) is a lipid mediator released from the phospholipid membranes that mediates important physiological functions in the nervous system via activation of four EP receptors (EP1-4). Dinoprostone 18-22 prostaglandin E receptor 1 (subtype EP1) Mus musculus 192-197 26639895-3 2016 PGE2, a product of COX-mediated metabolism of arachidonic acid, binds to four receptors, termed EP1-4. Dinoprostone 0-4 prostaglandin E receptor 1 (subtype EP1) Mus musculus 96-101 26690700-5 2016 Further, we showed that inflammation-induced PGE2 targeted EP1 receptors on striatal dopamine D1 receptor-expressing neurons and that this signaling sequence induced aversion through GABA-mediated inhibition of dopaminergic cells. Dinoprostone 45-49 prostaglandin E receptor 1 (subtype EP1) Mus musculus 59-62 27190998-2 2016 The various biological functions governed by PGE2 are mediated through its four distinct prostaglandin E receptors (EPs), designated as EP1, EP2, EP3, and EP4, among which the EP4 receptor is the one most widely distributed in the heart. Dinoprostone 45-49 prostaglandin E receptor 1 (subtype EP1) Mus musculus 136-139 27298516-1 2016 Prostaglandin E2 (PGE2), a major metabolite of arachidonic acid produced by cyclooxygenase pathways, exerts its bioactive responses by activating four E-prostanoid receptor subtypes, EP1, EP2, EP3, and EP4. Dinoprostone 0-16 prostaglandin E receptor 1 (subtype EP1) Mus musculus 183-186 27298516-1 2016 Prostaglandin E2 (PGE2), a major metabolite of arachidonic acid produced by cyclooxygenase pathways, exerts its bioactive responses by activating four E-prostanoid receptor subtypes, EP1, EP2, EP3, and EP4. Dinoprostone 18-22 prostaglandin E receptor 1 (subtype EP1) Mus musculus 183-186 26065856-7 2015 Only PG E receptor 1 (EP1) receptor antagonists (SC51089:IC50 ~ 1 muM, AH6809:IC50 ~ 7.5 muM) restored the normal TF and sirtuin 1 (SIRT1) levels in MCECs before PGE2 (EC50 ~ 2.5 mM) or CSE/IL-1beta exposure. Dinoprostone 162-166 prostaglandin E receptor 1 (subtype EP1) Mus musculus 22-25 26416179-5 2015 We found that overexpression of HA in RAW264.7 cells induced significant secretion of prostaglandin E2 (PGE2), which mediates a variety of innate and adaptive immune responses through four E-type prostanoid (EP) receptor subtypes (EP1-4). Dinoprostone 86-102 prostaglandin E receptor 1 (subtype EP1) Mus musculus 189-236 26416179-5 2015 We found that overexpression of HA in RAW264.7 cells induced significant secretion of prostaglandin E2 (PGE2), which mediates a variety of innate and adaptive immune responses through four E-type prostanoid (EP) receptor subtypes (EP1-4). Dinoprostone 104-108 prostaglandin E receptor 1 (subtype EP1) Mus musculus 189-236 26065856-9 2015 In conclusion, PGE2 increases both TF expression and activity through the regulation of the EP1/SIRT1 pathway. Dinoprostone 15-19 prostaglandin E receptor 1 (subtype EP1) Mus musculus 92-95 25847406-3 2015 Prostaglandin E2 (PGE2 ) levels rise locally with insult to the nervous system, and PGE2 is known to modulate these processes mainly through its E prostanoid (EP) receptors, EP1-4. Dinoprostone 0-16 prostaglandin E receptor 1 (subtype EP1) Mus musculus 174-179 26121313-11 2015 Na-K-ATPase alpha1 (NaK) was increased by PGE2 via EP1 and EP4. Dinoprostone 42-46 prostaglandin E receptor 1 (subtype EP1) Mus musculus 51-54 26121313-16 2015 Finally, PGE2 significantly increased fluid reabsorption by 31 and 46% in isolated perfused mouse PT from C57BL/6 and FVB mice, respectively, and this was attenuated in FVB-EP1 null mice. Dinoprostone 9-13 prostaglandin E receptor 1 (subtype EP1) Mus musculus 173-176 26121313-17 2015 Altogether PGE2 acting on EP1 and EP4 receptors may prove to be important mediators of PT injury, and salt and water transport. Dinoprostone 11-15 prostaglandin E receptor 1 (subtype EP1) Mus musculus 26-29 26232001-4 2015 Therefore, it is now important to search for downstream targets capable of preferentially modulating PGE2 signaling, and the four E prostanoid receptors, EP1-4, which are the main targets of PGE2, remain a viable therapeutic option. Dinoprostone 191-195 prostaglandin E receptor 1 (subtype EP1) Mus musculus 154-159 26121313-0 2015 Prostaglandin E2 increases proximal tubule fluid reabsorption, and modulates cultured proximal tubule cell responses via EP1 and EP4 receptors. Dinoprostone 0-16 prostaglandin E receptor 1 (subtype EP1) Mus musculus 121-124 26121313-1 2015 Renal prostaglandin (PG) E2 regulates salt and water transport, and affects disease processes via EP1-4 receptors, but its role in the proximal tubule (PT) is unknown. Dinoprostone 6-27 prostaglandin E receptor 1 (subtype EP1) Mus musculus 98-101 26121313-5 2015 EP1 was increased by PGE2 and TGFbeta, but EP4 was unchanged. Dinoprostone 21-25 prostaglandin E receptor 1 (subtype EP1) Mus musculus 0-3 26121313-9 2015 PGE2 increased p27 via EP1 and EP4, but TGFbeta increased p21; PGE2-induced p27 was attenuated by TGFbeta. Dinoprostone 0-4 prostaglandin E receptor 1 (subtype EP1) Mus musculus 23-26 26121313-9 2015 PGE2 increased p27 via EP1 and EP4, but TGFbeta increased p21; PGE2-induced p27 was attenuated by TGFbeta. Dinoprostone 63-67 prostaglandin E receptor 1 (subtype EP1) Mus musculus 23-26 25997851-9 2015 Treatment of OPCs with an EP1/EP3 agonist 17 phenyl-trinor PGE2 reversed protection from a COX-2 inhibitor while inhibition of EP3 receptor protected OPCs from excitotoxicity. Dinoprostone 59-63 prostaglandin E receptor 1 (subtype EP1) Mus musculus 26-29 25847406-3 2015 Prostaglandin E2 (PGE2 ) levels rise locally with insult to the nervous system, and PGE2 is known to modulate these processes mainly through its E prostanoid (EP) receptors, EP1-4. Dinoprostone 84-88 prostaglandin E receptor 1 (subtype EP1) Mus musculus 174-179 26632188-2 2015 Prostaglandin E2 (PGE2), a lipid mediator, exerts its biological functions by binding to four subtypes of E-prostanoid (EP1-4). Dinoprostone 0-16 prostaglandin E receptor 1 (subtype EP1) Mus musculus 120-125 25446888-1 2015 PGE2 exerts anabolic and catabolic effects on bone through the discrete actions of four prostanoid receptors (EP1-4). Dinoprostone 0-4 prostaglandin E receptor 1 (subtype EP1) Mus musculus 110-115 25038274-1 2015 Prostaglandin E2 (PGE2) is one of the most typical lipid mediators produced from arachidonic acid (AA) by cyclooxygenase (COX) as the rate-limiting enzyme, and acts on four kinds of receptor subtypes (EP1-EP4) to elicit its diverse actions including pyrexia, pain sensation, and inflammation. Dinoprostone 0-16 prostaglandin E receptor 1 (subtype EP1) Mus musculus 201-208 25038274-1 2015 Prostaglandin E2 (PGE2) is one of the most typical lipid mediators produced from arachidonic acid (AA) by cyclooxygenase (COX) as the rate-limiting enzyme, and acts on four kinds of receptor subtypes (EP1-EP4) to elicit its diverse actions including pyrexia, pain sensation, and inflammation. Dinoprostone 18-22 prostaglandin E receptor 1 (subtype EP1) Mus musculus 201-208 25205726-7 2015 All inhibitors of EP1, EP2, EP3 and EP4 receptors suppressed the PAR1-triggered PGE2 release. Dinoprostone 80-84 prostaglandin E receptor 1 (subtype EP1) Mus musculus 18-21 26632188-2 2015 Prostaglandin E2 (PGE2), a lipid mediator, exerts its biological functions by binding to four subtypes of E-prostanoid (EP1-4). Dinoprostone 18-22 prostaglandin E receptor 1 (subtype EP1) Mus musculus 120-125 25785867-4 2015 Although four types of receptors, EP1 to EP4, mediate PGE2 signaling, it is unknown whether these receptors play a role in myogenesis. Dinoprostone 54-58 prostaglandin E receptor 1 (subtype EP1) Mus musculus 34-37 25894216-1 2015 Prostaglandin E2, the major COX-2 product, acts via 4 functionally distinct prostanoid receptors, EP(1-4). Dinoprostone 0-16 prostaglandin E receptor 1 (subtype EP1) Mus musculus 98-104 25352206-3 2015 Studies have found that the expression level of prostaglandin E2 (PGE2) in MCs increases under high glucose conditions, that PGE2 affects the proliferation and hypertrophy of MCs mainly through the EP1 pathway, and that the proliferation of MCs and the accumulation of extracellular matrix are the main events leading to glomerular fibrosis. Dinoprostone 48-64 prostaglandin E receptor 1 (subtype EP1) Mus musculus 198-201 26004410-8 2015 Thus, endogenous PGE2 produced by COX-1 plays a role in the gastric hyperemic response following barrier disruption of the stomach by interacting with capsaicin-sensitive afferent neurons, mainly through EP1 receptors, and facilitating the GMBF response to acid back-diffusion. Dinoprostone 17-21 prostaglandin E receptor 1 (subtype EP1) Mus musculus 204-207 25352206-3 2015 Studies have found that the expression level of prostaglandin E2 (PGE2) in MCs increases under high glucose conditions, that PGE2 affects the proliferation and hypertrophy of MCs mainly through the EP1 pathway, and that the proliferation of MCs and the accumulation of extracellular matrix are the main events leading to glomerular fibrosis. Dinoprostone 125-129 prostaglandin E receptor 1 (subtype EP1) Mus musculus 198-201 24622825-0 2014 Gastric cytoprotection by prostaglandin E2 and prostacyclin: relationship to EP1 and IP receptors. Dinoprostone 26-42 prostaglandin E receptor 1 (subtype EP1) Mus musculus 77-80 25426930-1 2014 Brain injuries promote upregulation of so-called proinflammatory prostaglandins, notably prostaglandin E2 (PGE2), leading to overactivation of a class of its cognate G-protein-coupled receptors, including EP1, which is considered a promising target for treatment of ischemic stroke. Dinoprostone 89-105 prostaglandin E receptor 1 (subtype EP1) Mus musculus 205-208 25426930-1 2014 Brain injuries promote upregulation of so-called proinflammatory prostaglandins, notably prostaglandin E2 (PGE2), leading to overactivation of a class of its cognate G-protein-coupled receptors, including EP1, which is considered a promising target for treatment of ischemic stroke. Dinoprostone 107-111 prostaglandin E receptor 1 (subtype EP1) Mus musculus 205-208 25139833-7 2014 This finding was further proven in vivo by co-implanting the PGE2-producing cells line and the EP1-positive cancer cells into the immune deficient mice, after that, it was observed that the PGE2-producing cells promoted all three types of cancer formation in the mice. Dinoprostone 190-194 prostaglandin E receptor 1 (subtype EP1) Mus musculus 95-98 24622825-7 2014 The effects of PGE2 on various gastric functions are mediated by different EP receptor subtypes; inhibition of acid secretion (EP3) and motility (EP1), stimulation of mucus secretion (EP4) and HCO3- secretion (EP1), and an increase in mucosal blood flow (EP2/EP4). Dinoprostone 15-19 prostaglandin E receptor 1 (subtype EP1) Mus musculus 146-149 24622825-7 2014 The effects of PGE2 on various gastric functions are mediated by different EP receptor subtypes; inhibition of acid secretion (EP3) and motility (EP1), stimulation of mucus secretion (EP4) and HCO3- secretion (EP1), and an increase in mucosal blood flow (EP2/EP4). Dinoprostone 15-19 prostaglandin E receptor 1 (subtype EP1) Mus musculus 210-213 24622825-8 2014 In conclusion, the presence of EP1 receptors is essential to the protective action of PGE2, either generated endogenously or administered exogenously, against HCl/ ethanol or indomethacin, and this action is functionally associated with the inhibition of gastric motility. Dinoprostone 86-90 prostaglandin E receptor 1 (subtype EP1) Mus musculus 31-34 23824501-2 2013 These conflicting roles of PGE2 could be attributed to its diverse receptor subtypes, EP1-EP4. Dinoprostone 27-31 prostaglandin E receptor 1 (subtype EP1) Mus musculus 86-89 23390011-2 2013 PGE2 signals through four different receptors (EP1-EP4) and targeting individual receptor(s) may avoid these side effects, while retaining significant anticancer benefits. Dinoprostone 0-4 prostaglandin E receptor 1 (subtype EP1) Mus musculus 47-54 24109429-1 2013 Although hemin-mediated neurotoxicity has been linked to the production of free radicals and glutamate excitotoxicity, the role of the prostaglandin E2 (PGE2)-EP1 receptor remains unclear. Dinoprostone 153-157 prostaglandin E receptor 1 (subtype EP1) Mus musculus 159-162 24109429-6 2013 To further investigate potential mechanisms of action, we measured changes in the intracellular calcium level [Ca(2+)]i following treatment with 17-phenyl trinor PGE2 (17-pt-PGE2) a selective EP1 agonist. Dinoprostone 162-166 prostaglandin E receptor 1 (subtype EP1) Mus musculus 192-195 23218714-1 2013 Recent preclinical studies demonstrate a role for the prostaglandin E(2) (PGE(2)) subtype 1 (EP1) receptor in mediating, at least in part, the pathophysiology of hypertension and diabetes mellitus. Dinoprostone 54-72 prostaglandin E receptor 1 (subtype EP1) Mus musculus 93-96 23160514-3 2013 The biologic actions of PGE2 are exerted through four different G-protein-coupled receptors; designated EP1-4, which couple to separate intracellular signaling pathways. Dinoprostone 24-28 prostaglandin E receptor 1 (subtype EP1) Mus musculus 104-109 23218714-1 2013 Recent preclinical studies demonstrate a role for the prostaglandin E(2) (PGE(2)) subtype 1 (EP1) receptor in mediating, at least in part, the pathophysiology of hypertension and diabetes mellitus. Dinoprostone 74-79 prostaglandin E receptor 1 (subtype EP1) Mus musculus 93-96 23385625-3 2013 Prostaglandin E2 (PGE2) is an important product of COX activity and plays an important role in various physiologic and pathophysiologic conditions through its EP receptors (EP1-EP4). Dinoprostone 0-16 prostaglandin E receptor 1 (subtype EP1) Mus musculus 173-180 23385625-3 2013 Prostaglandin E2 (PGE2) is an important product of COX activity and plays an important role in various physiologic and pathophysiologic conditions through its EP receptors (EP1-EP4). Dinoprostone 18-22 prostaglandin E receptor 1 (subtype EP1) Mus musculus 173-180 23385625-4 2013 Part of the toxic effect of PGE2 in the central nervous system has been reported to be through the EP1 receptor; however, the effect of the EP1 receptor in PD remains elusive. Dinoprostone 28-32 prostaglandin E receptor 1 (subtype EP1) Mus musculus 99-102 23482441-2 2013 The COX-2 product prostaglandin E2 (PGE2) promotes tumor growth and metastasis by acting on a family of four G protein-coupled receptors (EP1-4). Dinoprostone 18-34 prostaglandin E receptor 1 (subtype EP1) Mus musculus 138-143 23482441-2 2013 The COX-2 product prostaglandin E2 (PGE2) promotes tumor growth and metastasis by acting on a family of four G protein-coupled receptors (EP1-4). Dinoprostone 36-40 prostaglandin E receptor 1 (subtype EP1) Mus musculus 138-143 21739481-0 2012 The EP1 receptor for prostaglandin E2 promotes the development and progression of malignant murine skin tumors. Dinoprostone 21-37 prostaglandin E receptor 1 (subtype EP1) Mus musculus 4-7 22775220-11 2012 In the PGE(2)-stimulated melanocytes, mRNA expressions of EP-1, Tyr and Tyrp1 and phosphorylation of CREB protein were suppressed. Dinoprostone 7-13 prostaglandin E receptor 1 (subtype EP1) Mus musculus 58-62 21739481-2 2012 This effect of PGE2 is likely mediated by one or more of its 4 G-protein coupled membrane receptors, EP1-4. Dinoprostone 15-19 prostaglandin E receptor 1 (subtype EP1) Mus musculus 101-106 21739481-8 2012 These data suggest that the tumor promoting/progressing effects of EP1 require the PGE2 synthesized by COX-2. Dinoprostone 83-87 prostaglandin E receptor 1 (subtype EP1) Mus musculus 67-70 21268127-0 2011 Upregulation of the EP1 receptor for prostaglandin E2 promotes skin tumor progression. Dinoprostone 37-53 prostaglandin E receptor 1 (subtype EP1) Mus musculus 20-23 22234697-1 2012 Prostaglandin E(2) (PGE(2)) is a lipid mediator that acts by ligating 4 distinct G protein-coupled receptors, E prostanoid (EP) 1 to 4. Dinoprostone 0-18 prostaglandin E receptor 1 (subtype EP1) Mus musculus 110-134 22371360-2 2012 Recently prostaglandin E(2) (PGE(2)) and its receptor EP(1) (EP(1)R) have emerged as key players in angiotensin II (Ang II)-dependent hypertension (HTN) and related end-organ damage. Dinoprostone 9-27 prostaglandin E receptor 1 (subtype EP1) Mus musculus 54-59 22371360-2 2012 Recently prostaglandin E(2) (PGE(2)) and its receptor EP(1) (EP(1)R) have emerged as key players in angiotensin II (Ang II)-dependent hypertension (HTN) and related end-organ damage. Dinoprostone 9-27 prostaglandin E receptor 1 (subtype EP1) Mus musculus 61-67 21693121-0 2011 Central PGE2 exhibits anxiolytic-like activity via EP1 and EP4 receptors in a manner dependent on serotonin 5-HT1A, dopamine D1 and GABAA receptors. Dinoprostone 8-12 prostaglandin E receptor 1 (subtype EP1) Mus musculus 51-54 21440042-10 2011 Injection of PGE(2) into the subarachnoid space of the lumbar spinal cord, resulted in a similar mechanical sensitization in EP1(-/-) mice and in wild-type mice, while a tendency towards reduced reaction to noxious heat stimulation was observed in EP1(-/-) mice. Dinoprostone 13-19 prostaglandin E receptor 1 (subtype EP1) Mus musculus 125-128 21396778-10 2011 Prostaglandin E2 contributes to cystitis-related bladder pain via EP1 receptors in mice, indicating possible therapeutic usefulness of selective EP1 antagonists. Dinoprostone 0-16 prostaglandin E receptor 1 (subtype EP1) Mus musculus 66-69 21396778-10 2011 Prostaglandin E2 contributes to cystitis-related bladder pain via EP1 receptors in mice, indicating possible therapeutic usefulness of selective EP1 antagonists. Dinoprostone 0-16 prostaglandin E receptor 1 (subtype EP1) Mus musculus 145-148 21440042-10 2011 Injection of PGE(2) into the subarachnoid space of the lumbar spinal cord, resulted in a similar mechanical sensitization in EP1(-/-) mice and in wild-type mice, while a tendency towards reduced reaction to noxious heat stimulation was observed in EP1(-/-) mice. Dinoprostone 13-19 prostaglandin E receptor 1 (subtype EP1) Mus musculus 248-251 20599704-1 2010 Prostaglandin E(2) (PGE(2)) is a key lipid-derived compound which mediates important physiological functions in the nervous system via activation of four EP receptors (EP1-4). Dinoprostone 0-18 prostaglandin E receptor 1 (subtype EP1) Mus musculus 168-173 21116297-2 2011 Prostaglandin E(2) (PGE(2)), acting through its four receptor subtypes (EP1, EP2, EP3 and EP4), is involved in these stress responses. Dinoprostone 0-18 prostaglandin E receptor 1 (subtype EP1) Mus musculus 72-75 20678471-3 2010 Misoprostol acts on the same receptors as prostaglandin E(2) (PGE(2)), a natural lipid-derived compound, which mediates important physiological functions in the nervous system via activation of four EP receptors (EP1-4). Dinoprostone 42-60 prostaglandin E receptor 1 (subtype EP1) Mus musculus 213-218 20599704-1 2010 Prostaglandin E(2) (PGE(2)) is a key lipid-derived compound which mediates important physiological functions in the nervous system via activation of four EP receptors (EP1-4). Dinoprostone 20-26 prostaglandin E receptor 1 (subtype EP1) Mus musculus 168-173 20092576-10 2009 Therefore, the prostaglandin E(2)-EP1 signaling directly enhances GABAergic inputs to SNc dopaminergic neurons. Dinoprostone 15-33 prostaglandin E receptor 1 (subtype EP1) Mus musculus 34-37 20110555-9 2010 PGE2 mediates many lung effects via EP1 receptors, and EP1 blockade (with ONO-8713) lessened lung injury. Dinoprostone 0-4 prostaglandin E receptor 1 (subtype EP1) Mus musculus 36-39 20857620-10 2010 The underlying mechanisms of these actions of PGE2 in the stomach, duodenum, or small intestine are related to inhibition of stomach contraction (EP1), stimulation of duodenal HCO3- secretion (EP3/EP4), or suppression of bacterial invasion due to inhibition of intestinal contraction (EP4) and stimulation of mucus secretion (EP3/EP4) respectively, although the mechanisms related to the esophageal protection remain unknown. Dinoprostone 46-50 prostaglandin E receptor 1 (subtype EP1) Mus musculus 146-149 20188724-3 2010 NMDA-induced allodynia is induced by postsynaptic NMDA receptor activation, while PGE2-induced allodynia is triggered by the enhancement of presynaptic glutamate release via EP1 receptor activation. Dinoprostone 82-86 prostaglandin E receptor 1 (subtype EP1) Mus musculus 174-177 20194308-1 2010 Prostaglandin E(2) (PGE(2)) EP1 receptors (EP1Rs) may contribute to hypertension and related end-organ damage. Dinoprostone 0-18 prostaglandin E receptor 1 (subtype EP1) Mus musculus 28-31 20166995-8 2010 These results suggest that the HCO(3)(-) stimulatory effect of PGE(2) in the duodenum is mediated by both EP3 and EP4 receptors, being coupled intracellularly with Ca(2+) and cAMP, while that in the stomach is mediated by EP1 receptors, coupled with Ca(2+). Dinoprostone 63-69 prostaglandin E receptor 1 (subtype EP1) Mus musculus 222-225 19881295-8 2009 PDE3 and 4 inhibitors were found to increase EP1/3, EP4 and/or EP2 agonist-stimulated RANKL expression, indicating that PDE3 and PDE4 negatively regulate PGE2-induced RANKL mRNA expression through four EPs. Dinoprostone 154-158 prostaglandin E receptor 1 (subtype EP1) Mus musculus 45-50 19419302-3 2009 However, the PGE2 receptor (EP1, EP2, or EP4), and cell type in which it is expressed, which is responsible for PGE2 induction of RANKL during wear debris-induced osteolysis, has yet to be elucidated. Dinoprostone 13-17 prostaglandin E receptor 1 (subtype EP1) Mus musculus 28-31 19299433-2 2009 We tested the hypothesis that activation of type 1 prostaglandin E(2) (PGE(2)) receptor (EP1) increases skeletal muscle arteriolar tone and blood pressure in mice with type 2 diabetes. Dinoprostone 51-69 prostaglandin E receptor 1 (subtype EP1) Mus musculus 89-92 18792778-2 2009 The COX-2 product prostaglandin E(2) (PGE(2)) acts through four G-protein-coupled receptors designated EP1-4. Dinoprostone 18-36 prostaglandin E receptor 1 (subtype EP1) Mus musculus 103-108 18792778-2 2009 The COX-2 product prostaglandin E(2) (PGE(2)) acts through four G-protein-coupled receptors designated EP1-4. Dinoprostone 38-44 prostaglandin E receptor 1 (subtype EP1) Mus musculus 103-108 19322516-7 2009 In conclusion, PGE(2)-stimulated proliferation is mediated by MAPK via EP1 receptor-dependent PKC and EGF receptor-dependent PI3K/Akt signaling pathways in mouse ES cells. Dinoprostone 15-21 prostaglandin E receptor 1 (subtype EP1) Mus musculus 71-74 19389932-9 2009 These results indicate that prostaglandin E2 signaling via either EP1 or EP2 is largely to completely necessary for Toll-like receptor 4-dependent depletion of IPCs from the SGZ and suggest further pharmacological strategies to protect this important neurogenic niche. Dinoprostone 28-44 prostaglandin E receptor 1 (subtype EP1) Mus musculus 66-69 19073437-3 2008 We and others have shown that the EP1 receptor is important in mediating PGE2 toxicity. Dinoprostone 73-77 prostaglandin E receptor 1 (subtype EP1) Mus musculus 34-37 19157987-3 2009 Prostaglandin (PG) E(2) is a metabolite from arachidonic acid, and exerts its functions through G-protein-coupled receptors called EP1, EP2, EP3, and EP4. Dinoprostone 0-23 prostaglandin E receptor 1 (subtype EP1) Mus musculus 131-134 18032663-11 2007 These results suggest that PGE2 is formed in response to dopamine receptor stimulation in the striatum and amplifies both D1 and D2 receptor signaling via EP1. Dinoprostone 27-31 prostaglandin E receptor 1 (subtype EP1) Mus musculus 155-158 18480552-11 2008 These results suggest that EP1 receptor was present in bladder urothelium, and could be activated by PGE2 to release ATP. Dinoprostone 101-105 prostaglandin E receptor 1 (subtype EP1) Mus musculus 27-30 17967902-1 2007 Prostaglandin E2 (PGE2) exerts its actions via four subtypes of the PGE receptor, EP1-4. Dinoprostone 0-16 prostaglandin E receptor 1 (subtype EP1) Mus musculus 82-87 17967902-1 2007 Prostaglandin E2 (PGE2) exerts its actions via four subtypes of the PGE receptor, EP1-4. Dinoprostone 18-22 prostaglandin E receptor 1 (subtype EP1) Mus musculus 82-87 17967902-6 2007 These results suggest that PGE2 produced by dendritic cells in the lymph nodes acts on EP1 in naive T cells to promote Th1 differentiation. Dinoprostone 27-31 prostaglandin E receptor 1 (subtype EP1) Mus musculus 87-90 18230618-1 2008 Prostaglandin E(2), which exerts its functions by binding to four G protein-coupled receptors (EP1-4), is implicated in tumorigenesis. Dinoprostone 0-18 prostaglandin E receptor 1 (subtype EP1) Mus musculus 95-100 18032663-0 2007 Prostaglandin E2 acts on EP1 receptor and amplifies both dopamine D1 and D2 receptor signaling in the striatum. Dinoprostone 0-16 prostaglandin E receptor 1 (subtype EP1) Mus musculus 25-28 19847955-8 2007 CONCLUSION: COX-2-derived PGE2 may play an important role in resistance to HCl/EtOH damage in H. pylori-infected mice by activating EP1, EP2, and EP4. Dinoprostone 26-30 prostaglandin E receptor 1 (subtype EP1) Mus musculus 132-135 17600836-8 2007 The EP1 receptor antagonist SC-51089 and calcium channel blocker verapamil each attenuated the neuronal cell death induced by PGE2. Dinoprostone 126-130 prostaglandin E receptor 1 (subtype EP1) Mus musculus 4-7 17570497-5 2007 Furthermore, because PGE(2) is the major PG produced following UV exposure and PGE(2) manifests its biological activity via four membrane receptors (EP1, EP2, EP3, EP4), elucidating contributions of these receptors is essential for understanding the roles of PGs in UVB-induced effects. Dinoprostone 21-27 prostaglandin E receptor 1 (subtype EP1) Mus musculus 149-152 17401137-1 2007 Prostaglandin E2 (PGE(2)), a major product of cyclooxygenase, exerts its functions by binding to four G protein-coupled receptors (EP1-4) and has been implicated in modulating angiogenesis. Dinoprostone 0-16 prostaglandin E receptor 1 (subtype EP1) Mus musculus 131-136 17710229-2 2007 The present studies were aimed at elucidating the role of prostaglandin E2 (PGE2) E-prostanoid receptor subtype 1 (EP1) in regulating blood pressure. Dinoprostone 58-74 prostaglandin E receptor 1 (subtype EP1) Mus musculus 82-113 17710229-2 2007 The present studies were aimed at elucidating the role of prostaglandin E2 (PGE2) E-prostanoid receptor subtype 1 (EP1) in regulating blood pressure. Dinoprostone 58-74 prostaglandin E receptor 1 (subtype EP1) Mus musculus 115-118 17710229-2 2007 The present studies were aimed at elucidating the role of prostaglandin E2 (PGE2) E-prostanoid receptor subtype 1 (EP1) in regulating blood pressure. Dinoprostone 76-80 prostaglandin E receptor 1 (subtype EP1) Mus musculus 82-113 17710229-2 2007 The present studies were aimed at elucidating the role of prostaglandin E2 (PGE2) E-prostanoid receptor subtype 1 (EP1) in regulating blood pressure. Dinoprostone 76-80 prostaglandin E receptor 1 (subtype EP1) Mus musculus 115-118 17052707-4 2007 Results demonstrated a significant increase (50% or more) in the protein levels of aqueous humor of the EP1 knockout mice in response to PGE2, paracentesis or LPS. Dinoprostone 137-141 prostaglandin E receptor 1 (subtype EP1) Mus musculus 104-107 15920732-1 2005 Prostaglandin (PG) E(2) acts via four functionally antagonistic E-prostanoid (EP) receptors that are expressed on multiple cell types in the nervous system; these are designated EP1-4. Dinoprostone 0-23 prostaglandin E receptor 1 (subtype EP1) Mus musculus 178-183 16917495-2 2007 It is known that PGE2 signals via the E prostanoid receptors, EP1-4, but the role that each receptor plays in skin carcinogenesis is unclear. Dinoprostone 17-21 prostaglandin E receptor 1 (subtype EP1) Mus musculus 62-67 17199550-1 2007 BACKGROUND: Prostaglandin E(2) (PGE(2)), which exerts its biologic actions via EP receptors (EP(1), EP(2), EP(3,) and EP(4)), is a bioactive metabolite of arachidonic acid that is produced by cyclooxygenase (COX)-1 and/or COX-2. Dinoprostone 12-30 prostaglandin E receptor 1 (subtype EP1) Mus musculus 93-98 17008451-2 2007 Among various prostanoids affected by NSAIDs, prostaglandin E2 (PGE2), in particular, seems to play critical roles in IBD via the EP4 receptor, one of the four PGE2 receptor subtypes (EP1-4). Dinoprostone 46-62 prostaglandin E receptor 1 (subtype EP1) Mus musculus 184-187 17008451-2 2007 Among various prostanoids affected by NSAIDs, prostaglandin E2 (PGE2), in particular, seems to play critical roles in IBD via the EP4 receptor, one of the four PGE2 receptor subtypes (EP1-4). Dinoprostone 64-68 prostaglandin E receptor 1 (subtype EP1) Mus musculus 184-187 17175225-1 2006 Prostaglandin E2 (PGE2) is produced during inflammatory responses mediating a variety of both innate and adaptive immune responses through 4 distinct receptors: EP1 to EP4. Dinoprostone 0-16 prostaglandin E receptor 1 (subtype EP1) Mus musculus 161-164 17175225-1 2006 Prostaglandin E2 (PGE2) is produced during inflammatory responses mediating a variety of both innate and adaptive immune responses through 4 distinct receptors: EP1 to EP4. Dinoprostone 18-22 prostaglandin E receptor 1 (subtype EP1) Mus musculus 161-164 16997129-2 2006 We examined which of four distinct subtypes of PGE2 receptors (EP1-EP4) mediated the anorexigenic action of PGE2 using highly selective ligands. Dinoprostone 47-51 prostaglandin E receptor 1 (subtype EP1) Mus musculus 63-70 16670773-2 2006 We examined the signaling of the prostanoid-EP(1) receptor, since its endogenous agonist prostaglandin E(2) is abundant in the airway, but its functional implications are poorly defined. Dinoprostone 89-107 prostaglandin E receptor 1 (subtype EP1) Mus musculus 33-58 16540639-3 2006 The COX-2 product, prostaglandin E(2) (PGE(2)), acts through a family of G protein-coupled receptors designated EP1-4 that mediate intracellular signaling by multiple pathways. Dinoprostone 19-37 prostaglandin E receptor 1 (subtype EP1) Mus musculus 112-117 16185283-2 2005 The four E prostanoid (EP) receptors, designated EP1 through EP4, are known to bind prostaglandin E2 (PGE2), the major prostaglandin present in the skin. Dinoprostone 84-100 prostaglandin E receptor 1 (subtype EP1) Mus musculus 49-52 16185283-2 2005 The four E prostanoid (EP) receptors, designated EP1 through EP4, are known to bind prostaglandin E2 (PGE2), the major prostaglandin present in the skin. Dinoprostone 102-106 prostaglandin E receptor 1 (subtype EP1) Mus musculus 49-52 16189372-3 2005 PGE2 acts through four different receptor subtypes (EP1, EP2, EP3, and EP4) that may explain some of PGE2"s diverse effects. Dinoprostone 0-4 prostaglandin E receptor 1 (subtype EP1) Mus musculus 52-55 16189372-3 2005 PGE2 acts through four different receptor subtypes (EP1, EP2, EP3, and EP4) that may explain some of PGE2"s diverse effects. Dinoprostone 101-105 prostaglandin E receptor 1 (subtype EP1) Mus musculus 52-55 16190898-9 2005 The present study demonstrates that Tyr1472 phosphorylation of NR2B subunits by Fyn kinase may have dual roles in the retention of NMDA receptors in the postsynaptic density and in activation of nitric oxide synthase, and suggests that PGE2 is involved in the maintenance of neuropathic pain via the EP1 subtype. Dinoprostone 236-240 prostaglandin E receptor 1 (subtype EP1) Mus musculus 300-303 16789896-5 2005 In contrast, gastric HCO3- responses induced by PGE2 and mucosal acidification were prevented by the EP1 antagonist and disappeared in EP1, but not EP3-knockout mice. Dinoprostone 48-52 prostaglandin E receptor 1 (subtype EP1) Mus musculus 101-104 16108069-1 2005 Prostaglandin E2 (PGE2) mediates a variety of innate and adaptive immunity through four distinct receptors: EP1-EP4. Dinoprostone 0-16 prostaglandin E receptor 1 (subtype EP1) Mus musculus 108-115 16108069-1 2005 Prostaglandin E2 (PGE2) mediates a variety of innate and adaptive immunity through four distinct receptors: EP1-EP4. Dinoprostone 18-22 prostaglandin E receptor 1 (subtype EP1) Mus musculus 108-115 15976003-13 2005 In summary, these findings demonstrate that the EP4 receptor mediates PGE2-induced renin secretion and that EP1, EP3, and EP4 receptors all contribute to enhanced PGE2-mediated salt and water excretion in the HPS/aBS model. Dinoprostone 163-167 prostaglandin E receptor 1 (subtype EP1) Mus musculus 108-111 16789896-5 2005 In contrast, gastric HCO3- responses induced by PGE2 and mucosal acidification were prevented by the EP1 antagonist and disappeared in EP1, but not EP3-knockout mice. Dinoprostone 48-52 prostaglandin E receptor 1 (subtype EP1) Mus musculus 135-138 15127302-9 2004 Using RT-PCR, we confirmed the expression of the PGE2 (EP) receptor subtypes EP1, EP3 and EP4 but not of EP2 in cultured M-1 CCD cells. Dinoprostone 49-53 prostaglandin E receptor 1 (subtype EP1) Mus musculus 77-80 15723041-7 2005 The PGE2-induced phase shift is inhibited by the EP1 antagonist SC-51322. Dinoprostone 4-8 prostaglandin E receptor 1 (subtype EP1) Mus musculus 49-52 15723041-8 2005 These results suggest that PGE2 acts as an in vivo clock-resetting factor by means of the EP1 subtype of PGE receptors. Dinoprostone 27-31 prostaglandin E receptor 1 (subtype EP1) Mus musculus 90-93 15808664-1 2005 Prostaglandin E(2) (PGE(2)) mediates a variety of both innate and adaptive immunity responses through 4 distinct receptors, EP1-4. Dinoprostone 0-18 prostaglandin E receptor 1 (subtype EP1) Mus musculus 124-129 15808664-1 2005 Prostaglandin E(2) (PGE(2)) mediates a variety of both innate and adaptive immunity responses through 4 distinct receptors, EP1-4. Dinoprostone 20-26 prostaglandin E receptor 1 (subtype EP1) Mus musculus 124-129 15311063-0 2004 Detrusor responses to prostaglandin E2 and bladder outlet obstruction in wild-type and Ep1 receptor knockout mice. Dinoprostone 22-38 prostaglandin E receptor 1 (subtype EP1) Mus musculus 87-90 15311063-2 2004 We investigated whether the PGE2 receptor EP1 is involved in the regulation of normal micturition, the response to intravesical PGE2 administration, and the development of bladder hypertrophy and overactivity due to bladder outlet obstruction (BOO). Dinoprostone 28-32 prostaglandin E receptor 1 (subtype EP1) Mus musculus 42-45 15311063-10 2004 CONCLUSIONS: The EP1 receptor appears not to be essential for normal micturition or the mediation of bladder hypertrophy due to BOO but it seems to have a role in the development of detrusor overactivity caused by PGE2 and outlet obstruction. Dinoprostone 214-218 prostaglandin E receptor 1 (subtype EP1) Mus musculus 17-20 15813989-10 2005 Thus, the potentiation or sensitization of TRPV1 activity through EP1 or IP activation might be one important mechanism underlying the peripheral nociceptive actions of PGE2 or PGI2. Dinoprostone 169-173 prostaglandin E receptor 1 (subtype EP1) Mus musculus 66-69 11687951-13 2001 Thus, we have shown that skin tumor cells depend in part on PGE(2) signaling through the EP1 prostanoid receptor for their in vitro growth. Dinoprostone 60-66 prostaglandin E receptor 1 (subtype EP1) Mus musculus 89-92 12604682-10 2003 The effect of PGE(2) was antagonized by ONO-AE-829 (EP1 antagonist), whereas the capsaicin action was mitigated by indomethacin as well as sensory deafferentation but not by ONO-AE-829. Dinoprostone 14-20 prostaglandin E receptor 1 (subtype EP1) Mus musculus 52-55 12537309-7 2002 In contrast, contraction to agonists of homologous prostanoid receptors EP1 and TP (17-phenyl-trinor PGE2 and U46619) was unaffected (< 1%) by high concentrations of THG113 (100 micromol/L); THG113 (100 micromol/L) also did not affect contraction to numerous other agents including platelet activating factor, endothelin, and angiotensin II. Dinoprostone 101-105 prostaglandin E receptor 1 (subtype EP1) Mus musculus 72-82 11356942-12 2001 The present findings confirmed a role for endogenous PGE2 produced by COX-1 in adaptive gastric cytoprotection and suggested that this action is mediated by activation of EP1-receptors but not associated with capsaicin-sensitive afferent neurons. Dinoprostone 53-57 prostaglandin E receptor 1 (subtype EP1) Mus musculus 171-174 11502472-4 2001 The PGE2 influence on bone is mediated through four well-characterized receptors (EP1, EP2, EP3, and EP4). Dinoprostone 4-8 prostaglandin E receptor 1 (subtype EP1) Mus musculus 82-85 11375261-0 2001 Characterization of EP receptor subtypes responsible for prostaglandin E2-induced pain responses by use of EP1 and EP3 receptor knockout mice. Dinoprostone 57-73 prostaglandin E receptor 1 (subtype EP1) Mus musculus 107-110 11375261-3 2001 PGE2 could induce mechanical allodynia in EP1(+/+), EP3(+/+) and EP3(-/-) mice, but not in EP1(-/-) mice. Dinoprostone 0-4 prostaglandin E receptor 1 (subtype EP1) Mus musculus 42-45 11375261-6 2001 Activation of EP1 receptors appears to be upstream, rather than downstream, of NMDA receptor activation and NO production in the PGE2-induced allodynia. Dinoprostone 129-133 prostaglandin E receptor 1 (subtype EP1) Mus musculus 14-17 11160156-9 2001 Thus, the EP1 receptor for PGE2 plays a direct role in mediating algesia and in regulation of blood pressure. Dinoprostone 27-31 prostaglandin E receptor 1 (subtype EP1) Mus musculus 10-13 11238561-6 2001 This study shows that among the four PGE2 receptors (EP1-EP4), activation of EP3 is sufficient to mediate the proaggregatory actions of low PGE2 concentration. Dinoprostone 37-41 prostaglandin E receptor 1 (subtype EP1) Mus musculus 53-60 11338379-3 2001 In calvarial culture from EP1-, EP2-, and EP3- knockout mice, PGE2 stimulated bone resorption to a similar extent to that found in calvaria from the wild-type mice. Dinoprostone 62-66 prostaglandin E receptor 1 (subtype EP1) Mus musculus 26-29 11086097-0 2000 Prostaglandin E2 selectively enhances the IgE-mediated production of IL-6 and granulocyte-macrophage colony-stimulating factor by mast cells through an EP1/EP3-dependent mechanism. Dinoprostone 0-16 prostaglandin E receptor 1 (subtype EP1) Mus musculus 152-155 10749873-5 2000 In calvarial culture from EP1-, EP2-, and EP3-knockout mice, PGE(2) stimulated bone resorption to an extent similar to that found in calvaria from the wild-type mice. Dinoprostone 61-67 prostaglandin E receptor 1 (subtype EP1) Mus musculus 26-29 11001172-4 2000 Several important actions of PGE2 are exerted via each of the four PGE2 receptor subtypes: EP1, EP2, EP3 and EP4. Dinoprostone 29-33 prostaglandin E receptor 1 (subtype EP1) Mus musculus 91-94 11001172-5 2000 PGE2 participated in colon carcinogenesis via the EP1. Dinoprostone 0-4 prostaglandin E receptor 1 (subtype EP1) Mus musculus 50-53 11216473-6 2000 These results suggest that PGE2 contributes to colon carcinogenesis through binding to the EP1 receptor. Dinoprostone 27-31 prostaglandin E receptor 1 (subtype EP1) Mus musculus 91-94 10870520-9 2000 Thus, the coexistence of EP1 and EP4 receptors in the ciliary muscle suggests that the regulation of ciliary muscle tone by PGE2 is based on a complex mechanism involving multiple receptor subtypes. Dinoprostone 124-128 prostaglandin E receptor 1 (subtype EP1) Mus musculus 25-28 10807413-7 2000 RESULTS: Gastric lesions induced by HCl/ethanol were dose dependently prevented by PGE2: this effect was mimicked by sulprostone and 17-phenylPGE2 and was significantly antagonized by ONO-AE-829, an EP1 antagonist. Dinoprostone 83-87 prostaglandin E receptor 1 (subtype EP1) Mus musculus 199-202 10807413-9 2000 PGE2 caused an inhibition of gastric motility as well as an increase of mucosal blood flow and mucus secretion, the effects being mimicked by prostanoids activating EP1 receptors, EP2/EP3/EP4 receptors and EP4 receptors, respectively. Dinoprostone 0-4 prostaglandin E receptor 1 (subtype EP1) Mus musculus 165-168 10807413-10 2000 On the other hand, although HCl/ethanol caused similar damage in both wild-type mice and knockout mice lacking EP1 or EP3 receptors, the cytoprotective action of PGE2 observed in wild-type and EP3-receptor knockout mice totally disappeared in mice lacking EP1 receptors. Dinoprostone 162-166 prostaglandin E receptor 1 (subtype EP1) Mus musculus 256-259 10807413-11 2000 CONCLUSION: The gastric cytoprotective action of PGE2 is mediated by activation of EP1 receptors. Dinoprostone 49-53 prostaglandin E receptor 1 (subtype EP1) Mus musculus 83-86 10876798-3 2000 There have been four pharmacologically identified receptor subtypes, EP1 through EP4 for PGE2 and a single receptor type, FP for PGF2 alpha. Dinoprostone 89-93 prostaglandin E receptor 1 (subtype EP1) Mus musculus 69-72 10703923-1 2000 Prostaglandin E2 (PGE2) exerts its effects through the PGE receptor that consists of four subtypes (EP1, EP2, EP3, and EP4). Dinoprostone 0-16 prostaglandin E receptor 1 (subtype EP1) Mus musculus 100-103 34420370-7 2021 These data suggest that 6beta-hydroxytestosterone promotes angiotensin II-induced increase in systolic blood pressure and associated pathogenesis via cPLA2alpha activation and generation of eicosanoids, most likely prostaglandin E2 and thromboxane A2 that exerts prohypertensive effects by stimulating EP1/EP3 and TP receptors, respectively. Dinoprostone 215-231 prostaglandin E receptor 1 (subtype EP1) Mus musculus 302-309 10424714-7 1999 The HCO3- stimulatory action of PGE2 in the stomach was also observed dose-dependently in knockout mice lacking EP3-receptors but was absent in EP1-receptor knockout mice, while the stimulatory effect in the duodenum was observed in EP1-receptor knockout mice, similar to wild-type animals, but not in knockout mice lacking EP3-receptors. Dinoprostone 32-36 prostaglandin E receptor 1 (subtype EP1) Mus musculus 233-236 10424714-8 1999 These results indicate that PGE2 stimulates HCO3- secretion via different EP receptor subtypes in the stomach and duodenum; the former is mediated by EP1-receptors, while the latter mediated by EP3-receptors. Dinoprostone 28-32 prostaglandin E receptor 1 (subtype EP1) Mus musculus 150-153 9843913-1 1998 The actions of prostaglandin (PG) E2 are mediated by four distinct classes of PGE2 E-prostanoid (EP) receptors (EP1 through EP4). Dinoprostone 15-36 prostaglandin E receptor 1 (subtype EP1) Mus musculus 112-115 9751056-6 1998 PGE2 acts by interacting with four subtypes of PGE receptor, the EP1, EP2, EP3 and EP4 receptors. Dinoprostone 0-4 prostaglandin E receptor 1 (subtype EP1) Mus musculus 65-68 9556135-6 1998 EP1 receptor antagonist inhibited the PGE2-induced IL-6 secretion. Dinoprostone 38-42 prostaglandin E receptor 1 (subtype EP1) Mus musculus 0-3 9556135-13 1998 These results strongly suggest that PGE2 stimulates IL-6 synthesis through both Ca2+ mobilization from extracellular space via EP1 receptor and cAMP production via EP2 receptor in osteoblast-like cells, and that the PKC activation by PGE2 itself regulates oversynthesis of IL-6. Dinoprostone 36-40 prostaglandin E receptor 1 (subtype EP1) Mus musculus 127-130 9504958-0 1998 Prostaglandin E2 (PGE2) autoamplifies its production through EP1 subtype of PGE receptor in mouse osteoblastic MC3T3-E1 cells. Dinoprostone 0-16 prostaglandin E receptor 1 (subtype EP1) Mus musculus 61-64 9504958-0 1998 Prostaglandin E2 (PGE2) autoamplifies its production through EP1 subtype of PGE receptor in mouse osteoblastic MC3T3-E1 cells. Dinoprostone 18-22 prostaglandin E receptor 1 (subtype EP1) Mus musculus 61-64 7649181-12 1995 The expression of the EP1 receptor in the hypothalamus suggests that this prostanoid receptor is involved in mediating the fever response evoked by prostaglandin E2. Dinoprostone 148-164 prostaglandin E receptor 1 (subtype EP1) Mus musculus 22-25 7766667-9 1995 Furthermore, long-term exposure to TPA decreased PGE2 binding activity of EP1 due to the reduction of the EP1 mRNA level. Dinoprostone 49-53 prostaglandin E receptor 1 (subtype EP1) Mus musculus 74-77 7647986-3 1995 administration of prostaglandin E2 (PGE2) to conscious mice was reported to induce allodynia, a state of discomfort and pain evoked by innocuous tactile stimuli through prostaglandin E receptor subtype EP1 and hyperalgesia through prostaglandin E receptor subtypes EP2 and/or EP3. Dinoprostone 18-34 prostaglandin E receptor 1 (subtype EP1) Mus musculus 202-205 7647986-3 1995 administration of prostaglandin E2 (PGE2) to conscious mice was reported to induce allodynia, a state of discomfort and pain evoked by innocuous tactile stimuli through prostaglandin E receptor subtype EP1 and hyperalgesia through prostaglandin E receptor subtypes EP2 and/or EP3. Dinoprostone 36-40 prostaglandin E receptor 1 (subtype EP1) Mus musculus 202-205 7647986-16 1995 administration of PGE2 exerts allodynia through EP1 in the mouse spinal cord and that ONO-NT-012 is a highly potent, simple competitive antagonist for the PGE2-induced allodynia. Dinoprostone 18-22 prostaglandin E receptor 1 (subtype EP1) Mus musculus 48-51 7855308-5 1994 On the other hand, sulprostone strongly displaced the [3H]PGE2 binding to EP1 and EP3, but not to EP2. Dinoprostone 58-62 prostaglandin E receptor 1 (subtype EP1) Mus musculus 74-77 7921597-11 1994 17-Phenyl-omega-trinor PGE2 (EP1 > EP3) and 16,16-dimethyl PGE2 (EP1 = EP2 = EP3) were as potent as PGE2 in inducing allodynia, and more potent than sulprostone. Dinoprostone 23-27 prostaglandin E receptor 1 (subtype EP1) Mus musculus 29-32 7921597-19 1994 These results demonstrate that PGE2 may exert allodynia through the EP1-receptor and hyperalgesia through EP2- and EP3-receptors in the mouse spinal cord. Dinoprostone 31-35 prostaglandin E receptor 1 (subtype EP1) Mus musculus 68-71 10703923-1 2000 Prostaglandin E2 (PGE2) exerts its effects through the PGE receptor that consists of four subtypes (EP1, EP2, EP3, and EP4). Dinoprostone 18-22 prostaglandin E receptor 1 (subtype EP1) Mus musculus 100-103 10537280-6 1999 These results strongly suggest that prostaglandin E2 contributes to colon carcinogenesis to some extent through its action at the EP1 receptor. Dinoprostone 36-52 prostaglandin E receptor 1 (subtype EP1) Mus musculus 130-133 9348184-2 1997 Four major PGE2 receptor subtypes, EP1, EP2, EP3, and EP4, mediate various PGE2 effects via their coupling to distinct signaling pathways. Dinoprostone 11-15 prostaglandin E receptor 1 (subtype EP1) Mus musculus 35-38 9348184-3 1997 Previously, we have shown that the EP1, EP3, and EP4 genes are expressed in the periimplantation mouse uterus in a spatio-temporal manner, suggesting compartmentalized actions of PGE2 during this period. Dinoprostone 179-183 prostaglandin E receptor 1 (subtype EP1) Mus musculus 35-38 9313928-10 1997 The EP1 receptor bound 17-phenyl-PGE2, sulprostone and iloprost in addition to PGE2 and PGE1, with Ki values of 14-36 nM. Dinoprostone 33-37 prostaglandin E receptor 1 (subtype EP1) Mus musculus 4-7 9112287-5 1997 On the other hand, AFP-07 showed lower affinity for EP1, EP2, EP3, and EP4 than PGE2, but iloprost had the same affinity as PGE2 for the EP1, These results demonstrate that AFP-07 is a potent and highly selective agonist for the IP receptor. Dinoprostone 124-128 prostaglandin E receptor 1 (subtype EP1) Mus musculus 137-140 7715741-7 1995 The concentration-response curve of PGE2 was marginally shifted to the right by the EP1 receptor antagonist AH 6809 (6-isopropoxy-9-oxoxanthene-2- carboxylic acid; apparent pA2 3.97) and by the TP receptor antagonist vapiprost (4.50). Dinoprostone 36-40 prostaglandin E receptor 1 (subtype EP1) Mus musculus 84-87 34626853-2 2021 Prostaglandin E2, which signals through four G protein-coupled receptors (EP1-4), is a mediator of inflammation and is upregulated in diabetes. Dinoprostone 0-16 prostaglandin E receptor 1 (subtype EP1) Mus musculus 74-79 34405216-2 2021 PGE2 regulates blood pressure through its 4 G protein coupled receptors, i.e., EP1, EP2, EP3, and EP4. Dinoprostone 0-4 prostaglandin E receptor 1 (subtype EP1) Mus musculus 79-82 34483880-2 2021 However, our previous report that direct application of PGE2 induces an EP1-mediated constriction strongly argues against its direct action on arterioles during neurovascular coupling, the mechanisms sustaining functional hyperemia. Dinoprostone 56-60 prostaglandin E receptor 1 (subtype EP1) Mus musculus 72-75 35296155-2 2022 The purpose of this study was to determine the relevance and mechanism of CD COX-2/prostaglandin E2/EP1 signaling for the regulation of Na+ hemostasis during Na+ depletion. Dinoprostone 83-99 prostaglandin E receptor 1 (subtype EP1) Mus musculus 100-103 35602948-0 2022 NR5A2/LRH-1 regulates the PTGS2-PGE2-PTGER1 pathway contributing to pancreatic islet survival and function. Dinoprostone 32-36 prostaglandin E receptor 1 (subtype EP1) Mus musculus 37-43 35602948-8 2022 Our results define the LRH-1/PTGS2/PGE2/PTGER1 signaling axis as a key pathway mediating BL001 survival properties. Dinoprostone 35-39 prostaglandin E receptor 1 (subtype EP1) Mus musculus 40-46 35126177-7 2021 MpkCCD cells expressed mRNAs for the receptors of PGE2 (EP1/EP4), PGF2 (FP), and TxB2 (TP). Dinoprostone 50-54 prostaglandin E receptor 1 (subtype EP1) Mus musculus 56-59 35126177-10 2021 Moreover, in the presence of dDAVP, an EP1/3, but not EP4, agonist decreased the AQP2 abundance, and the addition of EP1 antagonists prevented the PGE2-mediated downregulation of AQP2. Dinoprostone 147-151 prostaglandin E receptor 1 (subtype EP1) Mus musculus 117-120 35126177-11 2021 Our study shows that in mpkCCDc14 cells, reduced EP4 receptor and increased EP1/FP receptor expression by dDAVP explains the differential effects of PGE2 and PGF2alpha on AQP2 abundance with or without dDAVP. Dinoprostone 149-153 prostaglandin E receptor 1 (subtype EP1) Mus musculus 76-79