PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27388564-12 2016 In addition, LTD4 and PGE2 treatment significantly elevated the plasma levels of cysteinyl leukotrienes and PGE2, as well as levels of IL-1beta, IL-2, IL-6, TNF-alpha and CXCL1/KC/GRO. Dinoprostone 22-26 interleukin 2 Mus musculus 145-149 9301525-6 1997 The addition of exogenous prostaglandin E2 inhibited IL-2 release, while exogenous leukotriene B4 enhanced IL-2 release. Dinoprostone 26-42 interleukin 2 Mus musculus 53-57 19787351-7 2010 Further analysis demonstrated that this may be significantly due to the ability of HPK1 (-/-) T cells to withstand PGE(2)-mediated suppression of T-cell proliferation, IL-2 production, and apoptosis. Dinoprostone 115-121 interleukin 2 Mus musculus 168-172 11876748-0 2002 Placentally derived prostaglandin E2 acts via the EP4 receptor to inhibit IL-2-dependent proliferation of CTLL-2 T cells. Dinoprostone 20-36 interleukin 2 Mus musculus 74-78 26416179-7 2015 In addition, we found that induction of PGE2 expression downregulates the expression of interferon (IFN)-gamma and interleukin (IL)-2, and promotes the secretion of IL-10 in vitro through the EP4 receptor. Dinoprostone 40-44 interleukin 2 Mus musculus 115-133 9617571-0 1998 PGE2 inhibits IL-2 and IL-4-dependent proliferation of CTLL-2 and HT2 cells. Dinoprostone 0-4 interleukin 2 Mus musculus 14-18 9617571-2 1998 Here we have used CTLL-2 and HT2 cells to investigate the effect of the inflammatory mediator prostaglandin E2 (PGE2) on IL-2- and IL-4-dependent proliferation. Dinoprostone 94-110 interleukin 2 Mus musculus 121-135 9617571-2 1998 Here we have used CTLL-2 and HT2 cells to investigate the effect of the inflammatory mediator prostaglandin E2 (PGE2) on IL-2- and IL-4-dependent proliferation. Dinoprostone 112-116 interleukin 2 Mus musculus 121-135 9617571-3 1998 PGE2 inhibited IL-2- as well as IL-4-dependent proliferation of both CTLL-2 and HT2 cells, with IL-4-dependent proliferation being more sensitive than IL-2-dependent proliferation and CTLL-2 cells being more sensitive than HT2 cells. Dinoprostone 0-4 interleukin 2 Mus musculus 15-19 9617571-5 1998 The data suggest that even in cases where synthesis of IL-2 and IL-4 is differentially affected by PGE2, IL-2- and IL-4-dependent T cells may still be similarly sensitive to PGE2 by way of their cytokine responsiveness. Dinoprostone 99-103 interleukin 2 Mus musculus 55-59 9617571-7 1998 PGE2 levels are an important consideration when CTLL-2 and HT2 cells are used for the measurement of IL-4 and IL-2. Dinoprostone 0-4 interleukin 2 Mus musculus 110-114 8595160-13 1996 The findings suggest that the reduced production of IL-2 induced an increase in the production of the PGE2 by progressed tumour lines is involved in the acquisition of resistance. Dinoprostone 102-106 interleukin 2 Mus musculus 52-56 9226467-8 1997 These results suggested that transfection with the gene for IL-2 is an effective strategy against the producing immunosuppressive factors such as PGE2. Dinoprostone 146-150 interleukin 2 Mus musculus 60-64 9089571-7 1997 Addition of PGE2, at concentrations produced by old M phi, decreased proliferation and IL-2 production by young but not old T cells. Dinoprostone 12-16 interleukin 2 Mus musculus 87-91 8674763-0 1996 Effect of pertussis toxin and PGE2 on the functioning of the IL-2 promoter in interleukin-1 treated EL4.NOB-1 thymoma cells. Dinoprostone 30-34 interleukin 2 Mus musculus 61-65 7687200-4 1993 Both interleukin-2 (IL-2) and interferon-gamma (IFN-gamma), two cytokines involved in activating the cellular contact sensitivity reaction, were downregulated by prostaglandin E2 (PGE2) and to a lesser extent by 6-keto PGF2 alpha (PGI2). Dinoprostone 162-178 interleukin 2 Mus musculus 5-18 8088856-0 1994 Effect of prostaglandin E2 on cytotoxic activity and granzyme A protease release by murine adherent IL-2 activated killer cells. Dinoprostone 10-26 interleukin 2 Mus musculus 100-104 7687200-4 1993 Both interleukin-2 (IL-2) and interferon-gamma (IFN-gamma), two cytokines involved in activating the cellular contact sensitivity reaction, were downregulated by prostaglandin E2 (PGE2) and to a lesser extent by 6-keto PGF2 alpha (PGI2). Dinoprostone 162-178 interleukin 2 Mus musculus 20-24 7687200-4 1993 Both interleukin-2 (IL-2) and interferon-gamma (IFN-gamma), two cytokines involved in activating the cellular contact sensitivity reaction, were downregulated by prostaglandin E2 (PGE2) and to a lesser extent by 6-keto PGF2 alpha (PGI2). Dinoprostone 180-184 interleukin 2 Mus musculus 5-18 7687200-4 1993 Both interleukin-2 (IL-2) and interferon-gamma (IFN-gamma), two cytokines involved in activating the cellular contact sensitivity reaction, were downregulated by prostaglandin E2 (PGE2) and to a lesser extent by 6-keto PGF2 alpha (PGI2). Dinoprostone 180-184 interleukin 2 Mus musculus 20-24 8386202-0 1993 Prostaglandin E2-induced changes in the phenotype, morphology, and lytic activity of IL-2-activated natural killer cells. Dinoprostone 0-16 interleukin 2 Mus musculus 85-89 8514459-1 1993 We had earlier shown that tumor-bearing results in an inactivation of IL-2-dependent effector cells by host macrophage-derived PGE2, and that chronic indomethacin therapy (CIT) aimed at blocking prostaglandin synthesis, combined with multiple rounds of IL-2, can cure experimental metastases of a variety of tumors in mice. Dinoprostone 127-131 interleukin 2 Mus musculus 70-74 8386202-3 1993 Inasmuch as uterine NK cell lytic activity is suppressed during pregnancy, apparently due to the effects of PGE2, we have analyzed the effect of PGE2 on the phenotype, morphology, and lytic activity of IL-2-activated NK cells as a model for NK cell differentiation at uterine implantation sites. Dinoprostone 145-149 interleukin 2 Mus musculus 202-206 8386202-4 1993 When cultures of IL-2-activated NK cells were supplemented with 1 microM PGE2, the cells increased in size and granularity, accompanied by an increase in the number of cells expressing the 4H12 Ag. Dinoprostone 73-77 interleukin 2 Mus musculus 17-21 1382857-6 1992 Altogether these data show that when splenocytes are cultured for more than 72 h in the presence of IL-2 and LPS their cytotoxic activity decreases, and it is likely that this diminution is linked to the endogenous production of prostaglandin E2 and INF alpha/beta. Dinoprostone 229-245 interleukin 2 Mus musculus 100-104 8436811-2 1993 PGE2 is an immunomodulator that selectively inhibits the production of lymphokines associated with Th1 cells (IL-2 and IFN-gamma) but not Th2 cells (IL-4 and IL-5). Dinoprostone 0-4 interleukin 2 Mus musculus 110-114 8210948-0 1993 Responsiveness of murine lymphokine-activated killer activity to prostaglandin E2 at late phase of interleukin-2 induction. Dinoprostone 65-81 interleukin 2 Mus musculus 99-112 8210948-1 1993 To elucidate the inhibitory effect of prostaglandin E2 (PGE2) on the generation of recombinant interleukin-2 (IL-2)-induced lymphokine-activated killer (LAK) activity, we have examined the association between cellular 3",5"-cyclic adenosine monophosphate (cAMP) and cytolytic activity of 3-day IL-2-cultured murine LAK cells, i.e. at late phase of IL-2 induction, in the presence and absence of PGE2. Dinoprostone 38-54 interleukin 2 Mus musculus 95-108 8210948-1 1993 To elucidate the inhibitory effect of prostaglandin E2 (PGE2) on the generation of recombinant interleukin-2 (IL-2)-induced lymphokine-activated killer (LAK) activity, we have examined the association between cellular 3",5"-cyclic adenosine monophosphate (cAMP) and cytolytic activity of 3-day IL-2-cultured murine LAK cells, i.e. at late phase of IL-2 induction, in the presence and absence of PGE2. Dinoprostone 38-54 interleukin 2 Mus musculus 110-114 8210948-1 1993 To elucidate the inhibitory effect of prostaglandin E2 (PGE2) on the generation of recombinant interleukin-2 (IL-2)-induced lymphokine-activated killer (LAK) activity, we have examined the association between cellular 3",5"-cyclic adenosine monophosphate (cAMP) and cytolytic activity of 3-day IL-2-cultured murine LAK cells, i.e. at late phase of IL-2 induction, in the presence and absence of PGE2. Dinoprostone 56-60 interleukin 2 Mus musculus 95-108 8210948-1 1993 To elucidate the inhibitory effect of prostaglandin E2 (PGE2) on the generation of recombinant interleukin-2 (IL-2)-induced lymphokine-activated killer (LAK) activity, we have examined the association between cellular 3",5"-cyclic adenosine monophosphate (cAMP) and cytolytic activity of 3-day IL-2-cultured murine LAK cells, i.e. at late phase of IL-2 induction, in the presence and absence of PGE2. Dinoprostone 56-60 interleukin 2 Mus musculus 110-114 8210948-2 1993 The results indicate that, at the late phase of IL-2 induction, LAK cells retain their responsiveness to PGE2 inhibition, and the inhibition can be partially suppressed by additional IL-2 in proportion to the decrease in the ratios of stimulated to basal cellular cAMP levels. Dinoprostone 105-109 interleukin 2 Mus musculus 48-52 8210948-2 1993 The results indicate that, at the late phase of IL-2 induction, LAK cells retain their responsiveness to PGE2 inhibition, and the inhibition can be partially suppressed by additional IL-2 in proportion to the decrease in the ratios of stimulated to basal cellular cAMP levels. Dinoprostone 105-109 interleukin 2 Mus musculus 183-187 2126942-5 1990 These results indicated that IL-2-induced LAK cell activity generated from the splenocytes of tumor-bearing mice was suppressed by IFN-gamma, and that PGE2 secreted from the macrophages of the splenocyte cultures served as the mediator in this IFN-gamma dose-dependent suppression of IL-2-induced LAK cell activity. Dinoprostone 151-155 interleukin 2 Mus musculus 29-33 1534385-11 1992 PGE2 might induce suppression by induction of suppressor cells or by direct suppression of interleukin-2. Dinoprostone 0-4 interleukin 2 Mus musculus 91-104 2028183-2 1991 The coculture of indomethacin with interleukin-2 (IL-2) augmented LAK cell activity in an indomethacin dose-response manner, and diminished PGE2 content in the corresponding culture supernatant in a reverse dose-response manner. Dinoprostone 140-144 interleukin 2 Mus musculus 35-48 2028183-2 1991 The coculture of indomethacin with interleukin-2 (IL-2) augmented LAK cell activity in an indomethacin dose-response manner, and diminished PGE2 content in the corresponding culture supernatant in a reverse dose-response manner. Dinoprostone 140-144 interleukin 2 Mus musculus 50-54 1446774-0 1992 Prostaglandin E2 (PGE2) differentially regulates the production of IL-2 and IL-3 by murine immune T-cells. Dinoprostone 0-16 interleukin 2 Mus musculus 67-71 1446774-0 1992 Prostaglandin E2 (PGE2) differentially regulates the production of IL-2 and IL-3 by murine immune T-cells. Dinoprostone 18-22 interleukin 2 Mus musculus 67-71 1446774-2 1992 In the paper, we have examined the role of prostaglandin (PGE2) production in the regulation of two cytokines, IL-2 and IL-3, which both play a key role in contact sensitivity and delayed type hypersensitivity reactions. Dinoprostone 58-62 interleukin 2 Mus musculus 111-115 2090199-1 1990 We have shown that macrophage-derived prostaglandin (PG)E2 inactivates all interleukin 2 (IL-2) dependent killer cell lineages in the tumor-bearing host, so that chronic indomethacin therapy (CIT) combined with multiple rounds of IL-2 can cure experimental and spontaneous metastases of a variety of murine tumors. Dinoprostone 38-58 interleukin 2 Mus musculus 75-88 2337895-1 1990 We have shown that prostaglandin E2-(PGE2) mediated inactivation of all killer lineage cells is a common event in the tumor-bearing host, so that chronic indomethacin therapy (CIT) combined with multiple rounds of IL-2 cures spontaneous and experimental metastases of a variety of murine tumors by activating killer cells in situ. Dinoprostone 19-35 interleukin 2 Mus musculus 214-218 2337895-1 1990 We have shown that prostaglandin E2-(PGE2) mediated inactivation of all killer lineage cells is a common event in the tumor-bearing host, so that chronic indomethacin therapy (CIT) combined with multiple rounds of IL-2 cures spontaneous and experimental metastases of a variety of murine tumors by activating killer cells in situ. Dinoprostone 37-41 interleukin 2 Mus musculus 214-218 2386979-2 1990 In the present study we demonstrate that prostaglandin E2 substantially inhibited the generation of both LAK and antibody-dependent cellular cytotoxicity (ADCC) activity by IL-2. Dinoprostone 41-57 interleukin 2 Mus musculus 173-177 2090199-1 1990 We have shown that macrophage-derived prostaglandin (PG)E2 inactivates all interleukin 2 (IL-2) dependent killer cell lineages in the tumor-bearing host, so that chronic indomethacin therapy (CIT) combined with multiple rounds of IL-2 can cure experimental and spontaneous metastases of a variety of murine tumors. Dinoprostone 38-58 interleukin 2 Mus musculus 90-94 2090199-1 1990 We have shown that macrophage-derived prostaglandin (PG)E2 inactivates all interleukin 2 (IL-2) dependent killer cell lineages in the tumor-bearing host, so that chronic indomethacin therapy (CIT) combined with multiple rounds of IL-2 can cure experimental and spontaneous metastases of a variety of murine tumors. Dinoprostone 38-58 interleukin 2 Mus musculus 230-234 2957320-5 1987 In the control experiments for immuno-modulating effect, prostaglandin E2 (PGE2) was found to suppress and indomethacin to increase IL-2 production. Dinoprostone 57-73 interleukin 2 Mus musculus 132-136 2521509-6 1989 These observations indicate that there is a subset of TH1 cells receptive to a stimulating activity of PGE2 in the presence of IL-2. Dinoprostone 103-107 interleukin 2 Mus musculus 127-131 2804471-9 1989 These results suggest that the major target (or targets) of PGE2 inhibition directly on T cells lies in the IL-2 signal transduction pathway rather than in the early activation events leading to T cell activation. Dinoprostone 60-64 interleukin 2 Mus musculus 108-112 35086457-15 2022 Furthermore, UC-MSC-derived PGE2 enhanced PD-L1 expression in RAW264.7 cells, which in turn promoted programmed cell death protein 1 (PD-1) expression and reduced IL-2 and IFN-gamma production in Jurkat T cells. Dinoprostone 28-32 interleukin 2 Mus musculus 163-167 3258857-6 1988 The cyclic adenosine monophosphate (cAMP)-elevating agents prostaglandin E2, dibutyryl cAMP, and theophylline inhibited IL-2 production during the early, IL-1-dependent programming stage. Dinoprostone 59-75 interleukin 2 Mus musculus 120-124 2957320-5 1987 In the control experiments for immuno-modulating effect, prostaglandin E2 (PGE2) was found to suppress and indomethacin to increase IL-2 production. Dinoprostone 75-79 interleukin 2 Mus musculus 132-136 3100448-11 1987 These results suggest that IL-2 and some unidentified factor released from plastic-adherent cells by LPS stimulation cooperatively induce IFN-gamma production in activated, Thy-1- and asialo GM1-positive NK-like cells appearing in inflammatory reactions and that prostaglandin E2 regulates IFN-gamma production in these cells. Dinoprostone 263-279 interleukin 2 Mus musculus 27-31 3871360-0 1985 Inhibition of interleukin 2 production by prostaglandin E2 is not absolute but depends on the strength of the stimulating signal. Dinoprostone 42-58 interleukin 2 Mus musculus 14-27 3497889-7 1987 PGE2 was also found to markedly suppress the enhanced production of IL-2 resulting from the addition of IL-1 to Con A stimulated lymphocytes, however, the amount of IL-2 produced in the cultures containing both IL-1 and PGE2 was always greater than that produced in the cultures which contained only PGE2. Dinoprostone 0-4 interleukin 2 Mus musculus 68-72 3497889-7 1987 PGE2 was also found to markedly suppress the enhanced production of IL-2 resulting from the addition of IL-1 to Con A stimulated lymphocytes, however, the amount of IL-2 produced in the cultures containing both IL-1 and PGE2 was always greater than that produced in the cultures which contained only PGE2. Dinoprostone 0-4 interleukin 2 Mus musculus 165-169 3497889-7 1987 PGE2 was also found to markedly suppress the enhanced production of IL-2 resulting from the addition of IL-1 to Con A stimulated lymphocytes, however, the amount of IL-2 produced in the cultures containing both IL-1 and PGE2 was always greater than that produced in the cultures which contained only PGE2. Dinoprostone 220-224 interleukin 2 Mus musculus 165-169 3497889-7 1987 PGE2 was also found to markedly suppress the enhanced production of IL-2 resulting from the addition of IL-1 to Con A stimulated lymphocytes, however, the amount of IL-2 produced in the cultures containing both IL-1 and PGE2 was always greater than that produced in the cultures which contained only PGE2. Dinoprostone 220-224 interleukin 2 Mus musculus 165-169 3497889-8 1987 This finding indicates that IL-1 could partially reverse or antagonize the suppressive effect of PGE2 on IL-2 production. Dinoprostone 97-101 interleukin 2 Mus musculus 105-109 3497889-9 1987 In addition, PGE2 at concentrations of 1.0 and 5.0 ng/ml was also found to inhibit the proliferation of IL-2 stimulated cultured T lymphocytes, but by only about 15-20%. Dinoprostone 13-17 interleukin 2 Mus musculus 104-108 2857750-3 1985 Physiologic concentrations of PGE2 inhibited the induction of IL 2 secretion by the T cell hybridomas tested, when they were activated either by TA3 cells or by mitogenic signals. Dinoprostone 30-34 interleukin 2 Mus musculus 62-66 2857750-4 1985 IL 2 production was inhibited in a dose-dependent manner by concentrations of PGE2 between 10(-7) and 10(-11) M, with 50% inhibition occurring at 10(-10) M. Pretreatment of the T hybridoma cells with 10(-7) M PGE2 for 1 hr before culture also resulted in marked inhibition of IL 2 secretion. Dinoprostone 78-82 interleukin 2 Mus musculus 0-4 2857750-4 1985 IL 2 production was inhibited in a dose-dependent manner by concentrations of PGE2 between 10(-7) and 10(-11) M, with 50% inhibition occurring at 10(-10) M. Pretreatment of the T hybridoma cells with 10(-7) M PGE2 for 1 hr before culture also resulted in marked inhibition of IL 2 secretion. Dinoprostone 78-82 interleukin 2 Mus musculus 276-280 2857750-4 1985 IL 2 production was inhibited in a dose-dependent manner by concentrations of PGE2 between 10(-7) and 10(-11) M, with 50% inhibition occurring at 10(-10) M. Pretreatment of the T hybridoma cells with 10(-7) M PGE2 for 1 hr before culture also resulted in marked inhibition of IL 2 secretion. Dinoprostone 209-213 interleukin 2 Mus musculus 0-4 3492986-7 1987 In separate experiments the effects of exogenous prostaglandin E2 on lymphocyte blastogenesis and IL-2 production were studied, and an increased susceptibility to the inhibitory effects of prostaglandin E2 was observed following thermal injury. Dinoprostone 189-205 interleukin 2 Mus musculus 98-102 3005278-3 1986 In intact cells, IL 2 inhibited both basal and PGE2-stimulated cAMP production; the amount of cAMP generated was dependent upon the relative concentrations of IL 2 and PGE2. Dinoprostone 47-51 interleukin 2 Mus musculus 17-21 3005278-3 1986 In intact cells, IL 2 inhibited both basal and PGE2-stimulated cAMP production; the amount of cAMP generated was dependent upon the relative concentrations of IL 2 and PGE2. Dinoprostone 47-51 interleukin 2 Mus musculus 159-163 3005278-3 1986 In intact cells, IL 2 inhibited both basal and PGE2-stimulated cAMP production; the amount of cAMP generated was dependent upon the relative concentrations of IL 2 and PGE2. Dinoprostone 168-172 interleukin 2 Mus musculus 17-21 3005278-4 1986 The effect of IL 2 on CT6 cell proliferation and cAMP production was mimicked by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), which, like IL 2, causes a translocation and activation of protein kinase C. While PGE2 stimulated adenylate cyclase activity in membrane preparations, neither IL 2 nor TPA inhibited either basal or stimulated membrane adenylate cyclase activity. Dinoprostone 226-230 interleukin 2 Mus musculus 14-18 3005278-4 1986 The effect of IL 2 on CT6 cell proliferation and cAMP production was mimicked by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), which, like IL 2, causes a translocation and activation of protein kinase C. While PGE2 stimulated adenylate cyclase activity in membrane preparations, neither IL 2 nor TPA inhibited either basal or stimulated membrane adenylate cyclase activity. Dinoprostone 226-230 interleukin 2 Mus musculus 155-159 3005278-4 1986 The effect of IL 2 on CT6 cell proliferation and cAMP production was mimicked by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), which, like IL 2, causes a translocation and activation of protein kinase C. While PGE2 stimulated adenylate cyclase activity in membrane preparations, neither IL 2 nor TPA inhibited either basal or stimulated membrane adenylate cyclase activity. Dinoprostone 226-230 interleukin 2 Mus musculus 155-159 3005278-5 1986 However, when CT6 cells were pretreated with IL 2 or TPA and membranes incubated with calcium and ATP, both basal and PGE2-and NaF-stimulated membrane adenylate cyclase activity was inhibited. Dinoprostone 118-122 interleukin 2 Mus musculus 45-49 2578327-6 1985 By contrast, PGE2 had profound inhibitory effects on the ability of T-cell hybridomas to secrete IL-2 in response to Ag/I or concanavalin A. Dinoprostone 13-17 interleukin 2 Mus musculus 97-101