PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33383445-6 2021 The results showed that IL-23R and IL-17A were upregulated to different degrees and reached the highest levels with both stimuli, indicating that IL-23 induced PBMCs to secrete PGE2, which further boosted the proportion of IL-23R+CD4+T cells to promote IL-17A secretion. Dinoprostone 177-181 interleukin 23 subunit alpha Homo sapiens 24-29 33383445-11 2021 Our findings suggest that the feedback loop of IL-23/IL-23R/PGE2/EP2+EP4/IL-23R/IL-17A plays a significant role in the pathogenesis of TAO and that IL-23R is one of the key targets. Dinoprostone 60-64 interleukin 23 subunit alpha Homo sapiens 47-52 29935220-9 2019 Analysis of human psoriatic skin biopsy specimens shows positive correlation between PGE2 signaling and the IL-23/TH17 pathway. Dinoprostone 85-89 interleukin 23 subunit alpha Homo sapiens 108-113 26412948-0 2015 PGE2 Elevates IL-23 Production in Human Dendritic Cells via a cAMP Dependent Pathway. Dinoprostone 0-4 interleukin 23 subunit alpha Homo sapiens 14-19 29237778-4 2018 PGE2 is also associated with modulation of autoimmunity through altering the IL-23/IL-17 axis and regulatory T cell (Treg) development. Dinoprostone 0-4 interleukin 23 subunit alpha Homo sapiens 77-82 26310818-7 2015 Importantly, we showed a reinforcing interaction between PGE2 and IGF-1 on mTORC1 signaling, with an increase in IL-23 production as a cellular outcome. Dinoprostone 57-61 interleukin 23 subunit alpha Homo sapiens 113-118 26412948-2 2015 Whether this differential effect of PGE2 on IL-23 production is cell-type- or species-specific has not been investigated in detail. Dinoprostone 36-40 interleukin 23 subunit alpha Homo sapiens 44-49 26412948-3 2015 The present study was designed to investigate the effect of PGE2 on IL-23 production in human DCs and the possible underlying mechanisms. Dinoprostone 60-64 interleukin 23 subunit alpha Homo sapiens 68-73 26412948-6 2015 Our results demonstrated that PGE2 promoted zymosan-induced IL-23 production in a concentration dependent manner. Dinoprostone 30-34 interleukin 23 subunit alpha Homo sapiens 60-65 26412948-7 2015 In addition, it was found that PGE2 is also able to elevate MyD88-mediated IL-23 p19 promoter activity. Dinoprostone 31-35 interleukin 23 subunit alpha Homo sapiens 75-84 26412948-8 2015 More importantly, ELISA data demonstrated that db-cAMP, a cAMP analog, and forskolin, an adenylate cyclase activator, can mimic the effect of PGE2 on zymosan-induced IL-23 production, and rp-cAMP, a protein kinase A (PKA) inhibitor, can block the effect of PGE2. Dinoprostone 142-146 interleukin 23 subunit alpha Homo sapiens 166-171 26412948-8 2015 More importantly, ELISA data demonstrated that db-cAMP, a cAMP analog, and forskolin, an adenylate cyclase activator, can mimic the effect of PGE2 on zymosan-induced IL-23 production, and rp-cAMP, a protein kinase A (PKA) inhibitor, can block the effect of PGE2. Dinoprostone 257-261 interleukin 23 subunit alpha Homo sapiens 166-171 26412948-9 2015 Moreover, PGE2 can increase zymosan-induced expression of the mRNA levels of both p19 and p40 subunits, which was mimicked by db-cAMP and forskolin. Dinoprostone 10-14 interleukin 23 subunit alpha Homo sapiens 82-85 26412948-10 2015 Our data suggest that PGE2 elevates the production of IL-23 in human Mo-DCs via a cAMP dependent pathway. Dinoprostone 22-26 interleukin 23 subunit alpha Homo sapiens 54-59 23645882-0 2013 Increased Th17 cells in the tumor microenvironment is mediated by IL-23 via tumor-secreted prostaglandin E2. Dinoprostone 91-107 interleukin 23 subunit alpha Homo sapiens 66-71 23817417-8 2013 These findings show a critical role for the COX-2/PGE2 pathway in driving Th17-mediated synovial inflammation in an IL-23- and monocyte-independent manner. Dinoprostone 50-54 interleukin 23 subunit alpha Homo sapiens 116-121 24170779-6 2014 PGE2 also stabilizes the suppressive function of myeloid-derived suppressor cells, inhibits the release of IL-12 p70 by macrophages and dendritic cells, and may enhance the production of IL-23. Dinoprostone 0-4 interleukin 23 subunit alpha Homo sapiens 187-192 23645882-5 2013 Our data further indicate that tumor-secreted PGE2 through EP2 and EP4 receptors enhanced IL-23 p19 gene transcription through binding to the cAMP-response element in the p19 promoter. Dinoprostone 46-50 interleukin 23 subunit alpha Homo sapiens 90-99 23645882-5 2013 Our data further indicate that tumor-secreted PGE2 through EP2 and EP4 receptors enhanced IL-23 p19 gene transcription through binding to the cAMP-response element in the p19 promoter. Dinoprostone 46-50 interleukin 23 subunit alpha Homo sapiens 96-99 23645882-6 2013 Blocking PGE2 synthesis by NS398, a COX2 inhibitor, abrogated the enhancement of p19 expression both in vitro and in vivo. Dinoprostone 9-13 interleukin 23 subunit alpha Homo sapiens 81-84 23645882-7 2013 Furthermore, blocking protein kinase A (PKA) by H89 completely abrogated the inductive effects of tumor-conditioned medium and PGE2 on p19 transcription, whereas the cAMP active analog, Forskolin, mimics the PGE2 effect. Dinoprostone 127-131 interleukin 23 subunit alpha Homo sapiens 135-138 23645882-8 2013 Taken together, our results indicate that tumor-secreted PGE2 induces IL-23, but not IL-12, production in the tumor microenvironment, leading to Th17 cell expansion. Dinoprostone 57-61 interleukin 23 subunit alpha Homo sapiens 70-75 23645882-9 2013 This inductive effect of PGE2 on IL-23 p19 transcription is mediated through cAMP/PKA signaling transduction pathway. Dinoprostone 25-29 interleukin 23 subunit alpha Homo sapiens 33-38 23645882-9 2013 This inductive effect of PGE2 on IL-23 p19 transcription is mediated through cAMP/PKA signaling transduction pathway. Dinoprostone 25-29 interleukin 23 subunit alpha Homo sapiens 39-42 22977257-0 2012 Prostaglandin E2-induced IL-23p19 subunit is regulated by cAMP-responsive element-binding protein and C/AATT enhancer-binding protein beta in bone marrow-derived dendritic cells. Dinoprostone 0-16 interleukin 23 subunit alpha Homo sapiens 25-33 22982753-8 2013 These effects of PGE2 were cAMP-dependent since the cAMP enhancer forskolin strongly reduced IL-23 and IL-12 production by monocytes. Dinoprostone 17-21 interleukin 23 subunit alpha Homo sapiens 93-98 22982753-9 2013 Taken together, PGE2 acts in an anti-inflammatory manner by lowering IL-23 production by monocytes while it has the opposite effect in DC. Dinoprostone 16-20 interleukin 23 subunit alpha Homo sapiens 69-74 22982753-0 2013 Prostaglandin E2 inhibits IL-23 and IL-12 production by human monocytes through down-regulation of their common p40 subunit. Dinoprostone 0-16 interleukin 23 subunit alpha Homo sapiens 26-31 22982753-3 2013 PGE2 has been shown to elevate the IL-23 production by dendritic cells (DC). Dinoprostone 0-4 interleukin 23 subunit alpha Homo sapiens 35-40 22982753-4 2013 Monocytes are also producers of IL-23 but the effect of PGE2 on IL-23 production by human monocytes has hardly been investigated. Dinoprostone 56-60 interleukin 23 subunit alpha Homo sapiens 64-69 22982753-5 2013 We show here that PGE2 blocks the production of IL-23 by LPS-stimulated monocytes in an IL-10 and IL-1beta independent manner. Dinoprostone 18-22 interleukin 23 subunit alpha Homo sapiens 48-53 22977257-2 2012 There is very little information on the molecular mechanisms involved in the PGE2-induced up-regulation of Il23a gene expression. Dinoprostone 77-81 interleukin 23 subunit alpha Homo sapiens 107-112 19273625-4 2009 In human purified naive T cells, PGE2 acts via prostaglandin receptor EP2- and EP4-mediated signaling and cyclic AMP pathways to up-regulate IL-23 and IL-1 receptor expression. Dinoprostone 33-37 interleukin 23 subunit alpha Homo sapiens 141-146 22542425-4 2012 Blocking PGE2 endogenous synthesis selectively reduces IL-23 production by DC in response to gonococcal stimulation, confirming recent data on PGE2/IL-23 crosstalk. Dinoprostone 9-13 interleukin 23 subunit alpha Homo sapiens 55-60 22542425-4 2012 Blocking PGE2 endogenous synthesis selectively reduces IL-23 production by DC in response to gonococcal stimulation, confirming recent data on PGE2/IL-23 crosstalk. Dinoprostone 9-13 interleukin 23 subunit alpha Homo sapiens 143-153 21884514-6 2011 Conversely, IL-23 plus IL-1beta partially opposed the PGE2-mediated repression of early interferon gamma (IFN-gamma) secretion from CD161(+) cells, as well as the PGE2-mediated depletion of IFN-gamma(+) CD161(+) cells. Dinoprostone 54-58 interleukin 23 subunit alpha Homo sapiens 12-17 21884514-6 2011 Conversely, IL-23 plus IL-1beta partially opposed the PGE2-mediated repression of early interferon gamma (IFN-gamma) secretion from CD161(+) cells, as well as the PGE2-mediated depletion of IFN-gamma(+) CD161(+) cells. Dinoprostone 163-167 interleukin 23 subunit alpha Homo sapiens 12-17 19273625-9 2009 These findings, together with the altered IL-12/IL-23 balance induced by PGE2 in dendritic cells, further highlight the crucial role of the inflammatory microenvironment in Th17 cell development and regulation. Dinoprostone 73-77 interleukin 23 subunit alpha Homo sapiens 48-53 18566439-0 2008 In vitro differentiation of dendritic cells in the presence of prostaglandin E2 alters the IL-12/IL-23 balance and promotes differentiation of Th17 cells. Dinoprostone 63-79 interleukin 23 subunit alpha Homo sapiens 97-102 17548652-0 2007 The proinflammatory effect of prostaglandin E2 in experimental inflammatory bowel disease is mediated through the IL-23-->IL-17 axis. Dinoprostone 30-46 interleukin 23 subunit alpha Homo sapiens 114-119 17548652-8 2007 These studies suggest that high levels of PGE(2) exacerbate the inflammatory process through the preferential expression and release of DC-derived IL-23 and the subsequent support of the autoreactive/inflammatory Th17 phenotype. Dinoprostone 42-48 interleukin 23 subunit alpha Homo sapiens 147-152 15180965-0 2004 Prostaglandin E2 induces IL-23 production in bone marrow-derived dendritic cells. Dinoprostone 0-16 interleukin 23 subunit alpha Homo sapiens 25-30 15180965-4 2004 Here, we examined the effects of PGE2, a well-known immunomodulator, on the production of IL-23 by bone marrow- derived dendritic cells (BM-DCs). Dinoprostone 33-37 interleukin 23 subunit alpha Homo sapiens 90-95 15180965-5 2004 Our results indicate that PGE2 increases the production of functional IL-23 from immature BM-DCs in a time- and dose-dependent manner. Dinoprostone 26-30 interleukin 23 subunit alpha Homo sapiens 70-75 15180965-6 2004 PGE2 induces both the expression of p19 and p40, without affecting p35 expression. Dinoprostone 0-4 interleukin 23 subunit alpha Homo sapiens 36-39 15180965-8 2004 Although PGE2 also induces IL-1beta and IL-6 expression in non-stimulated DCs, the stimulatory effect of PGE2 on IL-23 production is not mediated through IL-1beta or IL-6. Dinoprostone 105-109 interleukin 23 subunit alpha Homo sapiens 113-118 15180965-9 2004 GM-CSF, the pro-inflammatory cytokine required for the generation of BM-DCs, amplifies the IL-23 inducing activity of PGE2 in a synergistic manner. Dinoprostone 118-122 interleukin 23 subunit alpha Homo sapiens 91-96