PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21635971-7 2011 The results showed that PGE2 inhibited IFN-gamma, TNF-alpha and IL-4 production by CD4+ T cells 24h after cell culture. Dinoprostone 24-28 interleukin 4 Homo sapiens 64-68 30297869-9 2018 Furthermore, following androgen deprivation, elevated PGE2-EP2 signaling inhibited the expression of CD4 in thymocytes, and subsequently induced the polarization of CD4low naive T cells towards the IL-4-expressing TH17 phenotype via up-regulation of IL23R. Dinoprostone 54-58 interleukin 4 Homo sapiens 198-202 25793979-4 2015 Here we found that human immature DCs derived from the differentiation of monocytes cultured with GM-CSF and IL-4 release substantial concentrations of PGE2, which, however, were significantly inhibited after challenge with P. brasiliensis. Dinoprostone 152-156 interleukin 4 Homo sapiens 109-113 22262978-6 2012 IL-4 can inhibit basal and stimulated expression of COX-2 and microsomal PGE synthase 1 leading to decreased capacity for PGE(2) secretion. Dinoprostone 122-128 interleukin 4 Homo sapiens 0-4 26936936-0 2016 PLA2G5 regulates transglutaminase activity of human IL-4-activated M2 macrophages through PGE2 generation. Dinoprostone 90-94 interleukin 4 Homo sapiens 52-56 26936936-9 2016 Thus, our study shows a novel function of group V phospholipase A2 in regulating the transglutaminase activity of human interleukin-4-activated M2 macrophages through prostaglandin E2 generation and suggests that group V phospholipase A2 is a functionally relevant enzyme that may have therapeutic value for the treatment of human T-helper-2 inflammatory disorders. Dinoprostone 167-183 interleukin 4 Homo sapiens 120-133 23369567-4 2012 The establishment of a positive feedback loop between PGE2 and COX2, the key regulator of PGE2 synthesis, is both necessary and sufficient to promote the development of CD1a+ DCs to CD14+CD33+CD34+ monocytic MDSCs in granulocyte macrophage colony stimulating factor/IL-4-supplemented monocyte cultures, their stability, production of multiple immunosuppressive mediators and cytotoxic T lymphocyte-suppressive function. Dinoprostone 54-58 interleukin 4 Homo sapiens 266-270 21635971-8 2011 A comparison between IFN-gamma and IL-4 production showed that PGE2 enhanced the relative ratio of IL-4 to IFN-gamma in CD4+ T cells culture, and regulated CD4+ T cells toward Th2 cell development. Dinoprostone 63-67 interleukin 4 Homo sapiens 35-39 21635971-8 2011 A comparison between IFN-gamma and IL-4 production showed that PGE2 enhanced the relative ratio of IL-4 to IFN-gamma in CD4+ T cells culture, and regulated CD4+ T cells toward Th2 cell development. Dinoprostone 63-67 interleukin 4 Homo sapiens 99-103 17302909-10 2007 Furthermore, exogenous addition of prostaglandin E2 (PGE2) restored IL-4 inhibition on TGF-beta induced VEGF production. Dinoprostone 35-51 interleukin 4 Homo sapiens 68-72 20416182-20 2010 PGE2 influences the production of IFN-gamma and IL-4, and significantly influences peak appearance of IFN-gamma produced by T lymphocyte. Dinoprostone 0-4 interleukin 4 Homo sapiens 48-52 20416182-22 2010 PGE2 enhances the ratio of CD4+IL-4+T lymphocytes to CD4+IFN-gamma+T lymphocytes and the ratio of CD8+IL-4+T lymphocytes to CD8+IFN-gamma+T lymphocytes, and regulates development of T cells toward Th2/Tc2 cells. Dinoprostone 0-4 interleukin 4 Homo sapiens 31-35 20416182-22 2010 PGE2 enhances the ratio of CD4+IL-4+T lymphocytes to CD4+IFN-gamma+T lymphocytes and the ratio of CD8+IL-4+T lymphocytes to CD8+IFN-gamma+T lymphocytes, and regulates development of T cells toward Th2/Tc2 cells. Dinoprostone 0-4 interleukin 4 Homo sapiens 102-106 17302909-10 2007 Furthermore, exogenous addition of prostaglandin E2 (PGE2) restored IL-4 inhibition on TGF-beta induced VEGF production. Dinoprostone 53-57 interleukin 4 Homo sapiens 68-72 16827895-6 2006 PGE2 significantly and dose-dependently inhibited the proliferation and subsequent production of interleukin-4 by Cry j 1-specific TCLs and of interferon-gamma by PPD-specific TCLs upon antigen stimulation. Dinoprostone 0-4 interleukin 4 Homo sapiens 97-110 16771863-3 2006 Addition of the fluid to adherent peripheral blood monocytes cultured in GM-CSF/IL-4 stimulates release of prostaglandin E2 (PGE2) and IL-6. Dinoprostone 107-123 interleukin 4 Homo sapiens 80-84 16771863-3 2006 Addition of the fluid to adherent peripheral blood monocytes cultured in GM-CSF/IL-4 stimulates release of prostaglandin E2 (PGE2) and IL-6. Dinoprostone 125-129 interleukin 4 Homo sapiens 80-84 16771863-4 2006 Exposure of differentiating DC to the fluid during the 7-day culture in GM-CSF/IL-4 impairs their subsequent ability to secrete IL-12, IL-6 or PGE2 in response to lipopolysaccharide (LPS) stimulation. Dinoprostone 143-147 interleukin 4 Homo sapiens 79-83 16574063-0 2006 IL-4 regulates COX-2 and PGE2 production in human non-small cell lung cancer. Dinoprostone 25-29 interleukin 4 Homo sapiens 0-4 16574063-3 2006 We found that IL-4 inhibited constitutive COX-2 expression and PGE(2) production in A427 and H2122 NSCLC cell lines, and also suppressed IL-1beta-induced COX-2 expression in A549 and RH2 NSCLC cell lines. Dinoprostone 63-69 interleukin 4 Homo sapiens 14-18 16210363-5 2006 We report here that interferon-gamma and IL-4, representative of these respective classes of cytokines, attenuate IL-1beta-provoked PGE2 production. Dinoprostone 132-136 interleukin 4 Homo sapiens 41-45 16297873-3 2006 The data presented demonstrate that IL-4 alone can inhibit nitrite release in the presence and absence of IL-1beta and partially reverse the IL-1beta induced PGE2 release. Dinoprostone 158-162 interleukin 4 Homo sapiens 36-40 16297873-4 2006 When provided in combination, IL-4 and dynamic compression could further abrogate the IL-1beta induced nitrite and PGE2 release. Dinoprostone 115-119 interleukin 4 Homo sapiens 30-34 12792814-3 2003 Here we show that lipopolysaccharide (lps) induces COX-2 mRNA and protein synthesis as well as the release of PGE2 in human interleukin-4 and granulocyte/macrophage colony-stimulating factor-differentiated monocyte-derived DC cultivated in the presence of 1% human plasma. Dinoprostone 110-114 interleukin 4 Homo sapiens 124-190 15596223-1 2004 OBJECTIVE: We hypothesized that interleukin-4 (IL-4) and interleukin-10 (IL-10) diminish production of PGE2 by lipopolysaccharide (LPS)-stimulated cultured human decidual cells. Dinoprostone 103-107 interleukin 4 Homo sapiens 32-45 15596223-1 2004 OBJECTIVE: We hypothesized that interleukin-4 (IL-4) and interleukin-10 (IL-10) diminish production of PGE2 by lipopolysaccharide (LPS)-stimulated cultured human decidual cells. Dinoprostone 103-107 interleukin 4 Homo sapiens 47-51 15596223-5 2004 PGE2 concentration in cells co-incubated with IL-4 and LPS (8975+/-5249 pg/mL) was lower than in the LPS-alone group (p=0.005). Dinoprostone 0-4 interleukin 4 Homo sapiens 46-50 15596223-7 2004 CONCLUSIONS: IL-4 reduced LPS-stimulated PGE2 production in decidual cells while IL-10 did not. Dinoprostone 41-45 interleukin 4 Homo sapiens 13-17 15183150-5 2004 In contrast, human recombinant IL-4 inhibited PGE(2) production and shifted the cilomilast concentration-dependence curve to the right in both systems. Dinoprostone 46-52 interleukin 4 Homo sapiens 31-35 12562325-4 2003 The addition of increasing amounts of allergen during DC maturation with tumour necrosis factor-alpha, IL-1beta and prostaglandin E2 resulted in enhanced secretion of IL-6 and IL-12 by DC followed by increased production of Th1 (interferon-gamma; IFN-gamma) as well as Th2 (IL-4, IL-5) cytokines by CD4+ T cells. Dinoprostone 116-132 interleukin 4 Homo sapiens 274-278 11821061-3 2002 We show here that one effect of interleukin (IL)-4, which is used together with GM-CSF to generate moDCs, is the suppression of endogenous PGE2 production in moDCs. Dinoprostone 139-143 interleukin 4 Homo sapiens 32-50 11821061-6 2002 IL-4-mediated suppression of PGE2 biosynthesis in human moDCs explains the previously reported maturation-enhancing effect of exogenous PGE2. Dinoprostone 29-33 interleukin 4 Homo sapiens 0-4 11821061-6 2002 IL-4-mediated suppression of PGE2 biosynthesis in human moDCs explains the previously reported maturation-enhancing effect of exogenous PGE2. Dinoprostone 136-140 interleukin 4 Homo sapiens 0-4 11266376-10 2001 IL-4 and IL-13, which are known to activate PI 3-kinase, down-regulated HT-29 COX-2 mRNA, protein, and PGE2 production. Dinoprostone 103-107 interleukin 4 Homo sapiens 0-4 10570308-0 1999 Prostaglandin E2 selectively inhibits human CD4+ T cells secreting low amounts of both IL-2 and IL-4. Dinoprostone 0-16 interleukin 4 Homo sapiens 96-100 10570308-4 1999 It was found that the PGE2-sensitive T cells were characterized by low production (<200 pg/ml) of both IL-2 and IL-4, while PGE2-resistant T cells secreted high levels (>1000 pg/ml) of IL-2, IL-4, or both. Dinoprostone 22-26 interleukin 4 Homo sapiens 115-119 10570308-4 1999 It was found that the PGE2-sensitive T cells were characterized by low production (<200 pg/ml) of both IL-2 and IL-4, while PGE2-resistant T cells secreted high levels (>1000 pg/ml) of IL-2, IL-4, or both. Dinoprostone 22-26 interleukin 4 Homo sapiens 197-201 10570308-5 1999 The roles of IL-2 and IL-4 were confirmed by the finding that addition of exogenous lymphokines could restore PGE2-inhibited proliferation, and PGE2-resistant Th1-, Th2-, and Th0-like clones became PGE2 sensitive when IL-2, IL-4, or both were removed using Abs specific for the respective lymphokines. Dinoprostone 110-114 interleukin 4 Homo sapiens 22-26 10570308-5 1999 The roles of IL-2 and IL-4 were confirmed by the finding that addition of exogenous lymphokines could restore PGE2-inhibited proliferation, and PGE2-resistant Th1-, Th2-, and Th0-like clones became PGE2 sensitive when IL-2, IL-4, or both were removed using Abs specific for the respective lymphokines. Dinoprostone 110-114 interleukin 4 Homo sapiens 224-228 10570308-5 1999 The roles of IL-2 and IL-4 were confirmed by the finding that addition of exogenous lymphokines could restore PGE2-inhibited proliferation, and PGE2-resistant Th1-, Th2-, and Th0-like clones became PGE2 sensitive when IL-2, IL-4, or both were removed using Abs specific for the respective lymphokines. Dinoprostone 144-148 interleukin 4 Homo sapiens 22-26 10570308-5 1999 The roles of IL-2 and IL-4 were confirmed by the finding that addition of exogenous lymphokines could restore PGE2-inhibited proliferation, and PGE2-resistant Th1-, Th2-, and Th0-like clones became PGE2 sensitive when IL-2, IL-4, or both were removed using Abs specific for the respective lymphokines. Dinoprostone 144-148 interleukin 4 Homo sapiens 22-26 10385254-6 1999 PGE2 suppressed TCR-induced messenger RNA (mRNA) expression of IL-2, IL-4 and IL-5, as well as proliferation and CD25 expression. Dinoprostone 0-4 interleukin 4 Homo sapiens 69-73 10570308-8 1999 In summary, PGE2 predominantly suppressed CD45RA-RO+ CD4+ T cells with low secretion of both IL-2 and IL-4. Dinoprostone 12-16 interleukin 4 Homo sapiens 102-106 10431483-0 1999 Interleukin-4 adenoviral gene therapy reduces production of inflammatory cytokines and prostaglandin E2 by rheumatoid arthritis synovium ex vivo. Dinoprostone 87-103 interleukin 4 Homo sapiens 0-13 10431483-12 1999 In ST explants as well as RA synovial fibroblasts, IL-4 treatment decreased prostaglandin E2 (PGE2) production. Dinoprostone 76-92 interleukin 4 Homo sapiens 51-55 10431483-12 1999 In ST explants as well as RA synovial fibroblasts, IL-4 treatment decreased prostaglandin E2 (PGE2) production. Dinoprostone 94-98 interleukin 4 Homo sapiens 51-55 10431483-13 1999 CONCLUSIONS: Increased expression of IL-4 via gene therapy may decrease RA-associated inflammation by reducing proinflammatory cytokines and PGE2. Dinoprostone 141-145 interleukin 4 Homo sapiens 37-41 10336593-4 1999 OBJECTIVE: To assess interferon (IFN)-gamma, IL-4 and IL-5 mRNA expressions and their control by prostaglandin E2 (PGE2), which activates adenylyl cyclases, of peripheral T lymphocytes from patients with moderately severe asthma and healthy controls. Dinoprostone 97-113 interleukin 4 Homo sapiens 45-49 10336593-4 1999 OBJECTIVE: To assess interferon (IFN)-gamma, IL-4 and IL-5 mRNA expressions and their control by prostaglandin E2 (PGE2), which activates adenylyl cyclases, of peripheral T lymphocytes from patients with moderately severe asthma and healthy controls. Dinoprostone 115-119 interleukin 4 Homo sapiens 45-49 10336593-10 1999 Accumulation of mRNA for IFN-gamma, IL-4 and IL-5 mRNA were significantly diminished by 10-5 m PGE2 in both asthmatics and controls. Dinoprostone 95-99 interleukin 4 Homo sapiens 36-40 10336593-11 1999 In contrast, 10-6 m PGE2 significantly down-regulated IFN-gamma and IL-4 mRNAs (P < 0.05 for both IFN-gamma and IL-4, n = 4) in the control group, whereas this was not observed for IL-4 mRNA in the asthma group (n = 7). Dinoprostone 20-24 interleukin 4 Homo sapiens 68-72 10336593-11 1999 In contrast, 10-6 m PGE2 significantly down-regulated IFN-gamma and IL-4 mRNAs (P < 0.05 for both IFN-gamma and IL-4, n = 4) in the control group, whereas this was not observed for IL-4 mRNA in the asthma group (n = 7). Dinoprostone 20-24 interleukin 4 Homo sapiens 115-119 10336593-11 1999 In contrast, 10-6 m PGE2 significantly down-regulated IFN-gamma and IL-4 mRNAs (P < 0.05 for both IFN-gamma and IL-4, n = 4) in the control group, whereas this was not observed for IL-4 mRNA in the asthma group (n = 7). Dinoprostone 20-24 interleukin 4 Homo sapiens 115-119 10211885-0 1999 Inhibition of tumor necrosis factor alpha-induced prostaglandin E2 production by the antiinflammatory cytokines interleukin-4, interleukin-10, and interleukin-13 in osteoarthritic synovial fibroblasts: distinct targeting in the signaling pathways. Dinoprostone 50-66 interleukin 4 Homo sapiens 112-125 10211885-1 1999 OBJECTIVE: To investigate the effects of the antiinflammatory cytokines interleukin-4 (IL-4), IL-10, and IL-13 on tumor necrosis factor alpha (TNFalpha)-induced prostaglandin E2 (PGE2) release in the cellular signaling cascade on human osteoarthritis (OA) synovial fibroblasts. Dinoprostone 161-177 interleukin 4 Homo sapiens 72-85 10211885-1 1999 OBJECTIVE: To investigate the effects of the antiinflammatory cytokines interleukin-4 (IL-4), IL-10, and IL-13 on tumor necrosis factor alpha (TNFalpha)-induced prostaglandin E2 (PGE2) release in the cellular signaling cascade on human osteoarthritis (OA) synovial fibroblasts. Dinoprostone 161-177 interleukin 4 Homo sapiens 87-91 10211885-3 1999 RESULTS: IL-4, IL-10, and IL-13 at 5 ng/ml dramatically reduced TNFalpha-induced PGE2 release by approximately 90% (P < 0.0001). Dinoprostone 81-85 interleukin 4 Homo sapiens 9-13 10397407-3 1999 IL-4 (0.08-10 ng/ml) potently inhibited cytokine-stimulated PGE2 production over 16 h (maximal inhibition approximately 66% at 2.0 ng/ml IL-4). Dinoprostone 60-64 interleukin 4 Homo sapiens 0-4 10065757-6 1999 IL-4 and IFN-gamma suppressed PGE2 production by IL-1beta-stimulated PDL fibroblasts, but COX activity enhanced by IL-1beta treatment was significantly inhibited by IL-4, not by IFN-gamma. Dinoprostone 30-34 interleukin 4 Homo sapiens 0-4 10065757-9 1999 These data suggest that COX-2 is primarily responsible for PGE2 production by IL-1beta-stimulated human PDL fibroblasts and that IL-4 inhibited PGE2 production by IL-1beta-stimulated PDL fibroblasts through down-regulation of COX-2 expression, while IFN-gamma suppressed the PGE2 production with no effect on COX-2 expression. Dinoprostone 144-148 interleukin 4 Homo sapiens 129-133 10065757-9 1999 These data suggest that COX-2 is primarily responsible for PGE2 production by IL-1beta-stimulated human PDL fibroblasts and that IL-4 inhibited PGE2 production by IL-1beta-stimulated PDL fibroblasts through down-regulation of COX-2 expression, while IFN-gamma suppressed the PGE2 production with no effect on COX-2 expression. Dinoprostone 144-148 interleukin 4 Homo sapiens 129-133 9973539-6 1999 In monocytes, rhIL-4delta2 blocked inhibitory action of hIL-4 on LPS-induced cyclooxygenase-2 expression and subsequent prostaglandin E2 secretion. Dinoprostone 120-136 interleukin 4 Homo sapiens 15-20 9845672-10 1998 Increased production of prostaglandin E2 (PGE2) in response to TNF-alpha and IL-1beta treatment was attenuated by IL-4 pretreatment, by 52% and 72%, respectively. Dinoprostone 24-40 interleukin 4 Homo sapiens 114-118 9845672-10 1998 Increased production of prostaglandin E2 (PGE2) in response to TNF-alpha and IL-1beta treatment was attenuated by IL-4 pretreatment, by 52% and 72%, respectively. Dinoprostone 42-46 interleukin 4 Homo sapiens 114-118 10397407-3 1999 IL-4 (0.08-10 ng/ml) potently inhibited cytokine-stimulated PGE2 production over 16 h (maximal inhibition approximately 66% at 2.0 ng/ml IL-4). Dinoprostone 60-64 interleukin 4 Homo sapiens 137-141 10397407-7 1999 In the presence of arachidonic acid (10 microM), IL-4 again inhibited cytokine-stimulated, but not EGF-stimulated, PGE2 production. Dinoprostone 115-119 interleukin 4 Homo sapiens 49-53 9698603-2 1998 Lipopolysaccharide (LPS)-stimulated PGE2 synthesis and COX activity were suppressed significantly by IL-4, but were not affected significantly by IL-10, IL-13, or IFN-gamma. Dinoprostone 36-40 interleukin 4 Homo sapiens 101-105 9870074-4 1998 RESULTS: Both IL-10 and IL-4 inhibited IL-1 beta- and TNF-alpha-induced PGE2 production but had no significant effects on the production of PGE2 under basal conditions. Dinoprostone 72-76 interleukin 4 Homo sapiens 24-28 9870076-3 1998 We compared the effects of IL-4 and IL-13 on the production of cytokines and prostaglandin E2 (PGE2) in epithelial amnion-derived WISH cells. Dinoprostone 77-93 interleukin 4 Homo sapiens 27-31 9870076-6 1998 RESULTS: Both IL-4 and IL-13 inhibited PGE2 production with indistinguishable concentration-response curves, under basal or stimulated conditions. Dinoprostone 39-43 interleukin 4 Homo sapiens 14-18 9870076-7 1998 The maximal inhibition of IL-1 beta-stimulated PGE2 production (to 28% +/- 10% of control) was seen at 10 ng/ml of IL-4 or IL-13. Dinoprostone 47-51 interleukin 4 Homo sapiens 115-119 9698603-7 1998 IL-4, IL-10, and IL-13 significantly suppressed LPS-dependent PGE2 synthesis and COX-2 mRNA induction in monocytes, whereas only IL-4 significantly suppressed them in AM. Dinoprostone 62-66 interleukin 4 Homo sapiens 0-4 9704637-9 1998 Although IL-1-induced levels of PGE2 are reduced by IL-4, exogenous addition of PGE2 does not abrogate the inhibitory effects of IL-4 on MMP expression. Dinoprostone 32-36 interleukin 4 Homo sapiens 52-56 9528885-2 1998 The production of IFN-gamma and IL-4 and the development of Th cells into either high IFN-gamma or high IL-4 producers is strongly influenced by factors produced by antigen-presenting cells (APC), like IL-12 and prostaglandin E2 (PGE2). Dinoprostone 212-228 interleukin 4 Homo sapiens 32-36 9704637-10 1998 CONCLUSION: IL-4 inhibits IL-1 induction of both collagenase and stromelysin, as well as PGE2 production, in human synovial fibroblasts. Dinoprostone 89-93 interleukin 4 Homo sapiens 12-16 9704637-11 1998 The inhibition occurs at least in part at the level of transcription, does not affect binding of transcription factor AP-1, and appears to involve a mechanism that is independent of the ability of IL-4 to inhibit production of PGE2. Dinoprostone 227-231 interleukin 4 Homo sapiens 197-201 9870076-10 1998 CONCLUSIONS: The inhibition of PGE2 and IL-8 production by IL-4 in WISH cells is mimicked by IL-13. Dinoprostone 31-35 interleukin 4 Homo sapiens 59-63 9528885-2 1998 The production of IFN-gamma and IL-4 and the development of Th cells into either high IFN-gamma or high IL-4 producers is strongly influenced by factors produced by antigen-presenting cells (APC), like IL-12 and prostaglandin E2 (PGE2). Dinoprostone 212-228 interleukin 4 Homo sapiens 104-108 9528885-2 1998 The production of IFN-gamma and IL-4 and the development of Th cells into either high IFN-gamma or high IL-4 producers is strongly influenced by factors produced by antigen-presenting cells (APC), like IL-12 and prostaglandin E2 (PGE2). Dinoprostone 230-234 interleukin 4 Homo sapiens 104-108 9528885-4 1998 The aim of this study was to test whether the increased IL-4/IFN-gamma production ratio by Th cells in AD can be explained by an increased PGE2/IL-12 production ratio by the APC. Dinoprostone 139-143 interleukin 4 Homo sapiens 56-60 9500483-5 1998 Statistical comparisons between prostaglandin E2, cyclooxygenase-1, and cyclooxygenase-2 concentrations for each interleukin-4 concentration were performed using a one way analysis of variance. Dinoprostone 32-48 interleukin 4 Homo sapiens 113-126 9500483-6 1998 RESULTS: Incubation of human umbilical vein endothelial cells in media containing interleukin-4 resulted in a significant increase in both prostaglandin E2 and cyclooxygenase-2 for interleukin-4 concentrations greater than 50 ng/ml (p < 0.05). Dinoprostone 139-155 interleukin 4 Homo sapiens 82-95 9500483-6 1998 RESULTS: Incubation of human umbilical vein endothelial cells in media containing interleukin-4 resulted in a significant increase in both prostaglandin E2 and cyclooxygenase-2 for interleukin-4 concentrations greater than 50 ng/ml (p < 0.05). Dinoprostone 139-155 interleukin 4 Homo sapiens 181-194 9464843-4 1997 PGE2 primes naive T cells in a dose-dependent fashion for production of high levels of IL-4, IL-10 and IL-13, and very low levels of IL-2, interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha, and TNF-beta. Dinoprostone 0-4 interleukin 4 Homo sapiens 87-91 9464843-8 1997 Thus PGE2 does not act by increasing IL-4 production in priming cultures, and its effects are partly IL-4 independent and largely IL-2 independent. Dinoprostone 5-9 interleukin 4 Homo sapiens 101-105 9286387-2 1997 Addition of PGE2 (10(-9) M-10(-6) M) to the cultures performed in the presence of GM-CSF and IL-4 did not alter the morphology nor high levels of expression of class II MHC and co-stimulatory molecules on arising DC, although at concentrations above 10(-8) M, the acquisition of CD1a was selectively prevented. Dinoprostone 12-16 interleukin 4 Homo sapiens 93-97 9200435-6 1997 Control DC induced the development of Th0-like cells from superantigen-activated naive Th cells, whereas PGE2-DC promoted the development of Th cells that produced high amounts of IL-4 and IL-5. Dinoprostone 105-109 interleukin 4 Homo sapiens 180-184 9348319-3 1997 Here we investigated the effects of PGE2 on human dendritic cells (DCs) which develop in the presence of GM-CSF and IL-4. Dinoprostone 36-40 interleukin 4 Homo sapiens 116-120 9352015-6 1997 IL-1 beta and IL-4 also caused six- and two-fold increases, respectively, in culture fluid PGE2 concentrations. Dinoprostone 91-95 interleukin 4 Homo sapiens 14-18 9352015-8 1997 CONCLUSIONS: Based on these results, it is proposed that IL-1 beta and IL-4 may be involved in the initiation and promotion of labor by inducing EP1 levels and PGE2 production in amnion. Dinoprostone 160-164 interleukin 4 Homo sapiens 71-75 9057644-4 1997 IL-10 and IL-4 selectively inhibited their LPS-induced PGE2 production. Dinoprostone 55-59 interleukin 4 Homo sapiens 10-14 9057644-7 1997 LPS-induced PGE2 and thromboxane B2 (TXB2) production in aspirin-treated neutrophils was significantly inhibited by IL-10, IL-4, and NS-398. Dinoprostone 12-16 interleukin 4 Homo sapiens 123-127 9188940-12 1997 The IL-4 production is inhibited by interferon gamma and by prostaglandin E2. Dinoprostone 60-76 interleukin 4 Homo sapiens 4-8 9286387-6 1997 Compared to control DC, PGE2-DC induced development of Th cells secreting elevated amounts of IL-4 and IL-5, from naive precursors. Dinoprostone 24-28 interleukin 4 Homo sapiens 94-98 8660843-3 1996 Using DNA transfection and electrophoretic mobility shift assays (EMSA), we have examined the mechanisms for the transcriptional regulation of human IL-2 and IL-4 genes by PGE2. Dinoprostone 172-176 interleukin 4 Homo sapiens 158-162 8912884-2 1996 Our previous studies demonstrated that the suppression of monocyte matrix metalloproteinase production by IL-4 is a result of its inhibition of PGE2 synthesis, which was attributed to an effect on prostaglandin synthase. Dinoprostone 144-148 interleukin 4 Homo sapiens 106-110 8858999-5 1996 cAMP-elevating agents, such as PGE2, forskolin and dibutyryl cAMP, suppressed IL-2, IL-4 and IL-5 production by concanavalin A-stimulated PBMC in a manner similar to that of T-440. Dinoprostone 31-35 interleukin 4 Homo sapiens 84-88 8874384-0 1996 Interleukin-4, transforming growth factor beta 1, and dexamethasone inhibit superantigen-induced prostaglandin E2-dependent collagenase gene expression through their action on cyclooxygenase-2 and cytosolic phospholipase A2. Dinoprostone 97-113 interleukin 4 Homo sapiens 0-13 8874384-5 1996 IL-4, TGF-beta 1, and DXS abolished PGE2 production and the expression of COX-2 and cPLA2 but failed to affect the constitutive expression of COX-1 and secreted PLA2. Dinoprostone 36-40 interleukin 4 Homo sapiens 0-4 8912884-7 1996 Moreover, the ability of exogenously added PGE2 or Bt2cAMP to restore PGHS-2 production in IL-4-treated monocytes further suggested early disruption of the pathway. Dinoprostone 43-47 interleukin 4 Homo sapiens 91-95 8871051-4 1996 PGE2 favours Th2-like cytokine secretion profiles by inhibiting the production of the Th1-associated cytokines, IL-2 and IFN-gamma, and in the presence of sufficient levels of IL-2, upregulating the production of the Th2-associated cytokines, IL-4 and IL-5, IL-12, on the other hand, induces and enhances IFN-gamma secretion in activated CD4+ T-cells, thereby promoting the generation of Th1 cells. Dinoprostone 0-4 interleukin 4 Homo sapiens 243-247 8694577-0 1996 Interleukin-4 inhibits prostaglandin E2 production by freshly prepared adherent rheumatoid synovial cells via inhibition of biosynthesis and gene expression of cyclo-oxygenase II but not of cyclo-oxygenase I. Dinoprostone 23-39 interleukin 4 Homo sapiens 0-13 8694577-1 1996 OBJECTIVE: To characterise the effect of interleukin-4 (IL-4) on the biosynthesis of cyclo-oxygenases I (COX I) and II (COX II), the rate limiting enzymes of the synthesis of prostaglandin E2 (PGE2), in freshly prepared rheumatoid synovial cells. Dinoprostone 175-191 interleukin 4 Homo sapiens 41-54 8694577-1 1996 OBJECTIVE: To characterise the effect of interleukin-4 (IL-4) on the biosynthesis of cyclo-oxygenases I (COX I) and II (COX II), the rate limiting enzymes of the synthesis of prostaglandin E2 (PGE2), in freshly prepared rheumatoid synovial cells. Dinoprostone 175-191 interleukin 4 Homo sapiens 56-60 8694577-1 1996 OBJECTIVE: To characterise the effect of interleukin-4 (IL-4) on the biosynthesis of cyclo-oxygenases I (COX I) and II (COX II), the rate limiting enzymes of the synthesis of prostaglandin E2 (PGE2), in freshly prepared rheumatoid synovial cells. Dinoprostone 193-197 interleukin 4 Homo sapiens 41-54 8694577-1 1996 OBJECTIVE: To characterise the effect of interleukin-4 (IL-4) on the biosynthesis of cyclo-oxygenases I (COX I) and II (COX II), the rate limiting enzymes of the synthesis of prostaglandin E2 (PGE2), in freshly prepared rheumatoid synovial cells. Dinoprostone 193-197 interleukin 4 Homo sapiens 56-60 8694577-7 1996 IL-4 had suppressive effects on the production of PGE2 by untreated or lipopolysaccharide (LPS) stimulated synovial cells. Dinoprostone 50-54 interleukin 4 Homo sapiens 0-4 8694577-11 1996 CONCLUSIONS: These results suggest that IL-4 might inhibit overproduction of PGE2 in rheumatoid synovia via selective inhibition of the biosynthesis of COX II, and that this inhibition might be specific to macrophage-like synovial cells. Dinoprostone 77-81 interleukin 4 Homo sapiens 40-44 8690914-2 1996 LPS-stimulated PGE2 synthesis and cyclooxygenase activity were suppressed by IL-4, IL-10, or IL-13. Dinoprostone 15-19 interleukin 4 Homo sapiens 77-81 8816327-6 1996 In addition, the HSP and PGE2 treatment used inhibited the production of the Th1 cytokines IL-2 and IFNg but had a differential modulatory effect on Th2 cytokine production, namely enhancing the production of IL-6 whilst simultaneously impairing the synthesis of IL-4 and IL-10. Dinoprostone 25-29 interleukin 4 Homo sapiens 263-267 8690914-6 1996 These results suggest that the reduction of LPS-induced PGE2 synthesis and cyclooxygenase activity by IL-4, IL-10, and IL-13 in HPBM are mainly due to the down-regulation of cyclooxygenase-2 selectively induced by LPS. Dinoprostone 56-60 interleukin 4 Homo sapiens 102-106 8599837-3 1996 Costimulation with ionomycin and PGE2 resulted in the same level of IL-4 promoter activity as the stimulation with ionomycin alone. Dinoprostone 33-37 interleukin 4 Homo sapiens 68-72 8848551-5 1996 The purpose of this study was to evaluate the effect of the cytokine interleukin-4 (IL-4) on cyclooxygenase activity and PGE2 production in amnion. Dinoprostone 121-125 interleukin 4 Homo sapiens 69-82 8848551-5 1996 The purpose of this study was to evaluate the effect of the cytokine interleukin-4 (IL-4) on cyclooxygenase activity and PGE2 production in amnion. Dinoprostone 121-125 interleukin 4 Homo sapiens 84-88 8848551-7 1996 An increase in both COX-2 enzyme and prostaglandin E2 (PGE2) production was observed for all concentrations of IL-4 greater than 25 ng/ml (P < 0.05, n = 8). Dinoprostone 37-53 interleukin 4 Homo sapiens 111-115 8848551-7 1996 An increase in both COX-2 enzyme and prostaglandin E2 (PGE2) production was observed for all concentrations of IL-4 greater than 25 ng/ml (P < 0.05, n = 8). Dinoprostone 55-59 interleukin 4 Homo sapiens 111-115 8848551-9 1996 Our data suggest that the cytokine IL-4 may be involved in the pathogenesis of premature labor by inducing COX-2 in amnion tissue resulting in increased production of PGE2 and subsequent myometrial activity. Dinoprostone 167-171 interleukin 4 Homo sapiens 35-39 8555492-6 1996 PGE2 inhibited the Con A- and alpha CD3/alpha CD28-induced accumulation of IL-4 mRNA in a dose-dependent fashion. Dinoprostone 0-4 interleukin 4 Homo sapiens 75-79 8555492-7 1996 Con A-induced IL-4 mRNA was inhibited by 10(-4) to 10(-7) mol/L PGE2; alpha CD3/alpha CD28-induced IL-4 mRNA was inhibited by 10(-5) to 10(-8) mol/L PGE2. Dinoprostone 64-68 interleukin 4 Homo sapiens 14-18 8568141-7 1996 Increased AD monocyte production of inflammatory factors (e.g., PGE2) and cytokines appears to increase IL-4 production by Th2 while suppressing IFN-gamma production by Th1. Dinoprostone 64-68 interleukin 4 Homo sapiens 104-108 8555492-7 1996 Con A-induced IL-4 mRNA was inhibited by 10(-4) to 10(-7) mol/L PGE2; alpha CD3/alpha CD28-induced IL-4 mRNA was inhibited by 10(-5) to 10(-8) mol/L PGE2. Dinoprostone 149-153 interleukin 4 Homo sapiens 99-103 8555492-11 1996 Finally, it was shown that, in accordance with the mRNA studies, db-cAMP and PGE2 suppressed the IL-4 secretion in Con A- and alpha CD3/alpha CD28-activated T cells. Dinoprostone 77-81 interleukin 4 Homo sapiens 97-101 9244174-0 1996 Stimulation of prostaglandin E2 synthesis by interleukin-1beta is amplified by interferons but inhibited by interleukin-4 in human amnion-derived WISH cells. Dinoprostone 15-31 interleukin 4 Homo sapiens 108-121 7559810-1 1995 Several studies have shown that interleukin-4 (IL-4) down-regulates synthesis of prostaglandin E2 (PGE2). Dinoprostone 81-97 interleukin 4 Homo sapiens 32-45 7559810-1 1995 Several studies have shown that interleukin-4 (IL-4) down-regulates synthesis of prostaglandin E2 (PGE2). Dinoprostone 81-97 interleukin 4 Homo sapiens 47-51 7559810-1 1995 Several studies have shown that interleukin-4 (IL-4) down-regulates synthesis of prostaglandin E2 (PGE2). Dinoprostone 99-103 interleukin 4 Homo sapiens 32-45 7559810-1 1995 Several studies have shown that interleukin-4 (IL-4) down-regulates synthesis of prostaglandin E2 (PGE2). Dinoprostone 99-103 interleukin 4 Homo sapiens 47-51 7873203-3 1995 Dexamethasone and interleukin-4 (IL-4) inhibited the IL-1 beta-induced PGE2 synthesis; the former inhibited the IL-1 beta-induced cyclooxygenase activity whereas the latter failed. Dinoprostone 71-75 interleukin 4 Homo sapiens 18-31 7559810-9 1995 We conclude that IL-4 down-regulates LPS-induced release of PGE2, by reducing expression of the enzyme, PGHS-2. Dinoprostone 60-64 interleukin 4 Homo sapiens 17-21 7780037-3 1995 While IL-4 weakly affected the spontaneous PGE2 production, it strongly inhibited its production when cells were stimulated with IL-1 beta and TNF-alpha. Dinoprostone 43-47 interleukin 4 Homo sapiens 6-10 7780037-10 1995 Thus, by inhibiting synoviocyte proliferation and inhibiting their secretion of PGE2 and GM-CSF, IL-4 displays on synoviocytes a series of biological effects which complements its anti-inflammatory properties on monocytes. Dinoprostone 80-84 interleukin 4 Homo sapiens 97-101 7780006-2 1995 The ability of interleukin 4 (IL-4) to suppress the production of TNF alpha, IL-1, IL-6, and PGE2 by activated monocytes prompted us to investigate a possible regulatory role for IL-4 in human gestation. Dinoprostone 93-97 interleukin 4 Homo sapiens 15-28 7780006-2 1995 The ability of interleukin 4 (IL-4) to suppress the production of TNF alpha, IL-1, IL-6, and PGE2 by activated monocytes prompted us to investigate a possible regulatory role for IL-4 in human gestation. Dinoprostone 93-97 interleukin 4 Homo sapiens 30-34 7873203-8 1995 However, the inhibition of the IL-1 beta-induced PGE2 synthesis by IL-4 was not mediated by the down-regulation of cyclooxygenase-2. Dinoprostone 49-53 interleukin 4 Homo sapiens 67-71 7843254-1 1995 Prostaglandin E2 (PGE2) favors T helper type 2 (Th2)-like cytokine secretion profiles in murine and human CD4+ T cells by inhibiting the production of the Th1-associated cytokines interleukin-2 (IL-2) and interferon-gamma (IFN-gamma) and up-regulating the production of the Th2-associated cytokines IL-4 and IL-5 in a dose-dependent way. Dinoprostone 0-16 interleukin 4 Homo sapiens 299-303 7843254-1 1995 Prostaglandin E2 (PGE2) favors T helper type 2 (Th2)-like cytokine secretion profiles in murine and human CD4+ T cells by inhibiting the production of the Th1-associated cytokines interleukin-2 (IL-2) and interferon-gamma (IFN-gamma) and up-regulating the production of the Th2-associated cytokines IL-4 and IL-5 in a dose-dependent way. Dinoprostone 18-22 interleukin 4 Homo sapiens 299-303 7843254-7 1995 These different modulation patterns were directly related to the IL-2 availability, because (i) neutralizing antibody to IL-2 abrogated the up-regulatory effect of PGE2 on IL-4 and IL-5 secretion in experiments with high endogenous IL-2 levels, (ii) lack of differential cytokine modulation by PGE2 in conditions with low levels of endogenous IL-2 could be restored with exogenous IL-2, and (iii) cell viability was comparable in all conditions. Dinoprostone 164-168 interleukin 4 Homo sapiens 172-176 7873203-3 1995 Dexamethasone and interleukin-4 (IL-4) inhibited the IL-1 beta-induced PGE2 synthesis; the former inhibited the IL-1 beta-induced cyclooxygenase activity whereas the latter failed. Dinoprostone 71-75 interleukin 4 Homo sapiens 33-37 8003066-9 1994 In the presence of PGE2, TH1-like responses are suppressed and TH0-like responses are shifted toward a TH2-like pattern dominated by the production of IL-4 and IL-5. Dinoprostone 19-23 interleukin 4 Homo sapiens 151-155 7512590-3 1994 PGE2 further potentiated both IL-4- and IL-10-induced B cell growth as determined by [3H]TdR uptake and cellular enumeration. Dinoprostone 0-4 interleukin 4 Homo sapiens 30-45 8166209-0 1994 Interleukin-4 and transforming growth factor-beta 1 modulate the production of interleukin-1 receptor antagonist and of prostaglandin E2 by decidual cells. Dinoprostone 120-136 interleukin 4 Homo sapiens 0-51 8166209-4 1994 Interleukin-4 and transforming growth factor-beta inhibit the production of prostaglandin E2 by monocytes and amnion cells, respectively. Dinoprostone 76-92 interleukin 4 Homo sapiens 0-49 8166209-10 1994 RESULTS: Both interleukin-4 and transforming growth factor-beta 1 inhibited prostaglandin E2 production by decidual cells (p < 0.01). Dinoprostone 76-92 interleukin 4 Homo sapiens 14-65 8166209-14 1994 CONCLUSION: By suppressing the production of prostaglandin E2 and enhancing the production of interleukin-1 receptor antagonist by decidual cells, interleukin-4 and transforming growth factor-beta may have a role in inhibiting preterm labor in the setting of infection. Dinoprostone 45-61 interleukin 4 Homo sapiens 147-196 8018602-4 1994 Recombinant IL-4 also inhibited PGE2 production at the same degree as rIL-10. Dinoprostone 32-36 interleukin 4 Homo sapiens 12-16 8018594-4 1994 In contrast, in cells stimulated with phorbol myristate acetate (PMA)/A23187, PGE2 enhanced the production of IL-4 and IL-5, and only partially inhibited the production of other cytokines. Dinoprostone 78-82 interleukin 4 Homo sapiens 110-114 8267584-4 1993 IL-4 (10 ng/ml) alone did not affect prostaglandin E2 (PGE2) synthesis by mesangial cells, though, it inhibited IL-1 alpha- and TNF alpha-stimulated PGE2 synthesis by 48% and 81%, respectively. Dinoprostone 149-153 interleukin 4 Homo sapiens 0-4 8267044-5 1993 RESULTS: Interleukin-4 alone stimulated prostaglandin E2 production in chorion and decidual cells. Dinoprostone 40-56 interleukin 4 Homo sapiens 9-22 8267044-6 1993 Interleukin-4 significantly enhanced the stimulatory actions of phorbol 12-myristate 13-acetate, ionomycin, and epidermal growth factor but not interleukin-1 beta on prostaglandin E2 production. Dinoprostone 166-182 interleukin 4 Homo sapiens 0-13 8267044-7 1993 CONCLUSION: Interleukin-4 stimulates prostaglandin E2 production by chorion and decidual cells. Dinoprostone 37-53 interleukin 4 Homo sapiens 12-25 8390534-2 1993 We demonstrate that PGE2 selectively and dose dependently inhibits IL-2 and IFN-gamma production by mitogenically stimulated human PBL and CD4+ TLC, although at low concentrations IL-4 production is not affected and IL-5 production is even up-regulated. Dinoprostone 20-24 interleukin 4 Homo sapiens 180-184 8208751-4 1994 IL-4 alone stimulated PGE2 production in amnion cells in a concentration-related manner. Dinoprostone 22-26 interleukin 4 Homo sapiens 0-4 8208751-5 1994 IL-4 significantly enhanced the stimulatory actions of ionomycin and EGF on amnion cell PGE2 production. Dinoprostone 88-92 interleukin 4 Homo sapiens 0-4 8208751-6 1994 Ionomycin and IL-4 acted synergistically in their effects on PGE2 production by amnion cells whereas EGF and IL-4 acted more additively in this respect. Dinoprostone 61-65 interleukin 4 Homo sapiens 14-18 8397256-1 1993 The monocyte-derived inflammatory mediator, prostaglandin E2 (PGE2), can reduce IFN-gamma production, and this in turn may relate to IL-4 up-regulation of IgE synthesis and impaired delayed hypersensitivity in atopy. Dinoprostone 44-60 interleukin 4 Homo sapiens 133-137 8397256-1 1993 The monocyte-derived inflammatory mediator, prostaglandin E2 (PGE2), can reduce IFN-gamma production, and this in turn may relate to IL-4 up-regulation of IgE synthesis and impaired delayed hypersensitivity in atopy. Dinoprostone 62-66 interleukin 4 Homo sapiens 133-137 8390534-4 1993 The action of PGE2 may, therefore, be associated with elevation of intracellular cAMP levels, affecting IL-4 and IL-5 differentially from IL-2 and IFN-gamma production. Dinoprostone 14-18 interleukin 4 Homo sapiens 104-108 8391076-3 1993 Preincubation for 1 hour with either IFN-gamma or IL-4 prior to stimulation with Con A caused a significant inhibition of M phi PGE2 production. Dinoprostone 128-132 interleukin 4 Homo sapiens 50-54 8385653-0 1993 Effect of PGE2 on thymocyte proliferation induced by Con A or IL-4 + PMA. Dinoprostone 10-14 interleukin 4 Homo sapiens 62-66 8385653-2 1993 In this study, we have investigated, the effect of PGE2 on thymocyte proliferation induced by the combination of IL-4 plus PMA. Dinoprostone 51-55 interleukin 4 Homo sapiens 113-117 8385653-3 1993 PGE2 inhibits the proliferation of thymocytes activated by ConA, whatever the culture period; in contrast PGE2 shifts the kinetics of thymocyte proliferation after stimulation by IL-4 plus PMA, but does not sustain the proliferation beyond day 3. Dinoprostone 106-110 interleukin 4 Homo sapiens 179-183 8385653-5 1993 By use of the cAMP inducer, forskolin, or a cAMP analog, db-cAMP, we observed the same results, PGE2 increases the proliferation of CD8+ corticoresistant thymocytes (CRT) activated by IL-4 plus PMA, but inhibits that of CD4+ CRT. Dinoprostone 96-100 interleukin 4 Homo sapiens 184-188 8391076-5 1993 The inhibition of M phi metalloproteinase production by IFN-gamma and IL-4 was reversed by PGE2 or Bt2cAMP. Dinoprostone 91-95 interleukin 4 Homo sapiens 70-74 33383652-8 2020 Among eicosanoids, Prostaglandin E2 (PGE2) and prostaglandin D2 (PGD2) were significantly reduced in (IL-4)BM-Macs and (LPS+IFNgamma)BM-Macs lacking Pla2g5. Dinoprostone 19-35 interleukin 4 Homo sapiens 102-106 1557611-5 1992 The effect was dose dependent: IL-4 was effective at concentrations down to 0.5 U/ml, IFN-gamma down to 40 U/ml and PGE2 at nanomolar concentrations. Dinoprostone 116-120 interleukin 4 Homo sapiens 31-35 1309751-5 1992 IL-4 also suppressed ConA-stimulated 92-kDa type IV collagenase/gelatinase protein and zymogram enzyme activity that could be reversed by exogenous PGE2 or Bt2cAMP. Dinoprostone 148-152 interleukin 4 Homo sapiens 0-4 1476044-7 1992 PGE2 is able to suppress interleukin 4-induced IgE synthesis of human non-atopic mononuclear cells in vitro. Dinoprostone 0-4 interleukin 4 Homo sapiens 25-38 1483067-7 1992 PGE2 at a physiological concentration (10(-9) M) was also shown to enhance interleukin 4 induction of IgE synthesis by PBMC cultures. Dinoprostone 0-4 interleukin 4 Homo sapiens 75-88 2026443-0 1991 IL-4 suppresses IL-1 beta, TNF-alpha and PGE2 production by human peritoneal macrophages. Dinoprostone 41-45 interleukin 4 Homo sapiens 0-4 1845802-6 1991 These data indicate that the failure of PGE2 to inhibit IL-4 and IL-5 production was not due to an inability of PGE2 to induce an increase in intracellular cAMP, and suggested instead that the expression of IL-4 and IL-5 in Th2 cells is insensitive to elevated cAMP levels. Dinoprostone 40-44 interleukin 4 Homo sapiens 56-60 1845802-7 1991 When Th0 clones were examined, PGE2 was again found to differentially affect IL-2 and IL-4 production in three of five clones tested. Dinoprostone 31-35 interleukin 4 Homo sapiens 86-90 35396684-5 2022 Normal parasites induce predominantly a T helper 2 (Th2)-type cytokine response (IL-4 and IL-5) which is essential for parasite survival; here, we discuss in detail the downstream effects and cascades of inflammatory signaling of PGE2 and IL10 induced by normal parasites and the effect of blocking PGE2 receptors. Dinoprostone 230-234 interleukin 4 Homo sapiens 81-85 35240193-0 2022 Down-regulation of the expression of cyclooxygenase-2 and prostaglandin E2 by interleukin-4 is mediated via a reduction in the expression of prostanoid EP4 receptors in HCA-7 human colon cancer cells. Dinoprostone 58-74 interleukin 4 Homo sapiens 78-91 35240193-4 2022 In the present study, using an in silico analysis and pharmacological experiments, we demonstrated that interleukin (IL)-4, a signature cytokine of Th2 cells, down-regulated the expression of COX-2 and PGE2 in the human colon cancer cell line, HCA-7. Dinoprostone 202-206 interleukin 4 Homo sapiens 104-122 2533178-3 1989 The IL-4-mediated IgE synthesis is enhanced by IL-2, IL-5 and IL-6 and suppressed by IFN-gamma, IFN-alpha and PGE2. Dinoprostone 110-114 interleukin 4 Homo sapiens 4-8 33553650-7 2021 Stimulation with IL-4 and TNF-alpha induced the generation of PGE2 in supernatants of conjunctival fibroblasts, and this production was significantly downregulated by ketotifen fumarate or steroids. Dinoprostone 62-66 interleukin 4 Homo sapiens 17-21 8389628-0 1993 Phorbol ester, prostaglandin E2, forskolin and okadaic acid differentially modulate interleukin-4-versus interleukin-2-dependent immunoglobulin induction in human cellular models, in contrast to other selected modifiers of cellular activation. Dinoprostone 15-31 interleukin 4 Homo sapiens 84-97 8389628-8 1993 Prostaglandin E2 potently enhanced IgE production stimulated with IL4 alone but was inhibitory in the presence of anti-CD40 as a co-stimulatory signal. Dinoprostone 0-16 interleukin 4 Homo sapiens 66-69 1309751-0 1992 Interleukin 4 inhibition of prostaglandin E2 synthesis blocks interstitial collagenase and 92-kDa type IV collagenase/gelatinase production by human monocytes. Dinoprostone 28-44 interleukin 4 Homo sapiens 0-13 1309751-2 1992 Inasmuch as interleukin 4 (IL-4) has been shown to inhibit PGE2 synthesis by monocytes, we examined the effect of IL-4 on the production of human monocyte interstitial collagenase. Dinoprostone 59-63 interleukin 4 Homo sapiens 12-25 1309751-2 1992 Inasmuch as interleukin 4 (IL-4) has been shown to inhibit PGE2 synthesis by monocytes, we examined the effect of IL-4 on the production of human monocyte interstitial collagenase. Dinoprostone 59-63 interleukin 4 Homo sapiens 27-31 1309751-4 1992 The inhibition of PGE2 synthesis by IL-4 resulted in decreased interstitial collagenase protein and activity that could be restored by exogenous PGE2 or dibutyryl cyclic AMP (Bt2cAMP). Dinoprostone 18-22 interleukin 4 Homo sapiens 36-40 1309751-4 1992 The inhibition of PGE2 synthesis by IL-4 resulted in decreased interstitial collagenase protein and activity that could be restored by exogenous PGE2 or dibutyryl cyclic AMP (Bt2cAMP). Dinoprostone 145-149 interleukin 4 Homo sapiens 36-40 2143326-11 1990 PCA and PGE2 levels were concomitantly downregulated by IL-4 both in the FcRI-stimulated, FcRI+ and in the MDP-stimulated FcRI- MO subpopulations. Dinoprostone 8-12 interleukin 4 Homo sapiens 56-60 2786204-0 1989 Potential antiinflammatory effects of interleukin 4: suppression of human monocyte tumor necrosis factor alpha, interleukin 1, and prostaglandin E2. Dinoprostone 131-147 interleukin 4 Homo sapiens 38-51 2496134-2 1989 IL-4-induced IgE synthesis was dependent on CD4+ T cells and monocytes and was blocked by IFN-gamma, IFN-alpha, and prostaglandin E-2 (PGE-2). Dinoprostone 116-133 interleukin 4 Homo sapiens 0-4 2496134-2 1989 IL-4-induced IgE synthesis was dependent on CD4+ T cells and monocytes and was blocked by IFN-gamma, IFN-alpha, and prostaglandin E-2 (PGE-2). Dinoprostone 135-140 interleukin 4 Homo sapiens 0-4 2844892-0 1988 IFN-gamma and prostaglandin E2 inhibit IL-4-induced expression of Fc epsilon R2/CD23 on B lymphocytes through different mechanisms without altering binding of IL-4 to its receptor. Dinoprostone 14-30 interleukin 4 Homo sapiens 39-43 2844892-3 1988 PGE2 (at 10(-7) M) was found to inhibit by 50% the IL-4 mediated Fc epsilon R2/CD23 induction on Jijoye cells. Dinoprostone 0-4 interleukin 4 Homo sapiens 51-55 2844892-7 1988 Taken together these data suggest that PGE2 inhibits the IL-4 induced Fc epsilon R2/CD23 through an increase of intracellular cAMP. Dinoprostone 39-43 interleukin 4 Homo sapiens 57-61 2844892-10 1988 It could be excluded that IFN-gamma and PGE2 were acting via an alteration/desensitization of the IL-4R inasmuch as 24 h pre-incubation of Jijoye cells with these agents affected neither the affinity of 125I-IL-4 for its receptor (Kd = 0.8 to 1.5 x 10(-10) M) nor the maximal number of binding sites per Jijoye cells (Bmax = 390 to 550). Dinoprostone 40-44 interleukin 4 Homo sapiens 98-102 2844892-12 1988 These data demonstrate that PGE2 and IFN-gamma inhibit the IL-4-mediated induction of Fc epsilon R2/CD23 on B lymphocytes via different mechanisms that do not alter the interaction of IL-4 with its receptor. Dinoprostone 28-32 interleukin 4 Homo sapiens 59-63 2970644-5 1988 IL-4-induced IgE production was blocked in a dose-dependent way by interferon gamma (IFN-gamma), interferon alpha (IFN-alpha), and prostaglandin E2. Dinoprostone 131-147 interleukin 4 Homo sapiens 0-4 2970644-8 1988 IFN-gamma, IFN-alpha, and prostaglandin E2 also inhibited IL-4-induced expression of the low-affinity receptor for the Fc portion of IgE (CD23) on B cells, indicating that there is an association between CD23 expression and IL-4-induced IgE production. Dinoprostone 26-42 interleukin 4 Homo sapiens 58-62 2970644-8 1988 IFN-gamma, IFN-alpha, and prostaglandin E2 also inhibited IL-4-induced expression of the low-affinity receptor for the Fc portion of IgE (CD23) on B cells, indicating that there is an association between CD23 expression and IL-4-induced IgE production. Dinoprostone 26-42 interleukin 4 Homo sapiens 224-228 2965726-9 1988 Interestingly, IFN-gamma and PGE2 suppressed the IL-4-induced membrane expression of CD23 and class II MHC Ag in a dose-dependent way. Dinoprostone 29-33 interleukin 4 Homo sapiens 49-53 33720008-8 2021 Mechanistically, activation of the Wnt pathway following lipid lowering potentiates IL-4 responsiveness in macrophages via a PGE2/STAT3 axis. Dinoprostone 125-129 interleukin 4 Homo sapiens 84-88 33383652-8 2020 Among eicosanoids, Prostaglandin E2 (PGE2) and prostaglandin D2 (PGD2) were significantly reduced in (IL-4)BM-Macs and (LPS+IFNgamma)BM-Macs lacking Pla2g5. Dinoprostone 37-41 interleukin 4 Homo sapiens 102-106 33463295-7 2020 Further, fusion of macrophages into FBGCs induced by interleukin-4 (IL-4) and granulocyte-macrophage colony-stimulating factor (GM-CSF) was inhibited by PGE2 via EP2 signaling and by an EP2 agonist, but not an EP4 agonist. Dinoprostone 153-157 interleukin 4 Homo sapiens 53-66 33463295-7 2020 Further, fusion of macrophages into FBGCs induced by interleukin-4 (IL-4) and granulocyte-macrophage colony-stimulating factor (GM-CSF) was inhibited by PGE2 via EP2 signaling and by an EP2 agonist, but not an EP4 agonist. Dinoprostone 153-157 interleukin 4 Homo sapiens 68-72 31120777-5 2020 IL-4 and TNF-alpha induced the generation of PGE2 and COX-2 in conjunctival and corneal cells. Dinoprostone 45-49 interleukin 4 Homo sapiens 0-4