PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31917192-5 2020 In this study, we demonstrate that KRIT1 loss-of-function in stromal cells, such as fibroblasts, causes the up-regulation of NADPH oxidase isoform 1 (NOX1) and the activation of inflammatory pathways, which in turn promote an enhanced production of proangiogenic factors, including vascular endothelial growth factor (VEGF) and prostaglandin E2 (PGE2). Dinoprostone 328-344 KRIT1 ankyrin repeat containing Homo sapiens 35-40 31917192-5 2020 In this study, we demonstrate that KRIT1 loss-of-function in stromal cells, such as fibroblasts, causes the up-regulation of NADPH oxidase isoform 1 (NOX1) and the activation of inflammatory pathways, which in turn promote an enhanced production of proangiogenic factors, including vascular endothelial growth factor (VEGF) and prostaglandin E2 (PGE2). Dinoprostone 346-350 KRIT1 ankyrin repeat containing Homo sapiens 35-40