PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32227417-5 2020 PGE2 induced ANGPTL4 expression in a time- and dose-dependent manners in various HNSCC cell lines through the ERK pathway. Dinoprostone 0-4 mitogen-activated protein kinase 1 Homo sapiens 110-113 33247192-6 2020 Weak acid-induced PGE2 production was significantly inhibited by cytosolic phospholipase A2 (cPLA2), ERK, and transient receptor potential cation channel subfamily V member 4 (TRPV4), a pH-sensing ion channel, inhibitors. Dinoprostone 18-22 mitogen-activated protein kinase 1 Homo sapiens 101-104 33247192-8 2020 These results indicated that weak acids induce PGE2 production via TRPV4/ERK/cPLA2 in oesophageal epithelial cells, suggesting a role in GERD symptoms like heartburn. Dinoprostone 47-51 mitogen-activated protein kinase 1 Homo sapiens 73-76 32407837-16 2020 Mechanistically, PGE2 interfered with the phosphorylation of phospholipase C gamma-1 (PLCgamma1) and extracellular-signal regulated kinase (ERK). Dinoprostone 17-21 mitogen-activated protein kinase 1 Homo sapiens 101-138 32407837-16 2020 Mechanistically, PGE2 interfered with the phosphorylation of phospholipase C gamma-1 (PLCgamma1) and extracellular-signal regulated kinase (ERK). Dinoprostone 17-21 mitogen-activated protein kinase 1 Homo sapiens 140-143 32114020-6 2020 The release of PGE2 by bradykinin could be blocked inhibiting COX-2 and p65/NF-kB, ERK1/2 or p38 activation. Dinoprostone 15-19 mitogen-activated protein kinase 1 Homo sapiens 93-96 32385388-0 2020 Aberrant expression of the COX2/PGE2 axis is induced by activation of the RAF/MEK/ERK pathway in BRAFV595E canine urothelial carcinoma. Dinoprostone 32-36 mitogen-activated protein kinase 1 Homo sapiens 82-85 32385388-5 2020 Drug screening revealed that inhibition of RAF/MEK/ERK pathway, p38 and JNK pathway reduced PGE2 production in cUC cells. Dinoprostone 92-96 mitogen-activated protein kinase 1 Homo sapiens 51-54 32385388-6 2020 By pharmacological inhibition of the multiple components in the pathway, activation of the ERK MAPK pathway was shown to mediate overexpression of COX2 and production of PGE2 in BRAFV595E cUC cells. Dinoprostone 170-174 mitogen-activated protein kinase 1 Homo sapiens 91-94 32385388-10 2020 In conclusion, this study demonstrated that activation of ERK induces production of PGE2 in BRAFV595E cUC cells, which is also independently regulated by p38 and JNK. Dinoprostone 84-88 mitogen-activated protein kinase 1 Homo sapiens 58-61 32114020-8 2020 Thus, bradykinin, acting via B2 receptors, induced PGE2 release through ERK1/2 and p38-dependent pathways and consequent p65/NF-kB translocation to nucleus. Dinoprostone 51-55 mitogen-activated protein kinase 1 Homo sapiens 83-86 32303181-6 2020 PGE2 stimulation gave rise to a rapid increase of p38 but not ERK phosphorylation. Dinoprostone 0-4 mitogen-activated protein kinase 1 Homo sapiens 62-65 30367494-6 2019 PGE2 -induced increase in COX-2 expression and, thereby, in transcriptional increase in HIF-1alpha expression was due to EGFR activation, leading to the activation of Phosphoinositide 3-kinase/Akt, Extracellular signal -regulated kinases 1/2, p38 and Mitogen- and stress-activated protein kinase-1 (PI3K/Akt, Erk1/2, p38 and MSK-1). Dinoprostone 0-4 mitogen-activated protein kinase 1 Homo sapiens 198-241 31703303-7 2019 Extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation after PGE2 treatment significantly increased by ~2.5 times. Dinoprostone 73-77 mitogen-activated protein kinase 1 Homo sapiens 0-41 30367494-6 2019 PGE2 -induced increase in COX-2 expression and, thereby, in transcriptional increase in HIF-1alpha expression was due to EGFR activation, leading to the activation of Phosphoinositide 3-kinase/Akt, Extracellular signal -regulated kinases 1/2, p38 and Mitogen- and stress-activated protein kinase-1 (PI3K/Akt, Erk1/2, p38 and MSK-1). Dinoprostone 0-4 mitogen-activated protein kinase 1 Homo sapiens 243-246 30367494-6 2019 PGE2 -induced increase in COX-2 expression and, thereby, in transcriptional increase in HIF-1alpha expression was due to EGFR activation, leading to the activation of Phosphoinositide 3-kinase/Akt, Extracellular signal -regulated kinases 1/2, p38 and Mitogen- and stress-activated protein kinase-1 (PI3K/Akt, Erk1/2, p38 and MSK-1). Dinoprostone 0-4 mitogen-activated protein kinase 1 Homo sapiens 317-320 28651842-9 2017 These data show that SDX protects HREC from HG damage and suggest that it counteracts the activation of ERK/cPLA2/COX-2/PGE2 pathway by reducing AGE-related signaling and downstream NFkappaB activity. Dinoprostone 120-124 mitogen-activated protein kinase 1 Homo sapiens 104-107 29891646-5 2018 In vascular smooth muscle cells or aortic segments, PGE2 increased NADPH oxidase expression and activity and reduced mitochondrial membrane potential, effects that were abolished by antagonists of the PGE2 receptors (EP), EP1 and EP3, and by JNK (c-Jun N-terminal kinase) and ERK1/2 (extracellular-signal-regulated kinases 1/2) inhibition. Dinoprostone 52-56 mitogen-activated protein kinase 1 Homo sapiens 284-326 28877882-7 2018 Results show that FFSS-induced mechanotransduction as well as exogenous PGE2 activate the Akt-GSK3beta-beta-catenin (Ser552) and MAPK/ERK but not the cAMP-PKA signal transduction cascades. Dinoprostone 72-76 mitogen-activated protein kinase 1 Homo sapiens 129-133 28877882-7 2018 Results show that FFSS-induced mechanotransduction as well as exogenous PGE2 activate the Akt-GSK3beta-beta-catenin (Ser552) and MAPK/ERK but not the cAMP-PKA signal transduction cascades. Dinoprostone 72-76 mitogen-activated protein kinase 1 Homo sapiens 134-137 31502430-11 2019 Inhibiting PKC and ERK with respectively calphostin C and PD98059 abolished the effect of FTY720-P on the ATPase and on IkappaB, but not that of exogenous PGE2 indicating that the two kinases are upstream of NF-kappaB and PGE2. Dinoprostone 222-226 mitogen-activated protein kinase 1 Homo sapiens 19-22 29466417-14 2018 It was concluded that epinephrine inhibits the Na+/K+-ATPase by the sequential activation of alpha2 adrenergic receptors, Src, p38MAPK, and ERK leading to PGE2 release. Dinoprostone 155-159 mitogen-activated protein kinase 1 Homo sapiens 140-143 28197966-5 2017 The effect of FTY720P and PGE2 disappeared completely in presence of PF-04418948, a blocker of EP2 receptors, RpcAMP, an inhibitor of PKA, PD98059, an inhibitor of ERK, as well as in presence of PTIO, a nitric oxide synthase inhibitor, but was mimicked by butaprost, an EP2 agonist, dbcAMP, a cell permeable cAMP analogue, and SNAP1,a nitric oxide generator. Dinoprostone 26-30 mitogen-activated protein kinase 1 Homo sapiens 164-167 28197966-6 2017 PGE2 and dbcAMP increased the expression of phosphorylated ERK but not total ERK. Dinoprostone 0-4 mitogen-activated protein kinase 1 Homo sapiens 59-62 28197966-8 2017 It was concluded that FTY 720P induces PGE2 release which activates NOS leading to NO production and ERK activation. Dinoprostone 39-43 mitogen-activated protein kinase 1 Homo sapiens 101-104 28740516-9 2017 In conclusion, our findings reveal EP2-mediated FAK and ERK1/2 activation was essential for MSCs migration induced by PGE2, indicating that activation of EP2 receptor and FAK/ERK pathways may be a promising strategy to accelerate homing efficiency of MSCs, which in turn enhances therapeutic potential of MSCs transplantation. Dinoprostone 118-122 mitogen-activated protein kinase 1 Homo sapiens 56-59 28539604-3 2017 Thus, the glyceryl ester of prostaglandin E2, PGE2-G, mobilizes Ca2+ and activates protein kinase C and ERK, suggesting the involvement of a G protein-coupled receptor (GPCR). Dinoprostone 28-44 mitogen-activated protein kinase 1 Homo sapiens 104-107 28539604-3 2017 Thus, the glyceryl ester of prostaglandin E2, PGE2-G, mobilizes Ca2+ and activates protein kinase C and ERK, suggesting the involvement of a G protein-coupled receptor (GPCR). Dinoprostone 46-50 mitogen-activated protein kinase 1 Homo sapiens 104-107 27377703-5 2017 PGE2 induced the activation of Src, epidermal growth factor receptor (EGFR), c-Jun NH2 -terminal kinase (JNK), extracellular signal-regulated kinase (Erk), and p38 mitogen activated protein kinase (p38 MAPK). Dinoprostone 0-4 mitogen-activated protein kinase 1 Homo sapiens 111-148 27377703-5 2017 PGE2 induced the activation of Src, epidermal growth factor receptor (EGFR), c-Jun NH2 -terminal kinase (JNK), extracellular signal-regulated kinase (Erk), and p38 mitogen activated protein kinase (p38 MAPK). Dinoprostone 0-4 mitogen-activated protein kinase 1 Homo sapiens 150-153 27137893-2 2017 In the present study, we describe the PGE2 -dependent suppression and reversal of TGFbeta-induced events such as alpha-sma expression, stress fiber formation, and Ras/Raf/ERK/MAPK pathway-dependent activation of myofibroblast migration. Dinoprostone 38-42 mitogen-activated protein kinase 1 Homo sapiens 171-174 28280524-6 2017 The increased intracellular ROS caused by mechanical injury stimulates PGE2 production in a time-dependent manner via the activation of cyclooxygenase-2 (COX-2), which was stimulated by phosphorylation of extracellular signal-regulated protein kinase (ERK). Dinoprostone 71-75 mitogen-activated protein kinase 1 Homo sapiens 205-250 28280524-6 2017 The increased intracellular ROS caused by mechanical injury stimulates PGE2 production in a time-dependent manner via the activation of cyclooxygenase-2 (COX-2), which was stimulated by phosphorylation of extracellular signal-regulated protein kinase (ERK). Dinoprostone 71-75 mitogen-activated protein kinase 1 Homo sapiens 252-255 28280524-7 2017 These results indicate ROS-induced ERK activation leading to the activation of COX-2 and the synthesis of PGE2 in human keratinocytes responding to mechanical injury in the acute phase. Dinoprostone 106-110 mitogen-activated protein kinase 1 Homo sapiens 35-38 27414656-6 2016 DA also inhibited PGE2-induced expression of cyclooxygenase-2 and the activation of the Ras/Raf/ Erk pathway, which activates downstream targets for cell survival. Dinoprostone 18-22 mitogen-activated protein kinase 1 Homo sapiens 97-100 26394174-0 2015 C-Jun NH2-Terminal Kinase and p38 Inhibition Suppresses Prostaglandin E2-Stimulated Aromatase and Estrogen Receptor Levels in Human Endometriosis. Dinoprostone 56-72 mitogen-activated protein kinase 1 Homo sapiens 30-33 27795708-7 2016 Downregulation of both Akt and ERK leads consequently to NF-kB inhibition and reduced expression of inflammatory markers (COX-2 and PGE2). Dinoprostone 132-136 mitogen-activated protein kinase 1 Homo sapiens 31-34 26394174-2 2015 P38 and C-jun NH2-terminal kinase (JNK) inhibitors may have a therapeutic effect on endometriosis through regulation of prostaglandin E2 (PGE2)-induced estrogen metabolism. Dinoprostone 120-136 mitogen-activated protein kinase 1 Homo sapiens 0-3 26394174-2 2015 P38 and C-jun NH2-terminal kinase (JNK) inhibitors may have a therapeutic effect on endometriosis through regulation of prostaglandin E2 (PGE2)-induced estrogen metabolism. Dinoprostone 138-142 mitogen-activated protein kinase 1 Homo sapiens 0-3 26394174-6 2015 Activation of p38, JNK, ERK 1/2 and ERK 5 MAPKs by PGE2 were observed in ESCs, where PGE2-stimulated aromatase and ERbeta expression mainly through p38 and JNK pathway. Dinoprostone 51-55 mitogen-activated protein kinase 1 Homo sapiens 14-17 26394174-6 2015 Activation of p38, JNK, ERK 1/2 and ERK 5 MAPKs by PGE2 were observed in ESCs, where PGE2-stimulated aromatase and ERbeta expression mainly through p38 and JNK pathway. Dinoprostone 85-89 mitogen-activated protein kinase 1 Homo sapiens 14-17 26394174-6 2015 Activation of p38, JNK, ERK 1/2 and ERK 5 MAPKs by PGE2 were observed in ESCs, where PGE2-stimulated aromatase and ERbeta expression mainly through p38 and JNK pathway. Dinoprostone 85-89 mitogen-activated protein kinase 1 Homo sapiens 148-151 26394174-7 2015 P38 and JNK inhibition or small interfering RNA knockdown blocked PGE2-induced aromatase and ERbeta expression. Dinoprostone 66-70 mitogen-activated protein kinase 1 Homo sapiens 0-3 26394174-8 2015 PGE2 enhanced binding of downstream p38 and JNK transcription factors activating transcription factor-2 and c-Jun to aromatase and ERB promoter regions in ESCs. Dinoprostone 0-4 mitogen-activated protein kinase 1 Homo sapiens 36-39 26394174-9 2015 Moreover, treatment of endometriosis xenografts with inhibitors of p38 and JNK abrogated PGE2-amplified estradiol synthesis and xenograft growth. Dinoprostone 89-93 mitogen-activated protein kinase 1 Homo sapiens 67-70 26394174-10 2015 CONCLUSIONS: PGE2 activates p38 and JNK signaling pathways, further stimulating c-Jun and activating transcription factor-2 binding to aromatase and ERB promoter regions with elevated estradiol production. Dinoprostone 13-17 mitogen-activated protein kinase 1 Homo sapiens 28-31 26033830-2 2015 This is mediated in part through an EGFR-independent activation of mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (Erk) by prostaglandin E2 (PGE2). Dinoprostone 154-170 mitogen-activated protein kinase 1 Homo sapiens 101-105 26033830-2 2015 This is mediated in part through an EGFR-independent activation of mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (Erk) by prostaglandin E2 (PGE2). Dinoprostone 154-170 mitogen-activated protein kinase 1 Homo sapiens 146-149 26033830-2 2015 This is mediated in part through an EGFR-independent activation of mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (Erk) by prostaglandin E2 (PGE2). Dinoprostone 172-176 mitogen-activated protein kinase 1 Homo sapiens 101-105 26033830-2 2015 This is mediated in part through an EGFR-independent activation of mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (Erk) by prostaglandin E2 (PGE2). Dinoprostone 172-176 mitogen-activated protein kinase 1 Homo sapiens 146-149 25431425-11 2014 PGE2 also activated the Ras/Raf/Erk pathway, and pretreatment with PD98059 abolished the protective effect of PGE2. Dinoprostone 0-4 mitogen-activated protein kinase 1 Homo sapiens 32-35 25713071-10 2015 Treatment with PGE2 inhibited c-Raf activation by increasing inhibitory phosphorylation at Ser-259 in a PKA-dependent manner, thereby inhibiting downstream MEK-ERK signaling. Dinoprostone 15-19 mitogen-activated protein kinase 1 Homo sapiens 160-163 25811799-0 2015 Induction of COX-2-PGE2 synthesis by activation of the MAPK/ERK pathway contributes to neuronal death triggered by TDP-43-depleted microglia. Dinoprostone 19-23 mitogen-activated protein kinase 1 Homo sapiens 60-63 24760659-10 2014 Furthermore, PGE2 activates the EP2/EP4-cAMP-PI3K-ERK signaling pathway, which enhanced ERRa transcriptional potentiality by increasing ERRa phosphorylation and nuclear translocation, subsequently promoting the expression of its target genes, such as aromatase. Dinoprostone 13-17 mitogen-activated protein kinase 1 Homo sapiens 50-53 24916702-8 2014 Additionally, COX-2/PGE2/ERK signaling axis was essential for the anticancer effect of DSS. Dinoprostone 20-24 mitogen-activated protein kinase 1 Homo sapiens 25-28 24760659-7 2014 The activation of adenylate cyclase with Forskolin mimicked the PGE2-mediated enhancement of extracellular signal-regulated kinase (ERK) phosphorylation and ERRa target gene expression. Dinoprostone 64-68 mitogen-activated protein kinase 1 Homo sapiens 93-130 24760659-7 2014 The activation of adenylate cyclase with Forskolin mimicked the PGE2-mediated enhancement of extracellular signal-regulated kinase (ERK) phosphorylation and ERRa target gene expression. Dinoprostone 64-68 mitogen-activated protein kinase 1 Homo sapiens 132-135 25332857-6 2014 MEK and PI3K inhibitors suppressed production of matrix metalloproteinase-3 (MMP-3), vascular endothelial growth factor (VEGF) and prostaglandin E2 (PGE2) by MH7A cells, suggesting that c-Met-MEK-ERK and c-Met-PI3K-AKT pathways are involved positively regulating MH7A cell function. Dinoprostone 149-153 mitogen-activated protein kinase 1 Homo sapiens 196-199 24907113-9 2014 In vitro, binding of PGE2 to EP2 and EP4 receptors on monocytes activated the p38MAPK/ERK pathway and resulted in elevated secretion of TGFbeta. Dinoprostone 21-25 mitogen-activated protein kinase 1 Homo sapiens 86-89 22450688-0 2012 Prostaglandin E2 blocks menadione-induced apoptosis through the Ras/Raf/Erk signaling pathway in promonocytic leukemia cell lines. Dinoprostone 0-16 mitogen-activated protein kinase 1 Homo sapiens 72-75 24912820-14 2014 Treatment of PSC with PGE2 strongly stimulated cAMP accumulation, mediated by EP2 receptors, and also stimulated phosphorylation of extracellular signal-regulated kinase (ERK). Dinoprostone 22-26 mitogen-activated protein kinase 1 Homo sapiens 132-169 24912820-14 2014 Treatment of PSC with PGE2 strongly stimulated cAMP accumulation, mediated by EP2 receptors, and also stimulated phosphorylation of extracellular signal-regulated kinase (ERK). Dinoprostone 22-26 mitogen-activated protein kinase 1 Homo sapiens 171-174 24693448-9 2014 These results suggest that kakkonto decreased PGE2 production by inhibition of ERK phosphorylation which leads to inhibition of cPLA2 phosphorylation and its activation. Dinoprostone 46-50 mitogen-activated protein kinase 1 Homo sapiens 79-82 23064451-6 2013 Using HEK293T cells, we showed that PGE2 inhibits extracellular signal-regulated kinase (ERK) phosphorylation induced by a PAR2-activating peptide (PAR2-AP). Dinoprostone 36-40 mitogen-activated protein kinase 1 Homo sapiens 50-87 23064451-6 2013 Using HEK293T cells, we showed that PGE2 inhibits extracellular signal-regulated kinase (ERK) phosphorylation induced by a PAR2-activating peptide (PAR2-AP). Dinoprostone 36-40 mitogen-activated protein kinase 1 Homo sapiens 89-92 24561081-8 2014 Collectively, the results indicate that cyclic tensile force activates ERK1/2 and p38 MAP kinase signaling pathways, and induces COX-2 expression, which is responsible for the sequential PGE2 biosynthesis and release, and furthermore, mediates the increase in BMP-2 expression at the transcriptional level. Dinoprostone 187-191 mitogen-activated protein kinase 1 Homo sapiens 82-85 23861370-11 2013 PGE2 induced phosphorylation of MAPK1/MAPK3 through PTGER2 and up-regulated expression of cell adhesion proteins such as focal adhesion kinase and intercellular adhesion molecule-1. Dinoprostone 0-4 mitogen-activated protein kinase 1 Homo sapiens 32-37 23494562-3 2013 We have previously demonstrated that PGE2-enhanced extracellular signal-regulated kinase (Erk) phosphorylation via EP1 signaling pathway involved in PGE2-induced cell proliferation. Dinoprostone 37-41 mitogen-activated protein kinase 1 Homo sapiens 51-88 23494562-3 2013 We have previously demonstrated that PGE2-enhanced extracellular signal-regulated kinase (Erk) phosphorylation via EP1 signaling pathway involved in PGE2-induced cell proliferation. Dinoprostone 37-41 mitogen-activated protein kinase 1 Homo sapiens 90-93 23494562-3 2013 We have previously demonstrated that PGE2-enhanced extracellular signal-regulated kinase (Erk) phosphorylation via EP1 signaling pathway involved in PGE2-induced cell proliferation. Dinoprostone 149-153 mitogen-activated protein kinase 1 Homo sapiens 51-88 23494562-3 2013 We have previously demonstrated that PGE2-enhanced extracellular signal-regulated kinase (Erk) phosphorylation via EP1 signaling pathway involved in PGE2-induced cell proliferation. Dinoprostone 149-153 mitogen-activated protein kinase 1 Homo sapiens 90-93 23494562-4 2013 Based on the identification of the transcription factor cyclic AMP response element-binding protein (CREB) as an important regulator of MMP2 and Erk phosphorylate CREB at ser133, we hypothesize that CREB may be implicated in the signaling of PGE2 stimulation to MMP2 overproduction via EP1 receptor. Dinoprostone 242-246 mitogen-activated protein kinase 1 Homo sapiens 145-148 22450688-10 2012 Furthermore, PGE(2) activated the Ras/Raf/MEK pathway, which in turn initiated ERK activation, and ultimately protected menadione-induced apoptosis. Dinoprostone 13-19 mitogen-activated protein kinase 1 Homo sapiens 79-82 22080750-7 2012 PGE(2)-induced IL-8 production was accompanied by p38 phosphorylation and was significantly inhibited by a p38 inhibitor, SB-203580, but not by an ERK1/2 inhibitor, U-0126, or a JNK inhibitor, SP-600125. Dinoprostone 0-6 mitogen-activated protein kinase 1 Homo sapiens 50-53 21507199-11 2012 Studies showed involvement of ERK, p38 and COX-2 pathways in high IL-10 production, driven by lung tumour derived PGE2. Dinoprostone 114-118 mitogen-activated protein kinase 1 Homo sapiens 30-33 22080750-7 2012 PGE(2)-induced IL-8 production was accompanied by p38 phosphorylation and was significantly inhibited by a p38 inhibitor, SB-203580, but not by an ERK1/2 inhibitor, U-0126, or a JNK inhibitor, SP-600125. Dinoprostone 0-6 mitogen-activated protein kinase 1 Homo sapiens 107-110 20890108-3 2010 PGE2/EP4-receptor interaction activates CREB via the ERK/MEK pathway. Dinoprostone 0-4 mitogen-activated protein kinase 1 Homo sapiens 53-56 21848814-5 2011 In this study we found that EspT induces expression of the pro-inflammatory mediators cyclooxygenase-2 (COX-2) an enzyme involved in production of prostaglandin E(2) (PGE2), interleukin (Il)-8 and Il-1beta in U937 human macrophages by activating the nuclear factor kappa-B (NF-kappaB), the extracellular signal-regulated kinases 1 and 2 (Erk1/2) and c-Jun N-terminal kinase (JNK) pathways. Dinoprostone 147-165 mitogen-activated protein kinase 1 Homo sapiens 290-336 21940623-5 2011 We show that PGE2-induced MMP-9 expression is mediated primarily through the EP2/EP4 cAMP protein kinase A (PKA)/PI3K ERK signaling pathway, leading to c-Fos expression, and through JNK-mediated activation of c-Jun in a PKA/PI3K/ERK-independent manner. Dinoprostone 13-17 mitogen-activated protein kinase 1 Homo sapiens 124-127 21940623-5 2011 We show that PGE2-induced MMP-9 expression is mediated primarily through the EP2/EP4 cAMP protein kinase A (PKA)/PI3K ERK signaling pathway, leading to c-Fos expression, and through JNK-mediated activation of c-Jun in a PKA/PI3K/ERK-independent manner. Dinoprostone 13-17 mitogen-activated protein kinase 1 Homo sapiens 235-238 21940623-7 2011 PKA, PI3K, and ERK inhibitors abolished PGE2- and cAMP-induced c-Fos and MMP-9 up-regulation, and ERK activation was required for the binding of activator protein 1 (AP-1) transcription factor to the MMP-9 promoter. Dinoprostone 40-44 mitogen-activated protein kinase 1 Homo sapiens 15-18 21940623-8 2011 Our results describe a new molecular mechanism for the effect of PGE2 on MMP-9 production in DCs that could lead to future therapeutic approaches using ERK inhibitors to regulate DC migration. Dinoprostone 65-69 mitogen-activated protein kinase 1 Homo sapiens 152-155 21778143-0 2011 Positive feedback loop between prostaglandin E2 and EGF-like factors is essential for sustainable activation of MAPK3/1 in cumulus cells during in vitro maturation of porcine cumulus oocyte complexes. Dinoprostone 31-47 mitogen-activated protein kinase 1 Homo sapiens 112-119 21778143-6 2011 Furthermore, down-regulations of MAPK3/1 phosphorylation and expression of the target genes by NS398 was overcome by the addition of either PGE2 or EGF. Dinoprostone 140-144 mitogen-activated protein kinase 1 Homo sapiens 33-40 21778143-8 2011 These results indicated that PGE2 is involved in the sustainable activation of MAPK3/1 in cumulus cells via the induction of EGF-like factor, which is required for cumulus expansion and meiotic maturation of porcine COCs. Dinoprostone 29-33 mitogen-activated protein kinase 1 Homo sapiens 79-86 20015475-0 2010 Prostaglandin E2 activates cAMP response element-binding protein in glioma cells via a signaling pathway involving PKA-dependent inhibition of ERK. Dinoprostone 0-16 mitogen-activated protein kinase 1 Homo sapiens 143-146 20883667-0 2010 Analysis of isoform specific ERK signaling on the effects of interleukin-1beta on COX-2 expression and PGE2 production in human chondrocytes. Dinoprostone 103-107 mitogen-activated protein kinase 1 Homo sapiens 29-32 20883667-1 2010 The MAPK/ERK pathway is involved in IL-1beta-induced cyclooxygenase (COX-2) expression and prostaglandin E2 (PGE2) production; two factors that play important roles in OA pathogenesis. Dinoprostone 91-107 mitogen-activated protein kinase 1 Homo sapiens 9-12 20883667-1 2010 The MAPK/ERK pathway is involved in IL-1beta-induced cyclooxygenase (COX-2) expression and prostaglandin E2 (PGE2) production; two factors that play important roles in OA pathogenesis. Dinoprostone 109-113 mitogen-activated protein kinase 1 Homo sapiens 9-12 20883667-2 2010 In the present study, we find that IL-1beta induced COX-2 expression and PGE2 production in human chondrocytes via a process that required the activation of the MAPK/ERK pathway. Dinoprostone 73-77 mitogen-activated protein kinase 1 Homo sapiens 166-169 20883667-4 2010 COX-2 expression and PGE2 production were significantly suppressed to a similar degree by the silencing of ERK1 or ERK2 alone. Dinoprostone 21-25 mitogen-activated protein kinase 1 Homo sapiens 115-119 20883667-9 2010 In conclusion, each ERK isoform similarly influenced IL-1beta-mediated COX-2 expression and PGE2 production in human chondrocytes, and ERK1 and ERK2 displayed synergistic effects. Dinoprostone 92-96 mitogen-activated protein kinase 1 Homo sapiens 20-23 19820419-7 2010 The COX-2-positive BxPC-3 but not the COX-2-negative MiaPaCa-2 treated with 100-nmol/L PGE2 induced phosphorylated extracellular signal-related kinase that was blocked by the mitogen-activated protein kinase kinase inhibitor U0126, demonstrating the ability of PGE2 to activate ERK. Dinoprostone 87-91 mitogen-activated protein kinase 1 Homo sapiens 278-281 20093341-12 2010 Our results indicate that PGE(2)-induced CYP1B1 expression is mediated by ligand-independent activation of the ERalpha pathway as a result of the activation of ERK, Akt, and PKA in breast cancer cells. Dinoprostone 26-32 mitogen-activated protein kinase 1 Homo sapiens 160-163 17551669-0 2007 Prostaglandin E2 enhances mitogen-activated protein kinase/Erk pathway in human cholangiocarcinoma cells: involvement of EP1 receptor, calcium and EGF receptors signaling. Dinoprostone 0-16 mitogen-activated protein kinase 1 Homo sapiens 59-62 19623651-11 2009 Collectively, our findings suggest that PGE(2) upregulates c-Myc via the EP2/PKC/ERK pathway. Dinoprostone 40-46 mitogen-activated protein kinase 1 Homo sapiens 81-84 19082453-7 2009 Furthermore, the downstream proteins of FAK, paxillin and Erk2, were also activated by PGE2. Dinoprostone 87-91 mitogen-activated protein kinase 1 Homo sapiens 58-62 19082453-9 2009 PGE2 treatment also induced the phosphorylation of Erk2. Dinoprostone 0-4 mitogen-activated protein kinase 1 Homo sapiens 51-55 19082453-12 2009 These results demonstrated that PGE2 greatly induced HCC cell adhesion, migration, and invasion by activating FAK/paxillin/Erk pathway. Dinoprostone 32-36 mitogen-activated protein kinase 1 Homo sapiens 123-126 18340408-6 2008 The leptin-induced changes in arachidonic acid release and PGE2 generation were blocked by ERK inhibitor, PD98059, but not by PI3K inhibitor, wortmannin. Dinoprostone 59-63 mitogen-activated protein kinase 1 Homo sapiens 91-94 17477350-4 2007 In this study, we first determined that Raf effector pathway activation of the extracellular-regulated kinase (ERK) mitogen-activated protein kinase (MAPK) cascade alone was sufficient and necessary for COX-2 and PGE2 upregulation. Dinoprostone 213-217 mitogen-activated protein kinase 1 Homo sapiens 79-109 17477350-4 2007 In this study, we first determined that Raf effector pathway activation of the extracellular-regulated kinase (ERK) mitogen-activated protein kinase (MAPK) cascade alone was sufficient and necessary for COX-2 and PGE2 upregulation. Dinoprostone 213-217 mitogen-activated protein kinase 1 Homo sapiens 111-114 17477350-4 2007 In this study, we first determined that Raf effector pathway activation of the extracellular-regulated kinase (ERK) mitogen-activated protein kinase (MAPK) cascade alone was sufficient and necessary for COX-2 and PGE2 upregulation. Dinoprostone 213-217 mitogen-activated protein kinase 1 Homo sapiens 150-154 17477350-8 2007 Finally, we found that PGE2 stimulated the activation of Ras and ERK, but not Akt, and reduced matrix deprivation-induced apoptosis, in untransformed epithelial cells. Dinoprostone 23-27 mitogen-activated protein kinase 1 Homo sapiens 65-68 17427962-10 2007 Moreover, PGE2 and CAY10399 increased mitogen activated protein kinase/extracellular signal regulated kinase (MAPK/Erk) and Akt phosphorylation in PC-3 and DU145 cells, but not in LNCaP cells. Dinoprostone 10-14 mitogen-activated protein kinase 1 Homo sapiens 110-114 17427962-10 2007 Moreover, PGE2 and CAY10399 increased mitogen activated protein kinase/extracellular signal regulated kinase (MAPK/Erk) and Akt phosphorylation in PC-3 and DU145 cells, but not in LNCaP cells. Dinoprostone 10-14 mitogen-activated protein kinase 1 Homo sapiens 115-118 19623651-0 2009 Prostaglandin E(2) promotes cell proliferation via protein kinase C/extracellular signal regulated kinase pathway-dependent induction of c-Myc expression in human esophageal squamous cell carcinoma cells. Dinoprostone 0-18 mitogen-activated protein kinase 1 Homo sapiens 68-105 19584262-8 2009 In addition, exogenously administered PGE2 increased ERK phosphorylation. Dinoprostone 38-42 mitogen-activated protein kinase 1 Homo sapiens 53-56 19584262-11 2009 COX-2 stimulates ERK phosphorylation via PGE2. Dinoprostone 41-45 mitogen-activated protein kinase 1 Homo sapiens 17-20 17708577-0 2008 Evidence that PAR2-triggered prostaglandin E2 (PGE2) formation involves the ERK-cytosolic phospholipase A2-COX-1-microsomal PGE synthase-1 cascade in human lung epithelial cells. Dinoprostone 29-45 mitogen-activated protein kinase 1 Homo sapiens 76-79 17708577-0 2008 Evidence that PAR2-triggered prostaglandin E2 (PGE2) formation involves the ERK-cytosolic phospholipase A2-COX-1-microsomal PGE synthase-1 cascade in human lung epithelial cells. Dinoprostone 47-51 mitogen-activated protein kinase 1 Homo sapiens 76-79 18079197-0 2008 Roles of Rho guanosine 5"-triphosphatase A, Rho kinases, and extracellular signal regulated kinase (1/2) in prostaglandin E2-mediated migration of first-trimester human extravillous trophoblast. Dinoprostone 108-124 mitogen-activated protein kinase 1 Homo sapiens 9-103 17551669-3 2007 In the current study, the mechanism underlying PGE2-enhanced Erk phosphorylation in human cholangiocarcinoma cells was determined. Dinoprostone 47-51 mitogen-activated protein kinase 1 Homo sapiens 61-64 17551669-5 2007 The activation of EP1 receptors involved in PGE2-stimulated Erk activation and increasing the intracellular concentration of calcium was elucidated using selective EP1 receptor subtype antagonists and agonist. Dinoprostone 44-48 mitogen-activated protein kinase 1 Homo sapiens 60-63 17551669-6 2007 The intracellular calcium chelator, BAPTA-AM, was shown to block PGE2-induced Erk and EGFR phosphorylation. Dinoprostone 65-69 mitogen-activated protein kinase 1 Homo sapiens 78-81 17551669-7 2007 PGE2-induced Erk phosphorylation was abrogated by pretreatment with the EGF receptor kinase inhibitor, AG1478. Dinoprostone 0-4 mitogen-activated protein kinase 1 Homo sapiens 13-16 17551669-8 2007 Our findings suggest that in human cholangiocarcinoma cells, PGE2-enhanced phosphorylation of Erk is, at least in part, mediated through EP1 receptors and EGFR phosphorylation induced by increases in the intracellular concentration of calcium. Dinoprostone 61-65 mitogen-activated protein kinase 1 Homo sapiens 94-97 17631291-5 2007 We provide evidence that L-161,982, a selective EP4 receptor antagonist, completely blocks PGE(2)-induced ERK phosphorylation and cell proliferation of HCA-7 cells. Dinoprostone 91-97 mitogen-activated protein kinase 1 Homo sapiens 106-109 17617469-0 2007 Involvement of p38 MAP kinase in lipopolysaccharide-induced production of pro- and anti-inflammatory cytokines and prostaglandin E(2) in human choriodecidua. Dinoprostone 115-133 mitogen-activated protein kinase 1 Homo sapiens 15-18 17591797-0 2007 Helicobacter pylori VacA enhances prostaglandin E2 production through induction of cyclooxygenase 2 expression via a p38 mitogen-activated protein kinase/activating transcription factor 2 cascade in AZ-521 cells. Dinoprostone 34-50 mitogen-activated protein kinase 1 Homo sapiens 117-120 17591797-6 2007 VacA-induced PGE(2) production was markedly attenuated in AZ-521 cells stably expressing DN-p38. Dinoprostone 13-19 mitogen-activated protein kinase 1 Homo sapiens 92-95 17329433-6 2007 Immunohistochemical data showed specific localization of phosphorylated extracellular signal-regulated kinase 1/2 (pERK1/2), an upstream regulator of PGE2 release, to microglial cells and a neuronal localization of the PGE2 receptor E-prostanoid 2 (EP2). Dinoprostone 150-154 mitogen-activated protein kinase 1 Homo sapiens 72-113 17363696-7 2007 Inhibition of p38 MAPK activity abolished the induction of COX-2 protein and PGE2 accumulation by acrolein, while suppression of extracellular signal-regulated kinase (ERK) and JNK activity had no effect on the induction of COX-2 expression in experiments using inhibitors and siRNA. Dinoprostone 77-81 mitogen-activated protein kinase 1 Homo sapiens 14-17 17031853-0 2007 Prostaglandin E2 downregulates TNF-alpha-induced production of matrix metalloproteinase-1 in HCS-2/8 chondrocytes by inhibiting Raf-1/MEK/ERK cascade through EP4 prostanoid receptor activation. Dinoprostone 0-16 mitogen-activated protein kinase 1 Homo sapiens 138-141 16600383-10 2006 Inhibitors of NF-kappaB, MEK1/2 and p38 blocked MALP-2-inducible PGE(2) production. Dinoprostone 65-71 mitogen-activated protein kinase 1 Homo sapiens 36-39 16905765-0 2007 Seminal plasma and prostaglandin E2 up-regulate fibroblast growth factor 2 expression in endometrial adenocarcinoma cells via E-series prostanoid-2 receptor-mediated transactivation of the epidermal growth factor receptor and extracellular signal-regulated kinase pathway. Dinoprostone 19-35 mitogen-activated protein kinase 1 Homo sapiens 226-263 17085321-0 2006 Concomitant activation of extracellular signal-regulated kinase and induction of COX-2 stimulates maximum prostaglandin E2 synthesis in human airway epithelial cells. Dinoprostone 106-122 mitogen-activated protein kinase 1 Homo sapiens 26-63 17085321-4 2006 Inhibition of ERK almost completely abrogated PGE(2) synthesis in response to all stimuli. Dinoprostone 46-52 mitogen-activated protein kinase 1 Homo sapiens 14-17 17085321-5 2006 Sustained, maximum PGE(2) synthesis was observed when cells were stimulated such that ERK phosphorylation was concomitant with increased COX-2 protein expression. Dinoprostone 19-25 mitogen-activated protein kinase 1 Homo sapiens 86-89 16636012-10 2006 In addition, anti-IL-10-neutralizing antibody plus indomethacin could abrogate the inhibitory effects of endogenous IL-10 and prostaglandin E2 on the production of IL-12 by resident pMphi possibly through suppressing ERK activation. Dinoprostone 126-142 mitogen-activated protein kinase 1 Homo sapiens 217-220 16427328-0 2006 Peroxynitrite-modified collagen-II induces p38/ERK and NF-kappaB-dependent synthesis of prostaglandin E2 and nitric oxide in chondrogenically differentiated mesenchymal progenitor cells. Dinoprostone 88-104 mitogen-activated protein kinase 1 Homo sapiens 43-46 16357326-5 2006 PGE2 also caused phosphorylation of extracellular signal-regulated kinase (ERK), exocytosis, and production of prostaglandin D2 (PGD2), as well as leukotriene C4 (LTC4) when protein kinase A (PKA) was inhibited. Dinoprostone 0-4 mitogen-activated protein kinase 1 Homo sapiens 36-73 16357326-5 2006 PGE2 also caused phosphorylation of extracellular signal-regulated kinase (ERK), exocytosis, and production of prostaglandin D2 (PGD2), as well as leukotriene C4 (LTC4) when protein kinase A (PKA) was inhibited. Dinoprostone 0-4 mitogen-activated protein kinase 1 Homo sapiens 75-78 16357326-6 2006 An EP3 receptor-selective agonist, AE-248, mimicked PGE2-mediated ERK phosphorylation, exocytosis, and eicosanoid formation. Dinoprostone 52-56 mitogen-activated protein kinase 1 Homo sapiens 66-69 16357326-10 2006 PGE2 caused the expression of inducible cAMP early repressor (ICER) by a pathway involving PKA and ERK. Dinoprostone 0-4 mitogen-activated protein kinase 1 Homo sapiens 99-102 16272352-6 2005 PGE2 also blocked IL-1beta/TNF-alpha-stimulated ERK activation, and the ERK inhibitor, PD98059, mimicked PGE2 in blocking p65, but enhancing p50 nuclear translocation, suggesting that the effects of PGE2 on p65 and p50 are mediated via effects on ERK. Dinoprostone 0-4 mitogen-activated protein kinase 1 Homo sapiens 48-51 16272352-6 2005 PGE2 also blocked IL-1beta/TNF-alpha-stimulated ERK activation, and the ERK inhibitor, PD98059, mimicked PGE2 in blocking p65, but enhancing p50 nuclear translocation, suggesting that the effects of PGE2 on p65 and p50 are mediated via effects on ERK. Dinoprostone 105-109 mitogen-activated protein kinase 1 Homo sapiens 72-75 16272352-7 2005 PGE2 also enhanced the expression of IkappaBalpha in an ERK-independent manner, suggesting that PGE2 inhibits NF-kappaB activation by both ERK-dependent and -independent mechanisms. Dinoprostone 0-4 mitogen-activated protein kinase 1 Homo sapiens 56-59 16272352-7 2005 PGE2 also enhanced the expression of IkappaBalpha in an ERK-independent manner, suggesting that PGE2 inhibits NF-kappaB activation by both ERK-dependent and -independent mechanisms. Dinoprostone 0-4 mitogen-activated protein kinase 1 Homo sapiens 139-142 16272352-7 2005 PGE2 also enhanced the expression of IkappaBalpha in an ERK-independent manner, suggesting that PGE2 inhibits NF-kappaB activation by both ERK-dependent and -independent mechanisms. Dinoprostone 96-100 mitogen-activated protein kinase 1 Homo sapiens 56-59 16272352-7 2005 PGE2 also enhanced the expression of IkappaBalpha in an ERK-independent manner, suggesting that PGE2 inhibits NF-kappaB activation by both ERK-dependent and -independent mechanisms. Dinoprostone 96-100 mitogen-activated protein kinase 1 Homo sapiens 139-142 16272352-6 2005 PGE2 also blocked IL-1beta/TNF-alpha-stimulated ERK activation, and the ERK inhibitor, PD98059, mimicked PGE2 in blocking p65, but enhancing p50 nuclear translocation, suggesting that the effects of PGE2 on p65 and p50 are mediated via effects on ERK. Dinoprostone 105-109 mitogen-activated protein kinase 1 Homo sapiens 72-75 16272352-6 2005 PGE2 also blocked IL-1beta/TNF-alpha-stimulated ERK activation, and the ERK inhibitor, PD98059, mimicked PGE2 in blocking p65, but enhancing p50 nuclear translocation, suggesting that the effects of PGE2 on p65 and p50 are mediated via effects on ERK. Dinoprostone 105-109 mitogen-activated protein kinase 1 Homo sapiens 72-75 16272352-6 2005 PGE2 also blocked IL-1beta/TNF-alpha-stimulated ERK activation, and the ERK inhibitor, PD98059, mimicked PGE2 in blocking p65, but enhancing p50 nuclear translocation, suggesting that the effects of PGE2 on p65 and p50 are mediated via effects on ERK. Dinoprostone 105-109 mitogen-activated protein kinase 1 Homo sapiens 72-75 15304095-7 2004 In addition, inhibition of ERK or JNK1 reduced the increase of IGF-II-induced prostaglandin E(2) synthesis or cell proliferation. Dinoprostone 78-96 mitogen-activated protein kinase 1 Homo sapiens 27-30 16081678-10 2005 These results suggest that PGE(2) enhances neurotrophin-4 production by activating Sp1 via the EP3/phosphatidylinositol-specific phospholipase C/protein kinase Calpha/MEK1/ERK pathway. Dinoprostone 27-33 mitogen-activated protein kinase 1 Homo sapiens 172-175 16120814-9 2005 We conclude that PAR(2)-triggered PGE(2) formation in A549 cells involves a coordinated up-regulation of COX-2 and mPGES-1 involving cPLA(2), increased cytosolic Ca(2+), PKC, Src, MEK-ERK, p38 MAPK, Src-mediated EGF receptor trans-activation, and also metabolic products of both COX-1 and COX-2. Dinoprostone 34-40 mitogen-activated protein kinase 1 Homo sapiens 184-187 16120814-9 2005 We conclude that PAR(2)-triggered PGE(2) formation in A549 cells involves a coordinated up-regulation of COX-2 and mPGES-1 involving cPLA(2), increased cytosolic Ca(2+), PKC, Src, MEK-ERK, p38 MAPK, Src-mediated EGF receptor trans-activation, and also metabolic products of both COX-1 and COX-2. Dinoprostone 34-40 mitogen-activated protein kinase 1 Homo sapiens 189-192 16120814-9 2005 We conclude that PAR(2)-triggered PGE(2) formation in A549 cells involves a coordinated up-regulation of COX-2 and mPGES-1 involving cPLA(2), increased cytosolic Ca(2+), PKC, Src, MEK-ERK, p38 MAPK, Src-mediated EGF receptor trans-activation, and also metabolic products of both COX-1 and COX-2. Dinoprostone 34-40 mitogen-activated protein kinase 1 Homo sapiens 193-197 16024629-0 2005 Prostaglandin E2 activates mitogen-activated protein kinase/Erk pathway signaling and cell proliferation in non-small cell lung cancer cells in an epidermal growth factor receptor-independent manner. Dinoprostone 0-16 mitogen-activated protein kinase 1 Homo sapiens 60-63 16024629-3 2005 Previous reports have linked the COX-2 product prostaglandin E2 (PGE2) to the abnormal activation of the mitogen-activated protein kinase/Erk kinase pathway. Dinoprostone 47-63 mitogen-activated protein kinase 1 Homo sapiens 138-141 16024629-3 2005 Previous reports have linked the COX-2 product prostaglandin E2 (PGE2) to the abnormal activation of the mitogen-activated protein kinase/Erk kinase pathway. Dinoprostone 65-69 mitogen-activated protein kinase 1 Homo sapiens 138-141 16024629-4 2005 Here we show that PGE2 is able to rapidly stimulate Erk phosphorylation in a subset of non-small cell lung cancer (NSCLC) cell lines. Dinoprostone 18-22 mitogen-activated protein kinase 1 Homo sapiens 52-55 16024629-7 2005 Activation of the Erk pathway by PGE2 was also resistant to src kinase inhibitors but sensitive to the protein kinase C inhibition. Dinoprostone 33-37 mitogen-activated protein kinase 1 Homo sapiens 18-21 16024629-9 2005 Selective inhibition of EP receptors revealed the possible involvement of Ca2+-dependent signaling in PGE2-mediated activation of Erk. Dinoprostone 102-106 mitogen-activated protein kinase 1 Homo sapiens 130-133 16024629-10 2005 Our data indicate the presence of an EGFR-independent activation of the mitogen-activated protein kinase/Erk pathway by PGE2 in NSCLC cells. Dinoprostone 120-124 mitogen-activated protein kinase 1 Homo sapiens 105-108 15661807-6 2005 Inhibitors of MEK/ERK, p38 MAPK, protein kinases A and C impaired the migration of HuH-7 cells induced by PGE2, indicating the involvement of multiple pathways in the process. Dinoprostone 106-110 mitogen-activated protein kinase 1 Homo sapiens 18-21 15995627-5 2005 RESULTS: PGE2 significantly up-regulated VEGF mRNA and protein expression and increased the activation of EGFR and ERK2. Dinoprostone 9-13 mitogen-activated protein kinase 1 Homo sapiens 115-119 15995627-6 2005 Incubation of MKN28 cells with AG1478 significantly reduced PGE2-induced EGFR activity, ERK2 activity, and VEGF mRNA and protein expression. Dinoprostone 60-64 mitogen-activated protein kinase 1 Homo sapiens 88-92 15995627-7 2005 Meanwhile, incubation of MKN28 with PD098059 reduced PGE2-induced ERK2 activity and VEGF mRNA and protein expression, but had no effect on EGFR activity. Dinoprostone 53-57 mitogen-activated protein kinase 1 Homo sapiens 66-70 15995627-8 2005 CONCLUSION: Our data suggested that PGE2 up-regulates VEGF expression in gastric cancer cells via transactivation of EGFR-MAPK signaling pathways, which may be mechanisms underlying the contribution of COX-2 to tumor angiogenesis in gastric cancer. Dinoprostone 36-40 mitogen-activated protein kinase 1 Homo sapiens 122-126 15515144-10 2005 Inhibition of the ERK and p38 MAPK pathways inhibited COX-2 expression and PGE(2) production. Dinoprostone 75-81 mitogen-activated protein kinase 1 Homo sapiens 26-29 15615708-0 2005 Prostaglandin E2 induces MUC8 gene expression via a mechanism involving ERK MAPK/RSK1/cAMP response element binding protein activation in human airway epithelial cells. Dinoprostone 0-16 mitogen-activated protein kinase 1 Homo sapiens 72-75 15615708-0 2005 Prostaglandin E2 induces MUC8 gene expression via a mechanism involving ERK MAPK/RSK1/cAMP response element binding protein activation in human airway epithelial cells. Dinoprostone 0-16 mitogen-activated protein kinase 1 Homo sapiens 76-80 15615708-5 2005 Here, we show that ERK mitogen-activated protein kinase is essential for PGE2-induced MUC8 gene expression in normal human nasal epithelial cells and that p90 ribosomal S 6 protein kinase 1 (RSK1) mediates the PGE2-induced phosphorylation of cAMP-response element binding protein. Dinoprostone 73-77 mitogen-activated protein kinase 1 Homo sapiens 19-22 15780952-0 2005 IL-1-induced receptor activator of NF-kappa B ligand in human periodontal ligament cells involves ERK-dependent PGE2 production. Dinoprostone 112-116 mitogen-activated protein kinase 1 Homo sapiens 98-101 15780952-9 2005 IL-1alpha activated ERK phosphorylation and PD98059 greatly inhibited both COX-2 mRNA expression and PGE(2) production induced by IL-1alpha in PDL cells. Dinoprostone 101-107 mitogen-activated protein kinase 1 Homo sapiens 20-23 15780952-11 2005 These results suggest that IL-1alpha stimulates osteoclast formation by increasing the expression level of RANKL versus OPG via ERK-dependent PGE2 production in PDL cells. Dinoprostone 142-146 mitogen-activated protein kinase 1 Homo sapiens 128-131 15492268-2 2004 Here we tested the hypothesis that the COX-2 product prostaglandin E(2) (PGE(2)) increases cellular invasive potential by inducing matrix metalloproteinase-2 (MMP-2) expression and activity through an extracellular signal-regulated kinase (ERK)/Ets-1-dependent mechanism in pancreatic cancer. Dinoprostone 53-71 mitogen-activated protein kinase 1 Homo sapiens 201-238 15492268-2 2004 Here we tested the hypothesis that the COX-2 product prostaglandin E(2) (PGE(2)) increases cellular invasive potential by inducing matrix metalloproteinase-2 (MMP-2) expression and activity through an extracellular signal-regulated kinase (ERK)/Ets-1-dependent mechanism in pancreatic cancer. Dinoprostone 53-71 mitogen-activated protein kinase 1 Homo sapiens 240-243 15492268-2 2004 Here we tested the hypothesis that the COX-2 product prostaglandin E(2) (PGE(2)) increases cellular invasive potential by inducing matrix metalloproteinase-2 (MMP-2) expression and activity through an extracellular signal-regulated kinase (ERK)/Ets-1-dependent mechanism in pancreatic cancer. Dinoprostone 73-79 mitogen-activated protein kinase 1 Homo sapiens 201-238 15492268-2 2004 Here we tested the hypothesis that the COX-2 product prostaglandin E(2) (PGE(2)) increases cellular invasive potential by inducing matrix metalloproteinase-2 (MMP-2) expression and activity through an extracellular signal-regulated kinase (ERK)/Ets-1-dependent mechanism in pancreatic cancer. Dinoprostone 73-79 mitogen-activated protein kinase 1 Homo sapiens 240-243 11062012-6 2000 Since ERK is implicated in arachidonic acid availability, these data partly explain the ability of ceramide to induce PGE(2) release. Dinoprostone 118-124 mitogen-activated protein kinase 1 Homo sapiens 6-9 15106733-3 2004 The inhibition of the ERK pathway with selective inhibitor, PD098059, blocked cytokine-induced COX-2 expression and PGE2 release. Dinoprostone 116-120 mitogen-activated protein kinase 1 Homo sapiens 22-25 12493746-8 2003 Dedifferentiation-induced COX-2 expression and PGE(2) production were mediated by ERK1/2 and p38 kinase signaling. Dinoprostone 47-53 mitogen-activated protein kinase 1 Homo sapiens 93-96 11854442-2 2002 In this study, the regulatory mechanisms for PGE(2) production during phospholipase D (PLD) and p38-dependent activation of WISH cells were investigated. Dinoprostone 45-51 mitogen-activated protein kinase 1 Homo sapiens 96-99 11875501-5 2002 Here we provide evidence that prostaglandin E2 (PGE2) rapidly phosphorylates EGFR and triggers the extracellular signal-regulated kinase 2 (ERK2)--mitogenic signaling pathway in normal gastric epithelial (RGM1) and colon cancer (Caco-2, LoVo and HT-29) cell lines. Dinoprostone 30-46 mitogen-activated protein kinase 1 Homo sapiens 99-138 11875501-5 2002 Here we provide evidence that prostaglandin E2 (PGE2) rapidly phosphorylates EGFR and triggers the extracellular signal-regulated kinase 2 (ERK2)--mitogenic signaling pathway in normal gastric epithelial (RGM1) and colon cancer (Caco-2, LoVo and HT-29) cell lines. Dinoprostone 30-46 mitogen-activated protein kinase 1 Homo sapiens 140-144 11875501-5 2002 Here we provide evidence that prostaglandin E2 (PGE2) rapidly phosphorylates EGFR and triggers the extracellular signal-regulated kinase 2 (ERK2)--mitogenic signaling pathway in normal gastric epithelial (RGM1) and colon cancer (Caco-2, LoVo and HT-29) cell lines. Dinoprostone 48-52 mitogen-activated protein kinase 1 Homo sapiens 99-138 11875501-5 2002 Here we provide evidence that prostaglandin E2 (PGE2) rapidly phosphorylates EGFR and triggers the extracellular signal-regulated kinase 2 (ERK2)--mitogenic signaling pathway in normal gastric epithelial (RGM1) and colon cancer (Caco-2, LoVo and HT-29) cell lines. Dinoprostone 48-52 mitogen-activated protein kinase 1 Homo sapiens 140-144 11875501-6 2002 Inactivation of EGFR kinase with selective inhibitors significantly reduces PGE2-induced ERK2 activation, c-fos mRNA expression and cell proliferation. Dinoprostone 76-80 mitogen-activated protein kinase 1 Homo sapiens 89-93 11850726-7 2002 Selective blockade of ERK with PD98029 abrogated induction of PGE-2 by Ad vectors. Dinoprostone 62-67 mitogen-activated protein kinase 1 Homo sapiens 22-25 11752134-2 2002 In megakaryocyte-like human erythroleukemia (HEL) cells, ERK2 was found to be predominantly expressed and strongly activated by prostaglandin (PG) E(2), thrombin, and epinephrine. Dinoprostone 128-151 mitogen-activated protein kinase 1 Homo sapiens 57-61 14713309-6 2003 Furthermore, we show that ethanol-induced ERK activation triggers the stimulation of cyclo-oxygenase-2 (COX-2) and the release of prostaglandin E2, and that blockade of the mitogen-activated protein kinase kinase (MEK)/ERK pathway by PD98059 abolishes the up-regulation of COX-2 induced by ethanol plus ceramide, and decreases the ethanol-induced apoptosis. Dinoprostone 130-146 mitogen-activated protein kinase 1 Homo sapiens 42-45 12794156-11 2003 Moreover, p38 regulates MMP-1 mainly through a PGE(2)-dependent pathway, whereas ERK1/2-mediated MMP-1 and MMP-9 production involves the activation of additional MMP promoter sites through a PGE(2)-independent mechanism. Dinoprostone 47-53 mitogen-activated protein kinase 1 Homo sapiens 10-13 12096032-5 2002 PD98059 (MEK1 inhibitor) and SB203580 (p38(MAPK) inhibitor) reduced PGE(2) production as well as COX-2 expression in LPS-stimulated neutrophils. Dinoprostone 68-74 mitogen-activated protein kinase 1 Homo sapiens 39-42 9820549-10 1998 These results demonstrate that activation of MEK/ERK is critical for cytokine and PGE2 production by monocytes in response to LPS. Dinoprostone 82-86 mitogen-activated protein kinase 1 Homo sapiens 49-52 9765255-7 1998 Both early and delayed production of PGE2 counteract the mitogenic effect of PDGF-BB and thrombin because: (i) pretreatment with the COX inhibitor ibuprofen markedly enhances the mitogenic effect of both peptides; (ii) blocking early synthesis of PGE2 greatly enhances extracellular signal-regulated kinase (ERK) activation by both growth factors; (iii) enhancement of DNA synthesis by ibuprofen is only lost when the inhibitor is added after COX-2 induction has occurred. Dinoprostone 37-41 mitogen-activated protein kinase 1 Homo sapiens 269-306 9765255-7 1998 Both early and delayed production of PGE2 counteract the mitogenic effect of PDGF-BB and thrombin because: (i) pretreatment with the COX inhibitor ibuprofen markedly enhances the mitogenic effect of both peptides; (ii) blocking early synthesis of PGE2 greatly enhances extracellular signal-regulated kinase (ERK) activation by both growth factors; (iii) enhancement of DNA synthesis by ibuprofen is only lost when the inhibitor is added after COX-2 induction has occurred. Dinoprostone 37-41 mitogen-activated protein kinase 1 Homo sapiens 308-311 35356289-4 2022 In the progression of hepatocellular carcinoma, PGE2 can promote the proliferation and migration of liver cancer cells by affecting hepatocytes directly and the tumor microenvironment (TME) through ERK/COX-2/PGE2 signal pathway in hepatic stellate cells (HSC). Dinoprostone 48-52 mitogen-activated protein kinase 1 Homo sapiens 198-201 9753607-4 1998 The induction of COX-2 mRNA, COX-2 protein, and prostaglandin (PG)E2 by LPS was inhibited by the specific inhibitors of ERK and p38 MAPK, suggesting that the activation of ERK2 and p38 MAPK is involved in COX-2 expression in LPS-stimulated monocytes. Dinoprostone 48-68 mitogen-activated protein kinase 1 Homo sapiens 120-123 9753607-4 1998 The induction of COX-2 mRNA, COX-2 protein, and prostaglandin (PG)E2 by LPS was inhibited by the specific inhibitors of ERK and p38 MAPK, suggesting that the activation of ERK2 and p38 MAPK is involved in COX-2 expression in LPS-stimulated monocytes. Dinoprostone 48-68 mitogen-activated protein kinase 1 Homo sapiens 128-131 9753607-4 1998 The induction of COX-2 mRNA, COX-2 protein, and prostaglandin (PG)E2 by LPS was inhibited by the specific inhibitors of ERK and p38 MAPK, suggesting that the activation of ERK2 and p38 MAPK is involved in COX-2 expression in LPS-stimulated monocytes. Dinoprostone 48-68 mitogen-activated protein kinase 1 Homo sapiens 172-176 9753607-4 1998 The induction of COX-2 mRNA, COX-2 protein, and prostaglandin (PG)E2 by LPS was inhibited by the specific inhibitors of ERK and p38 MAPK, suggesting that the activation of ERK2 and p38 MAPK is involved in COX-2 expression in LPS-stimulated monocytes. Dinoprostone 48-68 mitogen-activated protein kinase 1 Homo sapiens 181-184 9753607-4 1998 The induction of COX-2 mRNA, COX-2 protein, and prostaglandin (PG)E2 by LPS was inhibited by the specific inhibitors of ERK and p38 MAPK, suggesting that the activation of ERK2 and p38 MAPK is involved in COX-2 expression in LPS-stimulated monocytes. Dinoprostone 48-68 mitogen-activated protein kinase 1 Homo sapiens 132-136 35356289-4 2022 In the progression of hepatocellular carcinoma, PGE2 can promote the proliferation and migration of liver cancer cells by affecting hepatocytes directly and the tumor microenvironment (TME) through ERK/COX-2/PGE2 signal pathway in hepatic stellate cells (HSC). Dinoprostone 208-212 mitogen-activated protein kinase 1 Homo sapiens 198-201 35110422-7 2022 In particular, these data suggest that gingipain-induced c-Fos expression via ERK is essential for AP-1 formation with c-Jun, and activation of AP-1 and NF-kappaB p65 plays a central role in COX-2 expression/PGE2 production. Dinoprostone 208-212 mitogen-activated protein kinase 1 Homo sapiens 78-81 35110422-8 2022 Thus, we show the (to our knowledge) novel finding that gingipains with the protease activity from P. gingivalis induce COX-2 expression and PGE2 production via activation of MEK/ERK/AP-1 and IkappaB kinase/NF-kappaB p65 in human monocytes. Dinoprostone 141-145 mitogen-activated protein kinase 1 Homo sapiens 179-182