PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17098744-12	2007	S1P injection induced COX-2 in the lungs and livers of mice and increased plasma prostaglandin E(2), and these effects were prevented by Galpha(12) deficiency.	Dinoprostone	81-99	sphingosine-1-phosphate receptor 1	Mus musculus	0-3	
25988659-8	2015	Addition of extracellular S1P to MLO-Y4 cells enhanced the synthesis and release of prostaglandin E2 (PGE2) under static cells and amplified OFF-induced PGE2 release.	Dinoprostone	84-100	sphingosine-1-phosphate receptor 1	Mus musculus	26-29	
25988659-8	2015	Addition of extracellular S1P to MLO-Y4 cells enhanced the synthesis and release of prostaglandin E2 (PGE2) under static cells and amplified OFF-induced PGE2 release.	Dinoprostone	102-106	sphingosine-1-phosphate receptor 1	Mus musculus	26-29	
25988659-8	2015	Addition of extracellular S1P to MLO-Y4 cells enhanced the synthesis and release of prostaglandin E2 (PGE2) under static cells and amplified OFF-induced PGE2 release.	Dinoprostone	153-157	sphingosine-1-phosphate receptor 1	Mus musculus	26-29	
18703638-8	2008	S1P produced dose-dependent increase in COX-2 expression, resulting in increased PGE(2) release from SEMFs.	Dinoprostone	81-87	sphingosine-1-phosphate receptor 1	Mus musculus	0-3	
18178864-11	2008	Our data underscore the importance of S1P in AC-mediated immune regulation, by stabilizing COX-2 mRNA in macrophages, a prerequisite for PGE2 formation.	Dinoprostone	137-141	sphingosine-1-phosphate receptor 1	Mus musculus	38-41	
12890694-5	2003	Sphingosine-1-phosphate (S1P) induced both COX-2 and PGE2 in a dose-responsive manner with an apparent ED50 of 100-300 nM.	Dinoprostone	53-57	sphingosine-1-phosphate receptor 1	Mus musculus	25-28	
12890694-10	2003	By contrast, cells treated with RNAi to S1P lyase or S1P phosphatase enhanced COX-2 induction leading to enhanced generation of PGE2.	Dinoprostone	128-132	sphingosine-1-phosphate receptor 1	Mus musculus	40-43	
12890694-10	2003	By contrast, cells treated with RNAi to S1P lyase or S1P phosphatase enhanced COX-2 induction leading to enhanced generation of PGE2.	Dinoprostone	128-132	sphingosine-1-phosphate receptor 1	Mus musculus	53-56	
12890694-12	2003	Collectively, these results provide novel evidence that SK1 and S1P are necessary for TNF to induce COX-2 and PGE2 production.	Dinoprostone	110-114	sphingosine-1-phosphate receptor 1	Mus musculus	64-67	
29028945-2	2017	Our previous studies indicate that the SphK1/S1P pathway mediates colon carcinogenesis at least by regulating cyclooxygenase 2 (COX-2) expression and prostaglandin E2 (PGE2) production.	Dinoprostone	150-166	sphingosine-1-phosphate receptor 1	Mus musculus	45-48	
29028945-2	2017	Our previous studies indicate that the SphK1/S1P pathway mediates colon carcinogenesis at least by regulating cyclooxygenase 2 (COX-2) expression and prostaglandin E2 (PGE2) production.	Dinoprostone	168-172	sphingosine-1-phosphate receptor 1	Mus musculus	45-48